A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
21720 results · page 411 of 724
Joseph J, Chandranaath A, Louis J et al. · 2025 · Cureus
Background Wound healing relies on a balance between extracellular matrix remodelling by matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs). Among all the MMPs, elevated MMP-9 levels are implicated in…
Alharazy S · 2024 · Pakistan journal of medical sciences
Background & objective Hypovitaminosis D has shown to be linked with T2DM development and control in numerous studies. The association of SNPs in genes related to VitD metabolism with T2DM has not been sufficiently studied. Consequently,…
Wang F, Wang C, Wang T et al. · 2025 · Proceedings of the National Academy of Sciences of the United States of America
Genotype-phenotype associations can be context-dependent and dynamic in nature leading to heterogeneity of genetic effects across different parts of the phenotype distribution. Quantile regression, an alternative to linear regression for…
Gu Y, Zhang W, Zhou J et al. · 2025 · International journal of nephrology
Background: Acute kidney injury (AKI) is a common postoperative event. Previous research suggests that intraoperative hypotension (IOH) is associated with postoperative AKI. This connection, however, has not been studied in patients…
Agbektas T, Genc HC, Zontul C et al. · 2025 · International journal of molecular sciences
(1) This cross-sectional study aims to elucidate the association between the XPO5 gene polymorphism (rs11544382) and colon cancer (CC). (2) Genotyping of XPO5 (rs11544382) was performed in 120 individuals (60 CC patients and 60 controls)…
Itoi M, Willcox MDP · 2024 · Contact lens & anterior eye : the journal of the British Contact Lens Association
Purpose This study aimed to assess the susceptibility of ocular isolates of Pseudomonas aeruginosa to two multi-purpose disinfectant solutions (MPDS) and to determine if there was a relationship with resistance to antibiotics. Methods…
Taft D, Quinones JM, Moreno ML et al. · 2024 · Preprint
Blood levels of uremic molecules generated through gut microbial metabolism are associated with disease risk, reduced quality of life, and mortality in patients with renal insufficiency. Modulation of the microbiome may offer therapeutic…
Nasirzadeh A, Mohammadzadeh F, Kazeminia S et al. · 2025 · Scientific reports
The presence of a known labor companion was shown to improve childbirth satisfaction. However, a companion's anxiety might affect the satisfaction of laboring women. Therefore, this study aimed to evaluate the relationship between the…
Alroba R, Alfakhri A, Badreldin HA et al. · 2024 · Preprint
Purpose: This study aims to investigate the potential causal relationship between the use of indapamide and rhabdomyolysis. Previous research and pharmacovigilance monitoring activities have suggested a potential association between…
Veenman F, Tibbertsma S, Wolvius EB et al. · 2025 · Caries research
Introduction Asthma and dental caries may be linked through frequent mouth breathing and the use of inhaled asthma medication. However, the current literature is inconclusive on whether asthma or asthma medications increase the risk of…
Watanabe RAS, Nishiyama F, Lyra L et al. · 2024 · Preprint
Background and Objectives Respiratory syncytial virus (RSV) is responsible for most cases of acute viral bronchiolitis (AVB) in childhood. The association of factors such as RSV subtype, viral load, and viral coinfection with severe…
Whelton SP, Yao J, Clish C et al. · 2026 · Journal of the American Heart Association
Background Aortic valve calcification (AVC) is the primary process leading to aortic stenosis. We examined whether polygenic risk scores (PRS) are associated with AVC beyond traditional atherosclerotic cardiovascular disease risk factors.…
Isaacs Q, Sofianos C, Muganza A et al. · 2026 · European burn journal
Background: Timely admission to a specialised burn unit is considered crucial for optimising outcomes in burn patients. However, the impact of delayed admission on hospital length of stay and clinical outcomes remains unclear, particularly…
Zhao J, Li W, Chen L et al. · 2024 · Frontiers in endocrinology
Objective Despite several observational studies attempting to investigate the potential association between type 1 diabetes mellitus (T1DM) and the risk of digestive cancers, the results remain controversial. The purpose of this study is…
Pietraszko P, Żórawski M, Bielecka-Richter E et al. · 2025 · International journal of molecular sciences
Mid-regional pro-adrenomedullin (MR-proADM) has emerged as a promising biomarker reflecting endothelial dysfunction and systemic inflammation. Its prognostic role in cardiovascular complications, particularly in the context of COVID-19…
Weber J, Heming M, Apolinário-Hagen J et al. · 2024 · Biological psychology
Valid approaches to conveniently measure stress reactivity are needed due to the growing evidence of its health-impairing effects. This study examined whether the Perceived Stress Reactivity Scale (PSRS) predicts cardiovascular and…
Kaabi YA, Abdelmola AA, Abdelwahab SI et al. · 2024 · Clinical laboratory
Background Type 2 diabetes mellitus (T2DM) is common in Saudi Arabia and represents a major health concern. Silent information regulator of transcription-1 (SIRT1) positively influences insulin sensitivity and might contribute to the…
Chiarelli PA, Chapman N, Flyer BE et al. · 2024 · Journal of neurosurgery. Pediatrics
Objective The optimal timing of ventricular shunt placement in low-weight and preterm infants remains an unresolved topic in modern pediatric neurosurgery. Shunt placement for hydrocephalus is performed over a wide range of infant weights,…
Quyen AT, Nakamura S, Watanabe K et al. · 2023 · Preprint
Abstract Although the correlation between loneliness and both the development and management of diabetes has been gradually uncovered, the finding was inclusive. Furthermore, this aspect has yet to be researched in the Japanese populace.…
Boucher V, Frenette J, Neveu X et al. · 2023 · Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
Approximately 15 % of individuals who sustained a mild Traumatic Brain Injury (TBI) develop persistent post-concussion symptoms (PPCS). We hypothesized that blood biomarkers drawn in the Emergency Department (ED) could help predict PPCS.…
Sawa K, Ihara Y, Imai T et al. · 2024 · Clinical lung cancer
Background The number of patients undergoing hemodialysis continues to increase globally, and the incidence of cancer is high among these patients. Immune checkpoint inhibitors are widely used in patients with advanced cancer, especially…
Seizer L, Löchner J, Renner TJ · 2026 · Brain, behavior, & immunity - health
The interaction between the immune system and the central nervous system has been implicated in the development of psychiatric disorders in adult patients. However, comprehensive data regarding pediatric psychiatry are still lacking. This…
Howard KA, Witrick B, Clark A et al. · 2026 · The Journal of surgical research
Introduction Implicit bias can influence behavior and decision-making, such as treatment decisions in clinical settings. Given documented Black-White disparities in vascular care, the purpose of this study was to describe the prevalence…
Pires S, Freitas M, Pinho F et al. · 2025 · Sensors (Basel, Switzerland)
Objective We aimed to quantify the mechanical pressure required to reach the deep cervical and thoracolumbar fasciae, to examine its association with pressure pain threshold (PPT) and adipose tissue thickness, and to determine whether PPT…
Haahr Vad O, Önnestam L, Bengtsson Boström K et al. · 2025 · PloS one
Aims The aim of the study was to investigate the association between breastfeeding duration and body mass index (BMI), overweight and obesity in children during follow-up until 16 years of age. Methods Observational cohort study of mothers…
Montoya-Delgado IB, Ochoa-García IV, Escobedo-Salcedo ZL et al. · 2026 · International journal of molecular sciences
Severe asthma (SA) is a chronic respiratory disease characterized by clinical heterogeneity and poor therapeutic response. Variants in the IL4 gene, including rs2243250 and rs2243248, have been associated with asthma susceptibility and…
Sacre H, Haddad C, Rizk R et al. · 2025 · Frontiers in public health
Objectives To investigate the association between food insecurity (FI), eating disorders (EDs), and orthorexia nervosa (ON) among Lebanese university students. Methods This cross-sectional study, conducted between 2021 and 2022, enrolled…
Wistrand H, Kaartinen NE, Jousilahti P et al. · 2024 · Integrated blood pressure control
Purpose The complex pathogenesis of hypertension, potentially involving inflammatory pathways, remains elusive. This study aimed to evaluate the relationship between 24-hour urinary sodium excretion and inflammatory cytokines alongside…
Schultze A, Ju S, Drysdale M et al. · 2025 · Pharmacology research & perspectives
We report findings from three SCCS conducted to quantify the association between fluoroquinolone (FQ) use for the treatment of uncomplicated urinary tract infection (uUTI) and tendon rupture, retinal detachment, and uveitis. Female…
Kayode GA, Zagkos L, Oboli G et al. · 2025 · PloS one
Background Subarachnoid haemorrhage (SAH) poses a life-threatening risk, contributing to half of all haemorrhagic strokes, with aneurysmal SAH (aSAH) affecting approximately 6 individuals per 100,000 annually. Following aSAH, the influx of…