The influence of telmisartan on metformin pharmacokinetics and pharmacodynamics
Jiagen Wen; Meizi Zeng; Zhaoqian Liu; Honghao Zhou; Heng Xu; Min Huang; Wei Zhang · 2019 · Journal of Pharmacological Sciences
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Metformin is the most widely used drug among type 2 diabetes mellitus patients. However, drug interaction on metformin will influence its glucose-lowering effect or increase its side effect of lactic acidosis. In this study, a randomized, two-stage, crossover study was conducted to unveil the potential drug interaction between metformin and the anti-hypertension drug, telmisartan. Totally, 16 healthy Chinese male volunteers were enrolled. Blood samples from various time-points after drug adminstration were analyzed for metformin quantification. Oral glucose tolerance test (OGTT) was conducted
Abstract by Jiagen Wen; Meizi Zeng; Zhaoqian Liu; Honghao Zhou; Heng Xu; Min Huang; Wei Zhang, Journal of Pharmacological Sciences (2019) — licensed CC BY 4.0.
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Metadata source: DOAJ · DOI 10.1016/j.jphs.2018.11.007