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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

21318 results · page 427 of 711

Replication FailureMedicine

The effects of temperature, urbanisation, and artificial light on phototaxis in eusocial and non-eusocial bees.

Webster E, Ng L, Prendergast K et al. · 2026 · Journal of insect physiology

Climate change and urbanisation are major drivers of global insect pollinator decline. However, the combined effects of these stressors remain poorly understood, particularly in relation to pollinator behaviour. Understanding how these…

View details →DOI: 10.1016/j.jinsphys.2025.104927
Replication FailureMedicine

[Adaptation Mechanism and Strategy of Ecological Resilience and High-quality Development in the Yellow River Basin].

Sheng YC, Chen X, Zhang YF et al. · 2026 · Huan jing ke xue= Huanjing kexue

Achieving ecological protection and high-quality development is the fundamental goal of sustainable development in the Yellow River Basin, and it is also an inevitable choice for the practice of the concept of Chinese-style modernization.…

View details →DOI: 10.13227/j.hjkx.202503345
Replication FailureMedicine

Association of vitamin D deficiency with incident depression in patients with hearing impairment: an observational retrospective cohort study.

Cheng WJ, Kao CL, Hung IY · 2026 · Frontiers in nutrition

Background Hearing impairment is associated with an elevated risk of depression, yet modifiable risk factors in this population remain poorly characterized. Although vitamin D deficiency (VDD) has been linked to depression in general…

View details →DOI: 10.3389/fnut.2026.1856953
Negative / Null Result ReportMedicine

Impact of an Individualized Dietary Intervention on Body Composition and Clinical Outcomes in Patients with Neovascular Age-Related Macular Degeneration: A Pilot Study.

Szulim D, Kucharska E, Machalińska A et al. · 2026 · Nutrients

Background/Objectives : Age-related macular degeneration (AMD) is a leading cause of permanent deterioration of central vision in elderly people. While anti-VEGF therapy remains the standard of care for neovascular AMD, disease progression…

View details →DOI: 10.3390/nu18121870
Negative / Null Result ReportMedicine

Standing work and low back pain: An experimental analysis of risk factors.

Osorio-Vasco J, Rojas-Mora J, Barrera-Causil C et al. · 2026 · Work (Reading, Mass.)

BackgroundStanding work is common across a wide range of industries and service sectors and has been associated with the development of low back pain.ObjectiveTo analyze changes in low back pain across eight experimental scenarios…

View details →DOI: 10.1177/10519815261438027
Negative / Null Result ReportMedicine

The Impact of a Unique Military Treatment Facility-Based Sports Medicine Model on Readiness in the Army: A Prospective Longitudinal Analysis Comparing 2 Military Health System Entry Portal Pathways on the Duration of Healthcare Management and the Incidence of Recurrence Within 24 Months.

Suttles S, Boeth RR, Frazier M et al. · 2026 · Military medicine

Objective Describe an innovative Sports Medicine clinic design implemented in an outpatient Physical Therapy (PT) clinic within a Military Treatment Facility (MTF) for both referral and direct access (DA) entry portal pathways, and to…

View details →DOI: 10.1093/milmed/usaf423
Negative / Null Result ReportMedicine

Effect of hydrogen peroxide disinfectant on the flexural strength of different custom impression tray materials fabricated using conventional and digital methods.

Lengerli Efe A, Özen Sütüven E, Uçar Y et al. · 2026 · International journal of computerized dentistry

Aim The aim was to evaluate the effect of hydrogen peroxide disinfectant exposure for 60 minutes -representing the longest exposure time recommended for achieving the widest antimicrobial spectrum- on the flexural strength (FS) of…

View details →DOI: 10.3290/j.ijcd.b7003304
Negative / Null Result ReportOpen accessMedicine

Haptic perception of 2.5D surface feature height.

Hwang I, Yun S, Park J · 2026 · Scientific reports

The present study investigates the human haptic perception of 2.5D dome-shaped surface features in terms of difference and absolute thresholds. We conducted two experiments to measure the thresholds, analyzing the effect of sample base…

View details →DOI: 10.1038/s41598-026-42333-1
Negative / Null Result ReportMedicine

What factors prolong symptoms in patients with hemorrhoidal disease who require surgery?

Zayas-Bórquez R, Diaz-Barrientos CZ, Canto-Losa J et al. · 2026 · Revista de gastroenterologia de Mexico (English)

Introduction and aims Hemorrhoidal disease is a common condition and may affect quality of life. Although it tends to respond to conservative treatment, some cases require surgery. The present study examined clinical and demographic…

View details →DOI: 10.1016/j.rgmxen.2026.05.004
Negative / Null Result ReportOpen accessMedicine

ANO1 (TMEM16A) Genetic Variants, Promoter Methylation, and Chloride Dysregulation in Pulmonary Hypertension.

Yaman İ, Korkmaz H, Akağaç AE et al. · 2026 · Journal of cardiovascular development and disease

Background Pulmonary arterial hypertension (PAH) is a rare and progressive disorder characterized by increased pulmonary vascular resistance and vascular remodeling. Genetic polymorphisms, epigenetic modifications, and ion channel…

View details →DOI: 10.3390/jcdd13060283
Negative / Null Result ReportOpen accessMedicine

Association between Helicobacter pylori infection and thyroid dysfunction in adults visiting a tertiary care hospital in Karachi, Pakistan: a cross-sectional study.

Jahangeer A, Jabeen R, Fatima S et al. · 2026 · BMC endocrine disorders

Background Thyroid dysfunction and Helicobacter pylori (H. pylori) infection are both highly prevalent in Pakistan. Several studies have proposed a potential immunological link between H. pylori infection and autoimmune thyroid disease,…

View details →DOI: 10.1186/s12902-026-02293-z
Negative / Null Result ReportOpen accessMedicine

Immunohistochemical expression of Stomatin-Like protein 2 and trophoblast cell surface antigen 2 in papillary thyroid carcinoma in comparison to other thyroid lesions.

Elmetwally AA, Khashaba MH, Wagih HM et al. · 2026 · Diagnostic pathology

BACKGROUND: Thyroid carcinoma is a common tumor affecting the Egyptian population accounting for 2% of newly diagnosed cases of cancer in Egypt yearly and constituting 7.73% of 5 year prevalence in Egypt. Stomatin-Like Protein 2 (SLP-2)…

View details →DOI: 10.1186/s13000-026-01772-0
Negative / Null Result ReportMedicine

The Association Between the STOP-Bang Score and the Integrated Pulmonary Index in Patients Undergoing Endobronchial Ultrasound with Sedation: The STOP OSA-IPI Cohort Study.

Ozden Sertcelik U, Turker M, Sertcelik A et al. · 2026 · Medicina (Kaunas, Lithuania)

Background and Perspectives : Obstructive sleep apnea (OSA) is a prevalent condition associated with increased perioperative risks. Endobronchial ultrasound (EBUS), a diagnostic and staging procedure requiring deep sedation, may pose…

View details →DOI: 10.3390/medicina62061034
Negative / Null Result ReportMedicine

Mood stabilizers and systemic inflammatory burden in euthymic patients with bipolar disorder: a comparative study of lithium and valproate.

Bakay H, Kılavuz FA · 2026 · Psychopharmacology

Rationale Systemic inflammation is increasingly recognized as a key component of the pathophysiology and neuroprogression of bipolar disorder (BD). Novel hematologic indices, including the NLR, PLR, SII, SIRI, and PIV, provide accessible…

View details →DOI: 10.1007/s00213-026-07111-x
Negative / Null Result ReportMedicine

Examination of the relationship between post-voiding residual urine volume and patient-reported urinary symptoms in postmenopausal women.

Umudova K, Demir Ö · 2026 · BMC women's health

Introduction and hypothesis Post-void residual (PVR) urine volume is routinely evaluated in women with urinary incontinence and/or pelvic organ prolapse (POP). However, its clinical relevance in postmenopausal women without these…

View details →DOI: 10.1186/s12905-026-04626-5
Negative / Null Result ReportMedicine

Study of phosphorylated ribosomal protein S6 (pS6) in the clinical outcomes of patients undergoing hepatectomy for metastatic colorectal cancer.

Henriques Cavalcanti Torres de Melo R, de Barros Silva PG, Neto HFEC et al. · 2026 · World journal of surgical oncology

Introduction Colorectal cancer (CRC) is one of the most prevalent malignancies worldwide, with up to 50% of patients developing metastatic disease, predominantly involving the liver. Hepatectomy remains the gold standard for resectable…

View details →DOI: 10.1186/s12957-026-04453-w
Negative / Null Result ReportMedicine

Mechanical diagnosis and therapy as a clinical diagnostic approach in lumbar disc herniation: association with radiological findings.

Aghdasi Z, Negahban H, Movahedi Aliabadi M et al. · 2026 · The Journal of manual & manipulative therapy

Background Lumbar disc herniation (LDH) is a leading causes of low back pain (LBP). Conservative approaches, such as the McKenzie Method of Mechanical Diagnosis and Therapy (MDT), are widely used as first-line treatments. MDT is based on…

View details →DOI: 10.1080/10669817.2026.2683051
Negative / Null Result ReportMedicine

Evaluation of the mechanical properties of 3D printed interim resins polymerized with different postpolymerization units.

Lee W, Kim S, Ahmed KE et al. · 2026 · The Journal of prosthetic dentistry

Statement of problem The effect of different postpolymerization units on the mechanical reliability and degree of conversion (DC) of 3-dimensional (3D) printed interim resins remains unclear, particularly when third-party units are used…

View details →DOI: 10.1016/j.prosdent.2026.05.038
Negative / Null Result ReportMedicine

The Association of G Protein-Coupled Estrogen Receptor (GPER) Polymorphisms with Ionizing Radiation Exposure in Healthcare Workers.

Öztürk Ü, Kurutaş EB, Üremiş N et al. · 2026 · Journal of clinical medicine

Background/Objectives: The G protein-coupled estrogen receptor (GPER) is known to interact with cellular stress responses and DNA damage pathways. Therefore, exposure to ionizing radiation may modulate the biological consequences of…

View details →DOI: 10.3390/jcm15124821
Negative / Null Result ReportMedicine

Impact of Preoperative Depression on Motor Recovery Following Brachial Plexus Reconstruction: A 24-Month Prospective Cohort Study.

Jianmongkol S, Wattanakamolchai S, Wainipitapong S et al. · 2026 · Hand (New York, N.Y.)

Background Depression is frequently diagnosed in patients experiencing traumatic injury and chronic neuropathic pain. Psychological factors may undermine patient motivation, potentially adversely affecting surgical outcomes. This study…

View details →DOI: 10.1177/15589447261453553
Negative / Null Result ReportMedicine

Independent and joint associations of social participation and depressive symptoms with incident stroke risk in older adults: a prospective cohort study based on CHARLS and ELSA.

Ma L, Ma Y, Huang Z et al. · 2026 · BMC public health

Stroke remains a leading cause of death and disability among older adults. Depressive symptoms and low social participation have been linked to stroke risk via behavioral and biological pathways. This study examined the independent and…

View details →DOI: 10.1186/s12889-026-28217-z