Acarbose, 17‐α‐estradiol, and nordihydroguaiaretic acid extend mouse lifespan preferentially in males
David E. Harrison; Randy Strong; David B. Allison; Bruce N. Ames; Clinton M. Astle; Hani Atamna; Elizabeth Fernández; Kevin Flurkey · 2013 · Aging Cell
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Four agents--acarbose (ACA), 17-α-estradiol (EST), nordihydroguaiaretic acid (NDGA), and methylene blue (MB)--were evaluated for lifespan effects in genetically heterogeneous mice tested at three sites. Acarbose increased male median lifespan by 22% (P < 0.0001), but increased female median lifespan by only 5% (P = 0.01). This sexual dimorphism in ACA lifespan effect could not be explained by differences in effects on weight. Maximum lifespan (90th percentile) increased 11% (P < 0.001) in males and 9% (P = 0.001) in females. EST increased male median lifespan by 12% (P = 0.002), but did not le
Abstract by David E. Harrison; Randy Strong; David B. Allison; Bruce N. Ames; Clinton M. Astle; Hani Atamna; Elizabeth Fernández; Kevin Flurkey, Aging Cell (2013) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1111/acel.12170