A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
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Nitin Shivappa, James R. Hébert, Ernst Rietzschel et al. · 2015 · British Journal Of Nutrition
Previous research has shown that nutrients and certain food items influence inflammation. However, little is known about the associations between diet, as a whole, and inflammatory markers. In the present study, we examined the ability of…
Silvana Galderisi, Alessandro Rossi, Paola Rocca et al. · 2014 · World Psychiatry
In people suffering from schizophrenia, major areas of everyday life are impaired, including independent living, productive activities and social relationships. Enhanced understanding of factors that hinder real-life functioning is vital…
Michelle L. O’Donoghue, Eugene Braunwald, Harvey D. White et al. · 2014 · JAMA
IMPORTANCE: Lipoprotein-associated phospholipase A2 (Lp-PLA2) has been hypothesized to be involved in atherogenesis through pathways related to inflammation. Darapladib is an oral, selective inhibitor of the Lp-PLA2 enzyme. OBJECTIVE: To…
Dan Frampton, Tommy Rampling, Aidan Cross et al. · 2021 · The Lancet Infectious Diseases
BACKGROUND: Emergence of variants with specific mutations in key epitopes in the spike protein of SARS-CoV-2 raises concerns pertinent to mass vaccination campaigns and use of monoclonal antibodies. We aimed to describe the emergence of…
Lei Wu, Lin Liu, Bin Gao et al. · 2013 · Langmuir
Although graphene oxide (GO) has been used in many applications to improve human life quality, its environmental fate and behavior are still largely unknown. In this work, a novel approach that combines experimental measurements and…
Elhadi Adam, Onisimo Mutanga, John Odindi et al. · 2014 · International Journal of Remote Sensing
Mapping of patterns and spatial distribution of land-use/cover (LULC) has long been based on remotely sensed data. In the recent past, efforts to improve the reliability of LULC maps have seen a proliferation of image classification…
Sarah R. Preis, Joseph M. Massaro, Udo Hoffmann et al. · 2010 · The Journal of Clinical Endocrinology & Metabolism
BACKGROUND: Neck circumference, a proxy for upper-body sc fat, may be a unique fat depot that confers additional cardiovascular risk above and beyond central body fat. METHODS AND RESULTS: Participants with neck circumference measures who…
Silvana Tenreyro, Gregory Thwaites · 2013
We estimate the impulse response of key US macro series to the monetary policy shocks identified by Romer and Romer (2004), allowing the response to depend flexibly on the state of the business cycle. We find strong evidence that the…
Charlotte J. Stagg, Gowri Jayaram, Damien Pastor et al. · 2011 · Neuropsychologia
Transcranial direct current stimulation (tDCS) is attracting increasing interest as a therapeutic tool for neurorehabilitation, particularly after stroke, because of its potential to modulate local excitability and therefore promote functional plasticity. Previous studies suggest that timing is important in determining the behavioural effects of brain stimulation. Regulatory metaplastic mechanisms exist to modulate the effects of a stimulation intervention in a manner dependent on prior cortical excitability, thereby preventing destabilization of existing cortical networks. The importance of s
Sèverine Sabia, Aline Dugravot, Jean‐François Dartigues et al. · 2017 · BMJ
This study found no evidence of a neuroprotective effect of physical activity. Previous findings showing a lower risk of dementia in physically active people may be attributable to reverse causation-that is, due to a decline in physical activity levels in the preclinical phase of dementia.
Palle Bekker Jeppesen, Richard Gilroy, M. Pertkiewicz et al. · 2011 · Gut
BACKGROUND AND AIMS: Teduglutide, a GLP-2 analogue, may restore intestinal structural and functional integrity by promoting repair and growth of the mucosa and reducing gastric emptying and secretion, thereby increasing fluid and nutrient…
Niklas Potrafke · 2014 · World Economy
Abstract Globalisation is blamed for many socioeconomic shortcomings. I discuss the consequences of globalisation by surveying the empirical globalisation literature. My focus is on the KOF indices of globalisation that have been used in…
Peter de Barros Damgaard, Rui Martiniano, Jack Kamm et al. · 2018 · Science
The Yamnaya expansions from the western steppe into Europe and Asia during the Early Bronze Age (~3000 BCE) are believed to have brought with them Indo-European languages and possibly horse husbandry. We analyzed 74 ancient whole-genome…
Almudena Marí Sáez, Sabrina Weiß, Kathrin Nowak et al. · 2014 · EMBO Molecular Medicine
The severe Ebola virus disease epidemic occurring in West Africa stems from a single zoonotic transmission event to a 2-year-old boy in Meliandou, Guinea. We investigated the zoonotic origins of the epidemic using wildlife surveys, interviews, and molecular analyses of bat and environmental samples. We found no evidence for a concurrent outbreak in larger wildlife. Exposure to fruit bats is common in the region, but the index case may have been infected by playing in a hollow tree housing a colony of insectivorous free-tailed bats (Mops condylurus). Bats in this family have previously been dis
Khawla Bourkhis, Mahmoud Sami Nabi · 2013 · Review of Financial Economics
Abstract The recent global financial crisis has induced a series of failure of many conventional banks and led to an increased interest in the Islamic banking business model. This paper attempts to answer empirically the following…
Kevin Gross, Bradley J. Cardinale, Jeremy W. Fox et al. · 2013 · The American Naturalist
The relationship between biological diversity and ecological stability has fascinated ecologists for decades. Determining the generality of this relationship, and discovering the mechanisms that underlie it, are vitally important for…
Melinda C. Power, Marc G. Weisskopf, Stacey Alexeeff et al. · 2010 · Environmental Health Perspectives
BACKGROUND: Traffic-related particles induce oxidative stress and may exert adverse effects on central nervous system function, which could manifest as cognitive impairment. OBJECTIVE: We assessed the association between black carbon (BC), a marker of traffic-related air pollution, and cognition in older men. METHODS: A total of 680 men (mean ± SD, 71 ± 7 years of age) from the U.S. Department of Veterans Affairs Normative Aging Study completed a battery of seven cognitive tests at least once between 1996 and 2007. We assessed long-term exposure to traffic-related air pollution using a validat
Thomas J. Lynch, Taral Patel, Luke Dreisbach et al. · 2010 · Journal of Clinical Oncology
PURPOSE To evaluate the efficacy of cetuximab plus taxane/carboplatin (TC) as first-line treatment of advanced non-small-cell lung cancer (NSCLC). PATIENTS AND METHODS This multicenter, open-label, phase III study enrolled 676…
Alexander Coppock, Thomas J. Leeper, Kevin Mullinix · 2018 · Proceedings of the National Academy of Sciences
The extent to which survey experiments conducted with nonrepresentative convenience samples are generalizable to target populations depends critically on the degree of treatment effect heterogeneity. Recent inquiries have found a strong…
Claus Z. Simonsen, Albert J. Yoo, Leif H. Sørensen et al. · 2018 · JAMA Neurology
Importance: Endovascular therapy (EVT) is the standard of care for select patients who had a stroke caused by a large vessel occlusion in the anterior circulation, but there is uncertainty regarding the optimal anesthetic approach during…
Boris Podobnik, Zhi‐Qiang Jiang, Wei‐Xing Zhou et al. · 2011 · Physical Review E
For stationary time series, the cross-covariance and the cross-correlation as functions of time lag $n$ serve to quantify the similarity of two time series. The latter measure is also used to assess whether the cross-correlations are…
André Lamy, P.J. Devereaux, Dorairaj Prabhakaran et al. · 2013 · New England Journal of Medicine
BACKGROUND: Previously, we reported that there was no significant difference at 30 days in the rate of a primary composite outcome of death, myocardial infarction, stroke, or new renal failure requiring dialysis between patients who…
Charles E. Geyer, Judy E. Garber, Richard D. Gelber et al. · 2022 · Annals of Oncology
BACKGROUND: The randomized, double-blind OlympiA trial compared 1 year of the oral poly(adenosine diphosphate-ribose) polymerase inhibitor, olaparib, to matching placebo as adjuvant therapy for patients with pathogenic or likely pathogenic variants in germline BRCA1 or BRCA2 (gBRCA1/2pv) and high-risk, human epidermal growth factor receptor 2-negative, early breast cancer (EBC). The first pre-specified interim analysis (IA) previously demonstrated statistically significant improvement in invasive disease-free survival (IDFS) and distant disease-free survival (DDFS). The olaparib group had fewe
Bapi Sarker, Dimitrios G. Papageorgiou, Raquel Silva et al. · 2013 · Journal of Materials Chemistry B
Microencapsulation of cells by using biodegradable hydrogels offers numerous attractive features for a variety of biomedical applications including tissue engineering. This study highlights the fabrication of microcapsules from an…
Ming Yang, Shuo Chen, Bo Huang et al. · 2020 · European Urology Focus
BACKGROUND: Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), involves multiple organs. Testicular involvement is largely unknown. OBJECTIVE: To determine the pathological changes…
Anna Müller, Michaela Wenzel, Henrik Strahl et al. · 2016 · Proceedings of the National Academy of Sciences
and different assays, including proteomics, ionomics, and fluorescence light microscopy. We found that daptomycin causes a gradual decrease in membrane potential but does not form discrete membrane pores. Although we found no evidence for…
Michela Carlana · 2019 · The Quarterly Journal of Economics
Abstract I study whether exposure to teacher stereotypes, as measured by the Gender-Science Implicit Association Test, affects student achievement. I provide evidence that the gender gap in math performance, defined as the score of boys…
Jelte M. Wicherts, Marjan Bakker, Dylan Molenaar · 2011 · PLoS ONE
BACKGROUND: The widespread reluctance to share published research data is often hypothesized to be due to the authors' fear that reanalysis may expose errors in their work or may produce conclusions that contradict their own. However, these hypotheses have not previously been studied systematically. METHODS AND FINDINGS: We related the reluctance to share research data for reanalysis to 1148 statistically significant results reported in 49 papers published in two major psychology journals. We found the reluctance to share data to be associated with weaker evidence (against the null hypothesis
Bojing Liu, Fang Fang, Nancy L. Pedersen et al. · 2017 · Neurology
OBJECTIVE: To examine whether vagotomy decreases the risk of Parkinson disease (PD). METHODS: Using data from nationwide Swedish registers, we conducted a matched-cohort study of 9,430 vagotomized patients (3,445 truncal and 5,978…
Chris Derksen, Ross Brown · 2012 · Geophysical Research Letters
Analysis of Northern Hemisphere spring terrestrial snow cover extent (SCE) from the NOAA snow chart Climate Data Record (CDR) for the April to June period (when snow cover is mainly located over the Arctic) has revealed statistically…