A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
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Steven H. Kelder, Dale S. Mantey, Duncan Van Dusen et al. · 2020 · Public Health Reports
Objectives: From 2017 to 2018, electronic cigarette (e-cigarette) use increased 78% among high school students and 48% among middle school students in the United States. However, few e-cigarette prevention interventions have been…
Matthew S. Willsey, Samuel R. Nason, Scott R. Ensel et al. · 2022 · Nature Communications
Despite the rapid progress and interest in brain-machine interfaces that restore motor function, the performance of prosthetic fingers and limbs has yet to mimic native function. The algorithm that converts brain signals to a control signal for the prosthetic device is one of the limitations in achieving rapid and realistic finger movements. To achieve more realistic finger movements, we developed a shallow feed-forward neural network to decode real-time two-degree-of-freedom finger movements in two adult male rhesus macaques. Using a two-step training method, a recalibrated feedback intention
Li He, Guoying Zhou, Junang Liu et al. · 2016 · PLoS ONE
The filamentous fungus Colletotrichum fructicola is found in all five continents and is capable of causing severe diseases in a number of economically important plants such as avocado, fig, cocoa, pear, and tea-oil trees. However, almost nothing is known about its patterns of genetic variation and epidemiology on any of its host plant species. Here we analyzed 167 isolates of C. fructicola obtained from the leaves of tea-oil tree Camellia oleifera at 15 plantations in seven Chinese provinces. Multilocus sequence typing was conducted for all isolates based on DNA sequences at fragments of four
Edward I. Chang, Hong Zhang, Jun Liu et al. · 2015 · Head & Neck
BACKGROUND: Risk factors and techniques for free flap salvage in head and neck reconstruction are poorly described. METHODS: We conducted a retrospective review of all head and neck free flaps performed from 2000 to 2010. RESULTS: Overall,…
Marco Marklewitz, Florian Zirkel, Innocent B. Rwego et al. · 2013 · Journal of Virology
Bunyaviruses are the largest known family of RNA viruses, infecting vertebrates, insects, and plants. Here we isolated three novel bunyaviruses from mosquitoes sampled in Côte d'Ivoire, Ghana, and Uganda. The viruses define a highly…
Yang Yang, Wu Youyou, Brian Uzzi · 2020 · Proceedings of the National Academy of Sciences
Replicability tests of scientific papers show that the majority of papers fail replication. Moreover, failed papers circulate through the literature as quickly as replicating papers. This dynamic weakens the literature, raises research…
Shujing Chen, Dingyu Zhang, Tianqi Zheng et al. · 2020 · Journal of Thrombosis and Thrombolysis
Few data are available on the incidence of deep vein thrombosis (DVT) in critically ill COVID-19 with thrombosis prophylaxis. This study retrospectively included 88 patients in the ICU with critically ill COVID-19 at Jinyintan Hospital in Wuhan, China. All patients underwent compression ultrasonography for identifying DVT. Firth logistic regression was used to examine the association of DVT with sex, age, hypoalbuminemia, D-dimer, and SOFA score. The median (interquartile range [IQR]) age and SOFA score of 88 patients were 63 (55-71) years old and 5 (4-6), respectively. Despite all patients re
Sebastian Steven, Kerstin Jurk, Maximilian Kopp et al. · 2016 · British Journal of Pharmacology
Abstract Background and Purpose Excessive inflammation in sepsis causes microvascular thrombosis and thrombocytopenia associated with organ dysfunction and high mortality. The present studies aimed to investigate whether inhibition of…
Antonio Aguilar‐Salvatierra, José Luis Calvo‐Guirado, Maximino González‐Jaranay et al. · 2015 · Clinical Oral Implants Research
OBJECTIVES: The aim of this study was to evaluate implant survival and primary stability parameters in patients with diabetes with different levels of glycosylated hemoglobin Alc (HbA1c) treated with immediate placement and…
Jody Hoffer Gittell, Caroline Logan, Jack L. Cronenwett et al. · 2018 · Health Care Management Review
BACKGROUND: Pressures are increasing for clinicians to provide high-quality, efficient care, leading to increased concerns about staff burnout. PURPOSE: This study asks whether staff well-being can be achieved in ways that are also…
Marc A. Judson, Kristin B. Highland, Soon-Ho Kwon et al. · 2011 · PubMed
BACKGROUND: Sarcoidosis associated pulmonary hypertension (SAPH) is associated with significant morbidity and mortality. There is a paucity of information concerning therapy for this condition. METHODS: We performed a prospective,…
Hung-Yu Liu, Kun‐Hsien Chou, Pei‐Lin Lee et al. · 2016 · Cephalalgia
Objectives To investigate the structural changes of hippocampus and amygdala and their relationships with migraine frequency and prognosis. Methods Hippocampus and amygdala volumes were measured by 3-T brain magnetic resonance imaging…
Sanjib Mohanty, Saroj K. Mishra, Rajyabardhan Patnaik et al. · 2011 · Clinical Infectious Diseases
BACKGROUND: Coma is a frequent presentation of severe malaria in adults and an important cause of death. The role of cerebral swelling in its pathogenesis, and the possible benefit of intravenous mannitol therapy to treat this, is…
Ramlawati Ramlawati, Eva Trisnawati, Nurfatwa Andriani Yasin et al. · 2020 · Management Science Letters
The purpose of this study was to determine the alternative external influence and job stress on employee satisfaction and to determine the effects of the alternative external influence, job satisfaction job stress on Turnover Intention on employees of PT Bank Mandiri Regional X South Sulawesi. Respondents in this study were 100 people. The analysis model used to determine the effect between variables was a structural model with the Partial Least Square (PLS) approach. The results show that external alternatives had a significant effect on job satisfaction, stress had no significant effect on j
N. de Korte, Johan P. Kuyvenhoven, Donald L. van der Peet et al. · 2011 · Colorectal Disease
AIM: Conservative treatment of mild colonic diverticulitis usually consists of observation, restriction of oral intake, intravenous fluids and antibiotics. The beneficiary effect of antibiotics remains unclear. The aim of this study is to…
Ashfaq Shuaib, Natan M. Bornstein, Hans‐Christoph Diener et al. · 2011 · Stroke
BACKGROUND AND PURPOSE: Fewer than 5% of patients with acute ischemic stroke are currently treated, and there is need for additional treatment options. A novel catheter treatment (NeuroFlo) that increases cerebral blood flow was tested to…
Andreas Schatz, Johanna Pach, Mariya Gosheva et al. · 2017 · Investigative Ophthalmology & Visual Science
Purpose: After promising results of an exploratory study, this study was designed to assess the safety and efficacy of transcorneal electrical stimulation (TES) over 1 year in patients with retinitis pigmentosa (RP). Methods: We included 52 RP patients in this prospective, randomized, partially-masked study which was done in accordance with rules of good clinical practice. Transcorneal electrical stimulation by Okustim was applied monocularly for 30 minutes per week for 52 consecutive weeks. Patients were assigned randomly to the groups: sham, 150%, or 200% of individual electrical phosphene t
Rosa Andias, Maritza Neto, Anabela G. Silva · 2018 · Physiotherapy Theory and Practice
PURPOSE: To compare the effectiveness of pain neuroscience education (PNE) and neck/shoulder exercises with no intervention in adolescents with chronic idiopathic neck pain (CINP). METHODS: Forty-three adolescents with CINP were randomly…
John E. Pachankis, Audrey Harkness, Kaitlin R. Maciejewski et al. · 2022 · Journal of Consulting and Clinical Psychology
OBJECTIVE: Effective Skills to Empower Effective Men (ESTEEM) represents the first intervention to address the psychological pathways through which minority stress undermines young sexual minority men's (SMM's) mental and sexual health…
Danny Bruce, Heather E. Stefanski, Benjamin G. Vincent et al. · 2017 · Journal of Clinical Investigation
Acute graft-versus-host disease (aGVHD) is the most common complication for patients undergoing allogeneic stem cell transplantation. Despite extremely aggressive therapy targeting donor T cells, patients with grade III or greater aGVHD of…
Sanjay Patole, Shripada Rao, Anthony D. Keil et al. · 2016 · PLoS ONE
BACKGROUND: Systematic reviews of randomised controlled trials report that probiotics reduce the risk of necrotising enterocolitis (NEC) in preterm neonates. AIM: To determine whether routine probiotic supplementation (RPS) to preterm neonates would reduce the incidence of NEC. METHODS: The incidence of NEC ≥ Stage II and all-cause mortality was compared for an equal period of 24 months 'before' (Epoch 1) and 'after' (Epoch 2) RPS with Bifidobacterium breve M-16V in neonates <34 weeks. Multivariate logistic regression analysis was conducted to adjust for relevant confounders. RESULTS: A total
David Gaist, Ellen Garde, Morten Blaabjerg et al. · 2016 · Brain
A small number of population-based studies reported an association between migraine with aura and risk of silent brain infarcts and white matter hyperintensities in females. We investigated these relations in a population-based sample of…
Jason R. Conn, Elizabeth Catchpoole, Naomi Runnegar et al. · 2017 · PLoS ONE
Febrile neutropenia (FN) is a medical emergency and can represent a life-threatening complication for hematology patients treated with intensive chemotherapy regimens. In clinical practice, the diagnostic yield of blood cultures and other investigations which aim to identify a causative organism or site of infection is low. We have retrospectively examined all blood cultures collected in a "real world" cohort of patients receiving chemotherapy for acute leukemia and patients with aggressive lymphoma treated with Hyper-CVAD/MTX-cytarabine, at a single tertiary center over a five-year period. In
Gregor D. Wehinger, Matthias Kraume, Viktor Berg et al. · 2016 · AIChE Journal
Dry reforming of methane (DRM) over nickel in a fixed‐bed reactor of spheres was studied experimentally and with CFD simulations. Temperature and mole fraction profiles were measured in a dedicated profile reactor as function of axial…
Roberta De Santis, Tatiana Cesaroni · 2016 · World Economy
Abstract Current account ( CA ) dispersion within European Union ( EU ) Member States has been increasing progressively since the 1990s. Interestingly, the persistent deficits in many peripheral countries have not been accompanied by a…
Simone Dietrich, Matthew S. Winters · 2015 · Journal of Experimental Political Science
Abstract Branding of foreign aid may undermine government legitimacy in developing countries when citizens see social services being provided by external actors. We run a survey experiment on a sample of Indian respondents. All subjects…
Mas Intan Purba, Demak Claudia Yosephine Simanjutak, Yois Nelsari Malau et al. · 2021 · International Journal of Data and Network Science
The purpose of this study is to analyze the effects of digital marketing (DM), e-commerce (EC), business sustainability (BS) and financial performance (FP) of Micro, Small and Medium Enterprises (MSMEs) during Pandemic Covid19 in Indonesia. The relationships between digital marketing and business sustainability, e-commerce and business sustainability, digital marketing and financial performance, e-commerce and financial performance, financial performance and business sustainability are investigated. This research is quantitative research with a questionnaire approach. Data processing tools use
Marie Louise Tørring, Peter Murchie, William Hamilton et al. · 2017 · British Journal of Cancer
BACKGROUND: The benefits from expedited diagnosis of symptomatic cancer are uncertain. We aimed to analyse the relationship between stage of colorectal cancer (CRC) and the primary and specialist care components of the diagnostic interval.…
Jan Stoop, Charles Noussair, Daan van Soest · 2012 · Journal of Political Economy
We conduct a field experiment to measure cooperation among groups of recreational fishermen at a privately owned fishing facility. Group earnings are greater when group members catch fewer fish. Consistent with classical economic theory,…
Patrick J. Leavey, Nadia N. Laack, Mark D. Krailo et al. · 2021 · Journal of Clinical Oncology
PURPOSE The primary aim of this phase III randomized trial was to test whether the addition of vincristine, topotecan, and cyclophosphamide (VTC) to interval compressed chemotherapy improved survival outcomes for patients with previously…