Unfolded Protein Response in Cancer: IRE1α Inhibition by Selective Kinase Ligands Does Not Impair Tumor Cell Viability
Paul E. Harrington; Kaustav Biswas; David J. Malwitz; Andrew S. Tasker; Christopher Mohr; Kristin L. Andrews; Ken Dellamaggiore; Richard Kendall · 2014 · ACS Medicinal Chemistry Letters
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract (excerpt)
The kinase/endonuclease inositol requiring enzyme 1 (IRE1α), one of the sensors of unfolded protein accumulation in the endoplasmic reticulum that triggers the unfolded protein response (UPR), has been investigated as an anticancer target.…
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Metadata source: OpenAlex · DOI 10.1021/ml500315b