Genome-wide association study identifies common variants associated with breast cancer in South African Black women
M Hayat; Wenlong Carl Chen; Chantal Babb de Villiers; Sang Hyuck Lee; Charles Curtis; Robert Newton; Tim Waterboer; Freddy Sitas · 2025 · Nature Communications
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Abstract
Abstract Genome-wide association studies (GWAS) have characterized the contribution of common variants to breast cancer (BC) risk in populations of European ancestry, however GWAS have not been reported in resident African populations. This GWAS included 2485 resident African BC cases and 1101 population matched controls. Two risk loci were identified, located between UNC13C and RAB27A on chromosome 15 (rs7181788, p = 1.01 × 10 −08 ) and in USP22 on chromosome 17 (rs899342, p = 4.62 × 10 −08 ). Several genome-wide significant signals were also detected in hormone receptor subtype analysis. The
Abstract by M Hayat; Wenlong Carl Chen; Chantal Babb de Villiers; Sang Hyuck Lee; Charles Curtis; Robert Newton; Tim Waterboer; Freddy Sitas, Nature Communications (2025) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1038/s41467-025-58789-0