Negative / Null Result ReportOpen accessMedicine
Helen M Collins, Susan A. Greenfield · 2024 · International Journal of Molecular Sciences
Alzheimer's disease (AD) is a progressive neurodegenerative disease with no effective treatments, not least due to the lack of authentic animal models. Typically, rodent models recapitulate the effects but not causes of AD, such as cholinergic neuron loss: lesioning of cholinergic neurons mimics the cognitive decline reminiscent of AD but not its neuropathology. Alternative models rely on the overexpression of genes associated with familial AD, such as amyloid precursor protein, or have genetically amplified expression of mutant tau. Yet transgenic rodent models poorly replicate the neuropatho
View details →DOI: 10.3390/ijms25116222Cited by 12 Negative / Null Result ReportOpen accessPsychology
Simone Di Plinio · 2022 · Frontiers in Psychology
Correlation coefficients are often compared to investigate data across multiple research fields, as they allow investigators to determine different degrees of correlation to independent variables. Even with adequate sample size, such differences may be minor but still scientifically relevant. To date, although much effort has gone into developing methods for estimating differences across correlation coefficients, adequate tools for variable sample sizes and correlational strengths have yet to be tested. The present study evaluated four different methods for detecting the difference between two
View details →DOI: 10.3389/fpsyg.2022.860213Cited by 12 Negative / Null Result Report
Jiahang Zhang, Shengai Cui · 2023 · Axioms
The number of random fields required to capture the spatial variability of soil properties and their impact on the performance of geotechnical systems is often varied. However, the number of random fields required to obtain higher-order…
View details →DOI: 10.3390/axioms12050481Cited by 12 Negative / Null Result ReportNeuroscience
Jessica Nicosia, David A. Balota · 2020 · Psychology and Aging
Recent evidence indicates that older adults' decreased ability to inhibit irrelevant information may lead to increased processing and greater memory for distractor information compared with younger adults. The present experiments examine…
View details →DOI: 10.1037/pag0000371Cited by 12 Negative / Null Result ReportOpen accessMaterials Science
Suriati Paiman, T. Hui Ling, M. Husham et al. · 2020 · Results in Physics
This paper focused on the growth of zinc oxide nanowires on unannealed and annealed indium tin oxide-coated-coated glass substrates on the structural, optical, and electrical properties towards surface acoustic wave (SAW) piezoelectric…
View details →DOI: 10.1016/j.rinp.2020.103185Cited by 12 Negative / Null Result ReportSocial Sciences
Xueqin Qian, Renáta Tichá, Roger J. Stancliffe · 2017 · Journal of Policy and Practice in Intellectual Disabilities
Abstract Although numerous studies in the U.K. and Australia have shown that Active Support (AS) is an effective intervention in increasing staff assistance and engagement for people with intellectual and developmental disabilities (IDD)…
View details →DOI: 10.1111/jppi.12204Cited by 12 Negative / Null Result ReportOpen accessEnergy
Jingwen Shi, Ning Li, Yan Liang et al. · 2025 · Angewandte Chemie International Edition
Abstract The transfer path of photogenerated charges greatly affects the final photocatalytic performance, but this important fact has not been clearly demonstrated experimentally. Here, we construct an ultrastable crystalline catalytic…
View details →DOI: 10.1002/anie.202502654Cited by 12 Negative / Null Result ReportOpen accessNeuroscience
Daniel F. Kripke, Caroline M. Nievergelt, Gregory J. Tranah et al. · 2013 · Journal of Circadian Rhythms
BACKGROUND: There are several indications that malfunctions of the circadian clock contribute to depression. To search for particular circadian gene polymorphisms associated with depression, diverse polymorphisms were genotyped in two samples covering a range of depressed volunteers and participants with normal mood. METHODS: Depression mood self-ratings and DNA were collected independently from a sample of patients presenting to a sleep disorders center (1086 of European origin) and from a separate sample consisting of 399 participants claiming delayed sleep phase symptoms and 406 partly-matc
View details →DOI: 10.1186/1740-3391-11-3Cited by 12 Negative / Null Result ReportOpen accessPsychology
Julia Holzer, Luisa Grützmacher, Marko Lüftenegger et al. · 2024 · Learning and Instruction
Despite broad theoretical consensus on the direct and indirect relevance of teacher emotions for instructional behavior and student outcomes, empirical evidence is inconclusive. Moreover, there is limited research in this area involving disadvantaged and younger student populations, and addressing students’ school well-being as an outcome explicitly. This study investigates associations between teacher emotions (joy, anger, anxiety), teacher-reports of instructional behavior (cognitive and motivational stimulation, classroom management, and social support), and students' reported school well-b
View details →DOI: 10.1016/j.learninstruc.2024.101926Cited by 12 Negative / Null Result ReportPsychology
Sarah E. Whiteman, Lindsay B. Kramer, Madison W. Silverstein et al. · 2020 · Assessment
The Posttraumatic Cognitions Inventory (PTCI) is one of the most widely used measure of posttraumatic cognitions. The original factor analysis of the PTCI provided evidence for a three-factor model of negative cognitions about self, world,…
View details →DOI: 10.1177/1073191120954915Cited by 12 Negative / Null Result ReportMedicine
Kun Man, Jiafeng Liu, Cindy Liang et al. · 2023 · ACS Applied Materials & Interfaces
Determining the mechanistic causes of lung diseases, developing new treatments thereof, and assessing toxicity whether from chemical exposures or engineered nanomaterials would benefit significantly from a preclinical human lung alveolar…
View details →DOI: 10.1021/acsami.3c04091Cited by 12 Negative / Null Result ReportOpen accessAgricultural and Biological Sciences
Rajrani Ruhel, Mohit Mazumder, Prabu Gnanasekaran et al. · 2021 · FEBS Journal
Geminivirus replication initiator protein (Rep) is a multifunctional viral protein required for replication. During the process of viral replication, Rep acts as a site- and strand-specific endonuclease, ligase, ATPase, and helicase. B'…
View details →DOI: 10.1111/febs.16053Cited by 12 Negative / Null Result ReportOpen accessEngineering
Amlan Jyoti Kalita, Maibam Pooya Chanu, Nayan M. Kakoty et al. · 2025 · Wearable Technologies
Electromyogram (EMG)-controlled prosthetic hands have advanced significantly during the past two decades. However, most of the currently available prosthetic hands fail to replicate human hand functionality and controllability. To measure the emulation of the human hand by a prosthetic hand, it is important to evaluate the functional characteristics. Moreover, incorporating feedback from end users during clinical testing is crucial for the precise assessment of a prosthetic hand. The work reported in this manuscript unfolds the functional characteristics of an EMG-CoNtrolled PRosthetIC Hand ca
View details →DOI: 10.1017/wtc.2025.7Cited by 12 Negative / Null Result ReportOpen accessMedicine
Ruijuan Liu, Xia Li, Jingyao Wei et al. · 2019 · Frontiers in Pharmacology
Despite its narrow therapeutic window and large inter-individual variability, cyclosporine A (CsA) is the first-line therapy following organ transplantation. Metabolized mainly by CYP3A and being a substrate of P-glycoprotein (P-gp), CsA is susceptible to drug-drug interactions. Baicalin (BG) is a drug used for adjuvant therapy of hepatitis in traditional Chinese medicine. Since its aglycone Baicalein (B) inhibits CYP3A and P-gP, co-administration might affect CsA pharmacokinetics. This study investigated the effect of BG on CsA pharmacokinetics. In a two-period study, 16 healthy volunteers re
View details →DOI: 10.3389/fphar.2019.00518Cited by 12 Negative / Null Result ReportOpen accessImmunology and Microbiology
Animamalar Mayavannan, Emily Shantz, Ian D. Haidl et al. · 2023 · Frontiers in Immunology
Introduction Chlamydia trachomatis ( C. trachomatis ) is a Gram-negative obligate intracellular bacterium that causes reproductive tract complications in women, including ectopic pregnancies and tubal factor infertility. We hypothesized that mast cells, which are common at mucosal barriers, may contribute to responses to Chlamydia infection and aimed to define human mast cell responses to C. trachomatis . Methods Human cord blood-derived mast cells (CBMCs) were exposed to C. trachomatis to assess bacterial uptake, mast cell degranulation, gene expression, and production of inflammatory mediato
View details →DOI: 10.3389/fimmu.2023.1166068Cited by 12 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Miruna C. Barbu, Carmen Amador, Alex S. F. Kwong et al. · 2022 · EBioMedicine
BACKGROUND: DNA methylation (DNAm) is associated with time-varying environmental factors that contribute to major depressive disorder (MDD) risk. We sought to test whether DNAm signatures of lifestyle and biochemical factors were associated with MDD to reveal dynamic biomarkers of MDD risk that may be amenable to lifestyle interventions. METHODS: , N=565), using CpG sites reported in previous well-powered methylome-wide association studies. We also compared their predictive accuracy for MDD to a MDD MS in an independent GS sub-sample (N=4,432). FINDINGS: =-0.069-0.083) remained significantly a
View details →DOI: 10.1016/j.ebiom.2022.104000Cited by 12 Negative / Null Result ReportOpen accessMedicine
Christine L. Nelson, Roderick S. Tang, Elizabeth A. Stillman · 2013 · Vaccine
MEDI-534 is the first live, attenuated and vectored respiratory syncytial virus (RSV) vaccine to be evaluated in seronegative children. It consists of a bovine/human parainfluenza virus type 3 (PIV3) backbone with the RSV fusion…
View details →DOI: 10.1016/j.vaccine.2013.04.015Cited by 12 Negative / Null Result ReportOpen accessDecision Sciences
Yusuf Wanjala Musi, Elegwa Mukulu, Margaret Oloko · 2018 · Journal of Management and Sustainability
Strategic planning is a very crucial phenomenon in all organisations. It is the tool that determines the destiny of the firm. The objective of this study was to investigate the influence of financial resource strategic planning on firm performance, to determine influence of human capital strategic planning on firm performance, to analyze the influence of material resource strategic planning on firm performance and to determine influence of information resource strategic planning on firm performance in agriculture research based institutions of Kenya. Although there had been previous internatio
View details →DOI: 10.5539/jms.v8n4p83Cited by 12 Negative / Null Result ReportOpen accessComputer Science
Nikunj Arora, Markku Suomalainen, Matti Pouke et al. · 2022 · IEEE Transactions on Visualization and Computer Graphics
We propose augmenting immersive telepresence by adding a virtual body, representing the user's own arm motions, as realized through a head-mounted display and a 360-degree camera. Previous research has shown the effectiveness of having a virtual body in simulated environments; however, research on whether seeing one's own virtual arms increases presence or preference for the user in an immersive telepresence setup is limited. We conducted a study where a host introduced a research lab while participants wore a head-mounted display which allowed them to be telepresent at the host's physical loc
View details →DOI: 10.1109/tvcg.2022.3150473Cited by 12 Negative / Null Result ReportOpen accessPsychology
Annika Gunst, Marlene Werner, Lourens Waldorp et al. · 2018 · Scientific Reports
Problems related to low sexual desire in women are common clinical complaints, and the aetiology is poorly understood. We investigated predictors of change in levels of sexual desire using a novel network approach, which assumes that mental disorders arise from direct interactions between symptoms. Using population-based data from 1,449 Finnish women, we compared between-subject networks of women whose sexual desire decreased, increased, or remained stable over time. Networks were estimated and analyzed at T1 (2006) and replicated at T2 (2013) using R. Domains included were, among others, sexu
View details →DOI: 10.1038/s41598-018-34138-8Cited by 12 Negative / Null Result ReportOpen accessMedicine
Stefan Bräuer, Iñaki Schniewind, Elisabeth Dinter et al. · 2025 · Acta Neuropathologica Communications
Parkinson's disease (PD) is a heterogeneous neurodegenerative disorder with a wide range of clinical phenotypes. Pathologically, it is characterized by neuronal inclusions containing misfolded, fibrillar alpha-synuclein (aSyn). Prion-like properties of aSyn contribute to the spread of aSyn pathology throughout the nervous system as the disease progresses. Utilizing these properties, seed amplification assays (SAA) enable the detection of aSyn pathology in living patients. We hypothesized that structurally distinct aSyn aggregates, or strains, may underlie the clinical heterogeneity of PD. To t
View details →DOI: 10.1186/s40478-024-01923-8Cited by 12 Negative / Null Result ReportOpen accessMedicine
Yang� Yang, Shengru Liang, Yuqian Li et al. · 2019 · Neuropsychiatric Disease and Treatment
BACKGROUND: Both protective and therapeutic functions of insulin-like growth factor-1 (IGF-1) in brain injury have been reported, but its effects on cognitive sequelae after septic encephalopathy (SE) remain unclear. MATERIALS AND METHODS:…
View details →DOI: 10.2147/ndt.s190845Cited by 12 Negative / Null Result ReportImmunology and Microbiology
Duan S. Loy, Bradley J. Blitvich, John Dustin Loy et al. · 2015 · Journal of General Virology
Infectious myonecrosis virus (IMNV) causes significant economic losses in farmed shrimp, where associated mortality in ponds can reach 70 %. To explore host/pathogen interactions, a next-generation sequencing approach using lymphoid organ…
View details →DOI: 10.1099/vir.0.000137Cited by 12 Negative / Null Result Report
Stephen F. Hall, Rebecca J. Griffiths, Brian O'Sullivan et al. · 2019 · Head & Neck
Abstract Background Distant metastases (DM) are a leading cause of death for patients with oropharyngeal cancer (OPSCC). The objective of this study was to compare the rates of DM after chemoradiotherapy (CRT) and radiotherapy alone (RT)…
View details →DOI: 10.1002/hed.25679Cited by 12 Negative / Null Result ReportOpen accessNursing
Shih‐Wei Huang, Horng‐Chyuan Lin, Yu-Feng Chou et al. · 2022 · Nutrients
Prolonged mechanical ventilation (PMV) is associated with poor outcomes and a high economic cost. The association between protein intake and PMV has rarely been investigated in previous studies. This study aimed to investigate the impact of protein intake on weaning from mechanical ventilation. Patients with the PMV (mechanical ventilation ≥6 h/day for ≥21 days) at our hospital between December 2020 and April 2022 were included in this study. Demographic data, nutrition records, laboratory data, weaning conditions, and survival data were retrieved from the patient’s electronic medical records.
View details →DOI: 10.3390/nu14204395Cited by 12 Negative / Null Result ReportOpen accessMedicine
Tongtian Ni, Ying Chen, Bing Zhao et al. · 2021 · Scientific Reports
Severe acute pancreatitis (SAP) is a life-threatening disease. Fluid Resuscitation Via Colon (FRVC) may be a complementary therapy for early controlled fluid resuscitation. But its clinical application has not been reported. This study aims to explore the impact of FRVC on SAP. All SAP patients with the first onset within 72 h admitted to the hospital were included from January 2014 to December 2018 through electronic databases of Ruijin hospital and were divided into FRVC group (n = 103) and non-FRVC group (n = 78). The clinical differences before and after the therapy between the two groups
View details →DOI: 10.1038/s41598-021-92065-7Cited by 12 Failed Experiment ReportAgricultural and Biological Sciences
Akshay Menon, Bryn Funnekotter, Anja Kaczmarczyk et al. · 2013 · PubMed
A cryopreservation protocol was developed for Lomandra sonderi (Asparagaceae), an endemic plant of southwest Western Australia used for mine site restoration. Thermal analysis of L. sonderi shoot tips using differential scanning…
Negative / Null Result ReportOpen accessMedicine
Xi Luo, Xiaodong Huang, Jingwei Luo et al. · 2022 · BMC Cancer
PURPOSE: Concurrent chemoradiotherapy (CCRT) is a standard treatment choice for locally advanced hypopharyngeal carcinoma. The aim of this study was to investigate whether induction chemotherapy (IC) followed by CCRT is superior to CCRT alone to treat locally advanced hypopharyngeal carcinoma. METHODS AND MATERIALS: Patients (n = 142) were randomized to receive two cycles of paclitaxel/cisplatin/5-fluorouracil (TPF) IC followed by CCRT or CCRT alone. The primary end point was overall survival (OS). The secondary end points included the larynx-preservation rate, progression-free survival (PFS),
View details →DOI: 10.1186/s12885-022-10306-yCited by 12 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Alexander A. Rashin, Marcin J. Domagalski, Michael T. Zimmermann et al. · 2014 · Acta Crystallographica Section D Biological Crystallography
Validation of general ideas about the origins of conformational differences in proteins is critical in order to arrive at meaningful functional insights. Here, principal component analysis (PCA) and distance difference matrices are used to…
View details →DOI: 10.1107/s1399004713028812Cited by 12 Negative / Null Result Report
Teng Liu, Jian‐She Wang · 2023 · Liver International
Abstract Background and Aims A recent study suggested that administration of ursodeoxycholic acid (UDCA) at dosages usually employed clinically may reduce rates of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection. A…
View details →DOI: 10.1111/liv.15660Cited by 12 