A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
21337 results · page 495 of 712
Ahn S, Goya B, Bertomo C et al. · 2025 · Preprint
ABSTRACT High dietary salt intake has powerful effects on cerebral blood vessels and has emerged as a risk factor for stroke and cognitive impairment. In mice, high salt diet (HSD) leads to reduced cerebral blood flow (CBF), tau…
Vilela WR, Platt N, Bechara LRG et al. · 2025 · Preprint
Abstract Microglia exhibit targeted responses to different stimuli, including lipids, which can differ depending on the environmental conditions they face. These responses involve inflammatory mediators and are crucial for maintaining…
Hinks A, Vlemmix E, Power GA · 2025 · The journals of gerontology. Series A, Biological sciences and medical sciences
The age-related loss of muscle mass is partly driven by a reduction in serial sarcomere number (SSN), and further SSN loss occurs during immobilization. Serial sarcomere number is associated with optimal force and power production and…
Matienzo ME, Lee J, Lim S et al. · 2025 · American journal of physiology. Cell physiology
Glucocorticoids (GCs) are potent regulators of energy balance and adipose tissue function, making them attractive targets for obesity treatments. The local activation and inactivation of GCs are mediated by two key enzymes:…
Czarnota P, Gromowski T, Golda A et al. · 2026 · Cell communication and signaling : CCS
Liver cancer often arises in the setting of chronic liver disease and remains a major global health challenge with limited effective treatments. Isoprenylcysteine Carboxyl Methyltransferase (ICMT) is an enzyme that catalyzes the…
Ricalde A, Chen JW, Lim LJ et al. · 2025 · Pediatric dentistry
Purpose: To investigate the color difference between groups and changes over time of resin-modified glass ionomer (RMGI) restorations placed immediately after silver diammine fluoride (SDF) treatment. Methods: Thirty-six specimens were…
Berger L, Mulder E, Zange J et al. · 2025 · Medicine and science in sports and exercise
Purpose During spaceflight, countermeasures are crucial to counteract cardiorespiratory and musculoskeletal deconditioning, similar to effects seen after prolonged immobilization. Within a bed rest study simulating the effects of…
Breen DM, Saavedra-Peña RM, Joaquim S et al. · 2026 · Diabetes, obesity & metabolism
Aims To evaluate the therapeutic potential of leptin treatment for weight loss maintenance preclinically, through a systematic evaluation of leptin efficacy (a) following a period of weight loss stability (as in published clinical…
Jefferies S, Gilkison C, Duff P et al. · 2025 · Public health
Objectives Aotearoa New Zealand employed one of the most stringent public health pandemic responses internationally. We investigated whether ethnic health equity was achieved in the response and outcomes, from COVID-19 elimination in June…
Park SJ, Park JS, Kang DH et al. · 2025 · Neurosurgery
Background and objectives Cement augmentation and hook fixation are popular prophylactic techniques against proximal junctional kyphosis (PJK) development. However, the efficacy of cement and hook has been inconsistent and conflicting.…
Plastina L, Gähwiler K, Gaertner VD et al. · 2025 · BMC pediatrics
Background To evaluate changes in end-expiratory lung impedance (EELI), a surrogate for end-expiratory lung volume (EELV), during a minimal-handling extubation protocol in very preterm infants in prone position. The protocol aimed to…
Grotemeyer A, Alexander S, Frieß L et al. · 2026 · NPJ Parkinson's disease
Neuroinflammation is deeply intertwined with dopaminergic (DA) neurodegeneration in Parkinson's disease (PD). We tested whether delphinidin, an anthocyanidin with reported inflammasome/NF-κB modulatory activity, alters neuroinflammation…
Paulsson M, Ekholm C, Rolfson O et al. · 2024 · Geriatric orthopaedic surgery & rehabilitation
Introduction Surgical treatment of distal femoral fractures (DFFs) in osteoporotic bone is challenging despite improvements in hardware and surgical techniques. The occurrence and degree of secondary displacement during healing after…
Ponsford R, Meiksin R, Sturgess J et al. · 2026 · Journal of epidemiology and community health
Background Relationships and sex education (RSE) impacts some sexual behaviours but could be strengthened by incorporating whole-school approaches (eg, building engagement, providing contraception). These can prevent pregnancies and…
Cao J, Guo M, Wang J et al. · 2025 · Fish physiology and biochemistry
Plant-based essential oils have been considered to be used as fish anesthetics and as suitable alternatives to synthetic anesthetics. In this study, we evaluated the effect of Cinnamomum camphora var. linaloofera Fujita essential oil…
Castro-Cordova P, Lopez-Garcia OK, Orozco J et al. · 2025 · Preprint
The most common cause of healthcare-associated diarrhea and colitis in the U.S., is Clostridioides difficile , a spore-forming pathogen. Two toxins, TcdA and TcdB, are major virulence factors essential for disease manifestations, while C.…
Henriksen K, Jørgensen A, Kaur S et al. · 2024 · Preprint
Immune-mediated beta-cell destruction and lack of alpha-cell responsiveness to hypoglycaemia are hallmarks of type 1 diabetes pathology. The incretin hormone glucose-dependent insulinotropic polypeptide (GIP) may hold therapeutic potential…
Pavicich MA, Maldonado ML, Nguyen TN et al. · 2025 · International journal of food microbiology
Apple fruit is widely consumed worldwide, but fungal contamination in the postharvest stage presents a significant food safety concern. This study evaluates the production and accumulation of Alternaria mycotoxins, including alternariol…
Cifelli A, Butt Z, Cifelli E et al. · 2026 · Case reports in neurological medicine
We present the case of a lady in her early 20s who developed over a few weeks progressive appendicular and limb ataxia and dysarthria. She was found to have a high titer of voltage-gated calcium channel antibodies (VGCCAs) and was started…
Moran MC, Tammone Santos A, Dominguez P et al. · 2025 · Veterinary immunology and immunopathology
Brucella ovis (B. ovis) is the etiological agent of ram-contagious epididymitis, the leading cause of reproductive disorders in flocks worldwide. Although the attenuated B. melitensis Rev.1 strain gives heterologous protection against this…
Seco-Cervera M, Gisbert-Ferrándiz L, Macias-Ceja DC et al. · 2025 · PloS one
Epigenetics has emerged as a modulator of inflammation-related diseases and changes in miRNA expression have been associated with regional location, inflamed mucosa and disease activity in Crohn´s disease (CD). We analyse here the…
Casadevall A · 2025 · The Journal of clinical investigation
Invasive fungal infections carry high morbidity and mortality, but there are no fungal vaccines. In this issue of the JCI, Okaa et al. report that endonuclease 2 (Eng2), an antigen shared by the Blastomyces, Histoplasma, and Coccidioides…
Cao L, Hu J, Mao X et al. · 2026 · Frontiers in oncology
Background Malignant phyllodes tumors (MPTs) of the breast are rare fibroepithelial neoplasms characterized by aggressive clinical behavior and limited evidence guiding systemic therapy in the metastatic setting. Immune checkpoint…
Castro LA, Chen DE, O'Scannlain A et al. · 2026 · Journal of the mechanical behavior of biomedical materials
Elastic fibers are critical for proper mechanical function of large arteries such as the aorta. Fragmentation, degradation, or reduced amounts of elastic fibers are associated with aortic diseases such as stiffening-induced hypertension…
Fage C, Loison S, Zwygart AC et al. · 2025 · Antiviral research
Influenza viruses pose a significant threat due to annual epidemics and pandemic potential. Resistance to current antivirals underscores the need for new drugs and strategies to prevent its emergence. We previously developed two novel…
Jacob A, Mahmoud A, Eldweik L et al. · 2025 · BMJ neurology open
Background Neuromyelitis optica spectrum disorder (NMOSD) is a rare relapsing autoimmune disease of the central nervous system (CNS). Management during pregnancy is challenging due to limited safety data for disease-modifying therapies.…
Tekin-Taş Z, Özger HS, Sultanova F et al. · 2025 · Infectious diseases & clinical microbiology
Objective Real-time multiplex polymerase chain reaction (PCR) test increases the detection of viral respiratory tract infections. This study aimed to evaluate the effect of real-time multiplex PCR on antibiotic use in viral respiratory…
Cajado AG, Lopes MH, Rangel GFP et al. · 2025 · European journal of pharmacology
Irinotecan-based anticancer therapy induces intestinal mucositis, increasing the risk of sepsis and patient death. The phosphoinositide 3-kinases (PI3K) are involved in cancer and inflammatory diseases, but their role in intestinal…
Etemadi R, Mansouri A, Salehidoost R et al. · 2025 · International journal of endocrinology
Objective Hungry bone syndrome (HBS), marked by severe and persistent hypocalcemia, frequently occurs after parathyroidectomy for primary hyperparathyroidism (PHPT). Despite its prevalence, there is limited research on this complication.…
Mütze U, Stengel J, Gleich F et al. · 2025 · Pediatrics
Objective Although newborn screening (NBS) programs were expanded with the implementation of tandem mass spectrometry in the late 1990s, the impact on long-term clinical and cognitive outcomes of adolescents and young adults with inherited…