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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

21318 results · page 426 of 711

Negative / Null Result ReportMedicine

The Effect of External Distractions on Simulated Laparoscopic Performance.

Ingram I, Hughes MA · 2024 · Journal of laparoendoscopic & advanced surgical techniques. Part A

Background: Surgeons are exposed to unavoidable distractions while operating. Distractions can cause stress, and stress can impair cognition and motor skills to the detriment of surgeon performance. This study assessed the impact of…

View details →DOI: 10.1089/lap.2024.0280
Negative / Null Result ReportOpen accessMedicine

Inflammation in atherosclerosis: a Big Idea that has underperformed so far.

Williams KJ · 2025 · Current opinion in lipidology

Purpose of review For many years, inflammation has been a major concept in basic research on atherosclerosis and in the development of potential diagnostic tools and treatments. The purpose of this review is to assess the performance of…

View details →DOI: 10.1097/mol.0000000000000973
Negative / Null Result Report

The Ability to Predict the Progression of the Change in Oct Angiography Values in the Visional Field and Retina Nerve Layer Tomography in Patients With Glaucoma Progress

Demir S, KÖYLÜ MT · 2023 · Preprint

INTRODUCTION To examine the ability of changes in optical coherence tomography angiography (OCTA) values to predict progression in the visual field (GA) and retinal nerve fiber layer (RNFL) in patients with glaucoma progression. METHODS…

View details →DOI: 10.21203/rs.3.rs-3778080/v1
Negative / Null Result ReportOpen accessMedicine

Evaluating the risk of atrial fibrillation in patients with chronic recurrent pericarditis prescribed colchicine: Observations using TriNetX global federated research network.

Kaşkal M, Bucci T, Alobaida M et al. · 2025 · European journal of clinical pharmacology

BACKGROUND: Chronic pericarditis is associated with significant cardiovascular morbidity, including atrial fibrillation (AF), heart failure (HF), and stroke. Colchicine is widely used in pericarditis management for its anti-inflammatory…

View details →DOI: 10.1007/s00228-025-03925-4
Negative / Null Result ReportOpen accessMedicine

Surveillance after treatment for head and neck cancer.

Koivunen P · 2026 · Current opinion in otolaryngology & head and neck surgery

Purpose of review Systematic follow-up protocols, often including regular imaging, are an essential component of posttreatment care for head and neck cancer, aimed at the early detection of disease relapse and mitigating treatment-related…

View details →DOI: 10.1097/moo.0000000000001102
Negative / Null Result ReportOpen accessMedicine

Hyperthermic intraperitoneal chemotherapy plus SOX chemotherapy versus SOX chemotherapy alone in patients with gastric cancer and peritoneal metastasis: a phase II randomized clinical trial.

Luo L, Zhang Z, Zeng H et al. · 2025 · Journal of gastrointestinal oncology

Background The prognosis of patients with gastric cancer with peritoneal metastasis (GCPM) is exceedingly poor. This study evaluated the efficacy and safety of hyperthermic intraperitoneal chemotherapy (HIPEC) with paclitaxel combined with…

View details →DOI: 10.21037/jgo-24-807
Failed Experiment ReportMedicine

Translating Pharmacokinetic-Pharmacodynamic Principles Into Improved Methodology for Clinical Trials That Compare Intermittent With Prolonged Infusion of Beta-Lactam Antibiotics.

Tilanus AM, Shields RK, Lodise TP et al. · 2025 · Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

Based on the fact that beta-lactam antibiotics demonstrate time-dependent killing, different dosing strategies have been implemented to increase the time that free (unbound) antibiotic concentrations remain above the minimal inhibitory…

View details →DOI: 10.1093/cid/ciaf038
Negative / Null Result ReportOpen accessMedicine

A ubiquitous organophosphate flame retardant disrupts energy and glucose homeostasis in mice.

Sewell KM, Oriakhi K, Ngo Tenlep SY et al. · 2026 · Ecotoxicology and environmental safety

Organophosphate flame retardants (OPFRs) are used in many consumer products, and their presence in our environment raises concerns about potential health dangers. In humans, exposure to OPFRs, such as tris(1,3-dichloro-2-propyl) phosphate…

View details →DOI: 10.1016/j.ecoenv.2026.119827
Negative / Null Result ReportOpen accessMedicine

An Observational Study on Clinical Insights and Outcome Prediction of Lupus Enteritis in Indian Systemic Lupus Erythematosus Patients.

Kotha S, Baisya R, Yerram KV et al. · 2025 · Mediterranean journal of rheumatology

Background Lupus enteritis (LE) is the most common serious gastrointestinal manifestation of SLE. Indian literature on LE is limited, while most of the data comes from China and Western series with recent efforts on developing prediction…

View details →DOI: 10.31138/mjr.300924.ioe
Negative / Null Result ReportOpen accessMedicine

An atypical manifestation of Giant cell arteritis (GCA): constitutional symptoms & lingual ulcer in a 78-Year-Old male with negative temporal artery biopsies.

Gow J, Roofeh D · 2025 · BMC rheumatology

Background Giant cell arteritis (GCA) is a large vessel vasculitis characterized by granulomatous inflammation classically affecting the carotid artery branches. GCA most often presents with one or more classic clinical features which…

View details →DOI: 10.1186/s41927-025-00505-y
Negative / Null Result ReportMedicine

Robotic carotid artery stenting: a multicenter, propensity score-matched analysis of clinical outcomes and cost-effectiveness.

Patel SA, Roy JM, Musmar B et al. · 2024 · Neurosurgical focus

Objective Preclinical studies suggest that robotic carotid artery stenting (CAS) could be superior to manual CAS. However, very limited comparative data exist for patients who have undergone robotic versus manual CAS. In addition, no data…

View details →DOI: 10.3171/2024.9.focus24479
Negative / Null Result ReportMedicine

The level of agreement between the numerical rating scale and visual analogue scale for assessing pain intensity in adults with chronic pain.

Goudman L, Pilitsis JG, Billet B et al. · 2024 · Anaesthesia

The numerical rating scale and visual analogue scale are used to quantify pain intensity. However, it has not yet been explored whether these scores are interchangeable in adults with chronic pain. Data from the prospective multicentre…

View details →DOI: 10.1111/anae.16151
Negative / Null Result ReportMedicine

Long-term impact of posterior reconstruction urethrovesical anastomosis during robot-assisted prostatectomy A secondary analysis of a randomized cohort.

Millan B, Hoogenes J, Uy M et al. · 2025 · Canadian Urological Association journal = Journal de l'Association des urologues du Canada

Introduction We aimed to assess early and late continence rates post-robot-assisted radical prostatectomy (RARP), comparing posterior reconstruction (PR) urethrovesical anastomosis (UVA) to conventional urethrovesical anastomosis (C-UVA).…

View details →DOI: 10.5489/cuaj.9121
Negative / Null Result ReportOpen accessMedicine

Children with Dyslexia Benefit from Short Combined Reading and Motor Training: Objective Measures Assessed by Eye Movements and Postural Sway Recordings.

Caldani S, Khoury E, Delorme R et al. · 2025 · Brain sciences

Background/Objectives: Children with dyslexia report poor motor control; several studies have shown poor eye movements control during reading and important body instability in these children. The present study aimed to test in children…

View details →DOI: 10.3390/brainsci15111218
Negative / Null Result ReportMedicine

Sensory Stimulation and Robot-Assisted Arm Training After Stroke: A Randomized Controlled Trial.

Egger M, Bergmann J, Krewer C et al. · 2024 · Journal of neurologic physical therapy : JNPT

Background and purpose Functional recovery after stroke is often limited, despite various treatment methods such as robot-assisted therapy. Repetitive sensory stimulation (RSS) might be a promising add-on therapy that is thought to…

View details →DOI: 10.1097/npt.0000000000000486
Negative / Null Result ReportOpen accessMedicine

Neuromuscular and Neurocognitive Performance Associated with ACL Injury Risk in Youth Handball Players: A Prospective Cohort Study.

Sinka GC, Pavlik A, Mayer Á et al. · 2026 · Sports (Basel, Switzerland)

Background Anterior cruciate ligament (ACL) injuries in youth athletes are multifactorial, and the relative contributions of neuromuscular and neurocognitive variables remain inadequately comprehended. Methods In this prospective cohort…

View details →DOI: 10.3390/sports14050185
Negative / Null Result ReportMedicine

Real-World Patient Eligibility and Feasibility of Transcatheter Edge-to-Edge Repair or Replacement Interventions for Tricuspid Regurgitation.

Abushouk A, Layoun H, Harb SC et al. · 2024 · Journal of cardiac failure

Novel transcatheter therapies for tricuspid regurgitation (TR) appear promising, yet their applicability to an all-comer TR population remains unclear. We aimed to assess the feasibility of emerging transcatheter tricuspid therapies in a…

View details →DOI: 10.1016/j.cardfail.2024.07.014
Failed Experiment Report

Effect of fluticasone-impregnated throat packs on postoperative sore throat (POST) and hoarseness of voice: A randomized clinical trial

Talapatra A, Mathew S, Kanakalakshmi ST et al. · 2024 · Preprint

Background Post-operative sore throat (POST) is one of the most common complaints post-endotracheal intubation and can be decreased through various interventions. This study aimed to determine the effect of fluticasone-impregnated versus…

View details →DOI: 10.12688/f1000research.139742.2
Failed Experiment ReportOpen accessMedicine

Sex Differences in the Effects of Etonogestrel on Respiratory Recovery in an In Vivo Rat Model of Central Chemoreflex Impairment.

Cardani S, Janes TA, Asif R et al. · 2026 · Acta physiologica (Oxford, England)

Aim Rhythmic breathing movements driven by the brainstem rely on chemosensory inputs to homeostatically adjust motor output to the prevailing metabolic demand. The central CO 2 chemoreflex is a critical component of this neural circuitry,…

View details →DOI: 10.1111/apha.70194
Negative / Null Result ReportOpen accessMedicine

Ivermectin to reduce malaria transmission- safety and efficacy results from the BOHEMIA cluster randomized trial in Mozambique.

Chaccour C, Nicolas P, Martinho S et al. · 2025 · EClinicalMedicine

Background Endectocides are a novel vector control tool that reduce the survival and fertility of blood sucking arthropods that feed upon treated humans or animals. Ivermectin mass drug administration is under evaluation as a complementary…

View details →DOI: 10.1016/j.eclinm.2025.103632
Negative / Null Result ReportOpen accessMedicine

The terpenes alpha-bisabolol and camphene modulate pruritus via an action on Cav3.2 T-type calcium channels.

Antunes FTT, Gadotti VM, Zamponi GW · 2025 · Molecular brain

Alpha-bisabolol and camphene have demonstrated analgesic effects in inflammatory pain models by blocking Cav3.2 calcium channels. As the pain pathway overlaps with mechanisms for itch, and because Cav3.2 channels have been associated with…

View details →DOI: 10.1186/s13041-025-01196-9
Negative / Null Result ReportMedicine

Long-term prognostic value of CT-based high-risk coronary lesion attributes and radiomic features of pericoronary adipose tissue in diabetic patients.

Yang W, Ding X, Yu Y et al. · 2024 · Clinical radiology

Aims To investigate the long-term prognostic value of coronary computed tomography angiography (CCTA)-derived high-risk attributes and radiomic features of pericoronary adipose tissue (PCAT) in diabetic patients for predicting major…

View details →DOI: 10.1016/j.crad.2024.08.018
Failed Experiment ReportOpen accessMedicine

IPMK-1 (inositol phosphate multikinase) is required for integrin adhesion complex organization and muscle cell adhesion in Caenorhabditis elegans.

Sagadiev S, Hudson R Jr, Wang Y et al. · 2026 · Genetics

Integrin adhesion complexes (IACs) are a network of proteins that anchor cells to the extracellular matrix. In Caenorhabditis elegans muscle IACs exist at the bases of dense bodies and M-lines, and at the boundaries of adjacent muscle…

View details →DOI: 10.1093/genetics/iyag048
Failed Experiment ReportOpen accessMedicine

Screening of Nonpathogenic Fusarium Species Suppressing Fusarium Crown and Root Rot in Asparagus Using Wheat Bran as an Inoculum Carrier.

Maeda Y, Akino S, Kondo N · 2026 · Microbes and environments

Fusarium crown and root rot (FCRR), caused by the fungus Fusarium oxysporum f. sp. asparagi, is one of the most destructive diseases affecting asparagus worldwide. Despite evidence of the suppression of FCRR by several nonpathogenic F.…

View details →DOI: 10.1264/jsme2.me25063