Failed Experiment ReportMedicine
Iepsen LB, Griebeler LB, de Almeida ICA et al. · 2026 · Topics in companion animal medicine
This study aimed to evaluate the sedative effects of acepromazine and dexmedetomidine in dogs and their influence on propofol requirements for anesthetic induction, electrocardiographic findings, heart rate and arterial blood pressure.…
View details →DOI: 10.1016/j.tcam.2026.101065 Replication FailureMedicine
Alallah J, Mohtisham F, Ahmed A et al. · 2026 · Journal of neonatal-perinatal medicine
BackgroundThe study examined the medical impact of tahneek with dates on hypoglycemia in high-risk newborns. Tahneek, an Islamic tradition, may offer benefits such as stimulating mouth muscles and aiding in breastfeeding initiation. The…
View details →DOI: 10.1177/19345798261435496 Replication FailureMedicine
Elenjickal EJ, Mavrakanas TA · 2026 · American journal of nephrology
Background Aldosterone regulates genes controlling fluid and electrolyte balance through mineralocorticoid receptor (MR) activation. Sustained MR activation promotes inflammation, fibrosis, sodium retention, and myocardial remodeling. MR…
View details →DOI: 10.1159/000551881 Replication FailureMedicine
Awwad A, Das Adhikari U, Burdo TH et al. · 2026 · AIDS (London, England)
Objective To determine whether pitavastatin reduces enterocyte injury, assessed by intestinal fatty acid-binding protein (I-FABP), among antiretroviral therapy-treated people with HIV (PWH) enrolled in the REPRIEVE mechanistic substudy.…
View details →DOI: 10.1097/qad.0000000000004572 Negative / Null Result ReportMedicine
Li J, Dai W, Alavi R et al. · 2026 · Journal of the American Heart Association
Background Empagliflozin, a sodium-glucose cotransporter 2 inhibitor, has demonstrated cardioprotective and neuroprotective effects in preclinical myocardial infarction (MI) and ischemic stroke settings by reducing acute myocardial and…
View details →DOI: 10.1161/jaha.125.047087 Negative / Null Result ReportMedicine
Sosnowski KJ, Ranse KL, Mitchell ML et al. · 2026 · Critical care medicine
Objectives To test whether the ABCDEF bundle, compared with usual care, decreases delirium incidence and duration, improves functional status in the ICU, and enhances 90-day post-ICU discharge quality of life in critically ill Australian…
View details →DOI: 10.1097/ccm.0000000000007154 Negative / Null Result ReportMedicine
Thorman IB, Sacknovitz A, Li AG et al. · 2026 · Annals of neurology
Objectives The objective of this study was to evaluate the effectiveness and adverse effect profile of prophylactic levetiracetam in preventing epilepsy after traumatic brain injury (TBI). Methods This retrospective cohort study used the…
View details →DOI: 10.1002/ana.78273 Negative / Null Result ReportMedicine
Niiya F, Satoh T, Kobayashi Y et al. · 2026 · Digestive diseases and sciences
Background Clinical evidence on whether acute cholangitis accelerates early stent failure via rapid bacterial adhesion and biofilm formation remains limited. We assessed the influence of pre-endoscopic retrograde cholangiopancreatography…
View details →DOI: 10.1007/s10620-026-09973-9 Negative / Null Result ReportMedicine
Chow EJ, Chen Y, Yasui Y et al. · 2026 · JAMA network open
Importance Survivors of childhood cancer have an increased risk of cardiovascular disease (CVD). However, many survivors at high risk do not receive recommended CVD screening tests as young adults. Objective To assess whether a…
View details →DOI: 10.1001/jamanetworkopen.2025.55863 Negative / Null Result ReportMedicine
Nersesian G, Rauch M, Lewin D et al. · 2026 · Artificial organs
Background Surgically implanted microaxial flow pumps (mAFP) are increasingly used for cardiogenic shock treatment. Standard mAFP explantation is performed bedside with a shortening of the vascular prosthesis, which may represent a…
View details →DOI: 10.1111/aor.70141 Negative / Null Result ReportMedicine
Maier LE, Douglas A, Foster K et al. · 2026 · The Journal of physiology
Parasympathetic activity is reduced in chronic hypoxia, but the underlying mechanism(s) are unclear. We investigated whether (i) arterial chemoreflex activation, (ii) increased pulmonary ventilation and/or (iii) pulmonary stretch, (iv)…
View details →DOI: 10.1113/jp290449 Negative / Null Result ReportMedicine
Na K, Qiu MH, Wang ZH et al. · 2026 · Zhonghua xin xue guan bing za zhi
Objective: To evaluate the efficacy and safety of ticagrelor versus clopidogrel in real-world patients with acute coronary syndrome (ACS) without standard modifiable cardiovascular risk factors (SMuRF-less) following percutaneous coronary…
View details →DOI: 10.3760/cma.j.cn112148-20260204-00080 Negative / Null Result ReportMedicine
Cui J · 2025 · Family process
Adverse childhood experiences (ACEs) are significant public health concerns with long-term consequences for children's mental health, physical well-being, and socioeconomic outcomes. This study examines whether younger maternal age at…
View details →DOI: 10.1111/famp.70096 Negative / Null Result ReportMedicine
de Freitas MDB, Rodrigues DC, de Paiva PEM et al. · 2026 · Parasites & vectors
Background Myiasis caused by Cochliomyia hominivorax larvae is a reemerging challenge in the Americas due to the recent reappearance of this species in areas where it had been eradicated and reports of doramectin inefficacy, despite its…
View details →DOI: 10.1186/s13071-026-07455-5 Negative / Null Result ReportMedicine
Rouphael C, Saliba E, Moukarzel M et al. · 2026 · Respiratory care
Background High-flow nasal cannula (HFNC) is a noninvasive oxygenation method that delivers humidified and heated oxygen mixtures at high flows while generating PEEP. Therefore, its use during endoscopic procedures with intravenous deep…
View details →DOI: 10.1177/19433654261445979 Replication FailureMedicine
Meerman M, Buijser M, Neto AS et al. · 2026 · Critical care medicine
Objectives To determine whether perioperative IV magnesium sulfate infusion, targeting serum magnesium concentrations of 1.5-2.0 mmol/L, reduces the incidence of postoperative atrial fibrillation (POAF) in patients undergoing cardiac…
View details →DOI: 10.1097/ccm.0000000000007162 Negative / Null Result ReportMedicine
Vaz CSL, Voss-Rech D, da Fonseca FN et al. · 2026 · Foodborne pathogens and disease
Oral phage therapy is a promising strategy for reducing harmful bacteria in broilers. However, it may lead to the spread of therapeutic phages in the farm environment, potentially increasing bacterial host tolerance. To determine the…
View details →DOI: 10.1177/15353141251366377 Replication FailureMedicine
Küçükatalay Ö, Kantarcı S, Dağlı U et al. · 2026 · JSLS : Journal of the Society of Laparoendoscopic Surgeons
Introduction Total laparoscopic hysterectomy (TLH) is widely performed for benign gynecologic conditions; however, postoperative pain particularly shoulder pain related to residual intraperitoneal CO 2 remains a clinical concern. This…
View details →DOI: 10.4293/jsls.2026.00012 Negative / Null Result Report
Pino-Martinez E, Pedrosa C, Silva-Marrero JI et al. · 2026 · Preprint
Abstract Sexual maturation of rainbow trout during grow-out at sea poses economic risks for aquaculture due to reduced growth, feed intake, and downgraded harvest quality. This study evaluated the effects of freshwater rearing systems and…
View details →DOI: 10.21203/rs.3.rs-9042484/v1 Negative / Null Result ReportOpen accessMedicine
Tamargo J, Agewall S, Ambrosio G et al. · 2026 · European heart journal. Cardiovascular pharmacotherapy
Despite recent advances in cardiovascular pharmacotherapy, prevention and treatment of many cardiovascular diseases remain limited with a clear need for more effective and safer pharmacological strategies. Here, we summarize the most…
View details →DOI: 10.1093/ehjcvp/pvag016 Negative / Null Result ReportMedicine
Saraiva S, McLean L · 2026 · Physiotherapy
Primary objectives (1) To evaluate whether hypopressive exercises (HEs) cause changes in intra-abdominal pressure (IAP) and/or electromyographic (EMG) activation of the levator ani muscles (LAMs), (2) to determine whether these effects…
View details →DOI: 10.1016/j.physio.2026.102316 Negative / Null Result ReportMedicine
Arabia A, Muñoz P, Álvarez-Real S et al. · 2026 · Plant Science.
Serotonin is a widely conserved signaling molecule essential for plant development and stress responses, but its role in fruit postharvest physiology remains largely unexplored. This study aimed to evaluate the effects of 100 μM exogenous…
Negative / Null Result ReportMedicine
Sárkány F, Priksz D, Juhász B et al. · 2026 · Basic research in cardiology
Clinical trial experience supports the use of myosin inhibitors in hypertrophic cardiomyopathy (HCM), while early proof-of-concept studies suggest potential benefit in selected patients with heart failure with preserved ejection fraction…
View details →DOI: 10.1007/s00395-026-01194-5 Negative / Null Result Report
Urashima AS, Coraini N, Teixeira O et al. · 2026 · Preprint
Abstract Sugarcane sett is the primary inoculum source of ratoon stunt (RSD). RSD-free setts and thermotherapy are measures to control it, but they are not disseminated in Brazil due to little information on the importance of RSD on modern…
View details →DOI: 10.21203/rs.3.rs-8855239/v1 Negative / Null Result ReportMedicine
Hsieh TH, Liang CC, Liang CY et al. · 2026 · Taiwanese journal of obstetrics & gynecology
Objective To explore whether preoperative overactive bladder (OAB) symptoms affect the outcome of single-incision slings (SIS) for urodynamic stress incontinence (USI). Materials and methods This retrospective study involved 106 patients…
View details →DOI: 10.1016/j.tjog.2025.07.033 Negative / Null Result ReportMedicine
Oldham L, Arnott G, Briffa M et al. · 2026 · Biology letters
Skill is the ability to do a challenging behaviour well. We examined how contest skill influences contest success, costs and whether skilful behaviour enhances welfare. We measured skill across three domains: accuracy, appropriateness…
View details →DOI: 10.1098/rsbl.2025.0563 Negative / Null Result ReportMedicine
Mangold MH, Kazmierczak J, Gerigk M et al. · 2026 · European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology
INTRODUCTION: Patients undergoing radical cystectomy (RC) face a heightened risk of infectious complications around the time of ureteral stent removal. This study aimed to determine whether a culture-guided antimicrobial strategy reduces…
View details →DOI: 10.1007/s10096-026-05514-4 Negative / Null Result ReportMedicine
Kim DH, Beathe J, Wetmore DS et al. · 2026 · Regional anesthesia and pain medicine
Background The adductor canal block (ACB), known for its motor-sparing properties, has gained popularity as part of the multimodal analgesic regimen in total knee arthroplasty (TKA) patients. However, the duration of single-injection…
View details →DOI: 10.1136/rapm-2026-107719 Negative / Null Result Report
Kalkonde Y, Jadhao S, Bhusari V et al. · 2026 · Preprint
Background: Stroke is the second leading cause of death globally. We tested whether it was feasible to deliver a community-based intervention package for prevention of stroke and, whether such an intervention would reduce stroke mortality…
View details →DOI: 10.12688/wellcomeopenres.26002.1 Negative / Null Result ReportOpen accessMedicine
Jacquier M, Laroye C, Bensoussan D et al. · 2026 · Respiratory research
Background Although mesenchymal stromal cells (MSCs) have shown promising effects in preclinical pneumonia models, their ability to improve outcomes in ventilator-associated pneumonia (VAP) remains poorly explored, despite VAP being a…
View details →DOI: 10.1186/s12931-025-03457-6 