Negative / Null Result ReportOpen accessMedicine (General)
Kelly Lim, Meng‐Ni Wu, Wei‐Chia Tsao et al. · 2026 · Kaohsiung Journal of Medical Sciences
ABSTRACT The long‐term cumulative impact of metabolic syndrome (MS) on cognitive decline remains uncertain. This study investigated how changes in MS status over 10 years relate to cognition and whether sex modifies this relationship. A total of 766 participants (mean baseline age: 54 years) from the Kaohsiung Atherosclerosis Longitudinal Study were enrolled. MS was defined using the modified National Cholesterol Education Program Adult Treatment Panel III criteria for Asian populations. Participants were categorized into four groups based on changes in MS status over the 10‐year follow‐up: ne
View details →DOI: 10.1002/kjm2.70138 Negative / Null Result ReportOpen accessNeurology. Diseases of the nervous system
Xing Zhang, Xiao-He Hou, Ya-Hui Ma et al. · 2020 · BMC Neurology
Abstract Background Inflammation plays an important role in atherosclerosis but the contribution of neutrophils to this process is unclear. We sought to assess whether neutrophil count is associated with intracranial atherosclerotic stenosis (ICAS). Methods A total of 2847 individuals were included in our study, including 1363 with acute ischemic stroke and 1484 normal controls without stroke. The presence of ICAS was confirmed by magnetic resonance angiography. The association between neutrophil count and ICAS was evaluated by multivariable logistic regression analysis. Results Among 2847 ind
View details →DOI: 10.1186/s12883-020-01641-3 Negative / Null Result ReportOpen accessScience (General)
Berliana Hamidah, Cennikon Pakpahan, Laksmi Wulandari et al. · 2024 · Heliyon
Excessive inflammatory response is a hallmark of severe COVID-19. This study investigated the associations between interferon-stimulated genes (ISGs) expression, genetic variation in the interferon α/β receptor 2 (IFNAR2) gene, and COVID-19 mortality.We investigated 67 patients with moderate-to-severe COVID-19. Of them, 22 patients (32.8 %) died because of COVID-19. We examined the expression of ISGs in total RNA of peripheral whole blood. We observed a significant increase in the expression of all ISGs examined in non-surviving patients, indicating a heightened interferon type I signaling act
View details →DOI: 10.1016/j.heliyon.2024.e39002 Negative / Null Result ReportOpen accessMedicine
Tamás Sebestyén, Zita Iloskics · 2020 · PLoS ONE
The spread of economic shocks in an increasingly interconnected global economy has been subject to several studies recently. These studies mostly focus on the synchronization of business cycles among economies and search for the relationship between trade linkages and shock contagion. In contrast to previous studies in the field, this paper focuses on the topological properties of the shock contagion network as measured by pairwise Granger causality between economic output of countries. This topological approach can bring new insights into the dynamics of contagion and the relationship between
View details →DOI: 10.1371/journal.pone.0238626 Negative / Null Result ReportOpen accessPediatrics
Radwa Iraqy, Mahmoud Hamdy, Laila Hussein et al. · 2026 · Egyptian Pediatric Association Gazette
Abstract Introduction Zinc plays a crucial role in both innate and adaptive immune responses by regulating intracellular signaling pathways in immune cells. Zinc deficiency has been implicated in up to 4.4% of infection-related deaths in developing countries. Acute lower respiratory infections (ALRIs), particularly pneumonia, are a leading cause of morbidity and mortality among young children which accounts for around 81% of deaths in the first two years of life. Method One hundred twenty children were enrolled in this study, divided in 2 groups: 60 critically ill children diagnosed with pneum
View details →DOI: 10.1186/s43054-026-00560-1 Negative / Null Result ReportOpen accessNeurosciences. Biological psychiatry. Neuropsychiatry
Lu He, Suzhen Lin, Hong Pan et al. · 2019 · Frontiers in Aging Neuroscience
Low DJ-1 protein level caused by DJ-1 gene mutation leads to autosomal recessive Parkinson’s disease (PD) due to impaired antioxidative activity. In sporadic PD patients, although mutations were rarely found, lower DJ-1 protein level was also reported. Dysregulation of DJ-1 gene expression might contribute to low DJ-1 protein level. Since the promoter is the most important element to initiate gene expression, whether polymorphisms in the DJ-1 promoter result in the dysregulation of gene expression, thus leading to low protein level and causing PD, is worth exploring. The DJ-1 promoter region w
View details →DOI: 10.3389/fnagi.2019.00024 Negative / Null Result ReportOpen accessDiseases of the musculoskeletal system
Natalia Pereira Machado, Eliana Nogueira, Karen Oseki et al. · Revista Brasileira de Reumatologia
ABSTRACT Objectives: Innate immunity is involved in the physiopathology of ankylosing spondylitis (AS), with the participation of Gram-negative bacteria, modulation of human leukocyte antigen (HLA) B27 and the involvement of pattern recognition receptors, such as Toll-like receptors (TLRs). The aim of this study was to investigate the clinical characteristics and frequency of TLR4 polymorphisms (Asp299Gly and Thr 399Ile) in a cohort of Brazilian patients with AS. Methods: A cross-sectional study was carried out involving 200 patients with a diagnosis of AS and a healthy control group of 200 in
View details →DOI: 10.1016/j.rbre.2016.07.004 Negative / Null Result ReportOpen accessNursing
Juliana Ribeiro da Silva Vernasque, Miriam Fernanda Sanches Alarcon, Daiana Bonfim et al. · 2025 · Revista Latino-Americana de Enfermagem
Objective: to evaluate the impact of a gamified educational intervention on violence against the elderly on the knowledge, perceptions and attitudes of university students. Method: a non-randomized clinical trial involving 44 university students from the health sciences, humanities and exact sciences, with 22 in the intervention group and 22 in the control group. The intervention group participated in hybrid activities on gamification applied to the topic of violence against the elderly. The evaluation was conducted using thematic cases validated by experts, with statistical analysis using Chi
View details →DOI: 10.1590/1518-8345.7874.4662 Negative / Null Result ReportOpen accessNutritional diseases. Deficiency diseases
Renyue Ji, Haisheng Wu, Hongli Lin et al. · 2025 · Diabetology & Metabolic Syndrome
Abstract Background Epidemiological research on the association between heavy metals and congestive heart failure (CHF) in individuals with abnormal glucose metabolism is scarce. The study addresses this research gap by examining the link between exposure to heavy metals and the odds of CHF in a population with dysregulated glucose metabolism. Method This cross-sectional study includes 7326 patients with diabetes and prediabetes from the National Health and Nutrition Examination Survey from 2011 to 2018. The exposure variables are five environmental heavy metals—cadmium (Cd), lead (Pb), mercur
View details →DOI: 10.1186/s13098-024-01556-w Negative / Null Result ReportOpen accessMedicine
Paschalina C Ezechukwu, Emmanuel O Ugwu, Samuel N Obi et al. · 2023 · International Journal of Medicine and Health Development
Background: Preeclampsia is one of the leading causes of maternal and perinatal morbidity and mortality in Nigeria and worldwide. It is not yet concluded as to whether or not elevated levels of serum creatinine and/or uric acid could be regarded as a predictive indicator for the severity of the disease. Objectives: To compare the mean serum levels of uric acid and creatinine in preeclamptic and normotensive pregnant women and assess for any associations between these renal biomarkers and the severity of preeclampsia in Nigeria. Materials and Methods: It was a cross-sectional analytical study o
View details →DOI: 10.4103/ijmh.ijmh_11_22 Negative / Null Result ReportOpen accessMedicine
Kibum Kim, Linda Kaitlyn Craft · 2022 · BMJ Open
Objective Non-invasive prenatal testing (NIPT) is a front-line screening for fatal chromosomal aneuploidy. In pregnant women with a risk of having fetal congenital disorders, NIPT is anticipated to reduce the needs of invasive prenatal diagnostic test (IPD). The objective of this study was to understand the acceptance of NIPT and the utility of NIPT to mitigate concerns about IPD in the US high-risk pregnancy management.Design and setting This was a retrospective observational research using healthcare records obtained from an academic healthcare system in the US. The study consisted of site-l
View details →DOI: 10.1136/bmjopen-2021-057658 Negative / Null Result Report
Audu K, Nurudeen YZ, Ogbadu EE et al. · 2026 · Preprint
Abstract This study aimed at investigating the effect of employee motivation on job satisfaction of selected Federal Universities in North Central, Nigeria. The specific objectives are to: (i) investigate the effect of employee career…
View details →DOI: 10.21203/rs.3.rs-8839962/v1 Negative / Null Result ReportOpen accessMedicine
Esmee M. Breddels, Johanna Simin, Romina Fornes et al. · 2022 · BMC Medicine
Abstract Background Approximately half of all women suffer from heartburn at some stage during pregnancy. The most effective treatment is proton pump inhibitors, but the safety of use during pregnancy cannot be guaranteed. This study aimed to elucidate the effect of proton pump inhibitors on the risk of pre-eclampsia, gestational diabetes mellitus, preterm birth, an Apgar score at 5 min below 7, and a child being small or large for its gestational age. Methods This Swedish population-based study included 1,089,514 live singleton deliveries between July 2006 and December 2016 in Sweden. Multipl
View details →DOI: 10.1186/s12916-022-02673-x Negative / Null Result ReportOpen accessDiseases of the genitourinary system. Urology
Manisha Ghate, Pallavi Shidhaye, Shraddha Gurav et al. · 2022 · Journal of the International Association of Providers of AIDS Care
Background : We aimed to determine the anti-SARS-CoV-2 IgG antibodies among people living with HIV (PLHIV) in Pune, India. Methods : This cross-sectional study was conducted between March 2021 and June 2021. Demographic and clinical information related to coronavirus disease 2019 (COVID-19) were recorded on structured questionnaires. Blood samples were collected and tested for anti-SARS-CoV-2 IgG antibodies using commercial ELISA. Results : Of the 405 HIV infected individuals enrolled in the study, 223(55.1%) were females. Mean age and CD4 count of participants were 42 years (SD: 10) and 626 c
View details →DOI: 10.1177/23259582221077943 Negative / Null Result ReportOpen accessSpecialties of internal medicine
Li Y, Yu T, Liu Z et al. · 2020 · Diabetes, Metabolic Syndrome and Obesity
Yan Li,1,* Tingwei Yu,2,* Zengyou Liu,2 Hengying Chen,3 Yao Liu,4 Yuanhuan Wei,4 Ruifang Sun,4 Hongmei Zhang,2 Wei Wang,2 Yihua Lu,2 Yingyu Zhou,1 Guifang Deng,4 Zheqing Zhang1 1Department of Nutrition and Food Hygiene, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou, People’s Republic of China; 2Department of Obstetrics, Union Shenzhen Hospital of Huazhong University of Science and Technology, Shenzhen, People’s Republic of China; 3Injury Prevention Research Center, Shantou University Medical College
Negative / Null Result ReportOpen accessNeoplasms. Tumors. Oncology. Including cancer and carcinogens
Justin G. Mygatt, Jennifer Cullen, Samantha A. Streicher et al. · 2020 · Cancer Medicine
Abstract Background The relationship between race, prostate tumor location, and BCR‐free survival is inconclusive. This study examined the independent and joint roles of patient race and tumor location on biochemical recurrence‐free (BCR) survival. Methods A retrospective cohort study was conducted among men with newly diagnosed, biopsy‐confirmed, NCCN‐defined low risk CaP who underwent radical prostatectomy (RP) at the Walter Reed National Military Medical Center from 1996 to 2008. BCR‐free survival was modeled using Kaplan‐Meier estimation curves and multivariable Cox proportional hazards (P
View details →DOI: 10.1002/cam4.2864 Negative / Null Result ReportOpen accessNeurology. Diseases of the nervous system
Yiyi Chen, Yiyi Chen, Yiyi Chen et al. · 2021 · Frontiers in Neurology
Background: High plasma levels of trimethylamine N-oxide (TMAO) and its precursor choline have been linked to stroke; however, their association with cerebral small vessel disease remains unclear. Here we evaluated the association of plasma levels of TMAO and choline with imaging markers of cerebral small vessel disease, including white matter hyperintensities, lacunes, and cerebral microbleeds.Methods: We performed a baseline cross-sectional analysis of a multicenter hospital-based cohort study from 2015 to 2018. The data were collected from 30 hospitals in China and included 1,098 patients w
View details →DOI: 10.3389/fneur.2021.648702 Negative / Null Result ReportOpen accessTherapeutics. Pharmacology
Tina Taule, Ole-Bjørn Tysnes, Jörg Aßmus et al. · 2025 · Journal of Rehabilitation Medicine
Objective: To determine whether early cognitive function in amyotrophic lateral sclerosis patients predicts future cognitive function and the decision to cease driving. Design: Observational study. Subjects: Patients with amyotrophic lateral sclerosis. Methods: Subjects underwent baseline assessments of cognitive function and driving ability within 4 months of diagnosis, with follow-up evaluation conducted 4 months thereafter. Two hypotheses were tested: (H1) cognitive status remains stable between baseline and follow-up, (H2) patients with baseline cognitive impairment cease driving earlier t
View details →DOI: 10.2340/jrm.v57.43483 Negative / Null Result ReportOpen accessInfectious and parasitic diseases
Watheq Thabet Taher, Amen A. Bawazir, Talal A. Sallam et al. · 2023 · BMC Infectious Diseases
Abstract Background Healthcare workers (HCWs) are at a higher risk of contracting COVID-19 due to their close contact with infected patients. However, the true burden of COVID-19 among HCWs in Yemen is unknown due to the inadequate availability of healthcare and the subclinical nature of the disease. This study aims to estimate the seroprevalence of SARS-CoV-2 infection among HCWs in two Yemeni governorates and identify associated factors using a cross-sectional design. Method A total of 404 HCWs were surveyed from June 2022 to September 2022 in Lahj and AL-Dhalea hospitals. A self-administere
View details →DOI: 10.1186/s12879-023-08760-5 Negative / Null Result ReportOpen accessMedicine
Abida Shaheen, Syed Mahboob Alam, Fahad Azam et al. · 2022 · PLoS ONE
Background and objective Gabapentinoids are the first-line drugs for neuropathic pain. These drugs are the substrate of organic cation transporter (OCTN1) for renal excretion and absorption across the intestinal epithelium. Gabapentinoids exhibit wide interindividual variability in daily dosage and therapeutic efficacy which makes titration regimens prolonged for optimal efficacy. The present study aimed to investigate the possible influence of the single nucleotide polymorphism (SNP) of OCTN1 on therapeutic efficacy and safety of gabapentinoids in neuropathic pain patients of the Pakistani po
View details →DOI: 10.1371/journal.pone.0266559 Negative / Null Result ReportOpen accessMedicine
Al-mustafa Mahmoud, Massad Islam, Alsmady Moaath et al. · 2010 · Saudi Journal of Kidney Diseases and Transplantation
Vertical infraclavicular brachial plexus block is utilized in patients with chronic renal failure at the time of creation of an arterio-venous fistula (AVF). The aim of this study is to test the effect of impaired renal function, with the resulting deranged serum electrolytes and blood gases, on the success rate and the onset of action of the local anesthetics used. In this prospective clinical study, we investigated the effect of the serum levels of sodium, potassium, urea, crea-tinine, pH, and bicarbonate on the onset of action of a mixture of lidocaine and bupivacaine administered to create
Negative / Null Result ReportOpen accessImmunologic diseases. Allergy
Cécile Gonnin, Michelle Leemans, Florence Canoui-Poitrine et al. · 2024 · Immunity & Ageing
Abstract Background Immune ageing complicates cancer treatment in older individuals. While immunotherapy targeting the PD-1/PD-L1 pathway can reinvigorate T cells, these cells tend to become senescent with age. This study investigates different CD8+ T cell subsets usually associated with senescence, in cancer patients over 70 years old who are undergoing anti-PD-1/PD-L1 immunotherapy, and examines the relationship between these senescent cells and prior chemotherapy exposure. We analyzed data from the Elderly Cancer Patient (ELCAPA) cohort, which included 35 patients enrolled between March 201
View details →DOI: 10.1186/s12979-024-00487-4 Negative / Null Result ReportOpen accessDiseases of the endocrine glands. Clinical endocrinology
Yina Piao, Mengxia Jin · 2026 · Therapeutic Advances in Endocrinology and Metabolism
Background: Stress-induced hyperglycemia ratio (SHR) has shown strong correlations with diabetes risk. However, its relationship with gestational diabetes mellitus (GDM) remains an area of limited research. Objective: Based on the National Health and Nutrition Examination Survey (NHANES) database, this cross-sectional study aims to explore the association between SHR and GDM. Methods: The study included 461 pregnant women from NHANES between 1999 and 2016. Logistic regression analysis was performed to investigate the relation between SHR and GDM, as well as the weighted tertiles of SHR. Strati
View details →DOI: 10.1177/20420188261431025 Negative / Null Result ReportOpen accessMicrobiology
Tony H. Chang, Julie D. Pourtois, Naomi L. Haddock et al. · 2025 · mSphere
ABSTRACT Lysogenic bacteriophages can integrate their genome into the bacterial chromosome in the form of a prophage and can promote genetic transfer between bacterial strains in vitro. However, the contribution of lysogenic bacteriophages to the incidence of antimicrobial resistance (AMR) in clinical settings is poorly understood. Here, in a set of 186 clinical isolates of Pseudomonas aeruginosa collected from respiratory cultures from 82 patients with cystic fibrosis, we evaluate the links between prophage counts and both genomic and phenotypic resistance to six anti-pseudomonal antibiotics:
View details →DOI: 10.1128/msphere.00904-24 Negative / Null Result ReportMedicine
Selma Celen Yuceturk, Sumeyye Aydogan Turkoglu, F. Kockar et al. · 2021 · Zeitschrift für Naturforschung C - A Journal of Biosciences
Abstract In this study, the chemical composition, antimicrobial, antioxidant, and anticancer effects of Thymus convolutus Klokov oil and its main compound camphor were investigated. The oil was isolated from T. convolutus using…
View details →DOI: 10.1515/znc-2020-0070 Negative / Null Result ReportOpen accessDentistry
Song Cai, SiYu Li, YaShi Zhou et al. · 2024 · BMC Oral Health
Abstract Background Sedentary behavior (SB) may contribute to obesity and lower extremity fluid retention, which may favor the development of obstructive sleep apnea (OSA). However, linking sedentary behavior to OSA is unclear. The purpose of this study was to determine if there is an association between SB and OSA. Methods Three typical questions in the NHANES questionnaire(①The frequency of feeling excessively sleepy per month. ②The frequency of gasping, snorting or stopping breathing per week. ③The frequency of snoring per week.) have been used for the assessment of OSA. A physical activity
View details →DOI: 10.1186/s12903-024-03960-0 Negative / Null Result ReportOpen accessDermatology
Jie Gao, Linting Wei, Xinghan Liu et al. · 2017 · Kidney & Blood Pressure Research
Background/Aims: IFN-γ was reported to be involved in the development and progression of Immunoglobulin A nephropathy (IgAN), however, few studies have investigated the association between IFN-γ polymorphisms and IgAN. Therefore, we performed a case-control study to assess the association between IFN-γ polymorphisms and the risk of IgAN. Methods: Sequenom MassARRAY was used to genotype two SNPs (rs1861494 and rs2430561) in 351 patients with IgAN and 310 healthy controls. Associations were evaluated as odd ratios (OR) with 95% confidence intervals (CI). Results: No association was found between
View details →DOI: 10.1159/000473889 Negative / Null Result ReportOpen accessMedicine
Anjali B Susan, Uttam B George, Jeyaraj D Pandian · 2022 · Journal of Clinical and Diagnostic Research
Introduction: Arterial Spin Labeling-Perfusion Weighted Imaging (ASL-PWI) assesses cerebral blood flow using magnetically labeled inflowing arterial blood water protons as freely diffusible tracer without exogenous contrast agent. Seizures are one of the sequelae of stroke with its mechanism not well studied. Aim: Qualitative assessment of cerebral perfusion in post stroke seizure patients using ASL-PWI and comparison of perfusion patterns in post stroke seizure patients and stroke patients. Materials and Methods: This was a case-control study among 100 stroke patients who underwent Magnetic R
View details →DOI: 10.7860/jcdr/2022/55267.16473 Negative / Null Result ReportOpen accessNeoplasms. Tumors. Oncology. Including cancer and carcinogens
Sung Ui Jung, Kwang Kuk Park, Song I Yang et al. · 2014 · Korean Journal of Clinical Oncology
Purpose: Mutations in the p53 gene and accumulation of p53 protein are the most common genetic events in gastric carcinomas. This study evaluates the association of p53 gene expression with clinicopathologic findings and prognosis of gastric cancer patients who underwent curative resection. Methods: Retrospective analysis was performed on 236 consecutive patients with gastric cancer who underwent surgery at the Kosin University Gospel Hospital between December 2011 and September 2012. Nuclear p53 expression was detected by immunohistochemistry. Results: p53 expression was detected in 213 patie
View details →DOI: 10.14216/kjco.14003 Negative / Null Result ReportOpen accessMedicine
Zoya maqsood , Shahid Jamal Siddiqui, Nimarta Bai et al. · 2025 · Journal of the Dow University of Health Sciences
Objective: To determine the frequency of raised intraocular pressure (IOP) following neodymium-doped yttrium aluminum garnet (Nd:YAG) laser capsulotomy in pseudophakic patients and to compare outcomes between high- and low-energy procedures. Methods: This descriptive cross-sectional study was conducted at the Department of Ophthalmology, Khairpur Medical College / Civil Hospital, Khairpur Mirs, Pakistan from April to September 2024. A total of 139 pseudophakic patients with posterior capsular opacification (PCO) undergoing Nd:YAG capsulotomy were enrolled. Baseline demographic and clinical dat
