n-Propanol extract of boiled and fermented koro benguk (Mucuna pruriens seed) shows a neuroprotective effect in paraquat dichloride-induced Parkinson's disease rat model
Yosua Kristian Adi; Rini Widayanti; Tri Wahyu Pangestiningsih · 2018 · Veterinary World
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Aim: n-Propanol extracts from fresh, boiled, and fermented seeds were studied to evaluate their neuroprotective effects in a Parkinson's disease (PD) rat model, based on the total number of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNpc). Materials and Methods: Rats were induced with paraquat dichloride at a dosage of 7 mg/kg BW intraperitoneally twice a week and at the same time supplemented with extract at a dosage of 70 mg/kg BW orally every day for 3 weeks. On the 24th day, all rats were perfused and fixed with 4% paraformaldehyde. The left part of the SNpc was proce
Abstract by Yosua Kristian Adi; Rini Widayanti; Tri Wahyu Pangestiningsih, Veterinary World (2018) — licensed CC BY 4.0.
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Metadata source: DOAJ · DOI 10.14202/vetworld.2018.1250-1254