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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

21277 results · page 252 of 710

Negative / Null Result ReportMedicine

vNOTES Pelvic Reconstruction and Presacral-Uterosacral Ligament Compound Suspension for Treatment of Multicompartment Pelvic Organ Prolapse: A Three-Year, Three-Arm, Open-Label, Randomized Controlled Trial.

Peng, Wang, Xiao et al. · 2026 · Journal of minimally invasive gynecology

To compare the effectiveness and safety of transvaginal natural orifice transluminal endoscopic surgery (vNOTES) pelvic reconstruction (PRC), vNOTES presacral-uterosacral ligament suspension (PULS), and sacrospinous ligament fixation…

View details →DOI: 10.1016/j.jmig.2026.06.024
Negative / Null Result ReportOpen accessComputer Science

The added value for MRI radiomics and deep-learning for glioblastoma prognostication compared to clinical and molecular information

D. Abler, O. Pusterla, A. Joye-Kühnis et al. · 2025 · arXiv

Background: Radiomics shows promise in characterizing glioblastoma, but its added value over clinical and molecular predictors has yet to be proven. This study assessed the added value of conventional radiomics (CR) and deep learning (DL) MRI radiomics for glioblastoma prognosis ( 6 months survival) on a large multi-center dataset. Methods: After patient selection, our curated dataset gathers 1152 glioblastoma (WHO 2016) patients from five Swiss centers and one public source. It included clinical (age, gender), molecular (MGMT, IDH), and baseline MRI data (T1, T1 contrast, FLAIR, T2)

Negative / Null Result Report

A Case Report of Korean Medicine Treatment, including Jakyakgamcho-tang, in a Patient with Unilateral Vocal Cord Paralysis That Did Not Improve After Injection Laryngoplasty

Ye-seul Park, Ja-eun Kwak, Ho-ryong Yoo et al. · 2024 · The Journal of Internal Korean Medicine

Background: Unilateral vocal cord paralysis can occur due to various causes. Among them, unilateral vocal cord paralysis that takes place after endotracheal intubation is often caused by damage to the left recurrent nerve branch during…

View details →DOI: 10.22246/jikm.2024.45.6.1309
Negative / Null Result Report

Do Polluters Outperform Non-Polluters?

Yigit Atilgan, K. Ozgur Demirtas, A. Doruk Gunaydin · 2024 · SSRN Electronic Journal

This paper investigates whether industrial companies with higher toxic emissions outperform those with lower toxic emissions. First, the highest polluters do not consistently outperform the lowest polluters in an almost stochastic…

View details →DOI: 10.2139/ssrn.4828452
Negative / Null Result ReportOpen accessPhysics

How to generate a significant effective temperature for cold dark matter, from first principles

Patrick McDonald · 2009 · arXiv

I show how to reintroduce velocity dispersion into perturbation theory (PT) calculations of structure in the Universe, i.e., how to go beyond the pressureless fluid approximation, starting from first principles. This addresses a possible deficiency in uses of PT to compute clustering on the weakly non-linear scales that will be critical for probing dark energy. Specifically, I show how to derive a non-negligible value for the (initially tiny) velocity dispersion of dark matter particles, , where δv is the deviation of particle velocities from the local bulk flow. The calculation is essen

Negative / Null Result ReportMedicine

Material fracture/retention rates of occluso-proximal composite resin restorations with polyethylene fibers in primary molars: an interim randomized controlled trial.

Rocha, Dos Anjos, Pinho et al. · 2026 · Journal of dentistry

This 12-month, double-blind, parallel, randomized controlled trial compared the material fracture/retention rates of occluso-proximal direct composite resin restorations associated with polyethylene fiber (CR+PF; Ribbond®) with…

View details →DOI: 10.1016/j.jdent.2026.106863
Negative / Null Result ReportMedicine

Generative Artificial Intelligence for Orthognathic Planning: Patient-Specific 3-Dimensional Jaw Reference Forms Conditioned on the Cranial Base.

Kim, Yang, Kuang et al. · 2026 · Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons

Conventional cephalometry relies on measurements derived from a limited set of landmarks and population-based norms, which may not fully capture individual skeletal form. Although evaluated independently, many cephalometric variables…

View details →DOI: 10.1016/j.joms.2026.06.005
Negative / Null Result ReportMedicine

Using a hand-held pupillometer to quantify pupil constriction as part of the accommodation reflex.

Olson, Perera, Kamal et al. · 2026 · Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia

Quantitative pupillometry (QP) provides a reliable measure of the pupillary light reflex. The pupil accommodation reflex (P-AR) occurs when there is a change in visual focus from near to far or from far to near. The ability to measure the…

View details →DOI: 10.1016/j.jocn.2026.112161
Negative / Null Result ReportMedicine

Clinical outcomes of endovascular treatment in patients with large ischemic strokes selected by non-contrast computed tomography within the extended time window.

Jiang, Zhu, Gan et al. · 2026 · European journal of radiology

This study aimed to investigate the effectiveness and safety of endovascular treatment (EVT) in patients with large ischemic strokes assessed by non-contrast CT (NCCT) within the extended time window. This study was a sub-analysis of a…

View details →DOI: 10.1016/j.ejrad.2026.113034
Negative / Null Result ReportMedicine

The effect of post-success handwashing on insight problem solving.

Zhao, Wang · 2026 · Acta psychologica

Handwashing, as a common physical cleansing behavior, not only serves a physiological cleaning function but is also believed to symbolically "wash away" emotional experiences or mental residues. Previous research has primarily focused on…

View details →DOI: 10.1016/j.actpsy.2026.107323
Negative / Null Result ReportMedicine

Does postoperative gabapentinoid prescription reduce chronic opioid use following short-segment lumbar instrumentation?

Karnati, Wu, Kaghazchi et al. · 2026 · Journal of neurosurgery. Spine

The aim of this study was to evaluate the impact of initial postoperative gabapentinoid prescription on chronic postoperative opioid use in patients who underwent short-segment lumbar instrumentation by using a large multicenter electronic…

View details →DOI: 10.3171/2026.2.spine25802
Negative / Null Result ReportMedicine

Evaluation of Large Language Models for Structured Data Extraction From Interstitial Lung Disease Clinical Notes: Comparative Study.

Chen, Maddali, Langlotz et al. · 2026 · Journal of medical Internet research

Most clinically relevant data are in unstructured clinical notes, which are verbose and imprecise, making structured data extraction a costly bottleneck for screening patients for studies or maintaining health care registries. This…

View details →DOI: 10.2196/90547
Negative / Null Result ReportMedicine

Effect of a Multidimensional Digital Health Intervention on Quality of Life in Breast Cancer Survivors: A Randomized Controlled Trial.

Fuentes-Expósito, Frid, Muñoz-Mateu et al. · 2026 · JCO clinical cancer informatics

We evaluated whether offering access to a multicomponent mHealth app improves quality of life (QoL) and psychosocial outcomes among breast cancer survivors under pragmatic, nonprescriptive conditions. In this single-center, randomized,…

View details →DOI: 10.1200/cci-26-00025
Negative / Null Result ReportMedicine

7-mm-Diamater Versus 5-mm-Diameter Immediate Post-Extraction Implants in the Molar Region: 1-Year Results from a Multicenter Randomized Controlled Trial.

Esposito, Bocari, Cho et al. · 2026 · The International journal of oral & maxillofacial implants

This multicenter randomized controlled trial compared the clinical effectiveness of 7.0-mm wide-diameter implants with 5.0-mm conventional-diameter implants placed immediately after molar extraction. Thirty-nine patients needing a single…

View details →DOI: 10.11607/jomi.11536
Negative / Null Result ReportMedicine

Effects of fermented Arundo donax juice on growth performance, immunocompetence, antioxidant capacity, and intestinal digestive enzyme activity in Arbor Acres broilers.

Li, Ma, Liu et al. · 2026 · Tropical animal health and production

In this study, we used lactic acid bacteria to ferment the byproduct of Arundo donax papermaking, Arundo donax juice (ADJ), to obtain fermented Arundo donax juice (FADJ). We aimed to investigate the effects of FADJ on the growth…

View details →DOI: 10.1007/s11250-026-05106-6
Negative / Null Result ReportMedicine

Comparative Evaluation of ChatGPT-5.4 Mini and Gemini 3 Flash in Scar Patient Education: Quality, Reliability, and Readability Analysis.

Zang, Yan, Dong et al. · 2026 · The Journal of craniofacial surgery

Scar is an inevitable pathological product of tissue injury repair, and pathological scars often occur in exposed areas, bringing severe psychological burden and economic losses to patients. With the popularization of digital healthcare,…

View details →DOI: 10.1097/scs.0000000000013099
Negative / Null Result ReportMedicine

Beyond peak wavelength: spectral bandwidth of blue and red-blue laser diodes modulates photosynthesis, canopy architecture, chlorophyll maintenance, and whole-plant growth.

Li, Sugita, Togawa et al. · 2026 · Frontiers in plant science

High planting densities in indoor horticulture often accelerate lower-leaf chlorophyll degradation, increasing trimming frequency, reducing effective photosynthetic area, and raising labor costs. While spectral composition has been widely…

View details →DOI: 10.3389/fpls.2026.1817114
Negative / Null Result ReportMedicine

Investigating the effect of casein phosphopeptide-amorphous calcium phosphate, fluoride varnish, and diode laser on enamel microhardness.

Hali, Mahmoudi, Namdar et al. · 2026 · Dental research journal

Laser therapy with fluoride-containing material, such as casein phosphopeptide-amorphous calcium phosphate (CPP-ACP), is a new technique for caries prevention. The purpose of this study is to investigate the effect of CPP-ACP, fluoride…

View details →DOI: 10.4103/drj.drj_556_24
Negative / Null Result ReportMedicine

Deep and repetitive transcranial magnetic stimulation improves motor dysfunction after basal ganglia infarction: preliminary findings on efficacy and electrophysiological mechanisms.

Yang, Zhu, Chen et al. · 2026 · Frontiers in neuroscience

To observe the therapeutic effects of deep transcranial magnetic stimulation (dTMS) and repetitive transcranial magnetic stimulation (rTMS) on upper and lower limb motor dysfunction in patients with basal ganglia infarction, and to…

View details →DOI: 10.3389/fnins.2026.1870537
Negative / Null Result ReportMedicine

Connective tissue graft with injectable platelet rich fibrin for treatment of RT1 gingival recession by tunnel technique: a randomized clinical and immunohistochemical study.

Mahmoud, Elrefaei, Shata et al. · 2026 · Frontiers in oral health

The literature regarding the use of injectable platelet- rich fibrin (i-PRF) for root coverage is scarce. Therefore, this RCT aimed to evaluate and compare the effect of using connective tissue graft (CTG) with and without i-PRF using the…

View details →DOI: 10.3389/froh.2026.1801423
Negative / Null Result ReportMedicine

Association of achieved LDL-C levels with global coagulability and clinical outcomes in patients with acute coronary syndrome receiving PCSK9 inhibitors: a prospective cohort study.

Fu, Yao, Zhang et al. · 2026 · Frontiers in cardiovascular medicine

The safety of achieving ultra-low low-density lipoprotein cholesterol (LDL-C) levels in acute coronary syndrome (ACS) patients on dual antiplatelet therapy (DAPT), particularly regarding global coagulability, specific platelet reactivity,…

View details →DOI: 10.3389/fcvm.2026.1804585
Negative / Null Result ReportMedicine

Pain-Related Impairment and Talar Tilt as Predictors of Surgical Decision Making in Advanced Varus Ankle Osteoarthritis.

Kurokawa, Taniguchi, Nakaniwa et al. · 2026 · Foot & ankle orthopaedics

Varus-type ankle osteoarthritis (OA) is often managed conservatively; however, surgical intervention is required in some patients. Identifying factors associated with transition to surgery may help optimize treatment timing. This…

View details →DOI: 10.1177/24730114261454964
Negative / Null Result ReportMedicine

Soil Nutrients, pH and Microorganisms Modulate Nitrogen Mineralization Dynamics Following Afforestation in Northeastern China.

Guo, Cao, Xiao et al. · 2026 · Plants (Basel, Switzerland)

Grain for Green, as an important ecological restoration method, profoundly affects soil nitrogen (N) cycling by altering the soil physicochemical properties and microbial community. Soil nitrogen mineralization is a key process in the…

View details →DOI: 10.3390/plants15121892