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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

21191 results · page 38 of 707

Negative / Null Result ReportOpen accessMedicine

An experimental study on the effects of a simulation game on students’ clinical cognitive skills and motivation

Mary Dankbaar, Jelmer Alsma, Els E. H. Jansen et al. · 2015 · Advances in Health Sciences Education

Simulation games are becoming increasingly popular in education, but more insight in their critical design features is needed. This study investigated the effects of fidelity of open patient cases in adjunct to an instructional e-module on students' cognitive skills and motivation. We set up a three-group randomized post-test-only design: a control group working on an e-module; a cases group, combining the e-module with low-fidelity text-based patient cases, and a game group, combining the e-module with a high-fidelity simulation game with the same cases. Participants completed questionnaires

View details →DOI: 10.1007/s10459-015-9641-xCited by 149
Negative / Null Result ReportOpen accessEnvironmental Science

The role of public and private natural space in children's social, emotional and behavioural development in Scotland: A longitudinal study

Elizabeth Richardson, Jamie Pearce, Niamh Shortt et al. · 2017 · Environmental Research

INTRODUCTION: Poor mental health in childhood has implications for health and wellbeing in later life. Natural space may benefit children's social, emotional and behavioural development. We investigated whether neighbourhood natural space and private garden access were related to children's developmental change over time. We asked whether relationships differed between boys and girls, or by household educational status. METHODS: were modelled to quantify their independent contributions to SDQ score change over time. RESULTS: Private garden access was strongly related to most SDQ domains, while

View details →DOI: 10.1016/j.envres.2017.07.038Cited by 149
Negative / Null Result ReportOpen accessComputer Science

Combining Retrieval, Statistics, and Inference to Answer Elementary Science Questions

Peter E. Clark, Oren Etzioni, Tushar Khot et al. · 2016 · Proceedings of the AAAI Conference on Artificial Intelligence

What capabilities are required for an AI system to pass standard 4th Grade Science Tests? Previous work has examined the use of Markov Logic Networks (MLNs) to represent the requisite background knowledge and interpret test questions, but…

View details →DOI: 10.1609/aaai.v30i1.10325Cited by 149
Negative / Null Result ReportNeuroscience

The Association Between Social Cognition and Executive Functioning and Symptoms of Anxiety and Depression in Adolescents With Autism Spectrum Disorders

Matthew J. Hollocks, Catherine R. G. Jones, Andrew Pickles et al. · 2014 · Autism Research

While high levels of anxiety and depression are now recognized as major co-occurring problems in children and young people with an autism spectrum disorder (ASD), research examining possible associations with individual differences in…

View details →DOI: 10.1002/aur.1361Cited by 148
Negative / Null Result ReportOpen accessComputer Science

Star Quality: Aggregating Reviews to Rank Products and Merchants

Mary McGlohon, Natalie Glance, Zach Reiter · 2010 · Proceedings of the International AAAI Conference on Web and Social Media

Given a set of reviews of products or merchants from a wide range of authors and several reviews websites, how can we measure the true quality of the product or merchant? How do we remove the bias of individual authors or sources? How do…

View details →DOI: 10.1609/icwsm.v4i1.14019Cited by 148
Negative / Null Result ReportOpen accessMedicine

Significant Association of Multiple Human Cytomegalovirus Genomic Loci with Glioblastoma Multiforme Samples

Padhma Ranganathan, Paul A. Clark, John S. Kuo et al. · 2011 · Journal of Virology

Viruses are appreciated as etiological agents of certain human tumors, but the number of different cancer types induced or exacerbated by viral infections is unknown. Glioblastoma multiforme (GBM)/astrocytoma grade IV is a malignant and…

View details →DOI: 10.1128/jvi.06097-11Cited by 148
Negative / Null Result ReportOpen accessDecision Sciences

Factors influencing purchase intention towards consumer-to-consumer e-commerce

M. Dachyar, Liska Banjarnahor · 2017 · Intangible Capital

Purpose: This study explores factors that influence consumer’s purchase intention at three consumer-to-consumer (C2C) e-commerce companies in Indonesia.Design/methodology/approach: 5 Expert opinions are used to determine the indicators of each factor and the Structural Equation Modelling (SEM) method is used to analyze the empirical data of 400 respondents for each company.Findings: It is found different significant factors that influence customer’s purchase intention in each company. Trust and risk are found to be significantly effect purchase intention in Company A. Meanwhile, the other two

View details →DOI: 10.3926/ic.1119Cited by 148
Replication FailurePsychology

Replication of “Experiencing Physical Warmth Promotes Interpersonal Warmth” by

Dermot Lynott, Katherine S. Corker, Jessica Wortman et al. · 2014 · Social Psychology

We report the results of three high-powered, independent replications of Study 2 from Williams and Bargh (2008) . Participants evaluated hot or cold instant therapeutic packs before choosing a reward for participation that was framed as a…

View details →DOI: 10.1027/1864-9335/a000187Cited by 148
Negative / Null Result ReportDentistry

Smoking, Diabetes Mellitus, Periodontitis, and Supportive Periodontal Treatment as Factors Associated With Dental Implant Survival: A Long-Term Retrospective Evaluation of Patients Followed for Up to 10 Years

Rachel Anner, Yoav Grossmann, Yael Anner et al. · 2010 · Implant Dentistry

OBJECTIVES: To evaluate the factors associated with long-term implant survival in a large cohort of patients in regular follow-up until data collection. METHODS: The study population consisted of 475 patients who were referred to a private…

View details →DOI: 10.1097/id.0b013e3181bb8f6cCited by 148
Negative / Null Result ReportOpen accessSocial Sciences

Primary Elections and Partisan Polarization in the U.S. Congress

Shigeo Hirano, James M. Snyder, Stephen Ansolabehere et al. · 2010 · Quarterly Journal of Political Science

Many observers and scholars argue that primary elections contribute to ideological polarization in U.S. politics. We test this claim using congressional elections and roll call voting behavior. Many of our findings are null. We find little…

View details →DOI: 10.1561/100.00008052Cited by 148
Negative / Null Result ReportOpen accessPhysics and Astronomy

Direct Test of Laser Tunneling with Electron Momentum Imaging

Ladan Arissian, Christopher Smeenk, F. Turner et al. · 2010 · Physical Review Letters

Tunneling is often used to describe multiphoton ionization of rare gas atoms in infrared fields. We test the tunneling approximation and its nonadiabatic extension by measuring the unperturbed momentum distribution along the κ direction of…

View details →DOI: 10.1103/physrevlett.105.133002Cited by 147
Negative / Null Result ReportEconomics, Econometrics and Finance

Wellness Incentives In The Workplace: Cost Savings Through Cost Shifting To Unhealthy Workers

Jill R. Horwitz, Brenna D. Kelly, John DiNardo · 2013 · Health Affairs

The Affordable Care Act encourages workplace wellness programs, chiefly by promoting programs that reward employees for changing health-related behavior or improving measurable health outcomes. Recognizing the risk that unhealthy employees…

View details →DOI: 10.1377/hlthaff.2012.0683Cited by 147
Negative / Null Result ReportOpen accessMedicine

Azacitidine, Venetoclax, and Gilteritinib in Newly Diagnosed and Relapsed or Refractory FLT3-Mutated AML

Nicholas J. Short, Naval Daver, Courtney D. DiNardo et al. · 2024 · Journal of Clinical Oncology

PURPOSE Azacitidine plus venetoclax is a standard of care for patients with newly diagnosed AML who are unfit for intensive chemotherapy. However, FLT3 mutations are a common mechanism of resistance to this regimen. The addition of…

View details →DOI: 10.1200/jco.23.01911Cited by 146
Negative / Null Result ReportOpen accessMedicine

Identification of subclasses of sepsis that showed different clinical outcomes and responses to amount of fluid resuscitation: a latent profile analysis

Zhongheng Zhang, Gensheng Zhang, Hemant Goyal et al. · 2018 · Critical Care

BACKGROUND AND OBJECTIVE: Sepsis is a heterogeneous disease and identification of its subclasses may facilitate and optimize clinical management. This study aimed to identify subclasses of sepsis and its responses to different amounts of fluid resuscitation. METHODS: This was a retrospective study conducted in an intensive care unit at a large tertiary care hospital. The patients fulfilling the diagnostic criteria of sepsis from June 1, 2001 to October 31, 2012 were included. Clinical and laboratory variables were used to perform the latent profile analysis (LPA). A multivariable logistic regr

View details →DOI: 10.1186/s13054-018-2279-3Cited by 146
Negative / Null Result ReportEconomics, Econometrics and Finance

The Impact of Unemployment Insurance on Job Search: Evidence from Google Search Data

Scott Baker, Andrey Fradkin · 2017 · The Review of Economics and Statistics

Job search is a key choice variable in theories of labor markets but is difficult to measure directly. We develop a job search activity index based on Google search data, the Google Job Search Index (GJSI). We validate the GJSI with both…

View details →DOI: 10.1162/rest_a_00674Cited by 146
Negative / Null Result ReportNeuroscience

Organization of Endothelial Cells, Pericytes, and Astrocytes into a 3D Microfluidicin VitroModel of the Blood–Brain Barrier

Jack D. Wang, El‐Sayed Khafagy, Khalil Khanafer et al. · 2016 · Molecular Pharmaceutics

The endothelial cells lining the capillaries supplying the brain with oxygen and nutrients form a formidable barrier known as the blood-brain barrier (BBB), which exhibits selective permeability to small drug molecules and virtually…

View details →DOI: 10.1021/acs.molpharmaceut.5b00805Cited by 146
Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology

Emergent patterns of collective cell migration under tubular confinement

Wang Xi, Surabhi Sonam, Thuan Beng Saw et al. · 2017 · Nature Communications

Collective epithelial behaviors are essential for the development of lumens in organs. However, conventional assays of planar systems fail to replicate cell cohorts of tubular structures that advance in concerted ways on out-of-plane curved and confined surfaces, such as ductal elongation in vivo. Here, we mimic such coordinated tissue migration by forming lumens of epithelial cell sheets inside microtubes of 1-10 cell lengths in diameter. We show that these cell tubes reproduce the physiological apical-basal polarity, and have actin alignment, cell orientation, tissue organization, and migrat

View details →DOI: 10.1038/s41467-017-01390-xCited by 146
Negative / Null Result ReportBusiness, Management and Accounting

Do female directors influence firms' environmental innovation? The moderating role of ownership type

Zhongju Liao, Manting Zhang, Xiaopeng Wang · 2018 · Corporate Social Responsibility and Environmental Management

Abstract As more and more females join boards of directors, their decisions concerning environmental innovation have also become the focus of scholars. Based on the upper echelons theory, feminist caring theory, and social role theory,…

View details →DOI: 10.1002/csr.1677Cited by 146
Failed Experiment Report

Some Code Smells Have a Significant but Small Effect on Faults

Tracy Hall, Min Zhang, David Bowes et al. · 2014 · ACM Transactions on Software Engineering and Methodology

We investigate the relationship between faults and five of Fowler et al.'s least-studied smells in code: Data Clumps, Switch Statements, Speculative Generality, Message Chains, and Middle Man. We developed a tool to detect these five…

View details →DOI: 10.1145/2629648Cited by 146
Negative / Null Result ReportOpen accessSocial Sciences

Back to the future, disability and the digital divide

Stephen J. Macdonald, John Clayton · 2012 · Disability & Society

The aim of this article is to explore disability and the digital divide using a quantitative methodology. The research investigates what impact digital technologies have had in improving the life-chances for disabled people from deprived neighbourhoods in the northeast of England. The study explores how disabled people engage with digital and assistive technologies in order to overcome disabling barriers and social exclusion. Unfortunately, the analysis found no evidence that digital and assistive technologies had any impact on reducing social exclusion for disabled people. In fact, the resear

View details →DOI: 10.1080/09687599.2012.732538Cited by 146
Negative / Null Result ReportOpen accessMathematics

Sample size considerations and predictive performance of multinomial logistic prediction models

Valentijn M. T. de Jong, Marinus J.C. Eijkemans, Ben Van Calster et al. · 2019 · Statistics in Medicine

Multinomial Logistic Regression (MLR) has been advocated for developing clinical prediction models that distinguish between three or more unordered outcomes. We present a full-factorial simulation study to examine the predictive…

View details →DOI: 10.1002/sim.8063Cited by 145
Negative / Null Result ReportOpen accessMedicine

Plasma Tau and Neurofilament Light in Frontotemporal Lobar Degeneration and Alzheimer Disease

Ignacio Illán‐Gala, Alberto Lleó, Anna Karydas et al. · 2020 · Neurology

OBJECTIVE: To test the hypothesis that plasma total tau (t-tau) and neurofilament light chain (NfL) concentrations may have a differential role in the study of frontotemporal lobar degeneration syndromes (FTLD-S) and clinically diagnosed…

View details →DOI: 10.1212/wnl.0000000000011226Cited by 145
Negative / Null Result ReportOpen accessPhysics and Astronomy

All-sky search for continuous gravitational waves from isolated neutron stars using Advanced LIGO O2 data

B. P. Abbott, R. Abbott, T. D. Abbott et al. · 2019 · Physical review. D/Physical review. D.

We present results of an all-sky search for continuous gravitational waves (CWs), which can be produced by fast-spinning neutron stars with an asymmetry around their rotation axis, using data from the second observing run of the Advanced…

View details →DOI: 10.1103/physrevd.100.024004Cited by 145
Negative / Null Result ReportOpen accessMedicine

Adjuvant Pembrolizumab versus Observation in Muscle-Invasive Urothelial Carcinoma

Andrea B. Apolo, Karla V. Ballman, Guru Sonpavde et al. · 2024 · New England Journal of Medicine

BACKGROUND: Muscle-invasive urothelial carcinoma is an aggressive disease with high rates of relapse. Whether pembrolizumab as adjuvant therapy would be effective in patients with high-risk muscle-invasive urothelial carcinoma after…

View details →DOI: 10.1056/nejmoa2401726Cited by 145
Negative / Null Result ReportOpen accessMedicine

Risk and clinicopathological features of osteosarcoma metastasis to the lung: A population-based study

Xiaoyi Huang, Jian Zhao, Jinyi Bai et al. · 2019 · Journal of bone oncology

Osteosarcoma is the most common primary sarcoma of the bone. Lung osteosarcoma metastases at diagnosis have a significantly poor prognosis, even when surgery plus chemotherapy are performed. Our goal was to analyze clinical and sarcoma…

View details →DOI: 10.1016/j.jbo.2019.100230Cited by 145
Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance

Systematic Tail Risk

Maarten R.C. van Oordt, Chen Zhou · 2016 · Journal of Financial and Quantitative Analysis

Abstract We test for the presence of a systematic tail risk premium in the cross section of expected returns by applying a measure of the sensitivity of assets to extreme market downturns, the tail beta. Empirically, historical tail betas…

View details →DOI: 10.1017/s0022109016000193Cited by 145
Negative / Null Result ReportOpen accessEnvironmental Science

Long-Term Exposure to Ambient Air Pollution and Incidence of Postmenopausal Breast Cancer in 15 European Cohorts within the ESCAPE Project

Zorana Jovanovic Andersen, Massimo Stafoggia, Gudrun Weinmayr et al. · 2017 · Environmental Health Perspectives

BACKGROUND: Epidemiological evidence on the association between ambient air pollution and breast cancer risk is inconsistent. OBJECTIVE: We examined the association between long-term exposure to ambient air pollution and incidence of postmenopausal breast cancer in European women. METHODS: ); traffic intensity; and elemental composition of PM. We estimated cohort-specific associations between breast cancer and air pollutants using Cox regression models, adjusting for major lifestyle risk factors, and pooled cohort-specific estimates using random-effects meta-analyses. RESULTS: =0.04]. CONCLUSI

View details →DOI: 10.1289/ehp1742Cited by 145
Negative / Null Result ReportOpen accessMedicine

Efficacy of Sym004 in Patients With Metastatic Colorectal Cancer With Acquired Resistance to Anti-EGFR Therapy and Molecularly Selected by Circulating Tumor DNA Analyses

Clara Montagut, Guillem Argilés, Fortunato Ciardiello et al. · 2018 · JAMA Oncology

IMPORTANCE: Acquired resistance to anti-EGFR therapy (epidermal growth factor receptor) is frequently due to RAS and EGFR extracellular domain (ECD) mutations in metastatic colorectal cancer (mCRC). Some anti-EGFR-refractory patients…

View details →DOI: 10.1001/jamaoncol.2017.5245Cited by 144
Negative / Null Result ReportOpen accessHealth Professions

Healthcare Capacity, Health Expenditure, and Civil Society as Predictors of COVID-19 Case Fatalities: A Global Analysis

Jahidur Rahman Khan, Nabil Awan, Md. Mazharul Islam et al. · 2020 · Frontiers in Public Health

Background The rapid growth in cases of COVID-19 has challenged national healthcare capacity, testing systems at an advanced ICU, and public health infrastructure level. This global study evaluates the association between multi-factorial healthcare capacity and case fatality of COVID-19 patients by adjusting for demographic, health expenditure, population density and prior burden of noncommunicable disease. It also explores the impact of government relationships with civil society as a predictor of infection and mortality rates. Methods Data were extracted from the Johns Hopkins University dat

View details →DOI: 10.3389/fpubh.2020.00347Cited by 144