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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

21742 results · page 535 of 725

Negative / Null Result ReportMedicine

Short-term Treatment with Metformin During Puberty Mitigates Metabolic Dysfunctions Programmed by Neonatal Overfeeding in Male Rats.

Raposo SR, Lopes RP, Barbosa LF et al. · 2026 · Archives of medical research

Objective To address the major public health problems of increased body weight and obesity, causing conditions such as hypertension and diabetes. Early obesity in childhood and adolescence has more severe long-term health consequences. The…

View details →DOI: 10.1016/j.arcmed.2026.103386
Negative / Null Result ReportOpen accessMedicine

Preliminary Assessment of Pisotriquetral Joint Kinematics Following Transverse Carpal Ligament Release: A Cadaveric Pilot Study.

Israeli R, Steinmetz C, Gannot G et al. · 2026 · Cureus

Introduction Transverse carpal ligament (TCL) release is the standard treatment for carpal tunnel syndrome; however, its potential to alter carpal biomechanics is unclear. Specifically, it has been hypothesized that TCL transection may…

View details →DOI: 10.7759/cureus.101067
Negative / Null Result ReportMedicine

4-year overall survival after the introduction of adjuvant therapy for patients with stage III melanoma: A population-based study.

Janssen JC, Schurink AW, Verhoef C et al. · 2026 · European journal of cancer (Oxford, England : 1990)

Background Adjuvant systemic therapy for resected stage III melanoma was introduced in clinical practice following the improved recurrence free survival in randomized controlled trials. However, after ten years of follow-up, adjuvant…

View details →DOI: 10.1016/j.ejca.2025.116202
Negative / Null Result ReportMedicine

Harvesting of Peroneus Longus Tendon Autograft.

Liang C, He J · 2025 · Journal of visualized experiments : JoVE

Autografts are always used in anterior cruciate ligament (ACL) reconstruction. Traditional sources, such as hamstring tendons, bone-patellar tendon-bone, and quadriceps tendon, are popular choices but may result in muscle imbalances and…

View details →DOI: 10.3791/66390
Negative / Null Result ReportMedicine

Medial Patellofemoral Ligament Reconstruction in Adolescent Patellofemoral Instability With High Tibial Tubercle-Trochlear Groove Intervals: A Comparison of With or Without Tibial Tubercle Osteotomy.

Grewal RS, Berger GK, Pennock AT et al. · 2026 · Journal of pediatric orthopedics

Background Patellofemoral instability is common in adolescent patients and is frequently associated with increased tibial tuberosity-trochlear groove (TT-TG) distances. Medial patellofemoral ligament (MPFL) reconstruction is a standard…

View details →DOI: 10.1097/bpo.0000000000003200
Negative / Null Result ReportMedicine

Efficacy of a Phase III Cardiac Rehabilitation Program on Physical Exercise in Patients with Ischemic Heart Disease: A Cluster Randomized Controlled Trial.

Santaularia N, Arnau A, Torà N et al. · 2026 · Journal of cardiopulmonary rehabilitation and prevention

Purpose Our purpose was to assess the efficacy of a phase III cardiac rehabilitation (CR) program, based on counseling in the maintenance of physical exercise, on the time spent on physical exercise per week in patients with ischemic heart…

View details →DOI: 10.1097/hcr.0000000000000993
Negative / Null Result ReportMedicine

Rediscovering a Neotropical anuran fluke: a morphological and phylogenetic study of <i>Rauschiella proxima</i> (Trematoda: Plagiorchioidea).

Queiroz MS, López-Hernández D, Anjos LA et al. · 2025 · Journal of helminthology

Species of the genus Rauschiella are trematodes of frogs and snakes in the Americas. The taxonomy of the group is complex, and most of the 18 currently valid species are known only from the original description. Moreover, genetic data are…

View details →DOI: 10.1017/s0022149x25100874
Negative / Null Result ReportMedicine

Outcomes of Pars Plana Vitrectomy in Inherited Retinal Degenerations.

Al-Moujahed A, Lu ES, Zhou HW et al. · 2026 · Ophthalmology. Retina

Purpose To describe the management and outcomes of pars plana vitrectomy (PPV) for common surgical retinal conditions, including epiretinal membrane (ERM), full-thickness macular hole (FTMH), and retinal detachment, in patients with…

View details →DOI: 10.1016/j.oret.2025.12.013
Negative / Null Result ReportMedicine

Procedural eptifibatide administration as an alternative to preprocedural dual antiplatelet therapy for patients undergoing flow diversion procedures: case series and review of the literature.

Mosallami Aghili SM, Santori D, Denice C et al. · 2025 · Journal of neurointerventional surgery

Introduction Pretreatment with dual antiplatelet agents (DAPT) has been standard practice for patients undergoing aneurysm treatment with flow diversion (FD). Rates of periprocedural diffusion lesions observed after FD procedures remain…

View details →DOI: 10.1136/jnis-2025-024406
Negative / Null Result ReportOpen accessMedicine

The impact of violation of the proportional hazards assumption on the discrimination of the Cox proportional hazards model.

Austin PC, Giardiello D · 2026 · Diagnostic and prognostic research

Background The Cox proportional hazards regression model is frequently used to estimate an individual's probability of experiencing an outcome within a specified prediction horizon. A key assumption of this model is that of proportional…

View details →DOI: 10.1186/s41512-026-00223-0
Negative / Null Result ReportMedicine

Instructed increase in fear activation during exposure exercises does not enhance treatment effects of cognitive behavioral therapy for panic disorder and agoraphobia.

Richter J, Hamm AO, Lang T et al. · 2026 · Behaviour research and therapy

The efficacy of exposure-based cognitive behavioral therapy (eCBT) for panic disorder and agoraphobia (PD/AG) is well established, but the mechanisms of action are still under debate. Here we investigated whether increased fear activation…

View details →DOI: 10.1016/j.brat.2025.104946
Negative / Null Result ReportMedicine

Improvements in pharmacokinetics, bleeding control, and cost analysis after PK-guided transition to extended-half-life factor IX in hemophilia B: A multicentric study.

Chovi-Trull M, Megías-Vericat JE, Palanques-Pastor T et al. · 2026 · Thrombosis research

Introduction Extended half-life factor IX concentrates (FIX-EHL) have been shown to improve clinical outcomes and reduce treatment burden in patients with hemophilia B (HB). Objectives To analyze the differences in pharmacokinetic (PK) and…

View details →DOI: 10.1016/j.thromres.2025.109580
Negative / Null Result ReportMedicine

Calcium silicate-based bone cement incorporated with carbon nanotubes (CNT)<i>: In vitro</i> and <i>in vivo</i>.

Silva LAS, Fernandes MS, Campos TMB et al. · 2026 · Journal of biomaterials applications

Calcium silicate cements (CaSiO 3 ) are widely used in bone repair treatments for both medical and dental applications. To meet the demands of tissue engineering, three calcium silicate cements were developed: a control group without…

View details →DOI: 10.1177/08853282251405355
Negative / Null Result ReportOpen accessMedicine

Opicapone for the Treatment of Nocturnal Hypokinesia in Patients With Parkinson's Disease: An Open-Label Pilot Clinical Trial.

Shin C, Kim JM · 2026 · Journal of movement disorders

Nocturnal hypokinesia (NH) is common in patients with moderate-stage Parkinson's disease (PD). This open-label, single-arm pilot study aimed to assess the effect of bedtime opicapone administration on NH and to evaluate the clinical…

View details →DOI: 10.14802/jmd.25250
Negative / Null Result ReportMedicine

Exploring Dynamic Brain Oscillations in Motor Imagery and Low-frequency Sound.

Dupont W, Poulin-Charronnat B, Madden-Lombardi C et al. · 2025 · Journal of cognitive neuroscience

Although both motor imagery (MI) and low-frequency sound listening have independently been shown to modulate brain activity, the potential synergistic effects that may arise from their combined application remains unexplored. Any further…

View details →DOI: 10.1162/jocn_a_02311
Negative / Null Result ReportMedicine

Long-Term Survival of Cronobacter sakazakii, Salmonella enterica, Listeria monocytogenes, and Enterobacter spp. in Powdered Infant Formula Based on Relative Humidity.

Fay ML, Khouja BA, Newkirk R et al. · 2025 · Journal of food protection

Powdered infant formula (PIF) has previously been shown to support the survival of bacterial foodborne pathogens including Cronobacter sakazakii, Listeria monocytogenes, and Salmonella enterica at various storage temperatures. However, the…

View details →DOI: 10.1016/j.jfp.2025.100670
Negative / Null Result ReportOpen accessMedicine

Investigating the Antioxidant and Immunomodulatory Effects of Quercetin Using Porcine PBMCs as an Inflammatory In Vitro Model.

Somogyi F, Pézsa NP, Jerzsele Á et al. · 2026 · Antioxidants (Basel, Switzerland)

As the human population continues to grow, the demand for pork increases, and the management of infectious diseases in swine from a One Health standpoint is becoming more important than ever. To prevent antimicrobial use as much as…

View details →DOI: 10.3390/antiox15030358
Negative / Null Result ReportMedicine

Folded-flap palatoplasty and traditional staphylectomy yield similar postoperative soft palate geometry in French Bulldogs undergoing airway surgery.

Farrell M, Singh A, Mayhew PD et al. · 2026 · Journal of the American Veterinary Medical Association

Objective To compare CT-derived anatomical geometry of the soft palate and clinical outcome following folded-flap palatoplasty (FFP) or traditional staphylectomy (TS). Methods Client-owned French Bulldogs were prospectively enrolled…

View details →DOI: 10.2460/javma.25.06.0376
Negative / Null Result ReportMedicine

The Effect of Surgeon Vocal Pitch and Gender on Patient Satisfaction.

Nuyen BA, Kruglik CP, Wang A et al. · 2026 · Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery

Objective Patient satisfaction scores, especially the "likelihood to recommend" (LTR) a provider, are becoming increasingly important as measures of surgical quality. In this study, we examined the influence of a surgeon's vocal pitch and…

View details →DOI: 10.1002/ohn.70059
Negative / Null Result Report

Pilot Testing a Narrative Psychoeducational Video to Reduce Stigma and Improve Mental Health Literacy and Help-Seeking Among Latinx Adults: Examining Gender Differences and Contextual Insights

Saravia DH, Silvan YA, Martinez JI · 2025 · Preprint

Abstract Despite similar rates of mental illness, non-Latinx Whites received care at higher rates compared to Latinxs (NIMH, 2024). Latinx adults report lower mental health literacy (MHL) and higher stigma compared to NLW, which can…

View details →DOI: 10.21203/rs.3.rs-7444634/v1