Nonmetastatic Medulloblastoma of Early Childhood: Results From the Prospective Clinical Trial HIT-2000 and An Extended Validation Cohort
Martin Mynarek; Katja von Hoff; Torsten Pietsch; Holger Ottensmeier; Monika Warmuth‐Metz; Brigitte Bison; Stefan M. Pfister; Andrey Korshunov · 2020 · Journal of Clinical Oncology
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
PURPOSE The HIT-2000-BIS4 trial aimed to avoid highly detrimental craniospinal irradiation (CSI) in children < 4 years of age with nonmetastatic medulloblastoma by systemic chemotherapy, intraventricular methotrexate, and risk-adapted local radiotherapy. PATIENTS AND METHODS From 2001-2011, 87 patients received systemic chemotherapy and intraventricular methotrexate. Until 2006, CSI was reserved for nonresponse or progression. After 2006, local radiotherapy was introduced for nonresponders or patients with classic medulloblastoma (CMB) or large-cell/anaplastic medulloblastoma (LCA). DNA met
Abstract by Martin Mynarek; Katja von Hoff; Torsten Pietsch; Holger Ottensmeier; Monika Warmuth‐Metz; Brigitte Bison; Stefan M. Pfister; Andrey Korshunov, Journal of Clinical Oncology (2020) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1200/jco.19.03057