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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

21277 results · page 247 of 710

Negative / Null Result Report

Biological Augmentation with subacromial bursa in arthroscopic rotator cuff repair: clinical outcomes and tendon assessment using Doppler ultrasonography

Freislederer F, Dimitriu M, Audigé L et al. · 2025 · Preprint

Abstract Background The subacromial bursa is a key source of mesenchymal stem cells that may support rotator cuff tendon healing. Since microvascularization contributes to tendon repair, we aimed to examine postoperative…

View details →DOI: 10.21203/rs.3.rs-6545398/v1
Negative / Null Result Report

Adjuvant effects on spray deposition and efficacy of diquat and glufosinate against Euphorbia heterophylla and Digitaria insularis

Prado E, Argioli AS, Funichello M et al. · 2025 · Preprint

Abstract Agricultural adjuvants are among the most critical factors influencing spray deposition and herbicide efficacy against weeds. This study evaluated spray deposition parameters by spraying different non-ionic adjuvants on Euphorbia…

View details →DOI: 10.21203/rs.3.rs-6474409/v1
Negative / Null Result ReportMedicine

The role of hyperthermia on abdominal tissue concentrations of cisplatin during and after intraperitoneal chemotherapy - insights from a porcine model.

Harlev C, Bue M, Petersen EK et al. · 2025 · European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology

Background Epithelial ovarian cancer remains a leading cause of mortality among gynecological malignancies, with a high incidence of peritoneal carcinomatosis at diagnosis. Hyperthermic intraperitoneal chemotherapy (HIPEC) has emerged as a…

View details →DOI: 10.1016/j.ejso.2025.110378
Negative / Null Result ReportOpen accessMedicine

Scheduled telephone support in internet-delivered cognitive behavioral therapy for depression: randomized controlled trials of two populations.

Pihlaja S, Lipsanen J, Ritola V et al. · 2026 · Frontiers in psychology

Among patients receiving internet-delivered cognitive behavioral therapy (iCBT) for depression in routine clinical practice, 101 patients were randomized to either iCBT as usual or to iCBT with add-on scheduled telephone support (STS).…

View details →DOI: 10.3389/fpsyg.2026.1704049
Negative / Null Result ReportMedicine

Concentration, Antibacterial Effect, and Safety of Combining Intra-articular Epsilon-Aminocaproic Acid and Vancomycin in Primary Total Knee Arthroplasty: A Randomized Study.

Zhang Y, Wei J, Su C et al. · 2025 · The Journal of arthroplasty

Background In this study, we aimed to investigate the intra-articular concentration, antibacterial effect, and safety of a combination of vancomycin and epsilon-aminocaproic acid (EACA) in primary total knee arthroplasty (TKA). Methods…

View details →DOI: 10.1016/j.arth.2025.12.032
Negative / Null Result ReportMedicine

Effect of Individualised Homeopathic Medicine as Adjunct to Fluticasone Furoate for Allergic Rhinitis: A Prospective, Randomised, Open-Label, Controlled Trial.

Dixit AK, Sahoo AK, Sidam S et al. · 2025 · Homeopathy : the journal of the Faculty of Homeopathy

Allergic rhinitis (AR) impairs quality of life, with intranasal corticosteroids like fluticasone furoate as standard of care (SOC). Individualised homeopathic medicines (IHMs) are increasingly used as adjuncts, but robust evidence is…

View details →DOI: 10.1055/a-2687-9635
Negative / Null Result ReportMedicine

Bilayer Fiber-Reinforced Composite-Hydrogel Scaffolds With Bioactive Glass for Bone Tissue Regeneration.

Gibreel M, Ohlsbom R, Perea-Lowery L et al. · 2026 · Journal of biomedical materials research. Part A

Bone tissue regeneration for large defects presents a significant challenge, demanding scaffolds that combine robust mechanical support alongside a bioactive environment. Hydrogels represent a promising solution for bone regeneration due…

View details →DOI: 10.1002/jbma.70037
Negative / Null Result ReportMedicine

Effects of OXXYSLAB Probiotic Supplementation on Blood Oxygenation and Hypoxic Symptoms in Healthy Individuals: A Controlled Normobaric Hypoxia Trial.

Marzola M, Marazzato M, Nutini R et al. · 2026 · High altitude medicine & biology

Marzola, Manuel, Massimiliano Marazzato, Roberto Nutini, Adriano Di Marzio, Francesca Baroli, Manuel Paolucci, Matteo De Angelis, Joanna Giuliano, Ambra Menichelli, Guglielmo Sferrati, Carmen Santangelo, Danilo Bondi, Gerardo Bosco, and…

View details →DOI: 10.1177/15578682261415833
Negative / Null Result ReportMedicine

Metabolic interoceptive rewards shape affect, but not action.

Fleming H, Whines A, Whelehan P et al. · 2026 · Biological psychology

Central to survival is our ability to learn that the sensory properties of food are associated with metabolic interoceptive signals (e.g., changing blood glucose). These signals influence cognition and brain activity, shaping the hedonic…

View details →DOI: 10.1016/j.biopsycho.2025.109187
Negative / Null Result ReportMedicine

Intranasal prime-boost immunization with trivalent influenza virus neuraminidase proteins and conserved HCA2 sequences fused to a circularly permuted E. coli heat-labile enterotoxin B subunit.

Hung HC, Jheng KW, Cheng HY et al. · 2026 · Vaccine

To develop a mucosal influenza vaccine, we used trivalent recombinant neuraminidase (NA) proteins in combination with a circularly permuted TT mutant of the E. coli heat-labile enterotoxin B subunit, LTB(TT), as a mucosal adjuvant.…

View details →DOI: 10.1016/j.vaccine.2026.128488
Negative / Null Result Report

Polypropylene Mesh Reinforcement Does Not Improve Acute Biomechanical Properties in Superior Capsular Reconstruction: An Ovine Model Study

Karademir G, Durbas A, Diril SK et al. · 2025 · Preprint

Abstract Background Superior capsular reconstruction (SCR) is a treatment option for irreparable rotator cuff tears (IRCTs), but graft failure remains a significant limitation. While fascia (FA) grafts are commonly utilized, their…

View details →DOI: 10.21203/rs.3.rs-8001106/v1
Negative / Null Result Report

Quality of Early Recovery after Ultrasound-guided Serratus Plane Block for Transapical Transcatheter Aortic Valve Implantation Surgery under General Anesthesia:a single-center randomized controlled trial

Xiao C, Jing S, Yang G et al. · 2025 · Preprint

Abstract Background Regional anesthesia techniques, including the serratus anterior plane block (SAPB), reduce postoperative pain after minimally invasive cardiac surgery. However, the evidence regarding its impact on transapical…

View details →DOI: 10.21203/rs.3.rs-7828277/v1
Negative / Null Result ReportMedicine

Burn severity modifies the impact of salvage logging on post-wildfire natural regeneration of Douglas-fir in interior British Columbia

McAulay J, Querejeta JI, Eskelson BNI et al. · 2025 · Forest Ecology and Management.

1.Exacerbated by climate change, wildfires in British Columbia, Canada, have increased in extent and severity, impacting forests, including commercially valuable species like interior Douglas-fir (Pseudotsuga menziesii var. glauca).…

Negative / Null Result ReportMedicine

Morphological effects of input data quantity in AI-powered dental crown design.

Broll A, Goldhacker M, Hahnel S et al. · 2025 · Journal of dentistry

Objectives This retrospective in vitro study evaluated the impact of input data quantity on the morphology of dental crowns generated by AI-based software. The hypothesis suggests that increased input data quantity improves the quality of…

View details →DOI: 10.1016/j.jdent.2025.105767
Negative / Null Result ReportMedicine

Saccharomyces cerevisiae postbiotics supplementation from gestation to weaning: Impacts on performance and immunity in pigs under low-biosecurity conditions.

Bui TH, Le DP, Ho TD et al. · 2026 · Veterinary journal (London, England : 1997)

This study investigated the effects of Saccharomyces cerevisiae fermentation-derived postbiotics (SCFP) on reproductive performance and immunity of sows and their offspring from gestation to weaning in a low biosecurity, small-scale pig…

View details →DOI: 10.1016/j.tvjl.2026.106556
Negative / Null Result ReportMedicine

Exploring mechanisms underlying the beneficial effect of whey protein isolate on the biocompatibility of the thermally obtained curdlan-based hydrogel

Klimek K, Kierys A, Matwijczuk A et al. · 2025 · Carbohydrate Polymers.

This work aimed to compare the biomedical potential of thermally obtained hydrogels consisting of curdlan and a curdlan–whey protein isolate mixture. The purpose of this paper was also to investigate and explain the mechanisms responsible…

Negative / Null Result Report

Can Machine Learning Predict Vessels Encapsulating Tumor Clusters Patterns and Histological Differentiation in Solitary Small (<5 cm) Hepatocellular Carcinoma?

Toshida K, Sugitani Y, Itoh S et al. · 2025 · Preprint

Abstract Background: Hepatocellular carcinoma (HCC) is a major cause of cancer-related mortality worldwide. While systemic therapies have improved outcomes, predicting tumor histopathology remains difficult. Machine learning (ML) offers a…

View details →DOI: 10.21203/rs.3.rs-7704748/v1
Negative / Null Result Report

Evaluation of the effect of photodynamic therapy using Rose Bengal Pigment in the Presence of Sodium Nitrite and carbon quantum dots Synthesized from Acyclovir Precursor on Growth inactivating of Herpes Simplex Virus

Farmany A, Razavi P, Parsania M et al. · 2025 · Preprint

Abstract Purpose To evaluate whether Rose Bengal (RB) with sodium nitrite (NaNO₂) and acyclovir derived carbon quantum dots (CQDs) can photodynamically inactivate herpes simplex virus type 1 (HSV 1) in vitro. Methods Acyclovir-derived CQDs…

View details →DOI: 10.21203/rs.3.rs-7694736/v1
Negative / Null Result ReportMedicine

Standard- versus high-dose tigecycline in pneumonia due to carbapenem-resistant Acinetobacter baumannii: A propensity score-matched retrospective study.

Özgen-Top Ö, Aysert-Yildiz P, Tekin-Taş Z et al. · 2026 · Infectious diseases now

Objectives This study aimed to compare the effectiveness and safety of standard-dose and high-dose tigecycline in pneumonia caused by carbapenem-resistant Acinetobacter baumannii (CRAB). Methods This retrospective, propensity score-matched…

View details →DOI: 10.1016/j.idnow.2025.105242
Negative / Null Result ReportMedicine

Whole-lesion histogram analysis of multi-model diffusion-weighted imaging for characterization and molecular classification of breast lesions.

Yuan Y, Huang M, Peng J et al. · 2026 · La Radiologia medica

Purpose To evaluate the value of whole-lesion histogram analysis derived from mono-exponential, bi-exponential, and stretched-exponential DWI models in differentiating benign from malignant breast lesions and exploring molecular subtypes.…

View details →DOI: 10.1007/s11547-025-02156-y
Negative / Null Result ReportMedicine

Neuroinflammation does not exacerbate post-traumatic stress-disorder (PTSD)-like brain measures or behaviour after a traumatic event in male rats.

Xavier S, Al-Saabary H, Foran D et al. · 2026 · Neuroscience

Post-traumatic stress disorder (PTSD) is strongly linked to neuroinflammation, with immune activation in brain regions such as the amygdala and hippocampus potentially contributing to its long-term persistence. Yet, whether…

View details →DOI: 10.1016/j.neuroscience.2025.12.014
Negative / Null Result Report

Agreements between 24-2 and 24-2C Test Grids for Chloroquine/Hydroxychloroquine Retinopathy Patients and High-Risk Patients

Ratanawongphaibul K, Wongwachira C, Suwajanakorn D et al. · 2025 · Preprint

Abstract Purpose To compare the SITA Standard 24-2 and SITA Faster 24-2C tests in patients with chloroquine/hydroxychloroquine (CQ/HCQ) retinopathy and those at high risk. Methods A prospective, cross-sectional study of 75 participants who…

View details →DOI: 10.21203/rs.3.rs-6769459/v1
Negative / Null Result ReportMedicine

Evaluation of pharmacy unit inspection utilizing a mobile application with smart glasses.

Abdel-Kerem A, Wei W, Calzado A et al. · 2025 · American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists

Purpose This study aimed to evaluate the impact of integrating smart glasses with a pharmacy compliance mobile application on the efficiency of completing medication unit inspections. The goal was to compare traditional inspection methods…

View details →DOI: 10.1093/ajhp/zxaf083
Negative / Null Result ReportMedicine

Provisional Treatment of Volumetric Muscle Loss With Insulin-like Growth Factor 1 Releasing Muscle Void Fillers.

Clark AR, Adams AT, McKinley TO et al. · 2026 · The Journal of surgical research

Introduction Volumetric muscle loss (VML) resulting from severe extremity injuries in combat remains a significant clinical challenge, particularly in austere environments. Current research emphasizes the development and evaluation of…

View details →DOI: 10.1016/j.jss.2025.11.043
Negative / Null Result ReportMedicine

Antigenic Imprinting and Immune Response Dynamics: Neutralization Against Emerging SARS-CoV-2 Omicron Variants Following Breakthrough Infections.

Li J, Wang X, Li J et al. · 2025 · Journal of medical virology

The recently mutated Omicron variant of SARS-CoV-2 exhibits extremely high infectivity and strong evolution and immune escape capabilities. Given the unique epidemic prevention policies of China, we collected 16 sets of sera from…

View details →DOI: 10.1002/jmv.70681
Negative / Null Result ReportMedicine

Assessing the Impact of Visualizations of Quantitative and Qualitative Risk Information on the Comprehension of Hypothetical Risk-Based Breast Cancer Screening Results.

van Strien-Knippenberg IS, Timmermans DRM, Weber M et al. · 2025 · Health communication

This study aimed to assess whether, in the context of communicating risk-based breast cancer screening results, visualizations of risk information consisting of an icon array depicting quantified breast cancer risk and simplified drawings…

View details →DOI: 10.1080/10410236.2025.2582779
Negative / Null Result Report

Vibratory stimulation and not action observation or mirror therapy reduces paralyzed hand spasticity in chronic stroke survivors

Nakano H, Nakagawa K, Ikuno T et al. · 2024 · Preprint

Objective Post-stroke spasticity prevalence increases with time from stroke onset, and negatively impacts the patient’s quality of life. Vibratory stimulation (VS) to the spastic muscles can reduce spasticity, whereas action observation…

View details →DOI: 10.1101/2024.12.03.24318436