Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Kyohei Nishino, Atsushi Nishida, Ryo Inoüe et al. · 2017 · Journal of Gastroenterology
BACKGROUND: The mucosa-associated gut microbiota directly modulates epithelial and mucosal function. In this study, we investigated the mucosa-associated microbial community in patients with inflammatory bowel disease (IBD), using endoscopic brush samples. METHODS: A total of 174 mucus samples from 43 patients with ulcerative colitis (UC), 26 with Crohn's disease (CD) and 14 non-IBD controls were obtained by gentle brushing of mucosal surfaces using endoscopic cytology brushes. The gut microbiome was analyzed using 16S rRNA gene sequencing. RESULTS: There were no significant differences in mic
View details →DOI: 10.1007/s00535-017-1384-4Cited by 474 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Falk Hildebrand, Thi Loan Anh Nguyen, Brigitta M. N. Brinkman et al. · 2013 · Genome biology
BACKGROUND: Murine models are a crucial component of gut microbiome research. Unfortunately, a multitude of genetic backgrounds and experimental setups, together with inter-individual variation, complicates cross-study comparisons and a global understanding of the mouse microbiota landscape. Here, we investigate the variability of the healthy mouse microbiota of five common lab mouse strains using 16S rDNA pyrosequencing. RESULTS: We find initial evidence for richness-driven, strain-independent murine enterotypes that show a striking resemblance to those in human, and which associate with calp
View details →DOI: 10.1186/gb-2013-14-1-r4Cited by 474 Negative / Null Result ReportBusiness, Management and Accounting
Angela K. Davis, David A. Guenther, Linda K. Krull et al. · 2015 · The Accounting Review
ABSTRACT We investigate the relation between corporate tax payments and corporate social responsibility. Because existing theory and empirical studies find inconsistent evidence on the relation between these constructs, we investigate…
View details →DOI: 10.2308/accr-51224Cited by 473 Negative / Null Result ReportOpen accessMedicine
Nazlı Dizman, Luís Meza, Paulo Gustavo Bergerot et al. · 2022 · Nature Medicine
Previous studies have suggested that the gut microbiome influences the response to checkpoint inhibitors (CPIs) in patients with cancer. CBM588 is a bifidogenic live bacterial product that we postulated could augment CPI response through modulation of the gut microbiome. In this open-label, single-center study (NCT03829111), 30 treatment-naive patients with metastatic renal cell carcinoma with clear cell and/or sarcomatoid histology and intermediate- or poor-risk disease were randomized 2:1 to receive nivolumab and ipilimumab with or without daily oral CBM588, respectively. Stool metagenomic s
View details →DOI: 10.1038/s41591-022-01694-6Cited by 473 Negative / Null Result ReportOpen accessMedicine
A. A. de Graaff, Thomas D’Hooghe, G.A.J. Dunselman et al. · 2013 · Human Reproduction
STUDY QUESTION: To what extent do the management of endometriosis and the symptoms that remain after treatment affect the quality of life in women with the disease? SUMMARY ANSWER: Many women with endometriosis had impaired quality of life…
View details →DOI: 10.1093/humrep/det284Cited by 473 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Tiantian Ren, Stan Boutin, Murray M. Humphries et al. · 2017 · Microbiome
BACKGROUND: Our understanding of gut microbiota has been limited primarily to findings from human and laboratory animals, but what shapes the gut microbiota in nature remains largely unknown. To fill this gap, we conducted a comprehensive study of gut microbiota of a well-studied North American red squirrel (Tamiasciurus hudsonicus) population. Red squirrels are territorial, solitary, and live in a highly seasonal environment and therefore represent a very attractive system to study factors that drive the temporal and spatial dynamics of gut microbiota. RESULT: For the first time, this study r
View details →DOI: 10.1186/s40168-017-0382-3Cited by 472 Negative / Null Result ReportOpen accessBusiness, Management and Accounting
Siliang Tong, Nan Jia, Xueming Luo et al. · 2021 · Strategic Management Journal
Abstract Companies are increasingly using artificial intelligence (AI) to provide performance feedback to employees, by tracking employee behavior at work, automating performance evaluations, and recommending job improvements. However,…
View details →DOI: 10.1002/smj.3322Cited by 471 Negative / Null Result ReportArts and Humanities
Zoltán Dörnyei, Letty Chan · 2013 · Language Learning
Recent theorizing on second language (L2) motivation has proposed viewing motivation as a function of the language learners’ vision of their desired future language selves. This would suggest that the intensity of motivation is partly…
View details →DOI: 10.1111/lang.12005Cited by 470 Negative / Null Result ReportOpen accessMedicine
Christiane Maria Prado Jerônimo, Maria Eduarda Leão de Farias, Fernando Val et al. · 2020 · Clinical Infectious Diseases
BACKGROUND: Steroid use for coronavirus disease 2019 (COVID-19) is based on the possible role of these drugs in mitigating the inflammatory response, mainly in the lungs, triggered by severe acute respiratory syndrome coronavirus 2…
View details →DOI: 10.1093/cid/ciaa1177Cited by 470 Negative / Null Result ReportBusiness, Management and Accounting
Mehmet Mehmetoglu, Marit Engen · 2011 · Journal of Quality Assurance in Hospitality & Tourism
The growing attention placed on experiences can be regarded as a mega-trend, and has given currency to the proposition that experiences function as a personal source of information for the stories people tell about their lives and are…
View details →DOI: 10.1080/1528008x.2011.541847Cited by 469 Negative / Null Result ReportOpen accessImmunology and Microbiology
Jacob D. Estes, Levelle D. Harris, Nichole R. Klatt et al. · 2010 · PLoS Pathogens
The chronic phase of HIV infection is marked by pathological activation of the immune system, the extent of which better predicts disease progression than either plasma viral load or CD4(+) T cell count. Recently, translocation of microbial products from the gastrointestinal tract has been proposed as an underlying cause of this immune activation, based on indirect evidence including the detection of microbial products and specific immune responses in the plasma of chronically HIV-infected humans or SIV-infected Asian macaques. We analyzed tissues from SIV-infected rhesus macaques (RMs) to pro
View details →DOI: 10.1371/journal.ppat.1001052Cited by 468 Negative / Null Result ReportOpen accessAgricultural and Biological Sciences
Virginia Rauh, Frederica P. Perera, Megan K. Horton et al. · 2012 · Proceedings of the National Academy of Sciences
Prenatal exposure to chlorpyrifos (CPF), an organophosphate insecticide, is associated with neurobehavioral deficits in humans and animal models. We investigated associations between CPF exposure and brain morphology using magnetic…
View details →DOI: 10.1073/pnas.1203396109Cited by 468 Negative / Null Result ReportOpen accessMedicine
Janine Giese‐Davis, Kate Collie, Kate M. Rancourt et al. · 2010 · Journal of Clinical Oncology
PURPOSE: Numerous studies have examined the comorbidity of depression with cancer, and some have indicated that depression may be associated with cancer progression or survival. However, few studies have assessed whether changes in…
View details →DOI: 10.1200/jco.2010.28.4455Cited by 468 Negative / Null Result ReportSocial Sciences
Suharno Pawirosumarto, Purwanto Katijan Sarjana, Rachmad Gunawan · 2017 · International Journal of Law and Management
Purpose The purpose of this paper is to determine the effect of the work environment, leadership style and organizational culture on job satisfaction and its implication toward the performance of the employees. Design/methodology/approach…
View details →DOI: 10.1108/ijlma-10-2016-0085Cited by 466 Negative / Null Result ReportOpen accessMathematics
Daniel J. Wilson · 2019 · Proceedings of the National Academy of Sciences
-value (HMP), which controls the FWER while greatly improving statistical power by combining dependent tests using generalized central limit theorem. I show that the HMP effortlessly combines information to detect statistically significant signals among groups of individually nonsignificant hypotheses in examples of a human GWAS for neuroticism and a joint human-pathogen GWAS for hepatitis C viral load. The HMP simultaneously tests all ways to group hypotheses, allowing the smallest groups of hypotheses that retain significance to be sought. The power of the HMP to detect significant hypothesi
View details →DOI: 10.1073/pnas.1814092116Cited by 466 Negative / Null Result ReportOpen accessMedicine
Alan Pollack, Gail Walker, Eric M. Horwitz et al. · 2013 · Journal of Clinical Oncology
PURPOSE: To determine if escalated radiation dose using hypofractionation significantly reduces biochemical and/or clinical disease failure (BCDF) in men treated primarily for prostate cancer. PATIENTS AND METHODS: Between June 2002 and…
View details →DOI: 10.1200/jco.2013.51.1972Cited by 466 Negative / Null Result ReportOpen accessMedicine
Mary E. Tinetti, Ling Han, David S. H. Lee et al. · 2014 · JAMA Internal Medicine
IMPORTANCE The effect of serious injuries, such as hip fracture and head injury, on mortality and function is comparable to that of cardiovascular events. Concerns have been raised about the risk of fall injuries in older adults taking…
View details →DOI: 10.1001/jamainternmed.2013.14764Cited by 466 Negative / Null Result ReportMedicine
MVE Veenendaal, R.C. Painter, Susanne R. de Rooij et al. · 2013 · BJOG An International Journal of Obstetrics & Gynaecology
OBJECTIVE: We previously showed that maternal under-nutrition during gestation is associated with increased metabolic and cardiovascular disease in the offspring. Also, we found increased neonatal adiposity among the grandchildren of women…
View details →DOI: 10.1111/1471-0528.12136Cited by 465 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
David E. Harrison, Randy Strong, David B. Allison et al. · 2013 · Aging Cell
Four agents--acarbose (ACA), 17-α-estradiol (EST), nordihydroguaiaretic acid (NDGA), and methylene blue (MB)--were evaluated for lifespan effects in genetically heterogeneous mice tested at three sites. Acarbose increased male median lifespan by 22% (P < 0.0001), but increased female median lifespan by only 5% (P = 0.01). This sexual dimorphism in ACA lifespan effect could not be explained by differences in effects on weight. Maximum lifespan (90th percentile) increased 11% (P < 0.001) in males and 9% (P = 0.001) in females. EST increased male median lifespan by 12% (P = 0.002), but did not le
View details →DOI: 10.1111/acel.12170Cited by 464 Negative / Null Result ReportOpen accessMedicine
Natalie Hofmann, Felista Mwingira, Seif Shekalaghe et al. · 2015 · PLoS Medicine
BACKGROUND: Planning and evaluating malaria control strategies relies on accurate definition of parasite prevalence in the population. A large proportion of asymptomatic parasite infections can only be identified by surveillance with molecular methods, yet these infections also contribute to onward transmission to mosquitoes. The sensitivity of molecular detection by PCR is limited by the abundance of the target sequence in a DNA sample; thus, detection becomes imperfect at low densities. We aimed to increase PCR diagnostic sensitivity by targeting multi-copy genomic sequences for reliable det
View details →DOI: 10.1371/journal.pmed.1001788Cited by 464 Negative / Null Result ReportMedicine
Amir Englund, Paul D. Morrison, Judith Nottage et al. · 2012 · Journal of Psychopharmacology
Community-based studies suggest that cannabis products that are high in Δ⁹-tetrahydrocannabinol (THC) but low in cannabidiol (CBD) are particularly hazardous for mental health. Laboratory-based studies are ideal for clarifying this issue…
View details →DOI: 10.1177/0269881112460109Cited by 462 Negative / Null Result ReportBusiness, Management and Accounting
Nabil Tamimi, Rose Sebastianelli · 2017 · Management Decision
Purpose The purpose of this paper is to explore the state of S&P 500 companies’ transparency by analyzing their Bloomberg ESG (Environmental-Social-Governance) disclosure scores. Additionally, the effects of industry sector, firm size,…
View details →DOI: 10.1108/md-01-2017-0018Cited by 461 Negative / Null Result ReportOpen accessAgricultural and Biological Sciences
Michael G. Branstetter, Bryan N. Danforth, James P. Pitts et al. · 2017 · Current Biology
The stinging wasps (Hymenoptera: Aculeata) are an extremely diverse lineage of hymenopteran insects, encompassing over 70,000 described species and a diversity of life history traits, including ectoparasitism, cleptoparasitism, predation, pollen feeding (bees [Anthophila] and Masarinae), and eusociality (social vespid wasps, ants, and some bees) [1]. The most well-studied lineages of Aculeata are the ants, which are ecologically dominant in most terrestrial ecosystems [2], and the bees, the most important lineage of angiosperm-pollinating insects [3]. Establishing the phylogenetic affinities o
View details →DOI: 10.1016/j.cub.2017.03.027Cited by 461 Negative / Null Result ReportOpen accessNeuroscience
Luigi Angelo Vaira, Giovanna Deiana, Alessandro Giuseppe Fois et al. · 2020 · Head & Neck
BACKGROUND: The first European case series are detecting a very high frequency of chemosensitive disorders in COVID-19 patients, ranging between 19.4% and 88%. METHODS: Olfactory and gustatory function was objectively tested in 72 COVID-19…
View details →DOI: 10.1002/hed.26204Cited by 460 Negative / Null Result ReportMedicine
Bradley C. Leibovich, Christine M. Lohse, Paul L. Crispen et al. · 2010 · The Journal of Urology
PURPOSE: There are significant differences in clinicopathological features among renal cell carcinoma histological subtypes but controversy exists regarding the independent impact of histological subtype on patient outcome after…
View details →DOI: 10.1016/j.juro.2009.12.035Cited by 460 Negative / Null Result ReportEconomics, Econometrics and Finance
Larelle Chapple, Peter Clarkson, Daniel L. Gold · 2013 · Abacus
In M arch 2008, the A ustralian Government announced its intention to introduce a national Emissions Trading Scheme ( ETS ), now expected to start in 2015. This impending development provides an ideal setting to investigate the impact an…
View details →DOI: 10.1111/abac.12006Cited by 459 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
US Preventive Services Task Force, Douglas K Owens, Karina W. Davidson et al. · 2019 · JAMA
Importance: Potentially harmful mutations of the breast cancer susceptibility 1 and 2 genes (BRCA1/2) are associated with increased risk for breast, ovarian, fallopian tube, and peritoneal cancer. For women in the United States, breast…
View details →DOI: 10.1001/jama.2019.10987Cited by 458 Negative / Null Result ReportOpen accessImmunology and Microbiology
Luis E. Escobar, Alvaro Molina-Cruz, Carolina Barillas‐Mury · 2020 · Proceedings of the National Academy of Sciences
Significance The COVID-19 pandemic is one of the most devastating in recent history. The bacillus Calmette−Guérin (BCG) vaccine against tuberculosis also confers broad protection against other infectious diseases, and it has been proposed that it could reduce the severity of COVID-19. This epidemiological study assessed the global linkage between BCG vaccination and COVID-19 mortality. Signals of BCG vaccination effect on COVID-19 mortality are influenced by social, economic, and demographic differences between countries. After mitigating multiple confounding factors, several significant assoc
View details →DOI: 10.1073/pnas.2008410117Cited by 458 Negative / Null Result ReportOpen accessImmunology and Microbiology
Hadi Zokaeifar, José Luís Balcázar, Che Roos Saad et al. · 2012 · Fish & Shellfish Immunology
We studied the effect of two probiotic Bacillus subtilis strains on the growth performance, digestive enzyme activity, immune gene expression and disease resistance of juvenile white shrimp (Litopenaeus vannamei). A mixture of two…
View details →DOI: 10.1016/j.fsi.2012.05.027Cited by 458 Negative / Null Result ReportEnvironmental Science
Jiaxiu He, Haoming Liu, Alberto Salvo · 2019 · American Economic Journal Applied Economics
We examine day-to-day fluctuations in worker-level output at two manufacturing sites in China. Ambient fine-particle (PM2.5) pollution is severe but significantly variable, largely due to exogenous atmospheric ventilation. We obtain an…
View details →DOI: 10.1257/app.20170286Cited by 457 