Negative / Null Result ReportOpen accessMedicine
Esmeraldo MA, Chambers S, Kravutske Y et al. · 2026 · Brain informatics
Purpose MELD Graph is a state-of-the-art artificial intelligence (AI) model for automated detection of focal cortical dysplasia (FCD), but its performance remains limited, highlighting the need to investigate which aspects of the pipeline…
View details →DOI: 10.1186/s40708-026-00299-w Negative / Null Result ReportOpen accessMedicine
Andová N, Repiská V, Priščáková P et al. · 2026 · Case reports in women's health
False-negative results in non-invasive prenatal testing are rare but clinically significant, particularly in the presence of biological factors such as feto-placental mosaicism. This report describes a pregnancy affected by fetal trisomy…
View details →DOI: 10.1016/j.crwh.2026.e00813 Negative / Null Result ReportOpen accessMedicine
Okuno-Ozeki N, Kohama Y, Taguchi H et al. · 2025 · Scientific reports
Reducing salt intake is crucial for managing hypertension. While efforts to reduce salt intake are based on the assumption that people have a preference for salt, it is also important to acknowledge that there is an aversion to high levels…
View details →DOI: 10.1038/s41598-025-09602-x Negative / Null Result ReportOpen accessMedicine
Eremichev R, Nikolaeva N, Khandokhin M et al. · 2025 · Biology
Recent discovery of menstruation in the Egyptian spiny mouse ( Acomys cahirinus) highlighted this species as a feasible model for the study of menstrual cycle physiology. However, reports on active menstrual bleeding in this animal were…
View details →DOI: 10.3390/biology14101365 Negative / Null Result ReportOpen accessMedicine
Yang R, Wang Y, Fu Q et al. · 2026 · BMJ open
Objectives To establish optimal pre-pregnancy body mass index (BMI)-specific gestational weight gain (GWG) ranges for twin pregnancies and compare their association with maternal and neonatal adverse outcomes against Institute of Medicine…
View details →DOI: 10.1136/bmjopen-2025-112189 Negative / Null Result ReportOpen accessMedicine
Saito A, Terai H, Kim TJ et al. · 2024 · Cancer medicine
Background Companion diagnostic tests play a crucial role in guiding treatment decisions for patients with non-small cell lung cancer (NSCLC). The Oncomine Dx Target Test (ODxTT) Multi-CDx System has emerged as a prominent companion…
View details →DOI: 10.1002/cam4.7077 Negative / Null Result ReportOpen accessMedicine
Awaly M, Norton M, Ahmed D et al. · 2025 · Cureus
Midline laparotomy remains essential in gynecological oncology, and rectus sheath catheters (RSCs) are commonly used for postoperative analgesia. We report the case of a 46-year-old woman who underwent midline laparotomy for a suspected…
View details →DOI: 10.7759/cureus.86892 Negative / Null Result ReportOpen accessMedicine
Salimkhanov R, Utkina M, Bagirova H et al. · 2025 · Frontiers in endocrinology
Multiple endocrine neoplasia type 1 (MEN-1; OMIM 131100) is a rare, autosomal dominant syndrome caused by heterozygous inactivating mutations in the MEN1 tumor suppressor gene (11q13; OMIM 613733). MEN-1 is characterized by polyglandular…
View details →DOI: 10.3389/fendo.2025.1662871 Negative / Null Result ReportOpen accessMedicine
Miquel-Rodríguez R, González-Toledo B, Pérez-Gómez MV et al. · 2024 · International journal of molecular sciences
Autosomal polycystic kidney disease (ADPKD) is the most common genetic form of kidney failure, reflecting unmet needs in management. Prescription of the only approved treatment (tolvaptan) is limited to persons with rapidly progressing…
View details →DOI: 10.3390/ijms25095036 Negative / Null Result ReportOpen accessMedicine
Vinyard DJ, Govindjee G · 2024 · Photosynthesis research
Photosystem II (PSII) uses light energy to oxidize water and to reduce plastoquinone in the photosynthetic electron transport chain. O 2 is produced as a byproduct. While most members of the PSII research community agree that O 2…
View details →DOI: 10.1007/s11120-024-01111-8 Negative / Null Result ReportOpen accessMedicine
Halalsheh H, Odeh N, Kiswani A et al. · 2026 · Cancers
Background Accurate staging is vital for optimizing outcomes in pediatric rhabdomyosarcoma (RMS). While [ 18 F]-FDG PET/CT is increasingly utilized, its specific impact on clinical management and its prognostic value compared to…
View details →DOI: 10.3390/cancers18101629 Negative / Null Result Report
McDaniel CS, Vannette RL, Arroyo-Flores A et al. · 2024 · Preprint
ABSTRACT Fire blight is a devastating disease affecting pome fruit trees that is caused by Erwinia amylovora and leads to substantial annual losses worldwide. While antibiotic-based management approaches like streptomycin can be effective,…
View details →DOI: 10.1101/2024.07.03.601912 Negative / Null Result ReportMedicine
Anez SG, Flail DB, Burkhart EP et al. · 2025 · Journal of natural products
Monotropa uniflora L. ("ghost pipe"), is a North American traditional medicinal plant which has recently seen an increase in consumption nationwide. However, a single 1889 study reported the presence of grayanotoxin I in M. uniflora,…
View details →DOI: 10.1021/acs.jnatprod.5c00805 Negative / Null Result Report
Håkansson G, Grossmann KR, Ådén U et al. · 2024 · Preprint
Aim Neonatal hypoxic-ischemic encephalopathy (HIE) injures the infant brain during the basic formation of the developing functional connectome. This study aimed to investigate long-term changes in the functional connectivity (FC) networks…
View details →DOI: 10.1101/2024.05.31.24308185 Methods Dead-EndMedicine
Psaltis PJ, Nguyen MT, Singh K et al. · 2025 · Cardiovascular research
Aims Low-dose colchicine reduces the risk of cardiovascular events after myocardial infarction (MI). The purpose of this study was to assess the effect of colchicine post-MI on coronary plaque morphology in non-culprit segments by optical…
View details →DOI: 10.1093/cvr/cvae191 Methods Dead-EndOpen accessMedicine
Kardjadj M, Chang TW, Chavez R et al. · 2025 · Microorganisms
Clinical success in treating complicated urinary tract infections (cUTIs) depends on accurate pathogen detection, given the common occurrence of polymicrobial infections and antimicrobial resistance. This multicenter, randomized,…
View details →DOI: 10.3390/microorganisms13040949 Failed Experiment ReportOpen accessMedicine
Sawada A, Yoneta K, Togashi E et al. · 2024 · Journal of physical therapy science
[Purpose] In gastric cancer patients, low muscle mass decreases overall survival and quality of life (QOL). Resistance exercise with leucine-enriched essential amino acid (LEAA) supplementation may prevent muscle mass loss. This study was…
View details →DOI: 10.1589/jpts.36.218 Negative / Null Result ReportMedicine
Strotzer QD, Nieberle F, Kupke LS et al. · 2024 · Radiology
Background Large language models have already demonstrated potential in medical text processing. GPT-4V, a large vision-language model from OpenAI, has shown potential for medical imaging, yet a quantitative analysis is lacking. Purpose To…
View details →DOI: 10.1148/radiol.240955 Negative / Null Result ReportOpen accessMedicine
Bäumges H, Jelinek S, Lange H et al. · 2025 · Cells
Fucose-containing glycoproteins and glycolipids broadly occur in humans as well as in many other species and are essential for a wide range of physiological processes, such as cell adhesion, fertilization, and tumor development. In humans,…
View details →DOI: 10.3390/cells14171355 Negative / Null Result ReportOpen accessMedicine
Leslie WD, Zarzour F, Binkley N et al. · 2025 · Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Statins are among the most widely prescribed medications in older individuals. Inconsistent data in humans suggest that statin medications may be associated with greater BMD and lower risk for osteoporosis. We identified 22 393 individuals…
View details →DOI: 10.1093/jbmr/zjaf077 Negative / Null Result ReportOpen accessMedicine
Sadiq DR, Mikhael EM · 2024 · Clinical ophthalmology (Auckland, N.Z.)
Background Glaucoma is a chronic progressive eye disorder. It is the primary cause of blindness. To prevent glaucomatous damage and blindness, the intra-ocular pressure (IOP) must be lowered to certain levels, this level is known as "IOP"…
View details →DOI: 10.2147/opth.s478850 Negative / Null Result ReportMedicine
Fruhauf F, Cibula D, Kocian R et al. · 2024 · International journal of gynecological cancer : official journal of the International Gynecological Cancer Society
Objectives To assess the diagnostic performance of ultrasonography in pre-operative assessment of lymph nodes in patients with cervical cancer, to compare the outcomes for pelvic and para-aortic regions, and to detect macrometastases and…
View details →DOI: 10.1136/ijgc-2024-005341 Failed Experiment ReportMedicine
Li XE · 2026 · The Canadian veterinary journal = La revue veterinaire canadienne
A 3-year-old neutered male domestic shorthair cat was evaluated for hematuria. Ultrasonography and CT scanning identified moderate right-side hydronephrosis associated with right proximal and distal ureteral strictures, as well as partial…
Failed Experiment Report
Camon C, Kip E, Lord R et al. · 2026 · Preprint
Menopausal hormone therapy (MHT) is prescribed for climacteric symptoms including hot flushes and weight gain and contains estrogens such as 17 beta-estradiol (17βE2). However, estrogen receptor activation by MHT may increase reproductive…
View details →DOI: 10.64898/2026.01.26.701850 Failed Experiment ReportMedicine
Kang A, Tian X, Mi Z et al. · 2026 · Environmental science & technology
Improving carbon productivity is essential for simultaneously achieving sustainable development goals and tackling climate change. While the Global Value Chains (GVCs) division enhances productive efficiency, its impact on carbon…
View details →DOI: 10.1021/acs.est.5c12491 Negative / Null Result Report
Yamamoto Y, Takeuchi K, Tabe S et al. · 2026 · Preprint
Summary The specific contribution of tissue-resident macrophages (TRMs) to pancreatic ductal adenocarcinoma (PDAC) progression remains unclear. Here, we found that a high abundance of TRM-derived tumor-associated macrophages (TRM-TAMs) is…
View details →DOI: 10.64898/2026.05.08.723679 Negative / Null Result Report
Rajan A, Prakash S, Singh D et al. · 2026 · Preprint
Parkinson’s disease (PD) is a progressive neurodegenerative disorder characterized by α-Synuclein (α-Syn) aggregation, dopaminergic neuronal loss, and chronic neuroinflammation. Chlorogenic acid (CA), a dietary polyphenol abundant in…
View details →DOI: 10.64898/2026.04.19.719432 Negative / Null Result Report
Fulghum K, Hayir A, Ankeriasniemi R et al. · 2026 · Preprint
ABSTRACT Alzheimer’s disease and related tauopathies are escalating public health threats, particularly in the context of obesity and metabolic dysfunction, which accelerate cerebral glucose hypometabolism, tau pathology,…
View details →DOI: 10.64898/2026.06.03.729999 Negative / Null Result ReportMedicine
Xing L, Lu B, Zhu X et al. · 2026 · Inflammation and regeneration
Background Mesenchymal stromal cells (MSCs) possess therapeutic potential largely reliant on intact mitochondrial function to maintain reparative function. However, obesity compromises MSC metabolism and reparative capacity. MOTS-c, a…
View details →DOI: 10.1186/s41232-026-00431-7 Negative / Null Result ReportMedicine
Zheng B · 2026 · Current molecular medicine
Background/objective Patients with renal artery stenosis (RAS) exhibit increased risk of cardiovascular death and all-cause death. Our previous finding showed that the presence of RAS is associated with poor coronary collateral development…
View details →DOI: 10.2174/0115665240462936260429182901 