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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

21733 results · page 496 of 725

Negative / Null Result ReportOpen accessMedicine

Optimal duration of neoadjuvant chemotherapy prior to CRS ± HIPEC for colorectal cancer: An assessment of survival and postoperative outcomes.

Bennett FJ, Oppat KM, Zaidi MY et al. · 2026 · Surgical oncology insight

Background Cytoreductive surgery (CRS) with or without heated intraperitoneal chemotherapy (HIPEC) represents a viable therapy for select patients with colorectal cancer (CRC) peritoneal metastases. Given recurrence rates, challenges…

View details →DOI: 10.1016/j.soi.2025.100210
Negative / Null Result ReportOpen accessMedicine

Weight and sleep health in OSA: exploring their link.

Beatty CJ, Landry SA, Mann DL et al. · 2026 · Frontiers in sleep

Objectives Weight loss is often recommended for individuals with obesity and OSA, however, weight loss is particularly hard for this population. This study investigates how weight and weight change are associated with sleep health in…

View details →DOI: 10.3389/frsle.2026.1828583
Negative / Null Result ReportMedicine

Differences in time to treatment and impact on overall survival in adolescents and young adults with Hodgkin lymphoma.

Cruz CA, Rodriguez ER, Thawani M et al. · 2025 · Leukemia & lymphoma

Delays in time to treatment (TTT) have been shown to affect cancer survival, yet this has not been investigated in adolescent and young adult (AYA) Hodgkin lymphoma (HL) patients. This retrospective analysis included 508 patients with TTT…

View details →DOI: 10.1080/10428194.2025.2499607
Negative / Null Result ReportMedicine

Lack of Association of Pediatric Surgical Patient Outcomes With Increased Disposable Operating Room Supply Costs.

Acker SN, Prendergast C, Inge TH et al. · 2024 · Journal of pediatric surgery

Introduction There is wide variation in the cost of disposable operating room supplies between surgeons performing the same operation at the same institution. The general relationship between variation in disposable supply cost and patient…

View details →DOI: 10.1016/j.jpedsurg.2024.03.046
Negative / Null Result ReportOpen accessMedicine

Assessment of the Association Between Whole Blood Viscosity and Coronary Artery Calcium Score.

Duyuler S, Türker Duyuler P, Kalaycı S et al. · 2026 · Medicina (Kaunas, Lithuania)

Background and Objectives : Whole Blood Viscosity (WBV), estimated using the De Simone formula, is a key hemodynamic parameter linked to endothelial dysfunction and atherosclerosis. Its association with significant coronary calcification,…

View details →DOI: 10.3390/medicina62010169
Negative / Null Result ReportMedicine

Unveiling connections: bisphenol A and vitamin D dynamics in breast milk among healthy lactating mothers.

Cinkilli Aktağ E, Yalçin SS, Yіrün A et al. · 2025 · International journal of environmental health research

Bisphenol A (BPA) has negative impact on human health. This study aims to explore the association between the levels of BPA and 25(OH) vitamin D in breastmilk. BPA exposure and vitamin D sources were recorded on the study form. Breastmilk…

View details →DOI: 10.1080/09603123.2024.2412118
Negative / Null Result ReportOpen accessMedicine

Nocturnal gastro-oesophageal reflux and pulmonary abnormalities on chest CT in a general population: the Swedish CArdioPulmonary BioImage Study.

Emilsson ÖI, Malinovschi A, Johnsson Å et al. · 2025 · Thorax

Background Nocturnal gastro-oesophageal reflux (nGER) is common in people with respiratory diseases, but its association with pulmonary abnormalities is not known. Aim Investigate the association between nGER and pulmonary abnormalities on…

View details →DOI: 10.1136/thorax-2024-222570
Negative / Null Result ReportOpen accessMedicine

Association between neutrophil extracellular traps, the Von Willebrand factor axis, and clinical outcome in stable coronary artery disease.

Bratseth V, Kindberg KM, Warlo EMK et al. · 2026 · Frontiers in cardiovascular medicine

Introduction Coronary artery disease (CAD) is the clinical manifestation of atherosclerosis, an inflammatory disorder of the coronary arteries, characterized by endothelial dysfunction, lipid accumulation, immune activation, and formation…

View details →DOI: 10.3389/fcvm.2026.1759117
Negative / Null Result ReportMedicine

Association of Psychotropic and Opioid Medication Use With Physical Function in Hospitalized Older Adults With Dementia.

Kim N, Resnick B, Galik E et al. · 2026 · Journal of gerontological nursing

Purpose To examine whether psychotropic medications (antipsychotics, sedatives, antiseizures, antidepressants, and anxiolytics) and opioids were associated with physical function in hospitalized older adults with dementia. Method A…

View details →DOI: 10.3928/00989134-20251104-01
Negative / Null Result ReportMedicine

Impact of Selective Serotonin Reuptake Inhibitors on Bleeding Rates in HeartMate 3 Left Ventricular Assist Device Patients Not Taking Aspirin.

Ganter M, Bowyer M, Relic E et al. · 2026 · Artificial organs

Background Selective serotonin reuptake inhibitor (SSRI) and serotonin-norepinephrine reuptake inhibitor (SNRI) therapy have been associated with increased bleeding risk in left ventricular assist device (LVAD) patients receiving warfarin…

View details →DOI: 10.1111/aor.70078
Negative / Null Result ReportMedicine

Lack of Association Between Dietary Fiber Intake and Kidney Failure Among Patients With Chronic Kidney Disease: The Chronic Kidney Disease-Japan Cohort Study.

Hattori K, Sakaguchi Y, Isaka Y et al. · 2025 · Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation

Objective It remains unclear whether dietary fiber intake improves kidney outcome. The objective of our study was to examine the association between dietary fiber intake and the risk of kidney failure among patients with proteinuric…

View details →DOI: 10.1053/j.jrn.2025.06.003
Negative / Null Result ReportMedicine

Postoperative Fever Following Pelvic and Acetabular Fixation: Incidence, Risk Factors, and Lack of Association With Surgical Site Infection.

Ayoub M, Curtis E, Vue Y et al. · 2025 · Orthopedics

Background Despite numerous studies showing postoperative fever can be a common and benign occurrence, there is still a significant and costly workup when fevers occur after surgery, including for orthopedic patients with pelvic ring and…

View details →DOI: 10.3928/01477447-20250506-01
Negative / Null Result Report

CD44v6 Promotes Proliferation, Migration, and Invasion in Cholangiocarcinoma Cells, but Lacks Independent Prognostic Significance

Myint KZ, Rattanasinganchan P, Moolthiya P et al. · 2025 · Preprint

Cholangiocarcinoma (CCA) is an aggressive malignancy of the bile duct epithelium. Alt-hough the CD44v6 splice variant is implicated in the progression of numerous cancers, its functional role and clinical relevance in CCA remain poorly…

View details →DOI: 10.20944/preprints202509.1220.v1
Negative / Null Result ReportMedicine

SARS-CoV-2 Vaccination and Disorders of Menstruation: A Population-Based Cohort Study.

Velez MP, Treacy K, Shellenberger J et al. · 2025 · Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC

This population-based study evaluated the association between SARS-CoV-2 vaccination and disorders of menstruation among all women in Ontario aged 18-44 years. Study exposure was receipt of a first dose of any SARS-CoV-2 vaccine from…

View details →DOI: 10.1016/j.jogc.2025.103159
Negative / Null Result ReportMedicine

25-Hydroxyvitamin D levels are associated with mortality and cardiovascular events in systemic lupus erythematosus.

Assawasaksakul T, Fava A, Goldman D et al. · 2026 · Annals of the rheumatic diseases

Objectives We assessed the association between 25-hydroxyvitamin D (25(OH)D) levels and rates of mortality and cardiovascular events (stroke, myocardial infarction, angina/bypass) in patients with systemic lupus erythematosus (SLE).…

View details →DOI: 10.1016/j.ard.2025.10.013
Negative / Null Result ReportMedicine

The role of susceptibility weighted imaging as a substitute to post-contrast T1-weighed images in detection of active multiple sclerosis lesions.

Rashad Ali F, Teiba MK, Sheha AS et al. · 2026 · Clinical radiology

Background and purpose Magnetic susceptibility levels of multiple sclerosis plaques increase as they convert from the active enhancing stage to the chronic or inactive nonenhancing stages. The purpose of our study was to discern whether a…

View details →DOI: 10.1016/j.crad.2025.107127
Negative / Null Result ReportOpen accessMedicine

Evaluation of the therapeutic value of conventional transpedal lymphography for the treatment of inguinal lymphatic fistulas after lymphadenectomy.

Wolfram C, Vogl TJ, Eichler K et al. · 2026 · CVIR endovascular

Purpose To evaluate therapeutic effectiveness and safety of lipiodol-based conservative transpedal lymphangiography in sealing persistent inguinal lymphatic fistulas after lymphadenectomy and to determine whether therapeutic success is…

View details →DOI: 10.1186/s42155-026-00713-8
Negative / Null Result ReportOpen accessMedicine

Distribution of Plasmodium falciparum apical membrane antigen-1 cluster one loop haplotypes and their association with malaria symptoms in Bandiagara, Mali.

Ouattara A, Adams M, Niangaly A et al. · 2026 · BMC infectious diseases

Although overall malaria incidence has decreased sharply over the past two decades, progress has stalled since 2015. The human host maintains a complex set of interactions with Plasmodium falciparum, the parasite species causing most…

View details →DOI: 10.1186/s12879-026-13189-7
Negative / Null Result ReportMedicine

GBA1 T369M and Parkinson's disease - Further evidence of a lack of association in the Swedish population.

Brolin KA, Bäckström D, Wallenius J et al. · 2025 · Parkinsonism & related disorders

Variants in GBA1 are important genetic risk factors in Parkinson's disease (PD). GBA1 T369M has been linked to an ∼80 % increased PD risk but the reports are conflicting and the relevance of GBA1 variants in different populations varies. A…

View details →DOI: 10.1016/j.parkreldis.2024.107191
Negative / Null Result ReportOpen accessMedicine

Lack of concordance among infant social attention measures.

Viktorsson C, Astor K · 2026 · Scientific reports

Infants’ tendency to focus on socially relevant cues is commonly referred to as ‘social attention’ and is often conceptualized as a unified construct. However, few studies have examined the concordance among measures that fall under this…

View details →DOI: 10.1038/s41598-026-36807-5
Negative / Null Result ReportMedicine

Long-term Ambient Air Pollution Exposure and Coronary Calcium Score in Men: Insights from the DANCAVAS Study.

Mohamed RA, Peronard Mayntz S, Møller JK et al. · 2025 · European journal of preventive cardiology

Aims This study assessed the relationship between air pollution exposure, fine particulate matter ≤2.5 µm (PM2.5) and nitrogen dioxide (NO2), and coronary calcium score (CCS) in a cohort of 60-75-year-old men from the Danish Cardiovascular…

View details →DOI: 10.1093/eurjpc/zwaf688
Negative / Null Result ReportMedicine

Physical activity and health-related quality of life among men with prostate cancer living in remote areas of Quebec A cross-sectional, observational study.

Gendron MP, El-Haouly A · 2025 · Canadian Urological Association journal = Journal de l'Association des urologues du Canada

Introduction The majority (97.5%) of men with prostate cancer (PCa) live for at least five years after diagnosis. The health-related quality of life (HRQoL) of such men is affected by the adverse effects of treatment. Men living in remote…

View details →DOI: 10.5489/cuaj.9077
Negative / Null Result ReportMedicine

Impact of Lordosis Distribution Index on Proximal Junctional Kyphosis and Clinical Outcomes in Patients Undergoing Thoracolumbar Fusion for Degenerative Flatback Syndrome.

Park JS, Kang DH, Lee CS et al. · 2025 · Spine

Study design Retrospective study using prospectively collected data. Objective To investigate the impact of the lordosis distribution index (LDI) on proximal junctional kyphosis (PJK) and clinical outcomes in patients with degenerative…

View details →DOI: 10.1097/brs.0000000000005489
Negative / Null Result ReportMedicine

Lack of association between the length of anogenital distance and vaginal pH in women with endometriosis.

Khan KN, Fujishita A, Hiraki K et al. · 2024 · The journal of obstetrics and gynaecology research

Aim We investigated the association between the length of anogenital distance (AGD) and intra-vaginal pH, an indicator of vaginal eubiosis or dysbiosis, in women with endometriosis. Methods A prospective cohort study was performed…

View details →DOI: 10.1111/jog.16129
Negative / Null Result ReportMedicine

Academic and Pre-Medical Advising Factors Associated with Admission to the John A. Burns School of Medicine Among Premedical Students at the University of Hawai'i at Mānoa.

Hosoda KK, Shiroma KY, Lee PM et al. · 2026 · Hawai'i journal of health & social welfare

The Medical School Hotline of the University of Hawai'i John A. Burns School of Medicine was founded in 1993, by Satoru Izutu PhD (former vice-dean of UH JABSOM). It is edited by Kathleen Kihmm Connolly PhD, HJH&W Contributing Editor.…

View details →DOI: 10.62547/nugk1824
Negative / Null Result ReportMedicine

The Infrapatellar Fat Pad Fibrosis Degree Does Not Influence Postoperative Pain 6 Months Following Patellofemoral Arthroplasty.

Franco D, Leite CBG, Schmidt S et al. · 2026 · The journal of knee surgery

This retrospective study investigates whether the degree of infrapatellar fat pad (IFP) fibrosis influences postoperative pain 6 months following patellofemoral arthroplasty (PFA). Furthermore, this study explores whether sex and patellar…

View details →DOI: 10.1055/a-2693-0621
Negative / Null Result ReportMedicine

Lack of Association between Vitamin D Genetic Polymorphism and Virological Characteristics of Hepatitis B Infection.

da Silva JC, Caetano AR, Mendonça ACDF et al. · 2025 · The journal of applied laboratory medicine

Background Exploring polymorphisms in vitamin D-related genes (VDR) within the Brazilian population provides a valuable model to contribute to the influence of the host genetic variants on chronic viral hepatitis B (CHB). Methods 126 CHB…

View details →DOI: 10.1093/jalm/jfae151