A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
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Maarten R.C. van Oordt, Chen Zhou · 2016 · Journal of Financial and Quantitative Analysis
Abstract We test for the presence of a systematic tail risk premium in the cross section of expected returns by applying a measure of the sensitivity of assets to extreme market downturns, the tail beta. Empirically, historical tail betas…
Zorana Jovanovic Andersen, Massimo Stafoggia, Gudrun Weinmayr et al. · 2017 · Environmental Health Perspectives
BACKGROUND: Epidemiological evidence on the association between ambient air pollution and breast cancer risk is inconsistent. OBJECTIVE: We examined the association between long-term exposure to ambient air pollution and incidence of postmenopausal breast cancer in European women. METHODS: ); traffic intensity; and elemental composition of PM. We estimated cohort-specific associations between breast cancer and air pollutants using Cox regression models, adjusting for major lifestyle risk factors, and pooled cohort-specific estimates using random-effects meta-analyses. RESULTS: =0.04]. CONCLUSI
Clara Montagut, Guillem Argilés, Fortunato Ciardiello et al. · 2018 · JAMA Oncology
IMPORTANCE: Acquired resistance to anti-EGFR therapy (epidermal growth factor receptor) is frequently due to RAS and EGFR extracellular domain (ECD) mutations in metastatic colorectal cancer (mCRC). Some anti-EGFR-refractory patients…
Jahidur Rahman Khan, Nabil Awan, Md. Mazharul Islam et al. · 2020 · Frontiers in Public Health
Background The rapid growth in cases of COVID-19 has challenged national healthcare capacity, testing systems at an advanced ICU, and public health infrastructure level. This global study evaluates the association between multi-factorial healthcare capacity and case fatality of COVID-19 patients by adjusting for demographic, health expenditure, population density and prior burden of noncommunicable disease. It also explores the impact of government relationships with civil society as a predictor of infection and mortality rates. Methods Data were extracted from the Johns Hopkins University dat
David S.P. Tan, Marjan Iravani, W. Glenn McCluggage et al. · 2011 · Clinical Cancer Research
PURPOSE: Ovarian clear cell carcinomas (OCCC) are a drug-resistant and aggressive type of epithelial ovarian cancer. We analyzed the molecular genetic profiles of OCCCs to determine whether distinct genomic subgroups of OCCCs exist.…
María‐Victoria Mateos, Albert Oriol, Joaquín Martínez‐López et al. · 2012 · Blood
Maintenance therapy has become a hot field in myeloma, and it may be particularly relevant in elderly patients because the major benefit results from the initial therapy. We report the results of a randomized comparison of maintenance with…
Muhammad Fahim Raza, Yichen Wang, Zhaohui Cai et al. · 2020 · PLoS Pathogens
Gut symbiotic bacteria have a substantial impact on host physiology and ecology. However, the contribution of gut microbes to host fitness during long-term low-temperature stress is still unclear. This study examined the role of gut microbiota in host low-temperature stress resistance at molecular and biochemical levels in the oriental fruit fly Bactrocera dorsalis. The results showed that after the gut bacteria of flies were removed via antibiotic treatment, the median survival time was significantly decreased to approximately 68% of that in conventional flies following exposure to a temperat
James A. Berkley, Moses M. Ngari, Johnstone Thitiri et al. · 2016 · The Lancet Global Health
BACKGROUND: Children with complicated severe acute malnutrition (SAM) have a greatly increased risk of mortality from infections while in hospital and after discharge. In HIV-infected children, mortality and admission to hospital are prevented by daily co-trimoxazole prophylaxis, despite locally reported bacterial resistance to co-trimoxazole. We aimed to assess the efficacy of daily co-trimoxazole prophylaxis on survival in children without HIV being treated for complicated SAM. METHODS: We did a multicentre, double-blind, randomised, placebo-controlled study in four hospitals in Kenya (two r
Sergio Livigni, Guido Bertolini, Carlotta Rossi et al. · 2014 · BMJ Open
OBJECTIVES: Coupled plasma filtration adsorption (CPFA, Bellco, Italy), to remove inflammatory mediators from blood, has been proposed as a novel treatment for septic shock. This multicenter, randomised, non-blinded trial compared CPFA…
Colleen M. Ganley, Leigh A. Mingle, Allison M. Ryan et al. · 2013 · Developmental Psychology
Stereotype threat has been proposed as 1 potential explanation for the gender difference in standardized mathematics test performance among high-performing students. At present, it is not entirely clear how susceptibility to stereotype…
Geir H. Bolstad, Thomas F. Hansen, Christophe Pélabon et al. · 2014 · Philosophical Transactions of the Royal Society B Biological Sciences
If genetic constraints are important, then rates and direction of evolution should be related to trait evolvability. Here we use recently developed measures of evolvability to test the genetic constraint hypothesis with quantitative…
Matthew C. Freeman, Thomas Clasen, Simon Brooker et al. · 2013 · American Journal of Tropical Medicine and Hygiene
We conducted a cluster-randomized trial to assess the impact of a school-based water treatment, hygiene, and sanitation program on reducing infection with soil-transmitted helminths (STHs) after school-based deworming. We assessed…
Ben Jones, Marie Juul Petersen · 2011 · Third World Quarterly
Abstract There is a growing body of research on religion and development, primarily from development scholars and practitioners. In many ways this represents a new departure for development studies, which has been largely uninterested in…
Sri Rahayu Natasia, Yuyun Tri Wiranti, Anggi Parastika · 2022 · Procedia Computer Science
The sudden change in the learning process during the Covid-19 pandemic has brought schools at all levels to adopt e-learning. In this study, we analyze user acceptance of NUADU platform in private schools in Balikpapan, Indonesia. The…
Haoxuan Liu, Yanxiao Jia, Xiaoguang Sun et al. · 2016 · Molecular Biology and Evolution
Accurate knowledge of the mutation rate provides a base line for inferring expected rates of evolution, for testing evolutionary hypotheses and for estimation of key parameters. Advances in sequencing technology now permit direct estimates…
Mitchel Seruya, Mark Fisher, Eduardo D. Rodriguez · 2013 · Plastic & Reconstructive Surgery
BACKGROUND: There has been rising interest in computer-aided design/computer-aided manufacturing for preoperative planning and execution of osseous free flap reconstruction. The purpose of this study was to compare outcomes between…
Stefan L. Frank · 2013 · Topics in Cognitive Science
The entropy-reduction hypothesis claims that the cognitive processing difficulty on a word in sentence context is determined by the word's effect on the uncertainty about the sentence. Here, this hypothesis is tested more thoroughly than…
Raphaël Moëne, Fabien Décaillet, E. Andersen et al. · 2010 · Journal of Periodontology
BACKGROUND: The purpose of this study is to evaluate the safety, patient acceptance, and short-term microbiologic effect of a new air-polishing device in subjects in maintenance care with residual pockets > or =5 mm. METHODS: This was an…
Rakesh Awasthi, Lida Pacaud, Edward Waldron et al. · 2020 · Blood Advances
The anti-CD19 chimeric antigen receptor (CAR)-T cell therapy tisagenlecleucel was evaluated in the global, phase 2 JULIET study in adult patients with relapsed/refractory diffuse large B-cell lymphoma (DLBCL). We correlated…
Heribert Limm, Harald Gündel, Mechthild Heinmüller et al. · 2010 · Occupational and Environmental Medicine
OBJECTIVE: To examine the long-term effects of a stress management intervention (SMI) based on the effort-reward imbalance (ERI) model, on psychological and biological reactions to work stress. METHODS: 174 lower or middle management…
U. Müller, James B. Rowe, Timothy Rittman et al. · 2012 · Neuropharmacology
BACKGROUND: Modafinil, a putative cognitive enhancing drug, has previously been shown to improve performance of healthy volunteers as well as patients with attention deficit disorder and schizophrenia, mainly in tests of executive functions. The aim of this study was to investigate the effects of modafinil on non-verbal cognitive functions in healthy volunteers, with a particular focus on variations of cognitive load, measures of motivational factors and the effects on creative problem-solving. METHODS: A double-blind placebo-controlled parallel design study evaluated the effect of 200 mg of m
Ravi A. Madan, James L. Gulley, Tito Fojo et al. · 2010 · The Oncologist
Therapeutic cancer vaccines represent a new class of agents in the treatment of cancer. Sipuleucel-T is an antigen-presenting cell-based vaccine that recently demonstrated a significant 4.8-month improvement in overall survival in advanced…
Miquel Pujol, J. M. Miró, Evelyn Shaw et al. · 2020 · Clinical Infectious Diseases
BACKGROUND: We aimed to determine whether daptomycin plus fosfomycin provides higher treatment success than daptomycin alone for methicillin-resistant Staphylococcus aureus (MRSA) bacteremia and endocarditis. METHODS: A randomized (1:1)…
Patricia Funk, Christina Gathmann · 2011 · The Economic Journal
Using new historical data from Swiss cantons, we estimate the effect of direct democracy on government spending. We use fixed effects to control for unobserved heterogeneity and new instruments to address potential endogeneity concerns. We…
Paula Pérez Sobrino · 2016 · Metaphor and Symbol
This article offers the first large-scale study of a multimodal corpus of 210 advertisements. First, the reader is presented with a description of the corpus in terms of the distribution of conceptual operations (for the purposes of this…
Tobias Ceulemans, Carly Stevens, Luc Duchateau et al. · 2014 · Global Change Biology
Nutrient pollution presents a serious threat to biodiversity conservation. In terrestrial ecosystems, the deleterious effects of nitrogen pollution are increasingly understood and several mitigating environmental policies have been…
Sutao Song, Zhichao Zhan, Zhiying Long et al. · 2011 · PLoS ONE
BACKGROUND: Support vector machine (SVM) has been widely used as accurate and reliable method to decipher brain patterns from functional MRI (fMRI) data. Previous studies have not found a clear benefit for non-linear (polynomial kernel) SVM versus linear one. Here, a more effective non-linear SVM using radial basis function (RBF) kernel is compared with linear SVM. Different from traditional studies which focused either merely on the evaluation of different types of SVM or the voxel selection methods, we aimed to investigate the overall performance of linear and RBF SVM for fMRI classification
Christophe Dessimoz, Manuel Gil · 2010 · Genome biology
BACKGROUND: The alignment of biological sequences is of chief importance to most evolutionary and comparative genomics studies, yet the two main approaches used to assess alignment accuracy have flaws: reference alignments are derived from the biased sample of proteins with known structure, and simulated data lack realism. RESULTS: Here, we introduce tree-based tests of alignment accuracy, which not only use large and representative samples of real biological data, but also enable the evaluation of the effect of gap placement on phylogenetic inference. We show that (i) the current belief that
Amelia Averitt, Chunhua Weng, Patrick Ryan et al. · 2020 · npj Digital Medicine
Randomized controlled trials (RCTs) are regarded as the most reputable source of evidence. In some studies, factors beyond the intervention itself may contribute to the measured effect, an occurrence known as heterogeneity of treatment effect (HTE). If the RCT population differs from the real-world population on factors that induce HTE, the trials effect will not replicate. The RCTs eligibility criteria should identify the sub-population in which its evidence will replicate. However, the extent to which the eligibility criteria identify the appropriate population is unknown, which raises conce
Allison J. Pieja, Eric Sundström, Craig S. Criddle · 2011 · Applied and Environmental Microbiology
Differences in carbon assimilation pathways and reducing power requirements among organisms are likely to affect the role of the storage polymer poly-3-hydroxybutyrate (PHB). Previous researchers have demonstrated that PHB functions as a…