Purging of highly deleterious mutations through severe bottlenecks in Alpine ibex
Christine Grossen; Frédéric Guillaume; Lukas F. Keller; Daniel Croll · 2020 · Nature Communications
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Human activity has caused dramatic population declines in many wild species. The resulting bottlenecks have a profound impact on the genetic makeup of a species with unknown consequences for health. A key genetic factor for species survival is the evolution of deleterious mutation load, but how bottleneck strength and mutation load interact lacks empirical evidence. We analyze 60 complete genomes of six ibex species and the domestic goat. We show that historic bottlenecks rather than the current conservation status predict levels of genome-wide variation. By analyzing the exceptionally well-ch
Abstract by Christine Grossen; Frédéric Guillaume; Lukas F. Keller; Daniel Croll, Nature Communications (2020) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1038/s41467-020-14803-1