A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
19735 results in Negative / Null Result Report · page 14 of 658
Andrés Rodríguez‐Pose, Roberto Ezcurra · 2010 · Journal of Economic Geography
The global drive towards decentralization has been increasingly justified on the basis that greater transfers of resources to subnational governments are expected to deliver greater efficiency in the provision of public goods and services…
Luis Paz‐Ares, Y Chen, Niels Reinmuth et al. · 2022 · ESMO Open
•Durvalumab plus EP showed sustained OS benefit over EP with a well-tolerated safety profile after median follow-up >3 years.•Three times more patients were estimated to be alive at 3 years when treated with durvalumab plus EP versus EP…
Tom G. Hansen, Jacob Krabbe Pedersen, Steen W. Henneberg et al. · 2011 · Anesthesiology
BACKGROUND: Although animal studies have indicated that general anesthetics may result in widespread apoptotic neurodegeneration and neurocognitive impairment in the developing brain, results from human studies are scarce. We investigated…
Linda Steg, Judith I. M. de Groot, Lieke Dreijerink et al. · 2011 · Society & Natural Resources
Results of two studies are reported, in which we compare the predictive power of three general behavioral antecedents (i.e., values, worldviews, and environmental concern) in explaining personal norms, behavioral intentions (i.e.,…
Hakan Berument, Nildağ Başak Ceylan, Nükhet Doğan · 2010 · The Energy Journal
This paper examines how oil price shocks affect the output growth of selected MENA countries that are considered either net exporters or net importers of this commodity, but are too small to affect oil prices. That an individual country’s…
Andrew J. Sharp, Elisavet Stathaki, Eugenia Migliavacca et al. · 2011 · Genome Research
X-chromosome inactivation (XCI) is a dosage compensation mechanism that silences the majority of genes on one X chromosome in each female cell. To characterize epigenetic changes that accompany this process, we measured DNA methylation…
Raymond Kan, Cesare Robotti, Jay Shanken · 2013 · The Journal of Finance
ABSTRACT Over the years, many asset pricing studies have employed the sample cross‐sectional regression (CSR) R 2 as a measure of model performance. We derive the asymptotic distribution of this statistic and develop associated model…
Guy E. Hawkins, Birte U. Forstmann, Eric‐Jan Wagenmakers et al. · 2015 · Journal of Neuroscience
For nearly 50 years, the dominant account of decision-making holds that noisy information is accumulated until a fixed threshold is crossed. This account has been tested extensively against behavioral and neurophysiological data for…
Karthik Muralidharan, Venkatesh Sundararaman · 2015 · The Quarterly Journal of Economics
Abstract We present experimental evidence on the impact of a school choice program in the Indian state of Andhra Pradesh that provided students with a voucher to finance attending a private school of their choice. The study design featured…
Suresh de Mel, David McKenzie, Christopher Woodruff · 2013 · American Economic Journal Applied Economics
A field experiment in Sri Lanka provides informal firms incentives to formalize. Information about the registration process and reimbursement of direct costs does not increase registration. Payments equivalent to one-half to one month (alternatively, two months) of the median firm's profits leads to registration of around one-fifth (alternatively, one-half) of firms. Land ownership issues are the most common reason for not registering. Follow-up surveys 15 to 31 months later show higher mean profits, but largely in a few firms that grew rapidly. We find little evidence for other changes in beh
N. V. Kharchenko, А. Э. Пискунов, E. Schilbach et al. · 2013 · arXiv (Cornell University)
Although they are the main constituents of the Galactic disk population, for half of the open clusters in the Milky Way reported in the literature nothing is known except the raw position and an approximate size. The main goal of this…
Jong‐Hag Choi, Jeong‐Bon Kim, Yoonseok Zang · 2010 · Auditing A Journal of Practice & Theory
SUMMARY: This study examines whether and how audit quality proxied by the magnitude of absolute discretionary accruals is associated with abnormal audit fees, that is, the difference between actual audit fee and the expected, normal level…
Lucy van Dorp, Damien Richard, Cedric Tan et al. · 2020 · Nature Communications
COVID-19 is caused by the coronavirus SARS-CoV-2, which jumped into the human population in late 2019 from a currently uncharacterised animal reservoir. Due to this recent association with humans, SARS-CoV-2 may not yet be fully adapted to its human host. This has led to speculations that SARS-CoV-2 may be evolving towards higher transmissibility. The most plausible mutations under putative natural selection are those which have emerged repeatedly and independently (homoplasies). Here, we formally test whether any homoplasies observed in SARS-CoV-2 to date are significantly associated with inc
Bahattin Büyükşahin, Jeffrey H. Harris · 2011 · The Energy Journal
The coincident rise in crude oil prices and increased number of financial participants in the crude oil futures market from 2000-2008 has led to allegations that “speculators” drive crude oil prices. As crude oil futures peaked at $147/bbl in July 2008, the role of speculators came under heated debate. In this paper, we employ unique data from the U.S. Commodity Futures Trading Commission (CFTC) to test the relation between crude oil prices and the trading positions of various types of traders in the crude oil futures market. We employ Granger Causality tests to analyze lead and lag relations
Ebru Günlü Küçükaltan, Mehmet AKSARAYLI, Nilüfer Şahin Perçin · 2010 · International Journal of Contemporary Hospitality Management
Purpose The aim of this paper is to identify the effects of job satisfaction on organizational commitment for managers in large‐scale hotels in the Aegean region of Turkey and, in addition, to examine whether there is a significant…
Bruce A. Rayton, Zeynep Y. Yalabik · 2014 · The International Journal of Human Resource Management
This study extends both Social Exchange Theory and the Job Demands-Resources model by examining the link between psychological contract breach (PCB) and work engagement, and by integrating job satisfaction into this exchange relationship.…
Shao-Wen Wei, Yu-Xiao Liu · 2013 · Journal of Cosmology and Astroparticle Physics
In this paper, the shadows cast by Einstein-Maxwell-Dilaton-Axion black hole and naked singularity are studied. The shadow of a rotating black hole is found to be a dark zone covered by a deformed circle. For a fixed value of the spin a,…
Olgun Kitapçı, Ceylan Akdogan, İ̇brahim Taylan Dörtyol · 2014 · Procedia - Social and Behavioral Sciences
The aims of this study are investigating the effect of service quality (SQ) dimensions on satisfaction, identifying the effect of satisfaction on word of mouth (WOM) communication and repurchase intention (RI) and searching a significant…
Amy Hsin, Christina Felfe · 2014 · Demography
This study tests the two assumptions underlying popularly held notions that maternal employment negatively affects children because it reduces time spent with parents: (1) that maternal employment reduces children's time with parents, and…
Paul Dolan, Matteo M. Galizzi · 2015 · Journal of Economic Psychology
No behavior sits in a vacuum, and one behavior can greatly affect what happens next. We propose a conceptual frame within which a broad range of behavioral spillovers can be accounted for when applying behavioral science to policy challenges. We consider behaviors which take place sequentially and are linked, at a conscious or unconscious level, by some underlying motive. The first behavior leads to another behavior which can either work in the same direction as the first (promoting spillover), or push back against it (permitting or purging spillover). Looking through this conceptual lens at t
Guillaume Lettre, Cameron D. Palmer, Taylor Young et al. · 2011 · PLoS Genetics
Coronary heart disease (CHD) is the leading cause of mortality in African Americans. To identify common genetic polymorphisms associated with CHD and its risk factors (LDL- and HDL-cholesterol (LDL-C and HDL-C), hypertension, smoking, and type-2 diabetes) in individuals of African ancestry, we performed a genome-wide association study (GWAS) in 8,090 African Americans from five population-based cohorts. We replicated 17 loci previously associated with CHD or its risk factors in Caucasians. For five of these regions (CHD: CDKN2A/CDKN2B; HDL-C: FADS1-3, PLTP, LPL, and ABCA1), we could leverage t
Catherine A. Charneski, Laurence D. Hurst · 2013 · PLoS Biology
Both for understanding mechanisms of disease and for the design of transgenes, it is important to understand the determinants of ribosome velocity, as changes in the rate of translation are important for protein folding, error attenuation, and localization. While there is great variation in ribosomal occupancy along even a single transcript, what determines a ribosome's occupancy is unclear. We examine this issue using data from a ribosomal footprinting assay in yeast. While codon usage is classically considered a major determinant, we find no evidence for this. By contrast, we find that posit
Yumei Li, Xinzhou Ge, Fanglue Peng et al. · 2022 · Genome biology
When identifying differentially expressed genes between two conditions using human population RNA-seq samples, we found a phenomenon by permutation analysis: two popular bioinformatics methods, DESeq2 and edgeR, have unexpectedly high false discovery rates. Expanding the analysis to limma-voom, NOISeq, dearseq, and Wilcoxon rank-sum test, we found that FDR control is often failed except for the Wilcoxon rank-sum test. Particularly, the actual FDRs of DESeq2 and edgeR sometimes exceed 20% when the target FDR is 5%. Based on these results, for population-level RNA-seq studies with large sample s
Sara Cools, Andreas Kotsadam · 2017 · World Development
Combining DHS data for 580,000 women from 30 different countries in Sub-Saharan Africa, we analyze how both the incidence and the acceptance of intimate partner violence vary across time and space, in a region with record high levels of violence against women. We review the existing literature regarding the impact of resources on intimate partner violence, extracting testable and often conflicting hypotheses at the micro and macro level, and on the interaction across levels. We propose to extend existing theory to take into account attitudes at the community level. In the empirical analysis, w
Christine Grossen, Frédéric Guillaume, Lukas F. Keller et al. · 2020 · Nature Communications
Human activity has caused dramatic population declines in many wild species. The resulting bottlenecks have a profound impact on the genetic makeup of a species with unknown consequences for health. A key genetic factor for species survival is the evolution of deleterious mutation load, but how bottleneck strength and mutation load interact lacks empirical evidence. We analyze 60 complete genomes of six ibex species and the domestic goat. We show that historic bottlenecks rather than the current conservation status predict levels of genome-wide variation. By analyzing the exceptionally well-ch
Emily Hencken Ritter, Courtenay R. Conrad · 2016 · American Political Science Review
Although scholarly consensus suggests that dissent causes repression, the behaviors are endogenous: governments and dissidents act in expectation of each other’s behavior. Empirical studies have not accounted well for this endogeneity. We…
Biren B. Kamdar, Lauren M. King, Nancy A. Collop et al. · 2013 · Critical Care Medicine
OBJECTIVES: To determine if a quality improvement intervention improves sleep and delirium/cognition. DESIGN: Observational, pre-post design. SETTING: A tertiary academic hospital in the United States. PATIENTS: 300 medical ICU patients.…
Justin Beardsley, Marcel Wolbers, Freddie Kibengo et al. · 2016 · New England Journal of Medicine
BACKGROUND: Cryptococcal meningitis associated with human immunodeficiency virus (HIV) infection causes more than 600,000 deaths each year worldwide. Treatment has changed little in 20 years, and there are no imminent new anticryptococcal…
Marieke J Bart, Simon R. Harris, Abdolreza Advani et al. · 2014 · mBio
Bordetella pertussis causes pertussis, a respiratory disease that is most severe for infants. Vaccination was introduced in the 1950s, and in recent years, a resurgence of disease was observed worldwide, with significant mortality in infants. Possible causes for this include the switch from whole-cell vaccines (WCVs) to less effective acellular vaccines (ACVs), waning immunity, and pathogen adaptation. Pathogen adaptation is suggested by antigenic divergence between vaccine strains and circulating strains and by the emergence of strains with increased pertussis toxin production. We applied com
Awadh A.Y. Al‐Qahtani, Steve Higgins · 2012 · Journal of Computer Assisted Learning
Abstract The study investigates the effect of e‐learning, blended learning and classroom learning on students’ achievement. Two experimental groups together with a control group from U mm A l‐ Q ura U niversity in S audi A rabia were…