Replication FailureOpen accessMathematics
Natesh Pillai, Aaron Smith · 2026 · arXiv
In Diaconis and Saloff-Coste (1996), the authors introduced the simple ``transvection" walk on $\mathrm{GL}_n(\mathbb F_2)$: at each step, choose two distinct rows and add one to the other. In Ben-Hamou (2025), the author recently proved that this walk has mixing time $O(n^2\log n)$. Inspired by applications in cryptography (see Sotiraki (2016)), Ben-Hamou and Peres (2018) conjectured that the first $k$ columns of this walk mixed in $O(nk \log(n))$ steps. Our main result is a proof of this conjecture uniformly in $n$ and $k.$ Our proof is based on a local-to-global entropy estimate, in the spi
Negative / Null Result ReportOpen accessComputer Science
Paul Röttger, Janet B. Pierrehumbert · 2021 · arXiv
Language use differs between domains and even within a domain, language use changes over time. For pre-trained language models like BERT, domain adaptation through continued pre-training has been shown to improve performance on in-domain downstream tasks. In this article, we investigate whether temporal adaptation can bring additional benefits. For this purpose, we introduce a corpus of social media comments sampled over three years. It contains unlabelled data for adaptation and evaluation on an upstream masked language modelling task as well as labelled data for fine-tuning and evaluation on
Negative / Null Result ReportOpen accessComputer Science
Mireille El-Assal, Pierre Tirilly, Ioan Marius Bilasco · 2023 · arXiv
Video analysis is a computer vision task that is useful for many applications like surveillance, human-machine interaction, and autonomous vehicles. Deep Convolutional Neural Networks (CNNs) are currently the state-of-the-art methods for video analysis. However they have high computational costs, and need a large amount of labeled data for training. In this paper, we use Convolutional Spiking Neural Networks (CSNNs) trained with the unsupervised Spike Timing-Dependent Plasticity (STDP) learning rule for action classification. These networks represent the information using asynchronous low-ener
Negative / Null Result ReportOpen accessComputer Science
Óscar García-Sierra, Ana Fernández-Pampillón Cesteros, Miguel Ortega-Martín · 2024 · arXiv
Subword tokenization algorithms used by Large Language Models are significantly more efficient and can independently build the necessary vocabulary of words and subwords without human intervention. However, those subwords do not always align with real morphemes, potentially impacting the models' performance, though it remains uncertain when this might occur. In previous research, we proposed a method to assess the morphological quality of vocabularies, focusing on the overlap between these vocabularies and the morphemes of a given language. Our evaluation method was built on three quality meas
Negative / Null Result ReportOpen accessNutrition. Foods and food supply
Kaijun Wang, Kaijun Wang, Jie Ma et al. · 2022 · Frontiers in Nutrition
Artemisia argyi leaf is a well-known species in traditional Chinese medicine, and its essential oil (AAEO) has been identified to exert various physiological activities. The aim of this study was to investigate the effects of AAEO on lipid metabolism and the potential microbial role in high-fat diet (HFD)-fed mice. A total of 50 male mice were assigned to five groups for feeding with a control diet (Con), a high-fat diet (HFD), and the HFD plus the low (LEO), medium (MEO), and high (HEO) doses of AAEO. The results demonstrated that dietary HFD markedly increased the body weight gain compared w
View details →DOI: 10.3389/fnut.2022.1024722 Negative / Null Result ReportOpen accessMedicine
Julie Labrosse, Marie Osdoit, Anne-Sophie Hamy et al. · 2020 · PLoS ONE
Although identified to be at a higher risk of relapse, no consensus exists on the treatment of breast cancer (BC) patients with no pathological complete response after neoadjuvant chemotherapy (NAC). The benefit of adjuvant chemotherapy (ADJ) in this context has scarcely been studied. We evaluated the benefit of administrating adjuvant chemotherapy in a real life cohort of BC patients with invasive residual disease after NAC. 1199 female BC patients with T1-3NxM0 invasive tumors receiving NAC at Institut Curie from 2002 to 2012 were included in the analysis. 1061 had been treated by NAC only,
View details →DOI: 10.1371/journal.pone.0234173 Negative / Null Result ReportOpen accessOrthopedic surgery
Yakup Ekinci, Mithat Oner, Ibrahim Karaman et al. · 2020 · Acta Orthopaedica et Traumatologica Turcica
Abstract Objective: The aim of this study was to compare simultaneous bilateral total knee arthroplasty (BTKA) and unilateral total knee arthroplasty (UTKA) in terms of morbidity, clinical and radiological findings and quality of life. Methods: The study included 48 simultaneous BTKAs (46 females, 2 males; mean age: 64.00±8.31 years) and 53 UTKAs (46 females, 7 males; mean age: 64.40±7.45 years) performed between November 2007 and June 2012. Groups were compared with respect to comorbidity, complications, blood transfusion, hospital stay, clinical and radiological (American Knee Society Score)
View details →DOI: 10.3944/aott.2014.3226 Negative / Null Result ReportOpen accessArctic medicine. Tropical medicine
Yuelin Xiong, Huatang Luo, Hao Wang et al. · 2026 · PLoS Neglected Tropical Diseases
Background Schistosomiasis, a neglected tropical disease (NTD), remains a public health concern in China. Health education is a fundamental intervention for its control. Even in transmission-interrupted areas like Wuhan, sustained awareness is crucial. However, recent literature on school-based interventions evaluating knowledge, attitudes and practices (KAP) among children in such areas is limited. Objective This study aimed to evaluate and compare the effectiveness of peer-led education versus routine health education in improving schistosomiasis-related KAP among elementary students in an u
View details →DOI: 10.1371/journal.pntd.0013857 Negative / Null Result ReportOpen accessOphthalmology
Jia-Wen Li, Yi-Jian Li, Xi-Su Hu et al. · 2020 · International Journal of Ophthalmology
AIM: To assess the biosafety of a poly(acrylamide-co-sodium acrylate) hydrogel (PAH) as a 3D-printed intraocular lens (IOL) material. METHODS: The biosafety of PAH was first evaluated in vitro using human lens epithelial cells (LECs) and the ARPE19 cell line, and a cell counting kit-8 (CCK-8) assay was performed to investigate alterations in cell proliferation. A thin film of PAH and a conventional IOL were intraocularly implanted into the eyes of New Zealand white rabbits respectively, and a sham surgery served as control group. The anterior segment photographs, intraocular pressure (IOP), bl
View details →DOI: 10.18240/ijo.2020.10.03 Negative / Null Result ReportOpen accessDentistry
Fatemeh Maleknejad, Saied Mostafa Moazzami, Elham Baradaran Nasseri et al. · 2011 · Journal of Dental Research, Dental Clinics, Dental Prospects
Background and aims. Adhesive permeability is hindered by application of an additional layer of hydrophobic resin, which increases its concentration within the hydrophilic layer, reduces its affinity to water, and enhances its physical properties. The aim of the present study was to evaluate the effect of a hydrophobic layer on the microleakage of class V composite restorations using different adhesives. Materials and methods. The adhesives including total-etch Scotchbond MP and Single Bond, and the self-etch Clearfil SE Bond and Clearfil S3 Bond were applied to 80 class V cavities in vitro on
Negative / Null Result ReportOpen accessMedicine
Yong Xue, Ai Zhao, Li Cai et al. · 2015 · PLoS ONE
OBJECTIVE:To explore the associations between picky eating behaviour and pre-schoolers' growth and development. Corresponding potential mechanisms, such as nutrient and food subgroup intake, as well as micronutrients in the blood, will be considered. METHODS:Picky eating behaviour was present if it was reported by parents. From various areas of China, 937 healthy children of 3-7 years old were recruited using a multi-stage stratified cluster sampling method. Children and their mothers' socio-demographic information and children's anthropometry, intelligence, blood samples, one 24-hour dietary
View details →DOI: 10.1371/journal.pone.0123664 Negative / Null Result ReportOpen accessInternal medicine
Tri Ratnaningsih, Novi W Sukirto, Arum Tri Wahyuningsih · 2020 · Acta Medica Indonesiana
Background: iron deficiency in pulmonary tuberculosis (TB) patients may weaken their immune system, causing difficulty in overcoming the infection. Accurate diagnosis of iron deficiency anemia (IDA) in pulmonary TB patients is essential. In order to prove the iron deficient state, diagnosis should focus on inflammatory factors, which could highly affect the outcome of iron status, such as measurement of serum ferritin (SF). Soluble Transferrin Receptor (sTfR) is the best parameter to diagnose iron deficiency in the inflammatory condition. This study aimed to understand the role of sTfR to iden
Negative / Null Result ReportOpen accessDiseases of the musculoskeletal system
Mohamed A. Mortada, Haidy E. Zidan, Noha A. Abdelsalam et al. · 2020 · Egyptian Rheumatology and Rehabilitation
Abstract Background Impaired deoxyribonucleic acid (DNA) repair may induce an autoimmune response in susceptible individuals. The association between DNA repair gene XRCC1 Arg399Gln gene polymorphism and susceptibility of systemic lupus erythematosus (SLE) is controversial. This study aimed to detect the association of XRCC1 Arg399Gln gene polymorphism with SLE and its clinical manifestations in the Egyptian population. Results A significant association was found between weight loss and genotype GG (P = 0.048); however, genotype AG was significantly associated with high serum creatinine and lo
View details →DOI: 10.1186/s43166-020-00009-2 Negative / Null Result ReportOpen accessImmunologic diseases. Allergy
Hiroyuki Kawahara, Satoshi Hara, Noriko Iwaki et al. · 2025 · Immunological Medicine
TAFRO syndrome is a systemic inflammatory disorder of unknown etiology, and its diagnosis requires the exclusion of autoimmune diseases. A 42-year-old Japanese woman presented with TAFRO syndrome-like manifestations, but had undiagnosed limited-cutaneous systemic sclerosis preventing a definitive diagnosis of TAFRO syndrome. However, her clinical course and pathological findings, including renal glomerular microangiopathy, were consistent with TAFRO syndrome. We performed a systematic review of the literature to evaluate how autoimmunity affects the clinical characteristics of TAFRO syndrome/i
View details →DOI: 10.1080/25785826.2025.2481675 Negative / Null Result ReportOpen accessMedicine
Amr Almaz Abdel-aziem, Amira Hussin Draz · 2013 · Medicine Science
The purpose of this study was to examine the effect of chronic ankle instability (CAI) on eccentric peak torque of the ankle musculature. The study included fifty participants divided into two groups; the first group consisted of twenty five subjects suffering from CAI, the second group consisted of twenty five subjects with no prior history of ankle injury as control group. Eccentric peak torque of invertors, evertors, plantar-flexors and dorsiflexors was recorded for each participant at angular velocities 30 and 90o/sec by using (Biodex Medical Systems, Inc, Shirley, NY, USA). Analysis of va
View details →DOI: 10.5455/medscience.2013.02.8048 Negative / Null Result ReportOpen accessMedicine (General)
A.G. Elsaid, N.M. Faheem · Brazilian Journal of Medical and Biological Research
Continuous industrial productivity and modern societies have resulted in excess artificial light. The altered circadian rhythm causes many diseases. During intrauterine life, the mother's maternal melatonin rhythm has a major role in influencing organ development. The aim of this study was to investigate the effect of maternal exposure to constant light on the structure and ultrastructure of neonatal skin. Twenty pregnant New Zealand rabbits were divided into two groups (n=10 each): control group (12-h light/dark) and constant light group (24-h light). Plasma maternal melatonin and corticoster
View details →DOI: 10.1590/1414-431x202010722 Negative / Null Result ReportOpen accessOrthopedic surgery
Ahmet Salduz, Fatih Dikici, Önder Ismet Kılıçoğlu et al. · 2017 · Journal of Orthopaedic Surgery
Purpose: The aim of our study is to investigate the bone ongrowth of two different alternative surfaces and the effect of nonsteroidal anti-inflammatory drugs (NSAIDs) on osseointegration. Methods: Hips of 40 New Zealand white rabbits were operated bilaterally. Hydroxyapatite (HA)-coated titanium rods were implanted into the right femur, and grit-blasted titanium rods were implanted into the left femur. They were divided into three groups. At the end of 8 weeks, both femora of the rabbits were removed and investigated biomechanically and histologically. Results: HA-coated implants had a signif
View details →DOI: 10.1177/2309499016684410 Negative / Null Result ReportOpen accessMedicine
XUE Bing, XI Hualei, YAO Lihong, XU Wanqiu, XU Xiaohang, LIN Song, PIAO Guiyan, WANG Xiumei · 2025 · 口腔疾病防治
Objective To investigate the effect of neurite outgrowth inhibitor extracellular peptide residues 1-40 (NEP1-40) combined with poly (lactic-co-glycolic acid) (PLGA) and gelatin electrospun fiber membrane on facial nerve repair in rats. Methods According to the principle of random grouping, 108 male SD rats were divided into four groups ( n = 27 in each group, approved by the ethics committee), namely, the sham group, control group, PLGA group, and NEP1-40 + PLGA group. A facial nerve fracture model was established for all of the groups except for the sham group. The control group received no f
View details →DOI: 10.12016/j.issn.2096-1456.202440237 Negative / Null Result ReportOpen accessEcology
Mnqobi Mamba, Nicolas J. Fasel, Themb'alilahlwa A.M. Mahlaba et al. · 2019 · Global Ecology and Conservation
Conversion of native habitats into agricultural monocultures is a major cause of biodiversity loss favouring a small number of generalist species. Rodents can cause significant declines in crop yield, hence understanding the factors affecting their population dynamics is of importance to the agricultural sector. Sugarcane plantations in African savannas harbour a low diversity of small mammals, with a single genus (Mastomys spp.) often dominating the community. Our study investigated the factors that shape the composition of the small mammal community and the life-history traits of the dominan
View details →DOI: 10.1016/j.gecco.2019.e00752 Negative / Null Result ReportOpen accessAnesthesiology
Hasanul Arifin, Heru Kurniawan · 2016 · Jurnal Anestesi Perioperatif
Serum creatinine has many limitations when being used to diagnose acute kidney injury (AKI), especially in the scope of intensive care unit due to its low sensitivity to depict the kidney dysfunctional level of critically-ill patients. Out of numerous new available biological markers, four biological markers are widely used all over the world to detect AKI, e.g. neutrophil gelatinase-associated lipocalin (NGAL), cystatin C, KIM-1, and interleukin-18. The purpose of this study was to determine the sensitivity and specificity of serum cystatin C and creatinine in establishing the diagnosis of ac
View details →DOI: 10.15851/jap.v4n2.819 Negative / Null Result ReportOpen accessDiseases of the digestive system. Gastroenterology
Xiaotong Xu, Jinglan Jin, Yuwei Liu et al. · 2023 · BMC Gastroenterology
Abstract Background and aims To investigate the usefulness of interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), protein C (PC), and thromboelastography (TEG) to serve as a predictor of portal vein thrombosis (PVT) in patients with liver cirrhosis. Additionally, we examined the clinical significance of the above indicators in terms of disease progression. Methods A total of 123 patients with liver cirrhosis were recruited from May 2021 to December 2021, according to the imaging findings. They were divided into the PVT group (n = 52) and the non-PVT group (n = 71). Furthermore, patients
View details →DOI: 10.1186/s12876-022-02632-z Negative / Null Result ReportOpen accessNeoplasms. Tumors. Oncology. Including cancer and carcinogens
Dong-Yun Kim, Eonju Park, Chan Yeong Heo et al. · 2021 · Breast
Purpose: This study investigated whether hypofractionated adjuvant radiotherapy (RT) increased breast-related complication(s) compared to conventional fractionated RT in reconstructed breast cancer patients. Methods: We conducted a retrospective review including 349 breast cancer patients who underwent immediate breast reconstruction following mastectomy or breast-conserving surgery (BCS) between 2009 and 2018 at two institutions. All patients were treated with adjuvant RT via either a conventional fractionated or hypofractionated regimen. We defined a major breast complication as a breast-rel
View details →DOI: 10.1016/j.breast.2020.11.020 Negative / Null Result ReportOpen accessEconomics as a science
gholamhossain khorshidi, Arash Naghash, milad mohamadian · 2014 · پژوهشهای اقتصادی
Nowadays, the issue of service quality for service-provider organizations specifically banks is of considerable importance. The service-provider organizations (specifically governmental banks) are aware from the necessity of getting satisfaction of customer and assessing quality of services. In this research, we evaluate and analyze the gap of expected and current service quality. In fact, the gap between customer´s expectations of bank services and customers perceptions is assessed based on the hierarchical service quality model (HSQM), which has been introduced by Brady and Cronin in 2001. T
Negative / Null Result ReportOpen accessMedicine
Hulya Colak, Ismail Sert, Yusuf Kurtulmus et al. · 2014 · Saudi Journal of Kidney Diseases and Transplantation
The objective of the study is to evaluate the relationship between serum testos-terone levels and cardiovascular risk factors (CVRF) in patients after kidney transplantation and with chronic kidney disease (CKD). Seventy-five male patients, aged between 18 and 68 years, who had kidney transplantation at least six months earlier, were enrolled into the study. Only renal transplant recipients and CKD patients with a creatinine level of 0.05). Serum testosterone levels were independent risk factors affecting IVC collapse index, systolic BP and LA. m-TORi and CNIs drugs might have no negative effe
View details →DOI: 10.4103/1319-2442.139862 Negative / Null Result ReportOpen accessTherapeutics. Pharmacology
Ha-yeong Baek, Seung-yoon Han, Il-kyu Ahn et al. · 2026 · Physical Therapy Korea
Background: Hip abductor muscles play a critical role in stabilizing the pelvis during functional activities. A decline in hip abductor strength is associated with impaired balance and an increased risk of falls, particularly in elderly females who experience physiological changes and age-related muscle loss. Although limb dominance has been proposed to influence lower extremity muscle strength in young adults, no studies have yet examined differences in hip abductor strength between the dominant and non-dominant limbs in elderly females. Furthermore, the relationship between hip abductor stre
View details →DOI: 10.12674/ptk.2026.33.1.83 Negative / Null Result ReportOpen accessTheory and practice of education
Riza Salar, Umit Turgut · 2021 · Science Education International
The learning characteristics of each student are different. Differentiated instruction considers individual differences, as such guides the learning journey rather than seeing these differences as a challenge. The purpose of this research was to compare the effects of differentiated instruction and 5E learning cycle in physics classes on the students' academic achievement and self-efficacy. We used the matching - pre-test/post-test - control group design to address the research questions. We conducted the study in three different schools, performed three experiments, and had three control grou
View details →DOI: 10.33828/sei.v32.i1.1 Negative / Null Result ReportOpen accessNeurology. Diseases of the nervous system
杨江胜，朱祖福，高志强，陆强彬，周国庆，方琪 · 2018 · Zhongguo cuzhong zazhi
目的 探讨高龄轻型缺血性卒中3 h内行阿替普酶静脉溶栓治疗的疗效及安全性。 方法 将我院2015年10月-2017年10月连续收治入院的发病3 h内48例高龄急性轻型缺血性卒中患者 随机分为阿替普酶静脉溶栓组24例和未溶栓组24例。比较两组患者入院时的一般情况，基线美国 国立卫生研究院卒中量表（National Institutes of Health Stroke Scale，NHISS）评分，治疗24 h后颅内出 血转化率，治疗后90 d改良Rankin量表（modified Rankin Scale，mRS）评分及90 d病死率。 结果 阿替普酶静脉溶栓组和未溶栓组患者一般临床资料、基线NIHSS评分比较，差异无统计学意 义。阿替普酶静脉溶栓组和未溶栓组治疗24 h后颅内出血转化率分别为4.17%和0（P =1.000），两组 90 d病死率均为4.17%（P =1.000），阿替普酶静脉溶栓组及未溶栓组90 d mRS评分为0～2分的比率 分别为83.33%和54.17%（P =0.029）。 结论 早期阿替普酶静脉溶栓治疗高龄急性轻型缺血性卒中不增加急性期颅内出血转化的风险， 可以改善高龄轻型缺血性卒中患者预后，不增加病死率。 Abstract: Objective To investigate the efficacy and safety of alteplase i
View details →DOI: 10.3969/j.issn.1673-5765.2018.04.005 Negative / Null Result ReportOpen accessMedicine
Zeyi Deng, Takayuki Uehara, Hiroyuki Maeda et al. · 2014 · PLoS ONE
To investigate the prevalence, genotypes, and prognostic values of Epstein-Barr virus (EBV) and human papillomavirus (HPV) infections in Japanese patients with different types of head and neck cancer (HNC).HPV and EBV DNA, EBV genotypes and LMP-1 variants, and HPV mRNA expression were detected by PCR from fresh-frozen HNC samples. HPV genotypes were determined by direct sequencing, and EBV encoded RNA (EBER) was examined by in situ hybridization.Of the 209 HNC patients, 63 (30.1%) had HPV infection, and HPV-16 was the most common subtype (86.9%). HPV E6/E7 mRNA expression was found in 23 of 60
View details →DOI: 10.1371/journal.pone.0113702 Replication Failure
· 2019 · Journal of Gynecology & Reproductive Medicine
Karyotyping is a technique to examine the chromosomes-abnormality or structural defects. Karyotyping can be used to detect a variety of genetic disorders. For example, a woman who has premature ovarian failure may have a chromosomal defect…
View details →DOI: 10.33140/jgrm.03.06.02 Negative / Null Result ReportOpen accessMedicine
Fatemeh Samiei Siboni, Zainab Alimoradi, Tahereh Sadegi · 2013 · مجله دانشگاه علوم پزشکی بیرجند
Background and Aim: Life style can cause stress and anxiety and consequently, hypertension. Regarding nurses' influencial role in implementing educational programs to increase patients’ self-control, the present research was designed to study the impact of a lifestyle promoting educational programs on controlling stress, anxiety, depression, and hypertewnsion in Qazvin Mino area in 2010. Materials and Methods: after the present study was a pre/post semi-experimental one conducted on 55 hypertensives. Living in Qazvin Minodar region. DAS (Depression, Anxiety, Stress)-21 general questionnaire an
