Negative / Null Result ReportOpen accessMedicine
Lusilla Lopez A, Fält UA, Buchwald P et al. · 2026 · Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland
Aim Treatment of complex anal fistulae remains a significant challenge for physicians and patients. A sphincter-preserving technique with bioactive platelet-rich fibrin matrix is one option. This three-year study aimed to evaluate the…
View details →DOI: 10.1111/codi.70447 Negative / Null Result ReportOpen accessMedicine
Marsh A, Quelch D, Mackonochie M et al. · 2026 · The international journal of neuropsychopharmacology
The incidence of cognitive disorders is rising, and medications to address cognitive impairments are limited. Phytochemical compounds have had some success in improving cognitive outcomes in preclinical studies. However, the evidence…
View details →DOI: 10.1093/ijnp/pyag003 Negative / Null Result ReportMedicine
Godoy MR, Brochado-Neto FC, Martins Cury MV et al. · 2025 · Journal of vascular surgery
Objective This study aimed to assess whether duplex ultrasound (DUS) surveillance yielded a better outcome compared with ankle-brachial index (ABI) surveillance after femoropopliteal endovascular therapy (EVT) in a cohort of patients…
View details →DOI: 10.1016/j.jvs.2025.07.043 Negative / Null Result ReportMedicine
Aggarwal A, Adie S, Harris IA et al. · 2025 · The Cochrane database of systematic reviews
Background Total knee replacement (TKR) is a common intervention for people with end-stage symptomatic knee osteoarthritis, resulting in significant improvements in pain, function and quality of life within three to six months. It is,…
View details →DOI: 10.1002/14651858.cd007911.pub4 Negative / Null Result ReportMedicine
Bi Z, Ren T, Wang Y · 2025 · Chinese journal of cancer research = Chung-kuo yen cheng yen chiu
The latest data from the NATALEE trial showed the absolute 3-year invasive disease-free survival benefit was 4.9% between the experimental and control groups. That is to say, in the intermediate-risk hormone receptor positive/human…
View details →DOI: 10.21147/j.issn.1000-9604.2025.01.08 Replication FailureMedicine
Minkhorst K, Munn A, MacDermid J et al. · 2025 · Archives of physical medicine and rehabilitation
Objective To evaluate whether the addition of an orthosis improved the efficacy of cortisone injection for the nonoperative management of trigger finger. Design Block randomized controlled trial. Setting Outpatient hand clinic.…
View details →DOI: 10.1016/j.apmr.2025.05.015 Negative / Null Result ReportOpen accessMedicine
Wee YC, Hewage U, Horwood C et al. · 2026 · Journal of clinical medicine
Background : Statins have anti-inflammatory properties beyond their lipid-lowering effects, but their impact on skin and soft tissue infections (SSTIs) remains unclear. This study evaluated whether statins improve clinical outcomes in…
View details →DOI: 10.3390/jcm15103755 Negative / Null Result ReportMedicine
Robertson NP · 2025 · Journal of neurology
The first of several phase 3 trials examining efficacy in relapsing MS has not been able to demonstrate a significant benefit and has also raised important safety concerns. More results are on their way and it will be important to…
View details →DOI: 10.1007/s00415-025-12892-w Negative / Null Result ReportMedicine
Tabibian K, Vadlakonda A, Coaston T et al. · 2025 · The American journal of cardiology
Despite advancements in cardiogenic shock (CS) management, mortality remains high. While hospital volume has been linked to reduced mortality across myriad complex procedures, the cross-volume effects of mechanical circulatory support…
View details →DOI: 10.1016/j.amjcard.2025.05.031 Negative / Null Result ReportMedicine
Ghotboddin Mohammadi S, Shafie D, Feizi A et al. · 2026 · Scientific reports
Chronic inflammation and dyslipidemia are common pathophysiological features of heart failure (HF). Astaxanthin, a potent marine-derived antioxidant, has shown anti-inflammatory and lipid-lowering properties. This study conducted to…
View details →DOI: 10.1038/s41598-026-58512-z Negative / Null Result ReportMedicine
Corbett A, Taylor R, Llewellyn D et al. · 2025 · Journal of the American Medical Directors Association
Objectives Preserved cognitive health with ageing is a public health imperative. Vitamin D deficiency is associated with poor cognition, but it is unclear whether supplementation would provide benefit, particularly in individuals with…
View details →DOI: 10.1016/j.jamda.2025.105711 Negative / Null Result ReportMedicine
Kallash M, Frishman WH · 2025 · Cardiology in review
Tadalafil is a phosphodiesterase inhibitor currently approved for use in erectile dysfunction (ED), benign prostatic hyperplasia (BPH), and pulmonary arterial hypertension (PAH). While tadalafil's benefits in ED and BPH have been…
View details →DOI: 10.1097/crd.0000000000000877 Negative / Null Result ReportMedicine
Elscot JJ, Kakar H, den Dekker WK et al. · 2025 · International journal of cardiology
Background Recent randomized trials have suggested that immediate complete revascularization (ICR) is a viable alternative to staged complete revascularization (SCR) in patients with acute coronary syndrome (ACS) and multivessel disease.…
View details →DOI: 10.1016/j.ijcard.2025.133496 Negative / Null Result ReportOpen accessMedicine
Šitum I, Mihaljević S, Blivajs I et al. · 2026 · Acta stomatologica Croatica
Objectives To compare the quality of recovery between total intravenous anaesthesia (TIVA) with propofol and balanced inhalational anaesthesia with sevoflurane in patients undergoing intraoral surgical procedures. Materials and methods We…
View details →DOI: 10.15644/asc60/1/4 Negative / Null Result Report
Turan O, Akdeniz C, Tuzcu V · 2025 · Preprint
Background: Septal accessory pathways (APs) are challenging ablation targets. The study aims to contribute to the pediatric literature by presenting our long-term experience of septal AP ablations with limited fluoroscopy. Methods: This is…
View details →DOI: 10.20944/preprints202502.1572.v2 Negative / Null Result ReportMedicine
Viswanath YKS, Mbarushimana S, Ammar A et al. · 2025 · Surgical endoscopy
Background Gastroesophageal reflux disease (GERD) is a common chronic condition affecting millions all over the world. It occurs due to the reflux of gastric acid into the oesophagus. Endoscopic therapies like STRETTA offer minimally…
View details →DOI: 10.1007/s00464-025-11781-7 Negative / Null Result ReportMedicine
Villanova V, Martinino A, Stanzani E et al. · 2025 · Surgical oncology
Extended pelvic lymph node dissection (EPLND) for rectal cancer is common in Asian countries to reduce local recurrence and improve survival. This umbrella review investigates the benefit of adding extended lymphadenectomy to the standard…
View details →DOI: 10.1016/j.suronc.2025.102215 Negative / Null Result ReportOpen accessMedicine
Kooli N, Ben Mansour H, Zenzri Y et al. · 2026 · Frontiers in oncology
Background Ewing's sarcoma (ES) is the second most common malignant bone tumor in patients under 20 years of age. The "Euro-Ewing 2012" trial established induction therapy with the 2-week-interval VDC/IE…
View details →DOI: 10.3389/fonc.2026.1710836 Negative / Null Result ReportOpen accessMedicine
Dixit NM, Chau E, Schaefer S · 2024 · American journal of preventive cardiology
Screening trials for cardiovascular disease have not demonstrated a reduction in all-cause mortality. The Danish Cardiovascular Screening trial (DANCAVAS) involved men aged 65-74 years old who were randomized to an invitation to undergo…
View details →DOI: 10.1016/j.ajpc.2024.100723 Negative / Null Result ReportMedicine
Dolińska E, Starosz A, Grubczak K et al. · 2026 · Scientific reports
This study aimed to evaluate the effects of non-surgical periodontal therapy (SRP) and SRP with an amino acid-buffered hypochlorite solution (NaOCl/AA + SRP) on subgingival plaque bacteria. Quantitative changes in Porphyromonas gingivalis,…
View details →DOI: 10.1038/s41598-026-54584-z Negative / Null Result ReportMedicine
Chiara RF, Letizia L, Francesca G et al. · 2026 · Orthodontics & craniofacial research
Objectives The present study aimed to evaluate the skeletal and dental changes in two different groups of mixed dentition Class II division 1 patients treated with Clear Aligners and with Rapid Maxillary Expansion and to assess the…
View details →DOI: 10.1111/ocr.70141 Negative / Null Result ReportMedicine
Affat SH, Kamoona HR · 2026 · Journal of molecular histology
Sleep amount and quality are important to maintain health, light exposure transported to the pineal gland via suprachiasmatic nucleus pineal pathway, and this affect melatonin synthesis. Melatonin exerts its action by receptors called MT1,…
View details →DOI: 10.1007/s10735-026-10817-z Negative / Null Result ReportOpen accessMedicine
Moor-Smith M, Kozak N, McCue M et al. · 2026 · The western journal of emergency medicine
Background Musculoskeletal back pain is a common presenting complaint to emergency departments (ED) worldwide. In this study we aimed to evaluate the effectiveness of transcutaneous electrical nerve stimulation (TENS) as an adjunct to…
View details →DOI: 10.5811/westjem.48818 Negative / Null Result ReportMedicine
Almosfer M, Sabico S, Wani K et al. · 2026 · Aging clinical and experimental research
Background The metabolic effects of Metformin (Met) and lifestyle modification in early type 2 diabetes mellitus (T2DM) management are well established, but their influence on bone remodeling remains uncertain in under-investigated…
View details →DOI: 10.1007/s40520-026-03423-2 Negative / Null Result ReportMedicine
Darmon J, Bastelica P, Huard M et al. · 2026 · Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie
Purpose To evaluate the 12-month efficacy and safety of open bleb revision (OBR) for Preserflo ® MicroShunt (PMS) (Santen, Osaka, Japan) bleb failure. Patients and methods All consecutive patients who underwent PMS OBR for primary bleb…
View details →DOI: 10.1007/s00417-026-07298-x Negative / Null Result ReportOpen accessMedicine
Orso F, Basile C · 2026 · European heart journal supplements : journal of the European Society of Cardiology
Vericiguat is a soluble guanylate cyclase stimulator that acts by restoring the nitric oxide-cyclic guanosine monophosphate pathway, which is markedly impaired in heart failure with reduced ejection fraction (HFrEF). The VICTORIA trial…
View details →DOI: 10.1093/eurheartjsupp/suag044 Negative / Null Result ReportOpen accessMedicine
Odeleye V, Singh N, Gautam S et al. · 2026 · Current cardiology reports
PURPOSE OF REVIEW: This article reviews the evidence for cardiovascular and renal risk reduction with glucagon-like peptide-1 receptor agonists (GLP-1 RAs) in type 2 diabetes mellitus (T2DM), based on randomized controlled trials,…
View details →DOI: 10.1007/s11886-026-02357-5 Negative / Null Result ReportOpen accessMedicine
Sampaio GKML, Sette-de-Souza PH, Vieira BR et al. · 2026 · Biomaterial investigations in dentistry
Objective The present study aimed to evaluate the surface roughness (SR) and color stability of conventional restorative glass ionomer cements (GICs) modified with the addition of red propolis ethanolic extract (RPEE) as an antimicrobial…
View details →DOI: 10.2340/biid.v13.45991 Negative / Null Result ReportMedicine
Neto SOP, Rosalen PL, da Cruz Pegoraro JV et al. · 2026 · Naunyn-Schmiedeberg's archives of pharmacology
This study aimed to evaluate the effect of topical application of a mouth gel formulation containing iron tetracarboxyphthalocyanine (FeTcPc) during non-surgical periodontal treatment. Forty-seven individuals with periodontitis underwent a…
View details →DOI: 10.1007/s00210-026-05517-0 Negative / Null Result ReportMedicine
Cardoso A, Naghibi M, Climent E et al. · 2026 · Allergy
Background Allergic rhinitis (AR) is an increasingly common chronic inflammatory condition of the nasal mucosa. While conventional anti-allergy treatments are widely used, they can come with side effects and are not always effective. As a…
View details →DOI: 10.1111/all.70360 