A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
19879 results in Negative / Null Result Report · page 492 of 663
Fields BC, Jain AJ, Prieto VG et al. · 2024 · The American Journal of dermatopathology
Abstract A 45-year-old woman with a history of previously treated left plantar foot melanoma presented with a left thigh mass. Fine needle aspiration findings were concerning for metastatic melanoma (MM). Imaging was remarkable for…
Misawa A, Kimura E, Inoue M et al. · 2025 · Journal of surgical case reports
Tension-free vaginal mesh repair surgery (TVM) has decreased due to complications related to mesh use and the lack of superiority compared to native tissue repair (NTR). In japan it is still performed as a treatment for pelvic organ…
Kasoha M, Findeklee S, Nigdelis MP et al. · 2024 · Biomedicines
Background Serum bone turnover markers might play a role in the prediction of the development of bone metastases in breast cancer (BC) patients. We conducted a retrospective cohort study to address the association of serum bone turnover…
Samatoshenkov I, Zakirova E, Samatoshenkova J et al. · 2026 · Cells
Peripheral arterial disease and critical limb-threatening ischemia remain major clinical challenges, particularly in patients who are not candidates for surgical or endovascular revascularization. These limitations have stimulated…
Sadek Azar R, Ramirez Roldan JF, Nuñez de la Vega JM · 2026 · Cureus
Introduction Perineal tears represent one of the main complications of vaginal delivery, with immediate and long-term consequences for maternal health. Although several factors have been associated with their occurrence, the role of…
Massardier E, Manchec O, Bérard E et al. · 2025 · Journal of experimental orthopaedics
Purpose Numerous studies have been published on the optimal management of the patella during total knee arthroplasty (TKA), but controversy remains. The aim of this study was to compare survivorship and functional outcomes with or without…
Jung JC, Ju JW, Chang HW et al. · 2024 · Journal of cardiothoracic and vascular anesthesia
Objectives This study evaluated the performances of the age, creatinine, and ejection fraction (ACEF) I and II scores and compare them with that of the European System for Cardiac Operative Risk Evaluation (EuroSCORE) II score in patients…
Tambaro FP, Fabozzi F, Masetti R et al. · 2026 · Frontiers in oncology
Deterioration of nutritional status in allogeneic hematopoietic stem cell transplantation (allo-HSCT) recipients is associated with increased morbidity. Enteral nutrition (EN) has been associated with more favorable outcomes than total…
Higuchi T, Igarashi K, Miwa S et al. · 2025 · Medicine
The clinical utility of P-glycoprotein (P-gp) in osteosarcoma remains controversial. This retrospective cohort study aimed to investigate the association between P-gp expression and clinicopathological factors, chemotherapy (CTx) response,…
Kim GH, Fass R · 2025 · Journal of neurogastroenterology and motility
Extraesophageal symptoms and signs of gastroesophageal reflux disease (GERD), such as throat clearing, globus sensation, hoarseness, cough, asthma, pulmonary fibrosis, otitis, sinusitis, and dental erosions, are common and pose diagnostic…
Hirayama H, Ishida K, Kodama H et al. · 2026 · OTO open
Objective This study aimed to evaluate the benefits of recipient site of closed incision negative pressure therapy (ciNPT) on postoperative complications in head and neck reconstruction. Study design A single-center retrospective…
Abbas AE, Kaneko T, Khalili H et al. · 2026 · Circulation. Cardiovascular interventions
Background Lower ( Methods Patients who underwent aortic valve-in-valve replacement with a balloon-expandable valve from July 2015 to December 2023 in the Society of Thoracic Surgeons/American College of Cardiology Transcatheter Valve…
Prior D, Yang J, Nuño MM et al. · 2025 · Pediatric blood & cancer
Background Cisplatin, etoposide, and bleomycin (PEb) have been the standard of care for patients with germ cell tumors (GCT). In the 1990s, an intergroup trial (POG9049/CCG8882) randomized patients with high-risk GCT, as defined by the…
Lavaire T, McLaughlin D, Liu S et al. · 2026 · Preprint
CoverCress is a new winter annual oilseed crop developed from field pennycress within the past 20 years. Field pennycress is commonly considered to be self-pollinated but little basic research has been published and there is some…
Lee HS, Kang SH, Eun HS et al. · 2026 · The Korean journal of helicobacter and upper gastrointestinal research
Objectives Metformin has been suggested to exert chemopreventive effects against gastric cancer. However, epidemiologic evidence remains inconsistent, and its impact on histologically confirmed precursor lesions, such as gastric dysplasia,…
Ion RM, Hutanu A, Sala DT et al. · 2024 · Preprint
Abstract Background: Bariatric surgery plays an impotant role in immnological modulation by reducing levels of systemic inflammatory markers, such as interkleukin-6 and tumor necrosis factor alpha. The goal of this study is to establish…
Dong X, Liu Y, Chu X et al. · 2024 · CNS neuroscience & therapeutics
Background The ideal blood pressure (BP) target in patients who undergo endovascular thrombectomy (EVT) with successful reperfusion is uncertain. Observational studies show that elevated BP during this period is associated with a higher…
Wilmshurst P, Pearson M, Walsh K et al. · 2026 · Diving and hyperbaric medicine
Introduction Transoesophageal echocardiography (TOE) is claimed to be the investigation of choice for detecting a persistent foramen ovale (PFO) with almost 100% diagnostic accuracy. If true, TOE would detect all large/clinically…
Lalaurie CJ, Dalby PA, McDonnell T · 2026 · Scientific reports
Beta-2-Glycoprotein I (β2GPI) is the main autoantigenic target of antiphospholipid syndrome (APS). β2GPI can adopt a number of structures; an extended J-shape, an O-shape and a transitional S-shape. It has also been shown previously that…
Schmidt M · 2026 · Biochemistry and molecular biology education : a bimonthly publication of the International Union of Biochemistry and Molecular Biology
Daily engagement games are widely used as motivational tools in applications ranging from language learning to medical licensing board preparations. In medical education, continuous engagement with basic science concepts has benefits for…
Demin K, Hwang JS, Che W et al. · 2026 · Preprint
Previous brain decoding studies indicate that an individual’s pain experience can be robustly predicted from distributed patterns of brain activity. Two brain decoders have notably been associated respectively with the nociceptive and…
Lee HJ, Bae Y, Woo JU et al. · 2026 · Preprint
Abstract Background Surgical success after the Maze procedure is conventionally defined as “freedom from atrial fibrillation (AF),” often grouping junctional rhythm (JR) with normal sinus rhythm (NSR). However, the specific hemodynamic…
Caneo M, Espinosa N, Aguilera A et al. · 2026 · Scientific reports
Sleep plays a critical role in memory consolidation, yet how coordination among sleep oscillations across hippocampo-cortical circuits relates to behavioral performance remains incompletely understood. Here, we examined how cross-regional…
Mohamed M, Riad NM, Naeem S et al. · 2026 · Preprint
Abstract Background: Neonatal sepsis (NS) continues to be a leading cause of illness and death in newborns. The lack of identifiable clinical indications and inconclusive blood cultures highlights the need for non-invasive biomarkers that…
Kamrani A, Khera AK, Raghav P et al. · 2026 · The Angle orthodontist
Objectives To evaluate and compare the effects of leukocyte-platelet-rich fibrin (L-PRF), injectable platelet-rich fibrin (i-PRF; submucosal), and i-PRF (intraligamental) on the rate of maxillary canine retraction. Materials and methods A…
Hurdogan O, Mirioglu S, Cebeci E et al. · 2026 · Clinical kidney journal
Background Fibrillary glomerulonephritis (FGN) is a very rare glomerular disease characterized by non-branching fibril deposition and DNAJB9 positivity. We aimed to analyze our cohort to better elucidate clinicopathologic features and…
Li D, Carnelley KB, Crawford MT et al. · 2026 · The Journal of social psychology
This is the first cross-cultural study of the contribution of romantic hostile attribution bias to relationship satisfaction that takes into account the role of attachment orientation. In two studies conducted 1 year apart, data were…
Caneo M, Espinosa N, Aguilera A et al. · 2026 · Preprint
Sleep plays a critical role in memory consolidation, yet how coordination among sleep oscillations across hippocampo–cortical circuits relates to behavioral performance remains incompletely understood. Here, we examined how cross-regional…
Ellis R, Shapiro DS, Bulbul S et al. · 2026 · Harefuah
Background People suffering from advanced dementia commonly develop eating difficulties. The recommendation is for careful hand feeding, but this is not always feasible. Research has tried to evaluate the efficacy of enteral tube feeding…
Bruttomesso MF, Morici GE, Arias MR et al. · 2026 · Journal of helminthology
Haemonchus contortus is considered the most pathogenic gastrointestinal nematode of sheep and, due to the increasing resistance to synthetic anthelmintics, it poses a serious challenge to small ruminant production systems. The aim of this…