A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
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Lorenz Roth, Joachim Saur, K. D. Retherford et al. · 2013 · Science
In November and December 2012, the Hubble Space Telescope (HST) imaged Europa's ultraviolet emissions in the search for vapor plume activity. We report statistically significant coincident surpluses of hydrogen Lyman-α and oxygen OI…
John P. Clancy, Steven M. Rowe, Frank J. Accurso et al. · 2011 · Thorax
BACKGROUND: VX-809, a cystic fibrosis transmembrane conductance regulator (CFTR) modulator, has been shown to increase the cell surface density of functional F508del-CFTR in vitro. METHODS: A randomised, double-blind, placebo-controlled…
Markus Waldén, I. Atroshi, Henrik Magnusson et al. · 2012 · BMJ
OBJECTIVE: To evaluate the effectiveness of neuromuscular training in reducing the rate of acute knee injury in adolescent female football players. DESIGN: Stratified cluster randomised controlled trial with clubs as the unit of…
Erin L. Kelly, Phyllis Moen, J. Michael Oakes et al. · 2014 · American Sociological Review
Schedule control and supervisor support for family and personal life are work resources that may help employees manage the work-family interface. However, existing data and designs have made it difficult to conclusively identify the…
Catherine Happer, Greg Philo · 2013 · Journal of Social and Political Psychology
The media play a central role in informing the public about what happens in the world, particularly in those areas in which audiences do not possess direct knowledge or experience. This article examines the impact the media has in the construction of public belief and attitudes and its relationship to social change. Drawing on findings from a range of empirical studies, we look at the impact of media coverage in areas such as disability, climate change and economic development. Findings across these areas show the way in which the media shape public debate in terms of setting agendas and focus
Dean Karlan, Jonathan Zinman · 2011 · Science
Microcredit institutions spend billions of dollars fighting poverty by making small loans primarily to female entrepreneurs. Proponents argue that microcredit mitigates market failures, spurs micro-enterprise growth, and boosts borrowers'…
Idoia Elola, Ana Oskoz · 2010 · Language learning & technology
The use of social technologies, such as wikis and chats, has brought a renewed attention to L2 collaborative writing.Yet, a question that still remains to be answered is the extent to which learners' writing is enhanced when using these…
J. Michael Wells, George R. Washko, MeiLan K. Han et al. · 2012 · New England Journal of Medicine
BACKGROUND: Exacerbations of chronic obstructive pulmonary disease (COPD) are associated with accelerated loss of lung function and death. Identification of patients at risk for these events, particularly those requiring hospitalization,…
Eva Haglind, Stefan Carlsson, Johan Stranne et al. · 2015 · European Urology
BACKGROUND: Robot-assisted laparoscopic radical prostatectomy (RALP) has become widely used without high-grade evidence of superiority regarding long-term clinical outcomes compared with open retropubic radical prostatectomy (RRP), the…
Tiffany N. Castillo, Michael A. Pouliot, Hyeon Joo Kim et al. · 2010 · The American Journal of Sports Medicine
BACKGROUND: Clinical studies claim that platelet-rich plasma (PRP) shortens recovery times because of its high concentration of growth factors that may enhance the tissue repair process. Most of these studies obtained PRP using different…
Αιμιλία Πρωτόγερου, Yannis Caloghirou, Spyros Lioukas · 2011 · Industrial and Corporate Change
This article seeks to empirically explore the relationship between dynamic capabilities and firm performance. In particular, it addresses the question of whether dynamic capabilities impact directly or indirectly on performance. In doing…
Roberto Castricini, Umile Giuseppe Longo, Massimo De Benedetto et al. · 2010 · The American Journal of Sports Medicine
BACKGROUND: After reinsertion on the humerus, the rotator cuff has limited ability to heal. Growth factor augmentation has been proposed to enhance healing in such procedure. PURPOSE: This study was conducted to assess the efficacy and…
Young‐Seoub Hong, Ki-Hoon Song, Jin‐Yong Chung · 2014 · Journal of Preventive Medicine and Public Health
Arsenic is a unique element with distinct physical characteristics and toxicity whose importance in public health is well recognized. The toxicity of arsenic varies across its different forms. While the carcinogenicity of arsenic has been…
Youngjoon Choi, Miju Choi, Munhyang Oh et al. · 2019 · Journal of Hospitality Marketing & Management
Hotel industry started to adopt service robots, which are considered a future workforce. However, no attempt was conducted to examine the dimensionality of service quality of service robots. This paper aims to understand the influence of…
Abdulaziz N. Alagaili, Thomas Briese, Nischay Mishra et al. · 2014 · mBio
The Middle East respiratory syndrome (MERS) is proposed to be a zoonotic disease; however, the reservoir and mechanism for transmission of the causative agent, the MERS coronavirus, are unknown. Dromedary camels have been implicated through reports that some victims have been exposed to camels, camels in areas where the disease has emerged have antibodies to the virus, and viral sequences have been recovered from camels in association with outbreaks of the disease among humans. Nonetheless, whether camels mediate transmission to humans is unresolved. Here we provide evidence from a geographic
Christopher J. Soto · 2019 · Psychological Science
The Big Five personality traits have been linked to dozens of life outcomes. However, metascientific research has raised questions about the replicability of behavioral science. The Life Outcomes of Personality Replication (LOOPR) Project…
Karen Kelly, Nasser K. Altorki, Wilfried Eberhardt et al. · 2015 · Journal of Clinical Oncology
PURPOSE: Epidermal growth factor receptor (EGFR) -tyrosine kinase inhibitors have proven efficacy in advanced non-small-cell lung cancer (NSCLC). We hypothesized that erlotinib would be efficacious in the adjuvant setting. PATIENTS AND…
Patrick Mismetti, Silvy Laporte, Olivier Pellerin et al. · 2015 · JAMA
IMPORTANCE: Although retrievable inferior vena cava filters are frequently used in addition to anticoagulation in patients with acute venous thromboembolism, their benefit-risk ratio is unclear. OBJECTIVE: To evaluate the efficacy and…
Jodie M Dodd, Deborah Turnbull, Andrew J McPhee et al. · 2014 · BMJ
OBJECTIVE: To determine the effect of antenatal dietary and lifestyle interventions on health outcomes in overweight and obese pregnant women. DESIGN: Multicentre randomised trial. We utilised a central telephone randomisation server, with…
Maria Grazia Bongiorni, Charles Kennergren, Christian Butter et al. · 2017 · European Heart Journal
AIMS: The European Lead Extraction ConTRolled Registry (ELECTRa), is a prospective registry of consecutive transvenous lead extraction (TLE) procedures conducted by the European Heart Rhythm Association (EHRA) in order to identify the…
Heather C. Hazlett, Michele D. Poe, Guido Gerig et al. · 2011 · Archives of General Psychiatry
CONTEXT: Brain enlargement has been observed in 2-year-old children with autism, but the underlying mechanisms are unknown. OBJECTIVE: To investigate early growth trajectories in brain volume and cortical thickness. DESIGN: Longitudinal…
Naihui Zhou, Yuxiang Jiang, Timothy Bergquist et al. · 2019 · Genome biology
BACKGROUND: The Critical Assessment of Functional Annotation (CAFA) is an ongoing, global, community-driven effort to evaluate and improve the computational annotation of protein function. RESULTS: Here, we report on the results of the third CAFA challenge, CAFA3, that featured an expanded analysis over the previous CAFA rounds, both in terms of volume of data analyzed and the types of analysis performed. In a novel and major new development, computational predictions and assessment goals drove some of the experimental assays, resulting in new functional annotations for more than 1000 genes. S
Michael D. Ward, Brian Greenhill, Kristin M. Bakke · 2010 · Journal of Peace Research
Abstract Large-n studies of conflict have produced a large number of statistically significant results but little accurate guidance in terms of anticipating the onset of conflict. The authors argue that too much attention has been paid to…
Neil A. Smart, Mark Waldron, Hashbullah Ismail et al. · 2015 · International Journal of Evidence-Based Healthcare
INTRODUCTION: Several established tools are available to assess study quality and reporting of randomized controlled trials; however, these tools were designed with clinical intervention trials in mind. In exercise training intervention…
A. Salarian, Fay B. Horak, Cris Zampieri et al. · 2010 · IEEE Transactions on Neural Systems and Rehabilitation Engineering
Timed Up and Go (TUG) test is a widely used clinical paradigm to evaluate balance and mobility. Although TUG includes several complex subcomponents, namely: sit-to-stand, gait, 180 degree turn, and turn-to-sit; the only outcome is the…
Sabine L. Vriezinga, Renata Auricchio, E. Bravi et al. · 2014 · New England Journal of Medicine
BACKGROUND: A window of opportunity has been suggested for reducing the risk of celiac disease by introducing gluten to infants at 4 to 6 months of age. METHODS: We performed a multicenter, randomized, double-blind, placebo-controlled…
R. Phillip Dellinger, Sean M. Bagshaw, Massimo Antonelli et al. · 2018 · JAMA
Importance: Polymyxin B hemoperfusion reduces blood endotoxin levels in sepsis. Endotoxin activity can be measured in blood with a rapid assay. Treating patients with septic shock and elevated endotoxin activity using polymyxin B…
Devon E. Hinton, Roberto Lewis‐Fernández · 2010 · Depression and Anxiety
BACKGROUND: There is considerable debate about the cross-cultural applicability of the posttraumatic stress disorder (PTSD) category as currently specified. Concerns include the possible status of PTSD as a Western culture-bound disorder…
Daniel F. McAuley, John G. Laffey, Cecilia O’Kane et al. · 2014 · New England Journal of Medicine
BACKGROUND: Studies in animals and in vitro and phase 2 studies in humans suggest that statins may be beneficial in the treatment of the acute respiratory distress syndrome (ARDS). This study tested the hypothesis that treatment with…
Stan B. Kaye, Jan Lubiński, Ursula A. Matulonis et al. · 2011 · Journal of Clinical Oncology
PURPOSE: Olaparib (AZD2281), an orally active poly (ADP-ribose) polymerase inhibitor that induces synthetic lethality in BRCA1- or BRCA2-deficient cells, has shown promising clinical efficacy in nonrandomized phase II trials in patients…