A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
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Ditte Caroline Andersen, Suganya Ganesalingam, Charlotte Harken Jensen et al. · 2014 · Stem Cell Reports
The mammalian heart has generally been considered nonregenerative, but recent progress suggests that neonatal mouse hearts have a genuine capacity to regenerate following apex resection (AR). However, in this study, we performed AR or sham…
Adeline Fayolle, Michael Swaine, Jean‐François Bastin et al. · 2014 · Journal of Biogeography
Abstract Aim In this study we identified large‐scale variation in tree species composition across tropical African forests and determined the underlying environmental and historical factors. Location Tropical forests from Senegal to…
Ben M Tappin, Leslie van der Leer, Ryan McKay · 2017 · Journal of Experimental Psychology General
Understanding how individuals revise their political beliefs has important implications for society. In a preregistered study (N = 900), we experimentally separated the predictions of 2 leading theories of human belief revision-desirability bias and confirmation bias-in the context of the 2016 U.S. presidential election. Participants indicated who they desired to win, and who they believed would win, the election. Following confrontation with evidence that was either consistent or inconsistent with their desires or beliefs, they again indicated who they believed would win. We observed a robust
Carsten C. Schermuly, René A. Schermuly, Bertolt Meyer · 2011 · International Journal of Educational Management
Purpose This paper aims to investigate the relationship between psychological empowerment, job satisfaction, and burnout among vice‐principals (VPs) in primary schools. Design/methodology/approach A total of 103 VPs at 103 different…
Jiqiang Li, Zhen‐Kun Yuan, Shiyou Chen et al. · 2019 · Chemistry of Materials
By combining the electron–phonon coupling effect and the static coupling formalism, we calculate, through the first-principles methods, the carrier capture cross sections of the three possible nonradiative recombination center (NRRC)…
Douglas C. Woodhams, CC Geiger, LK Reinert et al. · 2011 · Diseases of Aquatic Organisms
Amphibian conservation goals depend on effective disease-treatment protocols. Desirable protocols are species, life stage, and context specific, but currently few treatment options exist for amphibians infected with the chytrid fungus…
Ayala Maayan‐Metzger, Shirli Avivi, Irit Schushan‐Eisen et al. · 2011 · American Journal of Perinatology
We evaluated short-term neonatal outcomes among preterm infants according to type of feeding administered (human milk or formula). Retrospective data were collected on 400 preterm infants at gestational age ≤32 weeks. Groups were chosen…
Stewart R. Walsh, S.A.R. Nouraei, Tjun Yip Tang et al. · 2010 · Vascular and Endovascular Surgery
Remote ischemic preconditioning (RIPC) is a physiological mechanism whereby brief ischemia-reperfusion episodes attenuate damage by subsequent prolonged ischemic insults. It reduces myocardial injury following cardiac and aortic aneurysm…
Lena Koch‐Gallenkamp, Heike Bertram, Andrea Eberle et al. · 2016 · Health Psychology
OBJECTIVE: Fear of recurrence (FoR) is among the most important concerns for cancer survivors. Studies on potentially influencing variables, like time since diagnosis, cancer type, and sex, have yielded heterogeneous results. Also social…
Nicolaas Prins · 2012 · Journal of Vision
In their influential paper, Wichmann and Hill (2001) have shown that the threshold and slope estimates of a psychometric function may be severely biased when it is assumed that the lapse rate equals zero but lapses do, in fact, occur.…
Kathryn G. Ewens, Michelle R. Jones, Wendy Ankener et al. · 2011 · PLoS ONE
Polycystic ovary syndrome (PCOS) is the leading cause of anovulatory infertility in women. It is also associated with metabolic disturbances that place women at increased risk for obesity and type 2 diabetes. There is strong evidence for familial clustering of PCOS and a genetic predisposition. However, the gene(s) responsible for the PCOS phenotypes have not been elucidated. This two-phase family-based and case-control genetic study was designed to address the question of whether SNPs identified as susceptibility loci for obesity in genome-wide association studies (GWAS) are also associated w
Oliver Pain, Frank Dudbridge, Alastair G. Cardno et al. · 2018 · American Journal of Medical Genetics Part B Neuropsychiatric Genetics
This study aimed to test for overlap in genetic influences between psychotic-like experience traits shown by adolescents in the community, and clinically-recognized psychiatric disorders in adulthood, specifically schizophrenia, bipolar disorder, and major depression. The full spectra of psychotic-like experience domains, both in terms of their severity and type (positive, cognitive, and negative), were assessed using self- and parent-ratings in three European community samples aged 15-19 years (Final N incl. siblings = 6,297-10,098). A mega-genome-wide association study (mega-GWAS) for each p
Acel Jardón, O.J. Kuik, Richard S.J. Tol · 2017 · Atmósfera
En este trabajo se analiza la relacin emprica entre las emisiones de dixido de carbono (CO 2 ) per cpita y el crecimiento econmico en un panel de 20 pases de Amrica Latina y el Caribe durante el periodo 1971-2011. Dicha relacin emprica,…
Therésa M. Jones, Joanna Durrant, Ellie B. Michaelides et al. · 2015 · Philosophical Transactions of the Royal Society B Biological Sciences
The mechanisms underpinning the ecological impacts of the presence of artificial night lighting remain elusive. One suspected underlying cause is that the presence of light at night (LAN) supresses nocturnal production of melatonin, a key…
Kaori Kuramitsu, Deanna Sverdlov, Susan B. Liu et al. · 2013 · American Journal Of Pathology
Failure of fibrotic liver to regenerate after resection limits therapeutic options and increases demand for liver transplantation, representing a significant clinical problem. The mechanism underlying regenerative failure in fibrosis is…
Lee Tryhorn, Art Degaetano · 2010 · International Journal of Climatology
Abstract Accurate estimates of local changes in extreme precipitation are valuable for informing local policy decisions and estimating potential impacts on areas such as health, infrastructure, ecosystems and agriculture. To bridge the gap…
Shaban Mohammadi, Hadi Saeidi, Nader Naghshbandi · 2020 · International Journal of Productivity and Performance Management
Purpose The purpose of this study is to investigate the effect of board and audit committee characteristics on corporate social responsibility (CSR) in Iranian companies listed in stock exchanges. Design/methodology/approach This is a…
Dinesh Khanna, Yannick Allanore, Christopher P. Denton et al. · 2020 · Annals of the Rheumatic Diseases
OBJECTIVES: Riociguat is approved for pulmonary arterial hypertension and has antiproliferative, anti-inflammatory and antifibrotic effects in animal models of tissue fibrosis. We evaluated the efficacy and safety of riociguat in patients with early diffuse cutaneous systemic sclerosis (dcSSc) at high risk of skin fibrosis progression. METHODS: In this randomised, double-blind, placebo-controlled, phase IIb trial, adults with dcSSc of <18 months' duration and a modified Rodnan skin score (mRSS) 10-22 units received riociguat 0.5 mg to 2.5 mg orally three times daily (n=60) or placebo (n=61). T
Patrick J. Denard, Alexandre Lädermann, Stephen S. Burkhart · 2012 · Arthroscopy The Journal of Arthroscopic and Related Surgery
PURPOSE: The purpose of this study was to determine the long-term functional outcome of anatomic arthroscopic repair of type II SLAP lesions with suture anchors. METHODS: We examined all arthroscopic repairs of isolated type II SLAP…
Charles M. Rudin, Stephen V. Liu, Ross A. Soo et al. · 2023 · Journal of Clinical Oncology
PURPOSE The phase III SKYSCRAPER-02 study determined whether the benefits of atezolizumab plus carboplatin and etoposide (CE) could be enhanced by the addition of tiragolumab in untreated extensive-stage small-cell lung cancer (ES-SCLC).…
William J. Sandborn, Scott D. Lee, Dino Tarabar et al. · 2017 · Gut
Objective This phase II, randomised, double-blind, placebo-controlled clinical trial was designed to evaluate the efficacy and safety of PF-00547659, a fully human monoclonal antibody that binds to human mucosal addressin cell adhesion…
Alexander G. Thompson, Elizabeth Gray, Alexander Bampton et al. · 2019 · Journal of Neurology Neurosurgery & Psychiatry
Objective To evaluate the classifier performance, clinical and biochemical correlations of cerebrospinal fluid (CSF) levels of the chitinase proteins Chitotriosidase-1 (CHIT1), Chitinase-3-like protein 1 (CHI3L1) and Chitinase-3-like…
Ricard Pruna, Rosa Artells, Jordi Ribas et al. · 2013 · BMC Musculoskeletal Disorders
BACKGROUND: The biological mechanisms involved in non-contact musculoskeletal soft tissue injuries (NCMSTI) are poorly understood. Genetic risk factors may be associated with susceptibility to injuries, and may exert marked influence on recovery times. METHODS: Data on type and degree of injury and recovery time were collected in 73 male professional soccer players (43 White, 11 Black Africans and 19 Hispanics) who suffered total of 242 injuries (203 muscle, 24 ligament, and 15 tendon injuries). One single nucleotide polymorphism (SNPs) in the following genes were analyzed: Elastin (ELN); Titi
Jeffrey M. Timberlake, Elaina Johns‐Wolfe · 2016 · Urban Affairs Review
This research examines the impact of neighborhood ethnoracial composition on the likelihood that neighborhoods that could gentrify do gentrify over time. Drawing on findings from the gentrification and residential preference literatures,…
Bratislav Mišić, Joaquín Goñi, Richard F. Betzel et al. · 2014 · PLoS Computational Biology
The hippocampal formation is a key structure for memory function in the brain. The functional anatomy of the brain suggests that the hippocampus may be a convergence zone, as it receives polysensory input from distributed association areas throughout the neocortex. However, recent quantitative graph-theoretic analyses of the static large-scale connectome have failed to demonstrate the centrality of the hippocampus; in the context of the whole brain, the hippocampus is not among the most connected or reachable nodes. Here we show that when communication dynamics are taken into account, the hipp
A. Anastasi, D. Babusci, G. Bencivenni et al. · 2016 · Physics Letters B
The recent interest in a light gauge boson in the framework of an extra U(1) symmetry motivates searches in the mass range below 1 GeV. We present a search for such a particle, the dark photon, in e + e - U, U + -based on 28 million e + e - + - events collected at DA NE by the KLOE experiment. The + -production by initial-state radiation compensates for a loss of sensitivity of previous KLOE U e + e -, + -searches due to the small branching ratios in the - resonance region. We found no evidence for a signal and set a limit at 90% CL on the mixing strength between the photon and the
Matthew J. Lindquist, Torsten Santavirta · 2014 · Labour Economics
We evaluate the association between foster care placement during childhood and adult criminality. In contrast to previous studies, we allow associations to vary by gender and age at initial placement. We find that foster care predicts…
H. Mike Kim, Leesa M. Galatz, Rosalina Das et al. · 2010 · Connective Tissue Research
The purpose of this study was to examine the role of two of the three transforming growth factor beta (TGF-β) isoforms at the healing tendon-to-bone insertion. The supraspinatus tendons of 64 rats were transected at their bony insertions…
Joris D. Veltman, Margaretha Lambers, Menno van Nimwegen et al. · 2010 · British Journal of Cancer
BACKGROUND: Suppressive immune cells present in tumour microenvironments are known to augment tumour growth and hamper efficacy of antitumour therapies. The amino-bisphosphonate Zoledronic acid (ZA) is considered as an antitumour agent, as…
Étienne Cavaignac, V. Lafontan, Nicolas Reina et al. · 2013 · The Bone & Joint Journal
The significance of weight in the indications for unicompartmental knee replacement (UKR) is unclear. Our hypothesis was that weight does not affect the long-term rate of survival of UKRs. We undertook a retrospective study of 212 UKRs at…