Negative / Null Result ReportOpen accessDiseases of the digestive system. Gastroenterology
Tadataka Takagi, Fumikazu Koyama, Hiroyuki Kuge et al. · 2024 · Journal of the Anus, Rectum and Colon
Objectives: This study aimed to investigate the impact of the COVID-19 pandemic on the examination and treatment of colorectal cancer (CRC) and on the behaviors of patients and practitioners. Methods: This is a retrospective analysis of the CRC patients who presented to our department between April 2019 and March 2021 and underwent surgery. Clinical presentation of CRC and time from symptom onset to medical presentation were compared between the control (April 2019 to March 2020, n=124) and COVID-19 pandemic periods (April 2020 to March 2021, n=111). Results: Two hundred and thirty-five patien
View details →DOI: 10.23922/jarc.2023-034 Negative / Null Result ReportOpen accessEcology
Imed Nouri, Khouloud Chaabane, Rym Bouzaabia · 2026 · Nature Conservation
Immersive virtual reality is increasingly being used as a tool for promoting environmental awareness, particularly to strengthen engagement with nature. However, most research has focused on the short-term effects of a single exposure, neglecting the issue of sustainability and the potential reinforcement of effects through repeated exposure. Furthermore, few studies have examined the role of affective factors such as love and care for nature in this context. The aim of this study was to examine short- and long-term differences in levels of environmental awareness and pro-conservation behavior
View details →DOI: 10.3897/natureconservation.63.176597 Negative / Null Result ReportOpen accessMedicine
Sadan Soyyigit, Onur Baykara, Nur Buyru et al. · 2013 · Medicine Science
Chronic obstructive pulmonary disease (COPD) is a disease which genetic and environmental factors play an important role in COPD development. VDBP (Vitamin D Binding Protein ) gene might be responsible for COPD development. The purpose of this study to investigate the possible effect of VDBP on progression of COPD. We studied VDBP genotypes in 75 COPD patients, 36 smoker healthy subjects and 19 non-smoker healthy subjects with PCR-RFLP method to analyze the association between VDBP and COPD. In our study, the most frequently seen genotype was 1S-2 with a frequency of 32% in COPD group; and 1F-
View details →DOI: 10.5455/medscience.2012.01.8040 Negative / Null Result ReportOpen accessScience
Felix Willmer, Claire Reuter, Stephan Pramsohler et al. · 2023 · Life
Background: Athletes often experience poor sleep quality due to stress, altitude exposure, travel across different time zones, and pre-competition nervousness. Coaches use daytime naps to counteract the negative effects of fragmented nighttime sleep. Napping before competitions has also been used to enhance performance in athletes without sleep problems, with mixed results in previous studies, particularly for endurance performance. Thus, we investigated the effects of napping after partial sleep deprivation (PSD) on endurance performance and wakefulness in athletes. Methods: We recruited 12 h
View details →DOI: 10.3390/life13061414 Negative / Null Result ReportOpen accessPlant culture
Simone Pietro Garofalo, Vincenzo Giannico, Beatriz Lorente et al. · 2024 · Frontiers in Plant Science
IntroductionIn the context of climate change, monitoring the spatial and temporal variability of plant physiological parameters has become increasingly important. Remote spectral imaging and GIS software have shown effectiveness in mapping field variability. Additionally, the application of machine learning techniques, essential for processing large data volumes, has seen a significant rise in agricultural applications. This research was focused on carob tree, a drought-resistant tree crop spread through the Mediterranean basin. The study aimed to develop robust models to predict the net assim
View details →DOI: 10.3389/fpls.2024.1302435 Negative / Null Result ReportOpen accessDentistry
Sara Ordooei Javan, Reza Movahedian, Somayeh Hosseini Tabatabaei · 2025 · Dental Research Journal
Background: During the incremental technique of composite restorations, it is possible to be exposed to contamination of the oral environment. This study aimed to compare the effect of saliva contamination and different methods of saliva decontamination on microshear bond strength within composite surfaces. Materials and Methods: This in vitro study created 24 rectangular XT composite blocks using a silicone mold (24 mm × 10 mm × 10 mm). The blocks were divided into eight groups as follows: Group 1: Control group (without contamination); Group 2: Contaminated with saliva; Group 3: saliva + dri
View details →DOI: 10.4103/drj.drj_736_23 Negative / Null Result ReportOpen accessTherapeutics. Pharmacology
Jiagen Wen, Meizi Zeng, Zhaoqian Liu et al. · 2019 · Journal of Pharmacological Sciences
Metformin is the most widely used drug among type 2 diabetes mellitus patients. However, drug interaction on metformin will influence its glucose-lowering effect or increase its side effect of lactic acidosis. In this study, a randomized, two-stage, crossover study was conducted to unveil the potential drug interaction between metformin and the anti-hypertension drug, telmisartan. Totally, 16 healthy Chinese male volunteers were enrolled. Blood samples from various time-points after drug adminstration were analyzed for metformin quantification. Oral glucose tolerance test (OGTT) was conducted
View details →DOI: 10.1016/j.jphs.2018.11.007 Negative / Null Result ReportOpen accessGynecology and obstetrics
Yahya Irwanto · 2012 · Indonesian Journal of Obstetrics and Gynecology
Objective: To know whether the expression of Fas Ligand has correlation with incidene of metastasis of pelvic lymph node and lymph-vascular stromal invasion (LVSI). Methods: All patients diagnosed of cervical cancer stage IB or IIA who underwent radical hysterectomy in Dr. Cipto Mangunkusumo Central General Hospital from January 2008 until December 2009 were included in analytic cross sectional study. We tested expression of Fas Ligand in cervical cancer specimen by immunohystochemistry with monoclonal antibody. The expression of Fas Ligand was compared between the group of patients with a pos
View details →DOI: 10.32771/inajog.v36i4.325 Negative / Null Result ReportOpen accessScience (General)
Afsoon Motallebi, Mehdi Fathi, Fatemeh Mazhari et al. · 2024 · Heliyon
Background: This randomized clinical trial (RCT) investigated whether hypnosis would lead to favorable outcomes in reducing anxiety, enhancing cooperation, and improving physiological responses in school-aged children undergoing tooth extraction compared to nitrous oxide/oxygen (N2O/O2) and conventional behavior guidance (CBG). Methods: Sixty-six school-aged children (mean age: 7.87 ± 1.18 years) who needed one posterior primary tooth extraction were included. Children with low-to-moderate anxiety were randomly divided into three groups (n = 22 each): hypnosis, N2O/O2, and CBG. Anxiety levels
View details →DOI: 10.1016/j.heliyon.2024.e35223 Negative / Null Result ReportOpen accessMedicine
Joan Hermosura, Everett Lohman, Brenda Bartnik-Olson et al. · 2024 · PLoS ONE
Objectives The main purpose of this research study was to compare mean modified straight-leg raise test (mSLR) and hamstring muscle length (HL) between chronic non-specific low back pain (LBP) and healthy subjects to understand the possibility of neuropathic causes in LBP population as it may impact the diagnosis and treatment of LBP. Another purpose was to compare mean mSLR between those with lumbar nerve root impingement and those without as determine by magnetic resonance imaging (MRI). Methods The design of the study is cross sectional and included 32 subjects with ages ranging from 18-50
View details →DOI: 10.1371/journal.pone.0298257 Negative / Null Result ReportOpen accessDentistry
Sonam Mufti, Sarvagna Mayank Dadawala, Phoram Patel et al. · 2017 · Contemporary Clinical Dentistry
Background: One of the most common aesthetic problem encountered in the field of periodontology is gingival recession, which is, perceived by the patients as increase in length of teeth. The treatment of buccal gingival recession is a common requirement due to aesthetic concern or root sensitivity. This study was planned to evaluate the efficacy of PRF membrane compared to that of CTG in Miller's class I gingival recessions. Materials and Methods: 32 sites with Miller's Class I gingival recessions, out of which 16 sites received PRF (test) and 16 sites received CTG (control). Each patient had
View details →DOI: 10.4103/ccd.ccd_325_17 Negative / Null Result ReportOpen accessDentistry
Huiying Li, Huiying Li, Tong Wang et al. · 2025 · Frontiers in Dental Medicine
BackgroundReattachment of root fragments with appropriate adhesive materials is expected to be the last conservative treatment for preserving teeth with vertical root fractures (VRFs).ObjectiveThis study evaluated the biocompatibility of 4-META/MMA-TBB resin for root repair, compared with iRoot BP Plus, Fuji IX GIC, and Clearfil SA Luting. Fracture resistance and microleakage of the reattached roots were also tested.MethodsThe biocompatibility of set materials was evaluated on L929 fibroblasts. Cell Counting Kit-8 (CCK-8) assay, live/dead cells staining and flow cytometry were used to assess c
View details →DOI: 10.3389/fdmed.2025.1593189 Negative / Null Result ReportOpen accessDiseases of the digestive system. Gastroenterology
Saixin Li, Zheng Wang, Zheng Li et al. · 2024 · BMC Gastroenterology
Abstract Background T-tube cholangiography and choledochoscopy are commonly used techniques for detecting residual bile duct stones after biliary surgery. However, the utility of routine cholangiography before T-tube removal needs further investigation. This study aims to evaluate the diagnostic efficacy of various methods for detecting residual calculi following biliary surgery. Methods We retrospectively analyzed the clinical data of 287 adult patients who underwent common bile duct exploration with T-tube drainage, followed by T-tube cholangiography and choledochoscopy, at the Department of
View details →DOI: 10.1186/s12876-024-03474-7 Negative / Null Result ReportOpen accessMedicine
Rudhir Jaga, Dinell Behari, Anton P Doubell et al. · 2022 · African Journal of Emergency Medicine
Introduction: Intended for use by prehospital first responders, the Lubo TM cervical collar is an adjustable, radiolucent, single-use device that incorporates a mechanical jaw thrust mechanism. The combination enables non-invasive airway management in cases of trauma where cervical motion restriction is necessary. The potential benefits include use as an airway adjuvant maintaining upper airway patency, reducing provider task loading. The limited research on the device efficacy and safety requires further investigation.Methods: A randomized, crossover, interventional study was performed to com
View details →DOI: 10.1016/j.afjem.2022.07.008 Negative / Null Result ReportOpen accessGynecology and obstetrics
Janace J. Gifford, Jenna R. Pluchino, Rebecca Della Valle et al. · 2021 · Frontiers in Global Women's Health
Purpose: The purpose of this study was to assess the association between various risk factors with postpartum depression severity using a large dataset that included variables such as previous mental health status, social factors, societal factors, health care access, and other state-wide or region-specific variables.Methods: We obtained the most recently available (2016–2017) dataset from the Pregnancy Risk Assessment Monitoring System (PRAMS), which is a dataset compiled by the Centers for Disease Control (CDC) that collects state-specific, population-based data on maternal attitudes and exp
View details →DOI: 10.3389/fgwh.2021.726422 Negative / Null Result ReportOpen accessMedicine
Bejo Utomo Handayani, Luwih Bisono, Dadik Wahyu Wijaya et al. · 2025 · JAI (Jurnal Anestesiologi Indonesia)
Background: Antiseptics or germicides are chemical compounds used to kill or inhibit the growth of microorganisms on living tissue such as the surface of the skin and mucous membranes. Objective: To determine the comparative effectiveness of povidone iodine 10% antiseptic compared to octenidine hydrochloride 0.1% in neuraxial blockade in patients undergoing surgery at Haji Adam Malik General Hospital, Medan. Methods: This study is an experimental study of the two-group pre-test - post-test study type. This design is a design that groups patients into certain groups that receive different treat
View details →DOI: 10.14710/jai.v0i0.62613 Negative / Null Result ReportOpen accessBiology (General)
Yoshihide Usami, Yoshino Mizobuchi, Mai Ijuin et al. · 2022 · Marine Drugs
The enantiomers of 6-fluoro-, 6-bromo-, and 6-iodopericosine A were synthesized. An efficient synthesis of both enantiomers of pericoxide via 6-bromopericosine A was also developed. These 6-halo-substituted pericosine A derivatives were evaluated in terms of their antitumor activity against three types of tumor cells (p388, L1210, and HL-60) and glycosidase inhibitory activity. The bromo- and iodo-congeners exhibited moderate antitumor activity similar to pericosine A against the three types of tumor cell lines studied. The fluorinated compound was less active than the others, including perico
View details →DOI: 10.3390/md20070438 Negative / Null Result ReportOpen accessGeriatrics
Sun Ju Chang, Kyoung-eun Lee, Eunjin Yang et al. · 2022 · BMC Geriatrics
Abstract Background The Internet is considered an important channel for providing health information to older adults. We developed an intervention to improve eHealth literacy in older adults according to the information-motivation-behavioral skills (IMB) theory and Intervention Mapping. This study aimed to analyze the effect of a developed intervention on information, motivation, behavioral skills, and behaviors related to eHealth information in older adults. Methods Forty-six older adults over the age of 65 were recruited from two senior welfare centers in a city in South Korea. We divided th
View details →DOI: 10.1186/s12877-022-03545-y Negative / Null Result ReportOpen accessMedicine
Omar Mustafa, Ebtehal Mohamed, Ahmed Omer et al. · 2022 · Sudan Journal of Medical Sciences
Abstract Background: Tuberculosis (TB) is a major healthcare burden in Sudan and other developing countries, it is considered the second most common cause of death from infectious diseases after those due to AIDS. In Sudan, TB lymphadenitis (TBLA) remains one of the major health problems. This descriptive cross-sectional study was conducted at the University of Medical Sciences and Technology (UMST) and Total Labcare Diagnostic Center (TDC). The study aims to compare the sensitivity of Fine Needle Aspiration Cytology (FNAC) smears with that of the Polymerase Chain Reaction (PCR) for the diagno
View details →DOI: 10.18502/sjms.v17i3.12103 Negative / Null Result ReportOpen accessDiseases of the circulatory (Cardiovascular) system
Jing Zhang, Chengcheng Shao, Jiajia Zhu et al. · 2025 · Frontiers in Cardiovascular Medicine
BackgroundThis study investigated the clinical characteristics of in-hospital cardiac arrest (IHCA) in patients with acute myocardial infarction (AMI) complicated by cardiogenic shock and assessed the related in-hospital and post-discharge mortality.MethodsThis study included 148 patients with AMI complicated by cardiogenic shock who were admitted to the Cardiac Critical Care Center, Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University between September 1, 2021 and July 31, 2024. Study participants were divided into two groups according to the occurrence of IHCA (IHCA
View details →DOI: 10.3389/fcvm.2025.1663933 Negative / Null Result ReportOpen accessEnvironmental sciences
Fahrimal Yudha, Asmilia Nuzul, Aisyah Siti et al. · 2020 · E3S Web of Conferences
As one of the Local wisdom in Aceh, farmer prefers raising polled cow than horned cow for breeding purposes. They believe pole cow is more resilient in harsh conditions and reproductively better than the horned cow. The aim of this study was to evaluate blood profile and blood biochemistry of the aceh polled and horned cow. The blood profile examined includes erythrocyte value, erythrocyte indices MCV (Mean Corpuscular Volume), MCH (Mean Corpuscular Hemoglobin), MCHC (Mean Corpuscular Hemoglobin Concentration), thrombocyte, leukocyte, hematocrit, and hemoglobin, while blood biochemistry includ
View details →DOI: 10.1051/e3sconf/202015101056 Negative / Null Result ReportOpen accessEngineering (General). Civil engineering (General)
Amar Thamir Hamad, Musaab Al-Tamer · 2011 · Tikrit Journal of Engineering Sciences
In this study the characteristics of raw and treated wastewater from Ninava drug factory were evaluated. The results revealed that the strength of raw wastewater can be classified as medium concentrated wastewater with respect to its BOD5 since the average value is 231.7 mg/l. In addition a strong correlations were found between many characteristics of raw waste. The characteristics of produced effluent from waste water treatment plant of the factory were within the Iraqi specification for the disposed wastewater constraints in 1997, where the average is 7.8 for pH, 40mg/l for SS, 2.8 mg/l for
View details →DOI: 10.25130/tjes.18.4.12 Negative / Null Result ReportOpen accessMedicine
Hadi Ghaedi, Siamak Takesh, Ebrahim Banitalebi · 2020 · Journal of Shahrekord University of Medical Sciences
Background and aims: Exercise training is a well-established therapeutic tool for treating type 2 diabetes. The purpose of this study is to examine the beneficial effects of personalized sprint interval training (SIT) and combined aerobic endurance and resistance training (Com) on insulin resistance and glycated hemoglobin A1c (HbA1c) concentration in women with type 2 diabetes. Methods: Fifty-two overweight female type 2 diabetic patients (age 45-60 years and body mass index [BMI] > 30) with HbA1c value of 6.5% or higher and fasting blood glucose (FBG) ≥ 126 mg/dL (7.0 mmol/L) were selected.
View details →DOI: 10.34172/jsums.2020.18 Negative / Null Result ReportOpen accessDentistry
Gustavo Vicentis De Oliveira Fernandes, Nuno Bernardo Malta Santos, Rafael Amorim Cavalcanti De Siqueira et al. · 2021 · Journal of Indian Society of Periodontology
Background: Autologous platelet concentrate (APC)/platelet-rich fibrin (PRF) of second and third generations has increased use in periodontics to optimize wound healing. Few systematic reviews (SRs) have reported improved clinical outcomes, while other studies reported significantly better results for the connective tissue graft (CTG). There is still unclear clinical evidence about APC/PRF use to treat gingival recession (GR) defects. Then, the purpose of this SR was to evaluate the use of APC/PRF membranes (2nd and 3rd generations) in root coverage (RC) procedures and assess its efficacy as a
View details →DOI: 10.4103/jisp.jisp_515_20 Negative / Null Result ReportOpen accessInfectious and parasitic diseases
Chiu Rossa WK, Chim Stephen SC, Wu Alan KL et al. · 2005 · BMC Infectious Diseases
Abstract Background It has been postulated that genetic predisposition may influence the susceptibility to SARS-coronavirus infection and disease outcomes. A recent study has suggested that the deletion allele (D allele) of the angiotensin converting enzyme ( ACE ) gene is associated with hypoxemia in SARS patients. Moreover, the ACE D allele has been shown to be more prevalent in patients suffering from adult respiratory distress syndrome (ARDS) in a previous study. Thus, we have investigated the association between ACE insertion/deletion (I/D) polymorphism and the progression to ARDS or requ
View details →DOI: 10.1186/1471-2334-5-26 Negative / Null Result ReportOpen accessMedicine
Seyed Jalal Hashemi, Hamidreza Shetabi, Shayan Saki et al. · 2018 · مجله دانشکده پزشکی اصفهان
Background: The purpose of this study was to compare the effect of endotracheal intubation in three methods of oral, and nasal with and without the help of Magill forceps, on heart rate and blood pressure in patients undergoing maxillofacial surgery. Methods: In this single-blind randomized clinical trial study, 96 patients who underwent facial and maxillofacial surgery, were randomly divided into three groups of oral, and nasal (with or without the use of Magill forceps) endotracheal intubation. Heart rate and blood pressure were studied in patients before the intubation, and 0, 1, 2, 5, and
View details →DOI: 10.22122/jims.v36i499.10673 Negative / Null Result ReportOpen accessOrthopedic surgery
Jinli Guo, Chaona Gao, Haifeng Xin et al. · 2019 · Journal of Orthopaedic Surgery and Research
Abstract Purposes Hip fracture leads to decreased activity and an increased risk of pulmonary complications. The main purpose of this study was to observe the lung capacity, cough capacity of the elderly patient with acute hip fracture, and assess the effects and the feasibility of using a special-designed “upper-body yoga” training to treat elderly patients with hip fracture. Methods This was a prospective, randomized, and single-blind study. Eighty-four subjects aged over 65 years were randomly divided into either a control group or a yoga group to undergo an abdominal breathing program or a
View details →DOI: 10.1186/s13018-019-1295-6 Negative / Null Result ReportOpen accessDentistry
Alireza Eshghi, Maryam Hajiahmadi, Mohammad Hossein Nikbakht et al. · 2022 · International Journal of Dentistry
Introduction. Among the new therapeutic materials, MTA and Biodentine are recommended for pulpotomy and sealing the pulp. Considering the similar characteristics of these two materials and considering that their effects on the treatment of primary second molars with irreversible pulpitis have not been compared properly, this study aimed to compare clinical and radiographic success between MTA and Biodentine in pulpotomy of primary mandibular second molars with irreversible pulpitis. Materials and Methods. This study was conducted as a randomized double-blind clinical trial. Participants were s
View details →DOI: 10.1155/2022/6963944 Negative / Null Result ReportOpen accessAgriculture (General)
Jinglei Zhang, Shanshan Bai, Chunlin Jia et al. · 2025 · Agriculture
Agricultural expansion and intensification generally lead to a depletion in soil organic carbon (SOC). While converting cropland to grassland is a recognized strategy for SOC accumulation, the patterns of SOC accumulation under different grassland types and soil conditions remain unclear. This study evaluated the long-term effects of two perennial grasses—alfalfa (a legume) and switchgrass (a non-legume)—on SOC composition, specifically lignin phenols and amino sugars, in non-saline and saline–alkali soils, using a conventional wheat–maize rotation as a control. Our results showed that both al
View details →DOI: 10.3390/agriculture15222393 Negative / Null Result ReportOpen accessAnimal culture
Yosua Kristian Adi, Rini Widayanti, Tri Wahyu Pangestiningsih · 2018 · Veterinary World
Aim: n-Propanol extracts from fresh, boiled, and fermented seeds were studied to evaluate their neuroprotective effects in a Parkinson's disease (PD) rat model, based on the total number of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNpc). Materials and Methods: Rats were induced with paraquat dichloride at a dosage of 7 mg/kg BW intraperitoneally twice a week and at the same time supplemented with extract at a dosage of 70 mg/kg BW orally every day for 3 weeks. On the 24th day, all rats were perfused and fixed with 4% paraformaldehyde. The left part of the SNpc was proce
View details →DOI: 10.14202/vetworld.2018.1250-1254 