Lack of Association Between DJ-1 Gene Promoter Polymorphism and the Risk of Parkinson’s Disease
Lu He; Suzhen Lin; Hong Pan; Hong Pan; Ruinan Shen; Mengyan Wang; Zhihao Liu; Shiyao Sun · 2019 · Frontiers in Aging Neuroscience
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Abstract
Low DJ-1 protein level caused by DJ-1 gene mutation leads to autosomal recessive Parkinson’s disease (PD) due to impaired antioxidative activity. In sporadic PD patients, although mutations were rarely found, lower DJ-1 protein level was also reported. Dysregulation of DJ-1 gene expression might contribute to low DJ-1 protein level. Since the promoter is the most important element to initiate gene expression, whether polymorphisms in the DJ-1 promoter result in the dysregulation of gene expression, thus leading to low protein level and causing PD, is worth exploring. The DJ-1 promoter region w
Abstract by Lu He; Suzhen Lin; Hong Pan; Hong Pan; Ruinan Shen; Mengyan Wang; Zhihao Liu; Shiyao Sun, Frontiers in Aging Neuroscience (2019) — licensed CC BY 4.0.
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Metadata source: DOAJ · DOI 10.3389/fnagi.2019.00024