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Failure-mode index

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A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

21337 results · page 496 of 712

Negative / Null Result ReportOpen accessMedicine

Sensitivity of Romberg Test in Diagnosis of Peripheral Vestibular Disorders in Comparison with Caloric Test: Psychometric Study

Fatemeh Moghadasi-Boroujeni, Mansoureh Adel Ghahraman · 2020 · مجله پژوهش در علوم توانبخشی

Introduction: Romberg test is one of the balance screening tests. Since this test does not require special equipment, it is widely used in the evaluation of people suffering from balance disorders. This study aimed to determine the sensitivity of the Romberg test for the diagnosis of peripheral vestibular dysfunction compared with the caloric test that is the gold standard for the diagnosis of horizontal semicircular canal/superior vestibular nerve disorders.Materials and Methods: This study was a cross-sectional-comparative study and the sample was selected from those who referred to the audi

View details →DOI: 10.22122/jrrs.v16i0.3633
Negative / Null Result ReportOpen accessMedicine (General)

mRNA Expression and Methylation of the , , , , and Genes in Gastric Adenocarcinoma

Joel Del Bel Pádua, Carolline Fontes Alves Mariano, Alexandre Todorovic Fabro et al. · 2024 · Biomarker Insights

Background: Immunohistochemical prognostic significance of the homologous recombination-related proteins RAD51, ATM, BRCA1, and BRCA2 is known in gastric adenocarcinoma, one of the deadliest cancers. Objective and design: This retrospective cohort study aimed to evaluate mRNA expression and promoter methylation of some homologous recombination-related genes in this neoplasm. Methods: We evaluated mRNA expression and methylation of RAD51 , ATM , ATR , BRCA1 , and BRCA2 in tumor and non-tumor frozen samples from gastrectomy specimens by RT-qPCR and MS-HRM, correlating our results with previous i

View details →DOI: 10.1177/11772719231225206
Negative / Null Result ReportOpen accessDiseases of the genitourinary system. Urology

EVALUATION OF SEXUAL DYSFUNCTION IN PATIENTS WITH LUTS, RELATIONSHIP WITH TESTOSTERONE, LEPTIN AND SERUM LIPID LEVELS: RE-EVALUATION AFTER ALPHA BLOCKER TREATMENT

Aves Editorial Aves Editorial · 2019 · Urology Research and Practice

Abstract Introduction: Lower urinary tract symptoms (LUTS) associated with BPH and erectile dysfunction (ED) are common problems in aging male. In this study, we aimed to determine the causes of the relationship between LUTS and ED, and the possible effects of body mass index (BMI), serum leptin, free testosterone (fT) and lipid levels on LUTS and ED etiology. Materials and Methods: Between June 2003 and February 2004, 46 patients were recruited in this study. All patients underwent physical examination including digital rectal examination, urine analysis, uroflowmetry and residual urine volum

Negative / Null Result ReportOpen accessGynecology and obstetrics

Smoking decreases the level of circulating CD34+ progenitor cells in young healthy women - a pilot study

Baumann Gert, Gericke Christine, Mueller Simone et al. · 2010 · BMC Women's Health

Abstract Background Decreased levels of circulating bone marrow-derived progenitor cells have been associated with risk factors and cardiovascular diseases. Smoking is the most important modifiable risk factor for atherosclerosis in young women. The aim of this pilot study was to assess in healthy premenopausal women without other risk factors for cardiovascular disease the influence of nicotine abuse on the number of circulating progenitor cells in relation to endothelial function. Methods The number of endothelial progenitor cells, measured as colony-forming units in a cell-culture assay (EP

View details →DOI: 10.1186/1472-6874-10-20
Negative / Null Result ReportOpen accessPsychiatry

Psychological distress in survivors of farmers' suicides in drought prone Aurangabad and Jalna Districts of Marathwada region in Maharashtra, India

Manik Changoji Bhise, Arun Vishwambhar Marwale, Ashish Chandrakantrao Mohide et al. · 2019 · Annals of Indian Psychiatry

Background: Survivors of suicide experience psychological distress for years after suicide. In India, farmers' suicide survivors are special group, with unique set of stressors. There are very few studies examining this group in India. The objective was to assess psychological distress and its correlates in survivors of farmers' suicides. Methods: This was a cross-sectional study from two districts of Marathwada region of Maharashtra. A predesigned and pretested semi-structured questionnaire to assess sociodemographic variables was used. Self-reporting questionnaire-20 was administered to eval

View details →DOI: 10.4103/aip.aip_29_19
Negative / Null Result ReportOpen accessElectrical engineering. Electronics. Nuclear engineering

Raw material depletion and scenario assessment in European Union – A circular economy approach

Florinda F. Martins, Hélio Castro · 2020 · Energy Reports

Nowadays the production systems are linear and the consumption patterns are essentially based on products with a short life cycle, which contribute to increase the demand for raw materials and environmental impacts. The Circular Economy (CE) is playing a major role among scholars and practitioners. Many aspects are now defining this new trending paradigm such as the roles of product development, transformation and remanufacturing/recycling, and/or management of waste, ensuring the economic and environmental benefits. The increasing demand causes instability of the prices and markets, and there

View details →DOI: 10.1016/j.egyr.2019.08.082
Negative / Null Result ReportOpen accessNutrition. Foods and food supply

Food literacy among athletes: a cross-sectional study

Ines Farah KANFOUD, Ibrahim SERSAR, Meriem BENCHARIF et al. · 2026 · Revista Española de Nutrición Humana y Dietética

Introduction: Adopting good nutritional practices and strategies can be attributed to a better understanding of dietary knowledge and habits, thus promoting good sports performance. This study aimed to assess athletes' nutritional knowledge, eating habits, and adherence to the Mediterranean diet. Methodology: Cross-sectional survey of 70 adult athletes. Data were collected using a questionnaire assessing their eating habits, nutritional knowledge (Abridged Nutrition for Sport Knowledge Questionnaire, A-NSKQ), and adherence to the Mediterranean diet (Medi-Lite score). Statistical analyses were

View details →DOI: 10.14306/renhyd.30.2.2584
Negative / Null Result ReportOpen accessSports medicine

Effect of yoga on autonomic nervous system function in females

Rika Kimoto, Isao Kambayashi, Akane Akizuki et al. · 2021 · Journal of Physical Fitness and Sports Medicine

The autonomic nervous system (ANS) maintains homeostasis through the balance of the sympathetic and parasympathetic subsystems or divisions. Currently, analysis of heart rate variability (HRV) offers an indirect, non-invasive assessment of ANS function. An irregular lifestyle and stress are known to affect ANS balance, influencing many diseases. Moreover, ANS disorder plays an important role in climacteric symptoms in menopausal females. The purpose of this study was designed to assess the effects of yoga practice sessions (herein referred to as “yoga”) on ANS function and focused on the relat

View details →DOI: 10.7600/jpfsm.10.25
Negative / Null Result ReportOpen accessDentistry

Evaluation of tongue/mandible volume ratio in children with obstructive sleep apnea

Kavita Hotwani, Krishna Sharma, Arpan Jaiswal · Dental Press Journal of Orthodontics

ABSTRACT Objective: The present study was an attempt to investigate tongue/mandible volume ratio in children, using volumetric magnetic resonance imaging (MRI) for early screening and to aid in treatment planning. Methods: Volumetric evaluation of tongue volume/mandible volume ratio (TV/MV ratio) in children with obstructive sleep apnea (OSA) using MRI was carried out retrospectively on available DICOM MR images of children in the age group of 10-14 years. MRI image records of patients diagnosed with OSA were obtained from interventional radiology department records, at Sharad Pawar Dental Col

View details →DOI: 10.1590/2177-6709.23.4.072-078.oar
Negative / Null Result ReportOpen accessMedicine

Correlation between Duration of Antiretroviral Therapy and Glomerular Filtration Rate in People Living with HIV/AIDS: A Cross-sectional Study in Cirebon, West Java, Indonesia

Tiara Sekar Ayudhipasha, Menik Herdwiyanti, Sedayu Sedayu · 2025 · GHMJ (Global Health Management Journal)

Background: West Java ranks the highest Province with Human Immunodeficiency Virus (HIV) case in 2023. An estimated 1.648 patients estimated receive antiretroviral therapy (ART). Kidney disease contributes mortality amongst people living with HIV/AIDS (PLWH). Tenofovir disoproxil fumarate (TDF)-based ART was associated as risk factor of kidney disorders, indicate by declining glomerular filtration rate (GFR). However, there is limited study whether kidney disease among PLWH were related to ART use in Indonesia. Aims: To determine correlation between duration of antiretroviral therapy and glome

View details →DOI: 10.35898/ghmj-81s1182
Negative / Null Result ReportOpen accessPediatrics

Morphological and Morphometric Assessment of Adolescent Idiopathic Scoliosis According to Pelvic Axial Rotation—A Retrospective Cohort Study with 397 Patients

Nevzat Gönder, Cansu Öztürk, Rabia Taşdemir et al. · 2025 · Children

Background: A precise radiographic evaluation of adolescent idiopathic scoliosis (AIS) is essential for effective treatment planning and follow-up. The pelvic axial rotation (PAR) and horizontal balance of the pelvis are critical factors to consider throughout the treatment and monitoring of AIS. While some previous studies have examined spinal curvature in relation to PAR direction and the direction of the major curve (DMC) in AIS patients, this study aims to explore the relationship between scoliosis morphology, pelvic axial rotation (PAR), and the direction of the major curve in patients wi

View details →DOI: 10.3390/children12080991
Negative / Null Result ReportOpen accessMedicine

Evaluation of the relationship between muscle mass and serum myostatin levels in chronic hemodialysis patients

Derya Koyun, Gokhan Nergizoglu, Kemal Metin Kir · 2018 · Saudi Journal of Kidney Diseases and Transplantation

The loss of muscle mass and cachexia is commonly seen in hemodialysis (HD) patients and contribute to morbidity and mortality. The exact mechanism of this fact is multifactorial and still unclear. Myostatin, a transforming growth factor-ß family ligand, is released from the skeletal and heart muscle and may be responsible for muscle degradation and atrophy. The aim of this study is evaluation of the relationship between muscle mass and serum myostatin level in chronic HD patients. One hundred and forty HD patients (79 males, 28 diabetic, mean age; 53.96 ± 13.6) were included in this cross-sect

View details →DOI: 10.4103/1319-2442.239648
Negative / Null Result ReportOpen accessHistory of scholarship and learning. The humanities

Intergroup contact and religiosity as predictor of between group attitudes in conflict environment

Lalić Bojan R., Ranđelović Dušan J. · 2013 · Zbornik Radova Filozofskog Fakulteta u Prištini

The aim of this research was to identify relations between level of religiosity and level of contact on one side and social attitudes towards members of religious out-groups in conflict environment on the other side. This research was conducted on the sample of Christian Orthodox students in Kosovska Mitrovica (which is partially conflict environment) and the Muslims were the out-group towards whom attitudes were analyzed. Attitudes measures we used were social distance scale and semantic differential. Likert type scale was used for religiosity measure, quantity and quality of contact. Control

Negative / Null Result ReportOpen accessNeoplasms. Tumors. Oncology. Including cancer and carcinogens

High VCP/p97 expression associates with low PD-L1 TPS in oropharyngeal squamous cell carcinoma

Inga Marte Charlott Seuthe, Markus Ruwe, Franz Mitze et al. · 2025 · Discover Oncology

Abstract Objectives VCP/p97 inhibition is known to upregulate PD-L1. This study investigated the correlation between PD-L1 and VCP/p97 expression in OPSCC, as well as the expression and prognostic significance of VCP/p97 in OPSCC. Methods The study retrospectively included 56 patients with OPSCC. Immunohistochemical staining was performed to detect VCP/p97 and PD-L1 expression. The staining intensity of VCP/p97 and PD-L1 TPS and CPS was determined. HPV status was evaluated using immunohistochemical staining against p16 and HPV PCR. In addition, iTILs were assessed. Results High VCP/p97 express

View details →DOI: 10.1007/s12672-025-03839-8
Negative / Null Result ReportOpen accessVeterinary medicine

Evaluation of primary wound healing and potential complications after perioperative infiltration with lidocaine without adrenaline in surgical incisions in dogs and cats

Erica Anna Gumpert Herlofson, Francesca Tavola, Karolina Siri Engdahl et al. · 2023 · Acta Veterinaria Scandinavica

Abstract Background Pre-emptive local analgesia with the use of lidocaine is practised increasingly in veterinary medicine as part of applied multimodal analgesia, despite its controversial impact on wound healing. The purpose of this prospective, randomised, double-blinded, placebo-controlled clinical study was to evaluate if preoperative subcutaneous infiltration of lidocaine has a negative impact on primary wound healing of surgical incisions. Fifty-two companion animals (3 cats and 49 dogs) were enrolled in the study. The inclusion criteria were as follows: American Society of Anaesthesiol

View details →DOI: 10.1186/s13028-023-00686-x
Negative / Null Result ReportOpen accessAgriculture

Assessment of beet leaf yellowing virus tolerance based on leaf yellowing in sugar beet

Yosuke Kuroda, Kazuyuki Okazaki, Kenji Takashino et al. · 2025 · Agrosystems, Geosciences & Environment

Abstract Sugar beet (Beta vulgaris) production in Japan faces major challenges from virus yellows (VY), caused by beet leaf yellowing virus (BLYV) and transmitted by aphids. Outbreaks have reduced sugar yields, and breeding for tolerant varieties has not been conducted in Japan. This study marks the first step toward developing VY‐tolerant varieties by testing three hypotheses: (1) leaf yellowing can be induced by artificial inoculation, (2) tolerance varies among breeding materials, and (3) differences in tolerance to yellowing disease can be evaluated. From 2017 to 2020, four sugar beet mate

View details →DOI: 10.1002/agg2.70201
Negative / Null Result ReportOpen accessTherapeutics. Pharmacology

Population Pharmacokinetics and Exposure–Response Analysis of Serplulimab in Small Cell Lung Cancer Patients

Kun Wang, Yuanyuan Shen, Chen Hu et al. · 2025 · Clinical and Translational Science

ABSTRACT While PD‐L1 antibodies have demonstrated efficacy in small cell lung cancer, the therapeutic benefits remain limited. To address this unmet medical need, serplulimab was developed as an innovative monoclonal antibody targeting PD‐1. This study evaluated the pharmacokinetic (PK) properties of serplulimab and their relationship with efficacy and safety in patients with extensive‐stage small cell lung cancer (ES‐SCLC), using population pharmacokinetics (PopPK) and exposure–response (E–R) analysis to inform dose selection. Data from 1144 patients across eight Phase I–III clinical trials s

View details →DOI: 10.1111/cts.70322
Negative / Null Result ReportOpen accessMedicine

Correlation Between Exercise Frequency and Menstrual Cycle Characteristics in Perimenopausal Women Aged 45–50 Years

Ni Luh Kadek Alit Arsani, Luh Ari Arini, Luh Yenny Armayanti et al. · 2026 · Althea Medical Journal

Background: During perimenopause, declining estrogen levels often lead to altered menstrual patterns and other age-related health concerns. Consequently, the role of physical activity warrants closer examination. This study investigated the correlation between exercise frequency and menstrual cycle characteristics in premenopausal women Methods: A cross-sectional observational study was conducted in Singaraja City, Indonesia, from July to October 2024. A total of 150 premenopausal women aged 45–50 years were recruited through random sampling. Exercise frequency was measured using the World Hea

View details →DOI: 10.15850/amj.v13n2.4594
Negative / Null Result ReportOpen accessVeterinary medicine

The incidence and trends of proteinuria, azotemia and hypertension in cats receiving toceranib phosphate

Kimberly Williams, Valerie MacDonald-Dickinson, Arata Matsuyama · 2024 · Journal of Feline Medicine and Surgery

Objectives This retrospective study aimed to determine the incidence and trends of proteinuria, elevations in serum creatinine and urea, and systolic blood pressure in cats undergoing treatment with toceranib. Methods In total, 32 cats treated with toceranib for malignancies were analyzed. Cats were included if urinalysis and urine protein:creatinine ratio (UPC) measurements were available at 28 days (T1) and 56 days (T2) after starting the treatment. Cats with concurrent lower urinary tract disease, including urinary tract malignancy, were excluded. Friedman’s ANOVA compared variables between

View details →DOI: 10.1177/1098612x241266418
Negative / Null Result ReportOpen accessMedicine

Characteristics of atmospheric dustfall fluxes and particle size in an open pit coal mining area and surrounding areas

Yayuan Deng, Hongxuan Wu, Tingning Zhao et al. · 2025 · Scientific Reports

Abstract Atmospheric dustfall is solid air pollutant, which is mainly influenced by local sources, so it has a major impact on the local environment and the health of local residents. The objective of this study was to investigate the distribution characteristics of dustfall fluxes and particle size, and the meteorological factors affected them. Atmospheric dustfall was collected in an open-pit coal mining area and surrounding areas in the arid desert area of Northwest China from March to December 2018. Dustfall fluxes was measured, particle size was measured by using graphical methods and gra

View details →DOI: 10.1038/s41598-025-94161-4
Negative / Null Result ReportOpen accessDiseases of the musculoskeletal system

The role of suction drainage in the management of peri-operative bleeding in Total and Unicomcompartmental knee arthroplasty: a retrospective comparative study

Nicola Manta, Laura Mangiavini, Cristiana Balbino et al. · 2021 · BMC Musculoskeletal Disorders

Abstract Background Suction drainage is commonly applied after total knee arthroplasty (TKA) and unicompartmental knee arthroplasty (UKA) to reduce hematoma, swelling and to favor surgical wound healing. However, its efficacy remains controversial; thus, the purpose of this study is to evaluate drainage efficiency in the management of postoperative bleeding in TKA and UKA. Methods The cohort comprised 134 clinical records of patients affected by knee osteoarthritis (OA) who underwent either TKA or UKA. All the patients were subdivided into 2 groups: the first one with drainage and the second o

View details →DOI: 10.1186/s12891-021-04868-4
Negative / Null Result ReportOpen accessVeterinary medicine

Exploring the relationship between calcitonin, ionized calcium, and bone turnover in cats with and without naturally occurring hypercalcemia

Evangelia Maniaki, Carmen Pineda, Angie Hibbert et al. · 2024 · Frontiers in Veterinary Science

ObjectivesThis case-control study aimed to evaluate calcitonin response in naturally occurring hypercalcemia in cats and assess the relationships between calcitonin and ionized calcium (iCa) and examine relationships between calcitonin, iCa and bone turnover.MethodsHypercalcemic cats (persistently increased iCa concentration [>1.40 mmol/l]) were identified retrospectively via a medical database search; additional hypercalcemic and normocalcemic cats were recruited prospectively. Data regarding routine biochemical and urine testing, diagnostic imaging and additional blood testing were obtained.

View details →DOI: 10.3389/fvets.2024.1399942
Replication Failure

PENGARUH PENDIDIKAN KARYAWAN DAN PELATIHAN KARYAWAN TERHADAP KUALITAS KERJA KARYAWAN (Studi Kasus Karyawan PT. Anugrah Mandiri Sejaterah

Anisatul Fauziah · 2023 · SIGNIFICANT : Journal Of Research And Multidisciplinary

Persaingan dalam lingkungan kerja saat ini semakin ketat, ini menuntut perusahaan terus menerus mengembangkan usahanya untuk dapat bersaing dengan perusahaan lain. Oleh karena itu dibutuhkan pengelola manajemen perusahaan yang biasa…

View details →DOI: 10.62668/significant.v2i02.863
Negative / Null Result ReportOpen accessMedicine

Effect of baseline characteristics on mortality in the SURVIVE trial on the effect of levosimendan vs dobutamine in acute heart failure: Sub-analysis of the Finnish patients.

M. Kivikko, P. Pollesello, Tuukka Tarvasmäki et al. · 2016 · International Journal of Cardiology

BACKGROUND In the SURVIVE trial, including 1327 acute heart failure patients, no statistically significant difference between levosimendan and dobutamine in the 180-day all-cause mortality was seen. Country-specific differences in outcome…

View details →DOI: 10.1016/j.ijcard.2016.04.064
Negative / Null Result ReportOpen accessMedicine

Grading angiogenesis in oral squamous cell carcinoma: a histomorphometric study.

V. Wadhwan, Preeti Sharma, Chitrapriya Saxena et al. · 2015 · Indian Journal of Dental Research

CONTEXT Like normal tissues, tumors require an adequate supply of oxygen, metabolites and an effective way to remove waste products. This is achieved by angiogenesis, which is defined as the process by which new blood vessels are produced…

View details →DOI: 10.4103/0970-9290.156792
Negative / Null Result ReportOpen access

Microscale Dynamics of Larval Fish Assemblages in the Straits of Malacca Nearshore Coincided with Lunar Phases

Ali Md. Yeakub, Fatimah Md. Yusoff, Natrah Fatin Mohd. Ikhsan et al. · 2023 · Pertanika Journal of Tropical Agricultural Science

Marine fish larvae are an integral part of the marine environment because their abundance can become an ecological indicator. The abundance is dependent on the environmental variations that include but are not limited to lunar phases and…

View details →DOI: 10.47836/pjtas.46.4.18
Negative / Null Result ReportOpen accessMedicine

Cardiac Effects of in utero Exposure to Antiretroviral Therapy in HIV-Uninfected Children Born to HIV-Infected Mothers

S. Lipshultz, Paige L. Williams, B. Zeldow et al. · 2015 · AIDS (London)

Objectives:We evaluated the potential cardiac effects of in-utero exposures to antiretroviral drugs in HIV-exposed but uninfected (HEU) children. Design and methods:We compared echocardiographic parameters of left ventricular function…

View details →DOI: 10.1097/qad.0000000000000499
Negative / Null Result ReportMedicine

Reappraisal of Electrocardiographic Criteria for Localization of Idiopathic Outflow Region Ventricular Arrhythmias.

James K. Gabriels, M. Abdelrahman, Lakshmi Nambiar et al. · 2021 · Heart Rhythm

BACKGROUND Electrocardiographic (ECG) criteria have been proposed to localize the site of origin (SOO) of outflow region ventricular arrhythmias (VAs). Many factors influence the QRS morphology of VAs and may limit the accuracy of these…

View details →DOI: 10.1016/j.hrthm.2021.08.003
Negative / Null Result ReportMedicine

Trial of Electronic Medical Record Integrated Next-Generation Sequencing Ordering in Veterans Affairs Cancer Care

J. Stoeckle, S. Poland, H. Maynard et al. · 2024 · JCO Precision Oncology

PURPOSE Previous studies document underuse of next-generation sequencing (NGS). We examined the impact to oncology care for veterans of incorporating NGS ordering into the Veterans Affairs (VA) electronic medical record (EMR) at two New…

View details →DOI: 10.1200/po.23.00463
Negative / Null Result ReportOpen accessMedicine

Successful weight loss maintenance in relation to method of weight loss

Angela Marinilli Pinto, A. A. Gorin, Hollie A Raynor et al. · 2008 · Obesity

This study examined the relation between method of weight loss and long‐term maintenance among successful weight losers enrolled in a weight‐loss maintenance trial. Participants were 186 adults (mean age = 51.6 ± 10.7 years, mean BMI =…

View details →DOI: 10.1038/oby.2008.364