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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

19885 results in Negative / Null Result Report · page 524 of 663

Negative / Null Result ReportMedicine

Neopterin Levels in Pediatric Allogeneic Hematopoietic Stem Cell Transplantation: A Potential Biomarker for Acute Graft-Versus-Host Disease?

Kirkiz Kayalı S, Deveci TS, Gülbahar Ö et al. · 2026 · Transplantation proceedings

Introduction Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a curative treatment for hematologic disorders. Acute graft-versus-host disease (aGVHD) remains a major cause of nonrelapse mortality. Distinguishing aGVHD from…

View details →DOI: 10.1016/j.transproceed.2026.04.038
Negative / Null Result Report

Brain Tissue Oxygenation in Critically Ill Patients with Spontaneous Intracerebral Hemorrhage: A Prospective Observational Study

Ferreira AV, Dias M, Silva PA et al. · 2026 · Preprint

Abstract Background Brain tissue oxygen pressure (PbtO₂) monitoring is increasingly used in neurocritical care, but whether PbtO₂ provides complementary information beyond conventional parameters such as intracranial pressure (ICP) and…

View details →DOI: 10.21203/rs.3.rs-9684567/v1
Negative / Null Result Report

Evaluating spatial learning and memory ability of juvenile Sebastes schlegelii: A case study based on the cross-shaped convertible T-maze experiment

Zhao Y, Zhao Q, Yu X et al. · 2026 · Preprint

Abstract Learning behavior is an important acquired behavior in fish, and the capacity for learning and memory plays a crucial role in foraging or anti-predator behavior. In this study, we selected the juveniles of S. schlegelii as the…

View details →DOI: 10.21203/rs.3.rs-9638734/v1
Negative / Null Result ReportMedicine

Kinematic joint angles do not predict energy expenditure index in sub-acute and chronic stroke survivors: An exploratory study.

Patel J, Patil S · 2026 · Journal of bodywork and movement therapies

Background Stroke survivors exhibit gait inefficiencies with increased energy expenditure, potentially linked to kinematic deficits. This exploratory study examined whether peak sagittal joint angles predict Energy Expenditure Index (EEI)…

View details →DOI: 10.1016/j.jbmt.2026.05.002
Negative / Null Result ReportMedicine

Individual SGLT-2 Inhibitors and Risk of New-Onset Cancer in Type 2 Diabetes: A Nationwide Population-Based Cohort Study.

Kim, Seo, Nam et al. · 2026 · Cancer research and treatment

Preclinical studies suggest that sodium-glucose cotransporter-2 inhibitors (SGLT-2is) may have cancer-preventive effects; however, clinical evidence remains inconclusive. Therefore, this study aimed to evaluate the association between the…

View details →DOI: 10.4143/crt.2025.1243
Negative / Null Result ReportMedicine

Efficacy and safety of tirofiban after successful endovascular reperfusion in acute ischaemic stroke (ATTRACTION) in China: a multicentre, double-blind, randomised controlled trial.

Huang, Xu, Qin et al. · 2026 · Lancet (London, England)

Successful reperfusion after endovascular thrombectomy does not consistently result in functional independence in acute ischaemic stroke. We aimed to assess the efficacy and safety of tirofiban, a glycoprotein IIb/IIIa receptor antagonist,…

View details →DOI: 10.1016/s0140-6736(26)00983-9
Negative / Null Result ReportMedicine

Exploration of executive function measures in native English-speaking adults with varying education and reading levels.

Harris, Housman · 2026 · Applied neuropsychology. Adult

Neuropsychological performance is influenced by demographic/premorbid factors in addition to acquired cognitive impairment. This study examined relationships between educational attainment, reading ability, and executive functions in a…

View details →DOI: 10.1080/23279095.2026.2693225
Negative / Null Result ReportMedicine

Management of stiffness after total knee arthroplasty: influence of intervention timing and surgical technique on clinical outcomes.

Peretó Villaescusa, Coelho, Grillo et al. · 2026 · European journal of orthopaedic surgery & traumatology : orthopedie traumatologie

Postoperative knee stiffness following total knee arthroplasty (TKA) is a challenging complication that may require surgical intervention when conservative treatment fails. Although manipulation under anesthesia (MUA) and arthroscopic…

View details →DOI: 10.1007/s00590-026-04838-3
Negative / Null Result ReportMedicine

Comparison of the effectiveness of 30% Aloe vera cream and 20% urea cream as topical treatment for xerosis cutis in chronic kidney disease: a randomized clinical trial.

Fajriani, Djawad, Tabri et al. · 2026 · Dermatology reports

Xerosis is a prevalent skin disorder among patients with chronic kidney disease (CKD) undergoing hemodialysis (HD). While both Aloe vera cream 30% and urea cream 20% have been shown to improve skin hydration in cases of xerosis cutis,…

View details →DOI: 10.4081/dr.2026.10496
Negative / Null Result ReportMedicine

Clinical performance of a flowable bulk-fill composite compared with highly viscous glass ionomer cement in class II restorations of primary molars: A 1-year randomized clinical trial.

Fahmy, El-Geleel, Anwar et al. · 2026 · Journal of the American Dental Association (1939)

Caries is the most prevalent chronic disease in children, affecting more than 530 million people worldwide. Timely restoration of primary molars is critical for maintaining function and preventing premature tooth loss. The choice of…

View details →DOI: 10.1016/j.adaj.2026.03.026
Negative / Null Result ReportMedicine

Diversion proctitis during staged restorative proctocolectomy with ileal pouch anal anastomosis is not associated with subsequent cuffitis.

Dharia, Plietz, Hahn et al. · 2026 · International journal of colorectal disease

The aim of this study was to assess the impact of diversion proctitis (DP) between the first and second surgical stage on pouch outcomes in patients with ulcerative colitis (UC) who underwent three-stage restorative proctocolectomy (RPC)…

View details →DOI: 10.1007/s00384-026-05182-y
Negative / Null Result ReportMedicine

Police Reporting After Sexual Assault: Victim and Assault Characteristics That Predict Reporting Among Victims Who Seek Medical Forensic Care.

Goodman-Williams, Smith, Volz et al. · 2026 · Journal of interpersonal violence

Many sexual assault victims choose not to report their assault to police, and identifying characteristics that predict non-reporting can highlight areas for improvement in the criminal legal system's response to sexual assault. In the…

View details →DOI: 10.1177/08862605261455557
Negative / Null Result ReportMedicine

Water cooling to prevent electrocoagulation syndrome after endoscopic resection of colorectal neoplasm.

Zhipeng, Bing, Dongli et al. · 2026 · The American journal of gastroenterology

With the increasing frequency of electrocoagulation hemostasis used in endoscopic submucosal dissection (ESD), the incidence of postoperative bleeding is gradually decreasing, while the incidence of post-ESD electrocoagulation syndrome…

View details →DOI: 10.14309/ajg.0000000000004089
Negative / Null Result ReportMedicine

Pregabalin enhances the proliferative potential of pancreatic cancer in vitro but not in mice with pancreatic cancer.

Itaya, Sano, Kajiwara et al. · 2026 · BMC pharmacology & toxicology

We previously reported that mirogabalin, a selective voltage-gated calcium channel α2δ1/α2δ2 ligand, increases the proliferative potential of pancreatic cancer. However, the risk of pregabalin, a non-selective…

View details →DOI: 10.1186/s40360-026-01176-2
Negative / Null Result ReportMedicine

A Cross-Cultural Examination of Intrasexual Competition: The Links Between Mating Competition, Aggression, Appearance Enhancement, and Sexuality.

Meskó, Davis, Arnocky et al. · 2026 · Archives of sexual behavior

In the context of mating, individuals of the same sex often act as rivals in the pursuit, attraction, and retention of desirable partners. This study explored the relationships between intrasexual competition and various aspects of human…

View details →DOI: 10.1007/s10508-026-03464-8
Negative / Null Result ReportMedicine

Effects of 100% oxygen during deferred cord clamping on oxidative stress markers: a sub-study of a randomized controlled trial.

Katheria, Lakshminrusimha, Morales et al. · 2026 · Pediatric research

We sought to evaluate oxidative changes in premature infants receiving 100% oxygen compared with 30% during deferred cord clamping (DCC). Premature infants born at 22 0/7 to 28 6/7 weeks received DCC in conjunction with either 30% (LO…

View details →DOI: 10.1038/s41390-026-05199-7
Negative / Null Result ReportMedicine

Predictors of challenging initial intubation and association with outcomes in congenital diaphragmatic hernia.

Beverstock, Hagan, Fernandes et al. · 2026 · Journal of perinatology : official journal of the California Perinatal Association

To assess for differences in congenital diaphragmatic hernia patient characteristics between those requiring single or multiple intubation attempts, and to determine the relationship between number of intubation attempts and time to…

View details →DOI: 10.1038/s41372-026-02759-x
Negative / Null Result ReportMedicine

Does the Addition of Images to the Medication Dosage Calculation Exam Improve Metacognitive Components and Performance? A Randomized Prospective Study.

Weil-Lotan, Solnica, Benbenishty et al. · 2026 · Nurse educator

Accurate dosage calculation is vital for patient safety, making effective instructional methods a priority in nursing education. This study investigated whether embedding images of medications or syringes in medication calculation exams…

View details →DOI: 10.1097/nne.0000000000002215
Negative / Null Result ReportMedicine

Efficacy of AC-T Versus TAC Neoadjuvant Chemotherapy for Locally Advanced Breast Cancer: A Retrospective Analysis.

Mirzania, Anari, Emami et al. · 2026 · International journal of breast cancer

Locally advanced breast cancer (LABC) remains a major therapeutic challenge, with neoadjuvant chemotherapy (NAC) serving as a cornerstone of management. However, direct evidence comparing the efficacy of sequential (AC-T) and concurrent…

View details →DOI: 10.1155/ijbc/6630563
Negative / Null Result ReportMedicine

Effects of different durations of high-intensity interval training or continuous training with/without metformin on lipid profile and malondialdehyde level in a rat model of polycystic ovary syndrome.

Zolfaghari, Nouri Habashi, Aghazadeh · 2026 · Veterinary research forum : an international quarterly journal

Polycystic ovary syndrome (PCOS) is a complex endocrine disorder. Exercise is one of the interventions that leads to PCOS improvement. This study aimed to investigate the potential of different durations of high-intensity interval training…

View details →DOI: 10.30466/vrf.2025.2050200.4623
Negative / Null Result ReportMedicine

Acupuncture Versus Clomiphene for Ovulation Induction in Women With Polycystic Ovary Syndrome (PCOS): A Randomized Clinical Trial.

Hafizi, Azizi, Mahmoudinia et al. · 2026 · Health science reports

There is evidence of the beneficial effects of acupuncture in the treatment of polycystic ovary syndrome (PCOS). This study aimed to compare acupuncture with clomiphene in ovulation induction among infertile women with PCOS. This…

View details →DOI: 10.1002/hsr2.72673
Negative / Null Result ReportMedicine

Comparison of Single-Freezing Temperature-Guided and Conventional Time-to-Isolation-Guided Protocols of Cryoballoon in Atrial Fibrillation Ablation.

Liu, Zheng, Li et al. · 2026 · Cardiology research

The study aimed to compare the efficacy and safety of simplified single-freezing protocol with achieving -40 °C within 60 s of freezing as the observation index and the conventional time-to-isolation (TTI)-guided double-freezing…

View details →DOI: 10.14740/cr2202