Emergent patterns of collective cell migration under tubular confinement
Wang Xi; Surabhi Sonam; Thuan Beng Saw; Benoît Ladoux; Chwee Teck Lim · 2017 · Nature Communications
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Collective epithelial behaviors are essential for the development of lumens in organs. However, conventional assays of planar systems fail to replicate cell cohorts of tubular structures that advance in concerted ways on out-of-plane curved and confined surfaces, such as ductal elongation in vivo. Here, we mimic such coordinated tissue migration by forming lumens of epithelial cell sheets inside microtubes of 1-10 cell lengths in diameter. We show that these cell tubes reproduce the physiological apical-basal polarity, and have actin alignment, cell orientation, tissue organization, and migrat
Abstract by Wang Xi; Surabhi Sonam; Thuan Beng Saw; Benoît Ladoux; Chwee Teck Lim, Nature Communications (2017) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1038/s41467-017-01390-x