Failed Experiment ReportOpen accessMedical physics. Medical radiology. Nuclear medicine
Ma Li, Men Yu, Feng Lingling et al. · 2019 · Radiology and Oncology
The mainstay therapy for locally advanced non-small cell lung cancer is concurrent chemoradiotherapy. Loco-regional recurrence constitutes the predominant failure patterns. Previous studies confirmed the relationship between increased biological equivalent doses and improved overall survival. However, the large randomized phase III study, RTOG 0617, failed to demonstrate the benefit of dose-escalation to 74 Gy compared with 60 Gy by simply increasing fraction numbers.
View details →DOI: 10.2478/raon-2019-0006 Abandoned HypothesisOpen accessPhilosophy (General)
Mostafa Taqavi · 2019 · Journal of Philosophical Investigations
There are two main sections in this paper. First, we will show that some of the chief 20th-century theories of science either have failed to demonstrate that value judgments do not influence the context of consolidation and determination of science or have accepted the role of value judgments in the context of consolidation and determination of science and theorized accordingly. For this purpose, the ideas of logical positivists, Willard Quine, Karl Popper, Thomas Kuhn, Imre Lakatos, Paul Feyerabend, and Roy Bhaskar on science are briefly reviewed. Finally, the validity of the following statem
View details →DOI: 10.22034/jpiut.2019.27618.2029 Negative / Null Result ReportOpen accessDiseases of the circulatory (Cardiovascular) system
Oh Young Bang, Mi Ji Lee, Sookyung Ryoo et al. · 2015 · Journal of Stroke
Patent foramen ovale (PFO) is growing in clinical interest because of a renewed focus on embolic stroke of undetermined source (ESUS), the PFO attributable fraction (the 10-point Risk of Paradoxical Embolism score), technical advances in PFO diagnosis, and the emergence of endovascular device closure as a treatment option. However, recent randomized controlled trials of the management of patients with ESUS and PFO failed to demonstrate the superiority of closure over medical treatment. The mechanisms of stroke other than paradoxical embolism may be important in patients with ESUS and PFO. This
View details →DOI: 10.5853/jos.2015.17.3.229 Null DatasetOpen accessMaterials of engineering and construction. Mechanics of materials
· 2009 · eXPRESS Polymer Letters
The thermal and reaction to fire characteristics of a flame retardant unsaturated polyester (UP) ternary system are presented here. Thermal gravimetric analysis showed an improved thermal stability between 200–600°C with the addition of ammonium polyphosphate (APP) and aluminium trihydroxide (ATH) formulation. Cone calorimetry tests indicated that ATH is more efficient than calcium carbonate at delaying the ignition time, lowering the carbon monoxide yield and lowering the peak heat release (PHRR). However the addition of APP and ATH to the formulation failed to demonstrate any significant syn
View details →DOI: 10.3144/expresspolymlett.2009.92 Negative / Null Result ReportOpen accessPhysics
L. S. R. Cavalcante, D. R. da Costa, G. A. Farias et al. · 2021 · arXiv
The effect of an external in-plane electric field on neutral and charged exciton states in two-dimensional (2D) materials is theoretically investigated. These states are argued to be strongly bound, so that electron-hole dissociation is not observed up to high electric field intensities. Trions in the anisotropic case of monolayer phosphorene are demonstrated to especially robust under electric fields, so that fields as high as 100 kV/cm yield no significant effect on the trion binding energy or probability density distribution. Polarizabilities of excitons are obtained from the parabolicity o
Negative / Null Result ReportOpen accessComputer Science
Varun Kotte · 2026 · arXiv
Prompt-only, single-step LLM query rewriting, where a rewrite is generated from the query alone without retrieval feedback, is commonly used in production RAG pipelines, but its effect on dense retrieval is poorly understood. We present a systematic empirical study across three BEIR benchmarks, two dense retrievers, and multiple training configurations, and find strongly domain-dependent behavior: rewriting degrades nDCG@10 by 9.0 percent on FiQA, improves it by 5.1 percent on TREC-COVID, and has no significant effect on SciFact. We identify a consistent mechanism: degradations co-occur with r
Negative / Null Result ReportOpen accessAnimal culture
Samadi F, Sahneh M · 2015 · Poultry Science Journal
A total of 240, one-day-old quail chicks (Coturnix coturnix japonica) were used to study the effects of Artichoke leaf meal (ALM) and vitamin E in diet on growth performance, ileal microbial populations and intestinal morphology in a 42-d trial. This experiment was performed as a completely randomized design with 4 replicates of 15 quails each, using a 4 × 2 factorial arrangement with diet and gender as the main effects. Four dietary treatments were formulated by addition of 2 levels (1.5 and 3 percent) of ALM and 300 mg/Kg vitamin E to the basal diet. Supplementing basal diet with ALM did not
Negative / Null Result ReportMedicine
Beck QM, Sachet J, Cargnelli C et al. · 2026 · The Journal of clinical psychiatry
Objectives: Unwanted intrusive thoughts (UITs) of intentional infant-related harm are common among birthing parents. Evidence to date has failed to find any association with physical aggression toward the infant. However, the relationship…
View details →DOI: 10.4088/jcp.25m15985 Negative / Null Result ReportOpen accessMedicine
Xavier Jannot, Alpha Oumar Diallo, Judicaelle Didierjean et al. · 2025 · European Journal of Case Reports in Internal Medicine
We report the case of a 75-year-old woman admitted to the emergency department for confusion, gait disturbances and mutism associated with an inflammatory syndrome occurring 3 weeks after acute carbon monoxide intoxication. The main hypothesis upon arrival was infectious meningoencephalitis, and the patient was put on acyclovir and antibiotics in meningeal doses. After a short stay in intensive care, the patient’s condition did not improve, and the revaluation of her case history and imaging studies led to the diagnosis of post-interval syndrome secondary to carbon monoxide intoxication after
View details →DOI: 10.12890/2025_005235 Negative / Null Result ReportOpen accessDiseases of the blood and blood-forming organs
Daniel A. Ermann, Victoria A. Vardell, Lindsey Fitzgerald et al. · 2026 · eJHaem
ABSTRACT Introduction B‐cell prolymphocytic leukemia (B‐PLL) is a rare, aggressive leukemic B‐cell malignancy historically associated with poor outcomes and recently reclassified in the WHO Fifth Edition but retained as a distinct entity in the ICC. Methods We analyzed 950 patients labeled as B‐PLL in the National Cancer Database (2004–2019), identified using ICD‐O‐3 morphology code 9833/3. Results Median age was 72 years, and 72% received systemic therapy at diagnosis. Median overall survival (OS) was poor (2.8 years) and did not improve over time. Patients initially managed with active surve
View details →DOI: 10.1002/jha2.70299 Negative / Null Result ReportOpen accessAgriculture
Marjatta Uosukainen, Mauritz Vestberg · 1994 · Agricultural and Food Science
The importance of different rooting methods and the effects of arbuscular mycorrhizal (AMF) inoculation on the rooting rate, weaning survival and subsequent growth of microcuttings of Malus rootstock YP and the Finnish crab apple cultivars Hanna and Marjatta were studied in four experiments conducted at the Laukaa Research and Elite Plant Unit, Finland. Sucrose in the in vitro rooting medium gave the best support to weaning survival in comparision with glucose and fructose. Directly rooted microcuttings had a higher survival rate than in vitro rooted microcuttings. AMF inoculation did not impr
Negative / Null Result ReportOpen accessMedicine
M.Ghasemi, Z. Hajheidari, M. Golpour · 2007 · Journal of Mazandaran University of Medical Sciences
AbstractPemphigus Erythematosus specially its localized form is a rare autoimmune blistering disease combining features of Pemphigus Foliaceus and Lupus Erythematosus. We reported a 60 years old woman with skin lesion which presented Erythemato squamo plaque with oozing in the right cheek. The chief compliant was burning and pruritus. Skin biopsy was obtained and discoid Lupus Erythemato was reported. She was prescribed with topical steroid but did not improve. All of the lab tests such as Anti DNA, ESR, RF, CRP, CH50, C3, C4, ANA were normal. The biopsy repeated and Pemphigus Erythematosus wa
Negative / Null Result ReportOpen accessScience
NATALIA C. SILVA, KAREN M. LEÃO, JOÃO T. PÁDUA et al. · 2021 · Anais da Academia Brasileira de Ciências
Abstract To evaluate the addition of antioxidants in extenders on post-thaw bovine semen quality and in vitro embryo production efficiency. Six semen samples were collected from five Holstein bulls. In the experiment I, the samples were diluted with AndroMed® and Bovimix® and added antioxidants glutathione (1.5 and 2.5 mM) and melatonin (0.5 and 1.0 mM). In the experiment II, the best treatments obtained in experiment I were used for in vitro fecundation. Glutathione did not improve sperm viability. Melatonin had a negative effect on semen characteristics. Andromed® showed better results in sp
View details →DOI: 10.1590/0001-3765202120191229 Negative / Null Result ReportOpen accessNeurosciences. Biological psychiatry. Neuropsychiatry
H. Tanji, H. Nagasawa, T. Hayashi et al. · 1996 · Behavioural Neurology
We studied the chronic effect of thyrotropin releasing hormone (TRH) in a patient with spinocerebellar degeneration by measuring cerebral metabolic rate for glucose (CMRG1c) using 2-[18F]fluoro-2-deoxy-D-glucose (18FDG) and positron emission tomography (PET). A 56-year-old female, who had suffered from progressive ataxia for 2 years, was treated by intravenous administration of 2 mg TRH for 3 weeks, and CMRG1c of the brain was measured before and after treatment. CMRG1c was markedly decreased in the cerebellum and there was no significant difference before and after the treatment, i.e. mean CM
View details →DOI: 10.3233/ben-1996-93-409 Negative / Null Result Report
Eggeling-Böcker M, Karabetsos E, Christopoulou M et al. · 2025 · Preprint
Background: Technological advancements, such as the introduction of 5G, offer opportunities but also raise concerns. Although no evidence suggests negative effects of radiofrequency electromagnetic fields (RF-EMF) within defined exposure…
View details →DOI: 10.12688/openreseurope.19236.1 Negative / Null Result ReportOpen accessDiseases of the musculoskeletal system
Alexander C. Lehn, Cullen O'Gorman, Sarah Olson et al. · 2017 · Tremor and Other Hyperkinetic Movements
Background: Orthostatic tremor (OT) was first described in 1977. It is characterized by rapid tremor of 13–18 Hz and can be recorded in the lower limbs and trunk muscles. OT remains difficult to treat, although some success has been reported with deep brain stimulation (DBS). Case Report: We report a 68-year-old male with OT who did not improve significantly after bilateral thalamic stimulation. Discussion: Although some patients were described who improved after DBS surgery, more information is needed about the effect of these treatment modalities on OT, ideally i
View details →DOI: 10.7916/d8280jhr Negative / Null Result ReportOpen accessOphthalmology
Jemal Zeberga Shifa, Alemayehu Mekonnen Gezmu, Gezahen Negusse Ayane et al. · 2019 · The Pan-American Journal of Ophthalmology
A 22-year-old female patient was diagnosed to have HIV and treated by highly active antiretroviral therapy (HAART) since 2012 had developed a reduction of vision in both eyes secondary to cataract. The cataract was extracted from both eyes with no immediate postoperative complication. During follow-up, it was recognized that she had had bilateral Stage 3 macular hole in both eyes. The visual acuity in both eyes was 6/60 which did not improve with application of pinhole. Pars plana vitrectomy was done and sealed the macular hole in the left eye. The visual acuity remained the same in both eyes
View details →DOI: 10.4103/pajo.pajo_15_19 Negative / Null Result ReportOpen accessNeoplasms. Tumors. Oncology. Including cancer and carcinogens
Michele Bottosso, Gaia Griguolo, Severine Guiu et al. · 2025 · npj Breast Cancer
Abstract Brain metastases (BMs) are a common complication of advanced breast cancer (BC), and their management has significantly evolved. We evaluated the clinical impact of these changes dividing patients diagnosed with BCBMs at three Institutions according to year of BMs diagnosis: 2000-2007 (group A), 2008-2014 (group B) and 2015-2022 (group C). Stereotactic radiotherapy increased (p < 0.001), and WBRT decreased (p = 0.010) over time. Among HER2+ BC patients, more received anti-HER2 therapy after BM diagnosis in recent years (p < 0.011). Overall survival (OS) did not improve in the entire c
View details →DOI: 10.1038/s41523-025-00735-w Negative / Null Result ReportOpen accessInternal medicine
Dae-Yeon Kim, Hee-Soon Park, Dong-Jae Han et al. · 2013 · Kidney Research and Clinical Practice
Renal failure caused by scrub typhus is known to be reversible. In most cases, renal function is almost fully restored after appropriate antibiotic treatment. A 71-year-old man was diagnosed with scrub typhus complicated by renal failure. A renal biopsy revealed histopathologic findings consistent with acute tubulointerstitial nephritis. Renal function did not improve 18 months after discharge and the patient required continuous hemodialysis. Although severe renal failure requiring dialysis is a rare complication of scrub typhus, we describe a case of scrub typhus requiring maintenance hemodia
View details →DOI: 10.1016/j.krcp.2013.09.003 Negative / Null Result ReportOpen accessDentistry
Dragos Epistatu, Octavian-Marius Dinca, Cristian Vladan et al. · 2023 · Dentistry Journal
The aim of this study is to evaluate the long-term changes of sinus lift material. Materials and methods: We included a total number of 35 patients (20 men and 15 women), between 32 and 80 years old, evaluated on a timeframe of up to 11.6 years. Diverse biomaterials were used (allograft, xenograft, alloplastic, combinations of them), with autologous bone in some cases. Results: The appearance of the top plane of the bone over time took a large dome shape (36% of cases), a linear shape (32% of cases), an irregular shape (23% of cases), or had micro domes above the implants (7%). No significant
View details →DOI: 10.3390/dj11120273 Negative / Null Result ReportOpen accessPhysics
Benjamin Poole, Bartosz Barzdajn, Daniele Dini et al. · 2019 · arXiv
The thermal effects of plastic and frictional heat generation and elevated temperature were examined along with the role of adhesion in the context of galling wear, using a representative crystal plasticity, normally loaded, sliding surface model. Galling frequency behaviour was predicted for 316L steel. Deformation of the surfaces was dominated by the surface geometry, with no significant effect due to variations in frictional models. Plastic and frictional heating were found to have a minimal effect on the deformation of the surface, with the rapid conduction of heat preventing any highly lo
Negative / Null Result ReportOpen accessTechnology (General)
Szostek Karol, Szostek Roman · 2023 · Technical Transactions
The work presents the concept of a device for the measurement of the one-way speed of light. The minimum parameters of this device have also been determined based on the Special Theory of Ether without transverse contraction. The Special Theory of Ether is a relativistic theory of kinemat-ics with a universal frame of reference in which light propagates and is an alternative explanation for the null result of the Michelson-Morley experiment. An experiment based on the proposed device can be one of the ways to falsify the Special Theory of Relativity and Special Theory of Ether.
View details →DOI: 10.37705/techtrans/e2023003 Negative / Null Result ReportOpen accessNeurosciences. Biological psychiatry. Neuropsychiatry
Tom A. de Graaf, Tom A. de Graaf, Alexander T. Sack et al. · 2018 · Frontiers in Neuroscience
Experiments often challenge the null hypothesis that an intervention, for instance application of non-invasive brain stimulation (NIBS), has no effect on an outcome measure. In conventional statistics, a positive result rejects that hypothesis, but a null result is meaningless. Informally, however, researchers often do find null results meaningful to a greater or lesser extent. We present a model to guide interpretation of null results in NIBS research. Along a “gradient of surprise,” from Replication nulls through Exploration nulls to Hypothesized nulls, null results can be less or more surpr
View details →DOI: 10.3389/fnins.2018.00915 Negative / Null Result ReportOpen accessScience
Milton Gering, Tayla Johnson, Colin Tredoux · 2023 · South African Journal of Science
The effect of stress on face identification is not yet clear, with recent experiments finding positive, negative and null results. Here we report the results of two experiments examining the effect of stress on eyewitness performance in line-up face recognition tasks. Both experiments use a stress manipulation and live mock crime paradigm to examine the relationship between stress at encoding and subsequent line-up performance. Experiment 1 replicated an experiment by Sauerland et al. (Behav Sci Law. 2016;34(4):580–594) which induced stress using the Maastricht Acute Stress Test. The replicati
View details →DOI: 10.17159/sajs.2023/12102 Negative / Null Result ReportOpen accessOptics. Light
Alex Midasala · 2024 · Results in Optics
A viable solution to detect the one-way speed of light anisotropy in linear motion is by using an Isosceles triangle-shaped design for the experimental setup, from which two light pulses from both ends of one of the triangle’s sides are sent to the same clock upon the detection of the incident and the reflected pulse, thereby evading the need for synchronization. The relativistic effects are taken into account in the timing measurements by incorporating the Lorentz transformation equations of length contraction and time dilation, which produces a non-null result for the time difference of the
View details →DOI: 10.1016/j.rio.2024.100710 Negative / Null Result ReportOpen accessAstrophysics
Yuta Hamada, Masatoshi Yamada · 2017 · European Physical Journal C: Particles and Fields
Abstract The null result in the LHC may indicate that the standard model is not drastically modified up to very high scales, such as the GUT/string scale. Having this in the mind, we suggest a novel leptogenesis scenario realized in the false vacuum of the Higgs field. If the Higgs field develops a large vacuum expectation value in the early universe, a lepton number violating process is enhanced, which we use for baryogenesis. To demonstrate the scenario, several models are discussed. For example, we show that the observed baryon asymmetry is successfully generated in the standard model with
View details →DOI: 10.1140/epjc/s10052-017-5215-9 Negative / Null Result ReportOpen accessMedicine
Emma T L Cheng, Mohammad Cheik-Hussein, Noelle Lin et al. · 2023 · PLoS ONE
Background Pregabalin is a drug used to treat neuropathic pain, and its use has increased substantially since 2007. Early trials found a strong treatment effect on pain for post-herpetic neuralgia and diabetic neuropathy. However more recent studies have failed to replicate these results. Methods This meta-epidemiological study aimed to assess change in the reported effectiveness of pregabalin in neuropathic pain trials over time, and if a change is present, determine any associated factors. Data sources We performed electronic searches for published trials in Medline, Embase and Cochrane Cent
View details →DOI: 10.1371/journal.pone.0280593 Negative / Null Result ReportMedicine
Makkar RR, Chakravarty T, Gupta A et al. · 2025 · Journal of the American College of Cardiology
Background In the ACURATE IDE (Safety and Effectiveness Study of ACURATE Valve for Transcatheter Aortic Valve Replacement) randomized controlled trial, ACURATE neo2 failed to show noninferiority to commercially available balloon-expandable…
View details →DOI: 10.1016/j.jacc.2025.05.011 Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance
Markus Dertwinkel-Kalt, Max R. P. Grossmann · 2025 · arXiv
When environmental regulations are unpopular, policymakers often attribute resistance to information frictions and poor communication. We test this idea in the context of a major climate policy: Germany's Heating Law of 2023, which mandates the phase-out of fossil fuel heating. Through a survey experiment with property owners, we examine whether providing comprehensive information about the regulation's costs, requirements, and timeline affects adoption decisions and policy support. Despite successfully increasing factual knowledge, information provision has no significant effect on intended t
Replication FailureOpen accessInternal medicine
Kraemer Rachel, Claas Steven A, Devereux Richard B et al. · 2009 · BMC Medical Genetics
Abstract Background We conducted a genome-wide association study (GWAS) and validation study for left ventricular (LV) mass in the Family Blood Pressure Program – HyperGEN population. LV mass is a sensitive predictor of cardiovascular mortality and morbidity in all genders, races, and ages. Polymorphisms of candidate genes in diverse pathways have been associated with LV mass. However, subsequent studies have often failed to replicate these associations. Genome-wide association studies have unprecedented power to identify potential genes with modest effects on left LV mass. We describe here a
View details →DOI: 10.1186/1471-2350-10-43 