Negative / Null Result ReportOpen accessMedicine· cited by 13

Inhibition of Toll-like receptor 4 and Interleukin-1 receptor prevent SARS-CoV-2 mediated kidney injury

Daigo Nakazawa; Yohei Takeda; Masatoshi Kanda; Utano Tomaru; Haruko Ogawa; Takashi Kudo; Satoka Shiratori‐Aso; Kanako Watanabe‐Kusunoki · 2023 · Cell Death Discovery

WASTE classifies this as Negative / Null Result Report · AI classification, approximate

The study found no significant effect — useful as a negative control or null benchmark for your own design.

Abstract

Acute kidney injury (AKI) is a common and severe complication of the coronavirus disease 2019 (COVID-19). Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) directly affects the glomerular and tubular epithelial cells to induce AKI; however, its pathophysiology remains unclear. Here, we explored the underlying mechanisms and therapeutic targets of renal involvement in COVID-19. We developed an in vitro human kidney cellular model, including immortalized tubular epithelial and endothelial cell lines, demonstrating that SARS-CoV-2 directly triggers cell death. To identify the molecular

Abstract by Daigo Nakazawa; Yohei Takeda; Masatoshi Kanda; Utano Tomaru; Haruko Ogawa; Takashi Kudo; Satoka Shiratori‐Aso; Kanako Watanabe‐Kusunoki, Cell Death Discovery (2023) — licensed CC BY 4.0.

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