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Replication FailureOpen accessBiochemistry, Genetics and Molecular Biology· cited by 105

An epigenome-wide association study in whole blood of measures of adiposity among Ghanaians: the RODAM study

Karlijn Meeks; Peter Henneman; Andrea Venema; Tom Burr; Cecilia Galbete; Ina Danquah; Matthias B. Schulze; Frank P. Mockenhaupt · 2017 · Clinical Epigenetics

WASTE classifies this as Replication Failure · AI classification, approximate

A previously reported effect did not replicate here — verify it holds before you build on it.

Abstract

Epigenome-wide association studies (EWAS) have identified DNA methylation loci involved in adiposity. However, EWAS on adiposity in sub-Saharan Africans are lacking despite the high burden of adiposity among African populations. We undertook an EWAS for anthropometric indices of adiposity among Ghanaians aiming to identify DNA methylation loci that are significantly associated. The Illumina 450k DNA methylation array was used to profile DNA methylation in whole blood samples of 547 Ghanaians from the Research on Obesity and Diabetes among African Migrants (RODAM) study. Differentially methylat

Abstract by Karlijn Meeks; Peter Henneman; Andrea Venema; Tom Burr; Cecilia Galbete; Ina Danquah; Matthias B. Schulze; Frank P. Mockenhaupt, Clinical Epigenetics (2017) — licensed CC BY 4.0.

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Metadata source: OpenAlex · DOI 10.1186/s13148-017-0403-x