A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
21216 results · page 50 of 708
Yi‐Han Hsiao, Yung‐Tai Chen, Ching-Min Tseng et al. · 2015 · SLEEP
STUDY OBJECTIVES: To explore the association between the non-apnea sleep disorder (NSD) and autoimmune diseases. DESIGN: Cohort study. SETTING: Nationwide database research. PARTICIPANTS: 84,996 adult patients with NSD diagnoses recorded…
Jennifer L. Dearborn, Yiyi Zhang, Ye Qiao et al. · 2017 · Neurology
OBJECTIVE: To explore the association of intracranial atherosclerotic disease (ICAD) with mild cognitive impairment (MCI) and dementia. METHODS: From 2011 to 2013, 1,744 participants completed high-resolution vessel wall MRI from the…
Scott Carrell, Mark Hoekstra, James E. West · 2019 · American Economic Journal Economic Policy
This paper estimates the impact of racially diverse peers on white males’ subsequent behavior toward minorities. To overcome selection bias, we exploit data from the US Air Force Academy where students are randomly assigned to autonomous…
Helena Cousijn, Saskia Haegens, George Wallis et al. · 2014 · Proceedings of the National Academy of Sciences
Gamma band oscillations arise in neuronal networks of interconnected GABAergic interneurons and excitatory pyramidal cells. A previous study found a correlation between visual gamma peak frequency, as measured with magnetoencephalography,…
Ioannis Pavlidis, Panagiotis Tsiamyrtzis, Dvijesh Shastri et al. · 2012 · Scientific Reports
In the present study we quantify stress by measuring transient perspiratory responses on the perinasal area through thermal imaging. These responses prove to be sympathetically driven and hence, a likely indicator of stress processes in…
Véronique Campbell, Pierre Legendre, François-Joseph Lapointe · 2011 · BMC Evolutionary Biology
BACKGROUND: CADM is a statistical test used to estimate the level of Congruence Among Distance Matrices. It has been shown in previous studies to have a correct rate of type I error and good power when applied to dissimilarity matrices and to ultrametric distance matrices. Contrary to most other tests of incongruence used in phylogenetic analysis, the null hypothesis of the CADM test assumes complete incongruence of the phylogenetic trees instead of congruence. In this study, we performed computer simulations to assess the type I error rate and power of the test. It was applied to additive dis
Carlos Cruchaga · 2011 · Archives of Neurology
BACKGROUND: Apolipoprotein E (APOE) is the most statistically significant genetic risk factor for late-onset Alzheimer disease (LOAD). The linkage disequilibrium pattern around the APOE gene has made it difficult to determine whether all…
Thomas R. Lerner, Cristiane de Souza Carvalho‐Wodarz, Urška Repnik et al. · 2016 · Journal of Clinical Investigation
In extrapulmonary tuberculosis, the most common site of infection is within the lymphatic system, and there is growing recognition that lymphatic endothelial cells (LECs) are involved in immune function. Here, we identified LECs, which…
Anne‐Marie Linnen, Mark A. Ellenbogen, Christopher Cardoso et al. · 2011 · Stress
Oxytocin facilitates pro-social behaviour and is proposed as a regulatory factor controlling stress reactivity. Previous research on oxytocin and stress has focused on achievement-related stressors among male participants. The aims of the…
Rianne Haartsen, Emily J. H. Jones, Elena V. Orekhova et al. · 2019 · Translational Psychiatry
We conducted a replication study of our prior report that increased alpha EEG connectivity at 14-months associates with later autism spectrum disorder (ASD) diagnosis, and dimensional variation in restricted interests/repetitive behaviours. 143 infants at high and low familial risk for ASD watched dynamic videos of spinning toys and women singing nursery rhymes while high-density EEG was recorded. Alpha functional connectivity (7-8 Hz) was calculated using the debiased weighted phase lag index. The final sample with clean data included low-risk infants (N = 20), and high-risk infants who at 36
Karlijn Meeks, Peter Henneman, Andrea Venema et al. · 2017 · Clinical Epigenetics
Epigenome-wide association studies (EWAS) have identified DNA methylation loci involved in adiposity. However, EWAS on adiposity in sub-Saharan Africans are lacking despite the high burden of adiposity among African populations. We undertook an EWAS for anthropometric indices of adiposity among Ghanaians aiming to identify DNA methylation loci that are significantly associated. The Illumina 450k DNA methylation array was used to profile DNA methylation in whole blood samples of 547 Ghanaians from the Research on Obesity and Diabetes among African Migrants (RODAM) study. Differentially methylat
Daniel S. Thoma, Manuel Sancho‐Puchades, Dominik A. Ettlin et al. · 2011 · Journal Of Clinical Periodontology
AIM: To test whether a collagen matrix (CM) can improve early wound healing and aesthetics, and decrease wound sensitivity compared with spontaneous healing. METHODS: In 15 volunteers, 6-mm punch biopsies were harvested at both palatal…
John Chalmers, Jonathan Reuter · 2012 · Review of Financial Studies
Because life annuities can increase the level and decrease the volatility of lifetime consumption, economists have long been puzzled by the low demand for life annuities. One potential rational explanation is that adverse selection drives…
D. James Cooper, Jeffrey V. Rosenfeld, Lynnette Murray et al. · 2020 · Journal of Neurotrauma
Functional outcomes at 12 months were a secondary outcome of the randomized DECRA trial of early decompressive craniectomy for severe diffuse traumatic brain injury (TBI) and refractory intracranial hypertension. In the DECRA trial,…
Christopher T. Chan, Tom Greene, Glenn M. Chertow et al. · 2012 · Circulation Cardiovascular Imaging
BACKGROUND: An increase in left ventricular mass (LVM) is associated with mortality and cardiovascular morbidity in patients with end-stage renal disease. METHODS AND RESULTS: The Frequent Hemodialysis Network (FHN) Daily Trial randomized…
Manaf AlQahtani, Abdulkarim Abdulrahman, Abdulrahman Almadani et al. · 2021 · Scientific Reports
Convalescent plasma (CP) therapy in COVID-19 disease may improve clinical outcome in severe disease. This pilot study was undertaken to inform feasibility and safety of further definitive studies. This was a prospective, interventional and randomized open label pilot trial in patients with severe COVID-19. Twenty COVID-19 patients received two 200 ml transfusions of convalescent patient CP over 24-h compared with 20 who received standard of care. The primary outcome was the requirement for ventilation (non-invasive or mechanical ventilation). The secondary outcomes were biochemical parameters
Shiu‐Dong Chung, Hsin‐Tzu Liu, Heng Lin et al. · 2011 · Neurourology and Urodynamics
AIMS: Chronic inflammation has been implicated in the development of overactive bladder (OAB) and interstitial cystitis/bladder pain syndrome (IC/BPS). An elevation of C-reactive protein (CRP) has been associated with chronic inflammation…
Paul E. Harrington, Kaustav Biswas, David J. Malwitz et al. · 2014 · ACS Medicinal Chemistry Letters
The kinase/endonuclease inositol requiring enzyme 1 (IRE1α), one of the sensors of unfolded protein accumulation in the endoplasmic reticulum that triggers the unfolded protein response (UPR), has been investigated as an anticancer target.…
Marie Løvoll, Marta Alarcón, Britt Bang Jensen et al. · 2012 · Diseases of Aquatic Organisms
The newly described piscine reovirus (PRV) appears to be associated with the development of heart and skeletal muscle inflammation (HSMI) in farmed Atlantic salmon Salmo salar L. PRV seems to be ubiquitous among fish in Norwegian salmon…
David Figlio, Jeremy Freese, Krzysztof Karbownik et al. · 2017 · Proceedings of the National Academy of Sciences
Accurate understanding of environmental moderation of genetic influences is vital to advancing the science of cognitive development as well as for designing interventions. One widely reported idea is increasing genetic influence on…
Stephanie A. Kazanas, Jeanette Altarriba · 2015 · Evolutionary Psychology
Recently, researchers have begun to investigate the function of memory in our evolutionary history. According to Nairne and colleagues (e.g., Nairne, Pandeirada, and Thompson, 2008; Nairne, Thompson, and Pandeirada, 2007), the best…
Charles R. Ebersole, Maya B. Mathur, Erica Baranski et al. · 2020 · Advances in Methods and Practices in Psychological Science
Replication studies in psychological science sometimes fail to reproduce prior findings. If these studies use methods that are unfaithful to the original study or ineffective in eliciting the phenomenon of interest, then a failure to…
J. Vermorken, Pol Specenier · 2013 · Biologics
Head and neck cancer is the sixth most common cancer worldwide. At present, globally about 650,000 new cases of squamous cell carcinoma of the head and neck (SCCHN) are diagnosed each year. The epidermal growth factor receptor (EGFR) is…
E. Mahler, M. Blom, Nicol C. Voermans et al. · 2011 · Lara D. Veeken
OBJECTIVE: To assess the efficacy of rituximab on disease activity and muscle strength in patients with inflammatory myopathies refractory to conventional therapy. METHODS; Thirteen patients were treated with rituximab 1000 mg i.v., twice,…
Harrison G. Pope, Arthur M. Jacobs, Jean-Paul Mialet et al. · 2010 · Psychotherapy and Psychosomatics
BACKGROUND: In an exploratory study, we used a novel computerized battery of neuropsychological tests of attention to assess residual cognitive impairment in marijuana users. METHODS: We compared 25 college students who were heavy…
Andreas Seebeck, Devrimi Kaya · 2022 · European Accounting Review
We examine the communicative value of extended auditor reports in the United Kingdom (UK), where ISA 700 (UK and Ireland) requires auditors to disclose the risks of material misstatement that had the greatest effect on the audit – key…
Martin Mynarek, Katja von Hoff, Torsten Pietsch et al. · 2020 · Journal of Clinical Oncology
PURPOSE The HIT-2000-BIS4 trial aimed to avoid highly detrimental craniospinal irradiation (CSI) in children < 4 years of age with nonmetastatic medulloblastoma by systemic chemotherapy, intraventricular methotrexate, and risk-adapted local radiotherapy. PATIENTS AND METHODS From 2001-2011, 87 patients received systemic chemotherapy and intraventricular methotrexate. Until 2006, CSI was reserved for nonresponse or progression. After 2006, local radiotherapy was introduced for nonresponders or patients with classic medulloblastoma (CMB) or large-cell/anaplastic medulloblastoma (LCA). DNA met
Shilpa Trivedi, Nand Lal, Abbas Ali Mahdi et al. · 2013 · Journal of Periodontology
BACKGROUND: The aim of this study is to investigate the impact of diabetes, a known risk factor for periodontitis, on activities of antioxidant enzymes superoxide dismutase (SOD), glutathione reductase (GR), and catalase (CAT) as well as…
Miguel Martín, Aleix Prat, Álvaro Rodríguez-Lescure et al. · 2013 · Breast Cancer Research and Treatment
To identify a group of patients who might benefit from the addition of weekly paclitaxel to conventional anthracycline-containing chemotherapy as adjuvant therapy of node-positive operable breast cancer. The predictive value of PAM50…
John D. Bagert, Yushu Joy Xie, Michael J. Sweredoski et al. · 2014 · Molecular & Cellular Proteomics
An approach to proteomic analysis that combines bioorthogonal noncanonical amino acid tagging (BONCAT) and pulsed stable isotope labeling with amino acids in cell culture (pSILAC) provides accurate quantitative information about rates of cellular protein synthesis on time scales of minutes. The method is capable of quantifying 1400 proteins produced by HeLa cells during a 30 min interval, a time scale that is inaccessible to isotope labeling techniques alone. Potential artifacts in protein quantification can be reduced to insignificant levels by limiting the extent of noncanonical amino acid t