Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Maria Nikogհosyan, Siras Hakobyan, Anahit Hovhannisyan et al. · 2019 · Frontiers in Genetics
Background: During last decades a number of genome-wide association studies (GWAS) has identified numerous single nucleotide polymorphisms (SNPs) associated with different complex diseases. However, associations reported in one population are often conflicting and did not replicate when studied in other populations. One of the reasons could be that most of GWAS employ case-control design in one or a limited number of populations, but little attention was paid to global distribution of disease associated alleles across different populations. Moreover, the majority of GWAS have been performed on
View details →DOI: 10.3389/fgene.2019.00394Cited by 13 Negative / Null Result ReportOpen accessComputer Science
Robert Ranisch, Joschka Haltaufderheide · 2025 · Digital Society
Abstract Conversational agents are increasingly used in healthcare, with Large Language Models (LLMs) significantly enhancing their capabilities. When integrated into social robots, LLMs offer the potential for more natural interactions. However, while LLMs promise numerous benefits, they also raise critical ethical concerns, particularly regarding hallucinations and deceptive patterns. In this case study, we observed a critical pattern of deceptive behavior in commercially available LLM-based care software integrated into robots. The LLM-equipped robot falsely claimed to have medication remin
View details →DOI: 10.1007/s44206-025-00161-2Cited by 13 Negative / Null Result ReportOpen accessNeuroscience
Shao-Chin Hung, Aaron R. Seitz · 2011 · PLoS ONE
Consolidation, a process that stabilizes memory trace after initial acquisition, has been studied for over a century. A number of studies have shown that a skill or memory must be consolidated after acquisition so that it becomes resistant to interference from new information. Previous research found that training on a peripheral 3-dot hyperacuity task could retrogradely interfere with earlier training on the same task but with a mirrored stimulus configuration. However, a recent study failed to replicate this finding. Here we address the controversy by replicating both patterns of results, ho
View details →DOI: 10.1371/journal.pone.0024556Cited by 13 Negative / Null Result ReportOpen accessEngineering
Kyung Seo Joo, Sun Jin Sym, Kwangmin Kim et al. · 2025 · International Journal of Nanomedicine
Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal malignancies, largely because of its profoundly hypoxic and desmoplastic tumor microenvironment (TME), which hinders drug delivery and promotes resistance to…
View details →DOI: 10.2147/ijn.s548825Cited by 13 Negative / Null Result ReportOpen accessComputer Science
Sarah Kettley · 2026 · Edinburgh Napier Research Repository (Edinburgh Napier University)
The purpose of the research described in this thesis was to develop a design methodology for Wearable Computing concepts that could potentially embody authenticity. The Wearables community, still firmly rooted in the disciplines of engineering and ergonomics, had made clear its aspirations to the mainstream market (DeVaul et al 2001). However, at this point, there was a distinct lack of qualitative studies on user perceptions of Wearable products. A review of the market research literature revealed significant consumer demand for authenticity in goods and services, and it was this need that dr
View details →DOI: 10.17869/enu.236998Cited by 13 Negative / Null Result ReportOpen accessMedicine
Yusuke Kamatsuki, Marie Synnøve Qvale, Kathrin Steffen et al. · 2024 · The American Journal of Sports Medicine
Background: Anterior cruciate ligament (ACL) injury is one of the most severe injuries for athletes. It is important to identify risk factors because a better understanding of injury causation can help inform athletes about risk and increase their understanding of and motivation for injury prevention. Purpose: To investigate the relationship between anatomic factors and risk for future noncontact ACL injuries. Study Design: Cohort study; Level of evidence, 2. Methods: A total of 870, excluding 9 players with a new contact ACL injury and a player with a new noncontact ACL injury just before the
View details →DOI: 10.1177/03635465241292755Cited by 13 Negative / Null Result ReportOpen accessPhysics and Astronomy
Sara Kurkowska, Julia Brosch-Lenz, Yuni K. Dewaraja et al. · 2025 · Journal of Nuclear Medicine
Individualized radiopharmaceutical therapies guided by patient-specific absorbed dose (AD) assessments using nuclear medicine imaging have the potential to improve both efficacy and safety. Understanding sources of variability in AD calculations is critical for standardization. The Society of Nuclear Medicine and Molecular Imaging Dosimetry Task Force launched the 177Lu Dosimetry Challenge to evaluate variability across steps within the dosimetry workflow. This work aimed to assess the variability in ADs due to different fitting and integration methods. Methods: Anonymized datasets from 2 pati
View details →DOI: 10.2967/jnumed.124.268612Cited by 13 Negative / Null Result ReportOpen accessComputer Science
Rabab Ali Abumalloh, Mehrbakhsh Nilashi, Osama Halabi et al. · 2024 · Journal of Innovation & Knowledge
Recommendation agents (RAs) have proven to be effective decision-making tools for customers, as they can boost trust and loyalty when customers shop online. They can analyse large amounts of data using machine learning algorithms and…
View details →DOI: 10.1016/j.jik.2024.100569Cited by 13 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Zahraa S. Al-tameemi, Alejandra Rodríguez‐Verdugo · 2024 · mSystems
ABSTRACT Microbial communities are incredibly diverse. Yet, the eco-evolutionary processes originating and maintaining this diversity remain understudied. Here, we investigate the patterns of diversification for Pseudomonas putida evolving in isolation and with Acinetobacter johnsonii leaking resources used by P. putida . We experimentally evolved four experimental replicates in monoculture and co-culture for 200 generations. We observed that P. putida diversified into two distinct morphotypes that differed from their ancestor by single-point mutations. One of the most prominent mutations hit
View details →DOI: 10.1128/msystems.01053-24Cited by 13 Negative / Null Result ReportOpen accessComputer Science
Catriona L. Scrivener, Tijl Grootswagers, Alexandra Woolgar · 2026 · European Journal of Neuroscience
Multivariate pattern analysis (MVPA) is a popular technique that can distinguish between condition-specific patterns of activation. Applied to neuroimaging data, MVPA decoding for inference uses above chance decoding to identify statistically robust condition-specific information in neuroimaging data, which may be missed by univariate methods. However, several analysis choices influence decoding results, and the combined effects of these choices have not been fully evaluated. In particular, an increasingly popular approach is to average data from several trials together before training an MVPA
View details →DOI: 10.1111/ejn.70601Cited by 13 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Leah Zuroff, Vista Farkhondeh, Riley Bove et al. · 2025 · Drugs
Despite major advances in multiple sclerosis (MS) treatment, disability accumulation independent of relapse activity remains a significant challenge. Chronic demyelination is a key driver of neurodegeneration and disease progression,…
View details →DOI: 10.1007/s40265-025-02212-xCited by 12 Negative / Null Result ReportOpen accessMedicine
Lígia Ramos dos Santos, Jucimara Ferreira Figueiredo Almeida, Lúcia Helena Sagrillo Pimassoni et al. · 2019 · Genetics and Molecular Biology
Genome-wide associations studies (GWAS) are detecting new variants associated with late-onset of Alzheimer's disease (LOAD), a multifactorial neurodegenerative disorder. The variants rs744373 BIN1, rs11136000 CLU and rs3764650 ABCA7 uncovered by GWAS led to different AD pathways, such as metabolism, trafficking and endocytosis of lipids and inflammation. However, most of the association studies did not replicate these variants with significance. This could be due to a small power effect evident when these variants are tested independently with LOAD. Therefore, we aimed to investigate whether t
View details →DOI: 10.1590/1678-4685-gmb-2018-0320Cited by 12 Negative / Null Result ReportOpen accessMedicine
Qiaojuan Jane Su, James R. Ashenhurst, Wanwan Xu et al. · 2026 · Nature
The development of glucagon-like peptide 1 (GLP1) receptor agonists, including semaglutide and tirzepatide, has transformed the clinical management of overweight and obesity. However, substantial inter-person variability exists in both…
View details →DOI: 10.1038/s41586-026-10330-zCited by 12 Negative / Null Result ReportOpen accessAgricultural and Biological Sciences
Jing Mai, Ying Ning, Zhonglong Lin et al. · 2025 · Industrial Crops and Products
Many bacteria such as Bacillus , Pseudomonas , and Lactobacillus are widely present in flue-cured tobacco leaves during the aging process, indicating they play important roles in improving tobacco quality. In this study, we aimed to screen…
View details →DOI: 10.1016/j.indcrop.2025.121580Cited by 12 Negative / Null Result ReportOpen accessSocial Sciences
Laura Macchi, Francesco Poli, Laura Caravona et al. · 2019 · Europe’s Journal of Psychology
The previous research attempts to reduce the influence of the belief bias on deductive thinking have often been unsuccessful and, when they succeeded, they failed to replicate. In this paper, we propose a new way to see an old problem. Instead of considering the analytical abilities of the respondent, we focus on the communicative characteristics of the experimental task. By changing the pragmatics into play through a subtle manipulation of the instruction of the syllogism problem, we obtained a strong improvement in the accuracy of the performance in both untrained and trained in logic respon
View details →DOI: 10.5964/ejop.v15i3.1794Cited by 12 Negative / Null Result ReportOpen accessMedicine
Rosalyn Chi, Anthony J. Perkins, Yara Khalifeh et al. · 2024 · American Journal of Critical Care
BACKGROUND: Hypoalbuminemia has been associated with an increased risk of in-hospital delirium. However, the relationship between serum albumin levels and the duration and severity of delirium is not well defined. OBJECTIVE: To investigate…
View details →DOI: 10.4037/ajcc2024650Cited by 12 Negative / Null Result ReportOpen accessNeuroscience
Stefan Wiens, Erik van Berlekom, Malina Szychowska et al. · 2019 · Frontiers in Psychology
The mismatch negativity (MMN) has been of particular interest in auditory perception because of its sensitivity to auditory change. It is typically measured in an oddball task and is computed as the difference of deviant minus standard tones. Previous studies suggest that the oddball MMN can be reduced by crossmodal attention to a concurrent, difficult visual task. However, more recent studies did not replicate this effect. Because previous findings seem to be biased, we preregistered the present study and used Bayesian hypothesis testing to measure the strength of evidence for or against an e
View details →DOI: 10.3389/fpsyg.2019.01970Cited by 12 Negative / Null Result ReportOpen accessMaterials Science
Yangjian Cai, Ming Lu, Xian Qin et al. · 2025 · Nature Communications
Shell coating is known to suppress luminescence quenching in spherical upconversion nanoparticles. However, the emergence of anisotropic nanoparticles with facet-selective, directional growth complicates the coating process, and the use of…
View details →DOI: 10.1038/s41467-025-60347-7Cited by 12 Negative / Null Result ReportOpen accessNeuroscience
Clara E. James · 2012 · Frontiers in Psychology
A commentary on Musical expertise and statistical learning of musical and linguistic structures by Schön, D., and François, C. (2011). Front. Psychology 2:167. doi: 10.3389/ fpsyg.2011.00167 Both language and music consist of discrete elements organized in embedded hierarchical structures. Schön and François nicely expose in this review that musical expertise facilitates learning of both linguistic and musical structures. At the behavioral level, the musicians did not outperform the nonmusicians. However, ERP analyses showed that acquisition of boundary perception (segmentation) between units
View details →DOI: 10.3389/fpsyg.2012.00052Cited by 12 Negative / Null Result ReportOpen accessSocial Sciences
Eelco Harteveld, Lars Erik Berntzen, Andrej Kokkonen et al. · 2026 · European Journal of Political Research
Abstract Affective polarization (or antipathy between supporters of opposing political camps) is considered a threat to societal cohesion and democratic stability worldwide. However, causal evidence of its impact remains scarce, especially outside the United States. Our study examines the individual-level consequences of affective polarization by manipulating it in a survey experiment in nine countries (Brazil, France, Germany, Italy, Poland, Spain, Sweden, the United Kingdom, and the United States; N ≈ 18,000) and subsequently assessing the downstream consequences for social avoidance and dis
View details →DOI: 10.1017/s1475676526101273Cited by 12 Negative / Null Result ReportOpen accessMedicine
Akram I. Ahmad, Samita Garg, Jeffrey Jacobs et al. · 2026 · JAMA Internal Medicine
Importance: Glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) are known to increase the risk of retained gastric contents. High-quality data are lacking to guide periprocedure management of GLP-1 and GIP agonists. Objective: To compare the risk of clinically significant residual gastric volume (RGV) in patients who continue vs hold 1 dose of weekly or daily GLP-1 and GIP agonists prior to sedation. Design, Setting, and Participants: This randomized, single-masked clinical trial conducted at 2 large tertiary referral centers in the US included patients under
View details →DOI: 10.1001/jamainternmed.2026.0027Cited by 12 Negative / Null Result ReportOpen accessSocial Sciences
Suzanne M. Skevington, Kara Schick‐Makaroff, Christine Rowland et al. · 2024 · PLoS ONE
Gender inequalities in health-related quality of life (QoL) are generally few and small, even in large surveys. Many generic measures limit assessment to QoL overall and its physical and psychological dimensions, while overlooking internationally important environmental, social, and spiritual QoL domains. Unique cross-cultural legacy data was collected using four WHOQOL-100 surveys of adults living in 43 cultures world-wide (17,608 adults; ages 15-101). It was first used to examined gender profiles of its five QoL international domains, and their component facets. Few significant gender differ
View details →DOI: 10.1371/journal.pone.0310445Cited by 12 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Nikola Pavlović, Petar Todorović, Mirko Maglica et al. · 2025 · Biomolecules
The heart’s relentless contractile activity depends critically on mitochondrial function to meet its extraordinary bioenergetic demands. Mitochondria, through oxidative phosphorylation, not only supply ATP but also regulate metabolism, calcium homeostasis, and apoptotic signaling, ensuring cardiomyocyte viability and cardiac function. Mitochondrial dysfunction is a hallmark of cardiomyopathies and heart failure, characterized by impaired oxidative phosphorylation, excessive production of reactive oxygen species (ROS), dysregulated calcium handling, and disturbances in mitochondrial dynamics an
View details →DOI: 10.3390/biom15111572Cited by 12 Negative / Null Result ReportOpen accessNeuroscience
Meenakshi Khosla, Leila Wehbe · 2026 · Nature Communications
Neuroscientific studies rely heavily on a-priori hypotheses, which can bias results toward existing theories. Here, we use a hypothesis-neutral approach to study category selectivity in higher visual cortex. Using only stimulus images and their associated fMRI activity, we constrain randomly initialized neural networks to predict voxel activity. Despite no category-level supervision, units in the trained networks act as detectors for semantic concepts like 'faces' or 'words', providing solid empirical support for categorical selectivity. Importantly, this selectivity is mostly maintained when
View details →DOI: 10.1038/s41467-026-73938-9Cited by 12 Negative / Null Result ReportOpen accessNeuroscience
Alice Mason, Casimir J. H. Ludwig, Simon Farrell · 2016 · Quarterly Journal of Experimental Psychology
Reward is thought to enhance episodic memory formation via dopaminergic consolidation. Bunzeck, Dayan, Dolan, and Duzel [(2010). A common mechanism for adaptive scaling of reward and novelty. Human Brain Mapping, 31, 1380-1394] provided functional magnetic resonance imaging (fMRI) and behavioural evidence that reward and episodic memory systems are sensitive to the contextual value of a reward-whether it is relatively higher or lower-as opposed to absolute value or prediction error. We carried out a direct replication of their behavioural study and did not replicate their finding that memory p
View details →DOI: 10.1080/17470218.2016.1233439Cited by 12 Negative / Null Result ReportOpen accessEnvironmental Science
Catherine S. Jarnevich, Helen R. Sofaer, Pairsa Belamaric et al. · 2022 · NeoBiota
Aim : Species distribution models can guide invasive species prevention and management by characterizing invasion risk across space. However, extrapolation and transferability issues pose challenges for developing useful models for invasive species. Previous work has emphasized the importance of including all available occurrences in model estimation, but managers attuned to local processes may be skeptical of models based on a broad spatial extent if they suspect the captured responses reflect those of other regions where data are more numerous. We asked whether species distribution models fo
View details →DOI: 10.3897/neobiota.77.86364Cited by 12 Negative / Null Result ReportOpen accessMedicine
Prajakta Paritekar, Akshay Nayak, Y Umesh et al. · 2022 · Indian Journal of Ophthalmology
Purpose: To compare the efficacy of Kane formula with Sanders Retzlaff Kraff/Theoretical (SRK/T) and Barrett Universal II in predicting intraocular lens (IOL) power in Indian eyes. Methods: This retrospective study conducted in a tertiary…
View details →DOI: 10.4103/ijo.ijo_2014_21Cited by 12 Negative / Null Result ReportOpen accessComputer Science
Vincent Adegoke, Daqing Chen, Ebad Banissi et al. · 2017
In this paper, several ensemble cancer survivability predictive models are presented and tested based on three variants of AdaBoost algorithm. In the models we used Random Forest, Radial Basis Function Network and Neural Network algorithms…
View details →DOI: 10.1109/sst.2017.8188699Cited by 12 Negative / Null Result ReportOpen accessAgricultural and Biological Sciences
David García Alonso, Ignacio Buesa, Luis Flor et al. · 2025 · Frontiers in Plant Science
The intensification of drought conditions due to climate change poses a major challenge to sustainable grape production. Rootstocks are essential in supporting grapevine water uptake and drought resilience; however, their physiological responses to water stress are not fully understood. Under the hypothesis that root morphology and anatomy may be key traits in grapevine tolerance to water deficit, this study aimed to investigate these traits across diverse rootstocks under progressive water deficit and recovery phases. Thirteen genotypes, including commercial rootstocks and recently bred RG-se
View details →DOI: 10.3389/fpls.2025.1541523Cited by 12 Negative / Null Result ReportNeuroscience
Yanyan Yang, Hongan Wang, XU Hai-ping et al. · 2023 · Autism Research
The early start Denver model (ESDM) has been extensively studied as a promising early intervention approach for young children with autism spectrum disorder (ASD). Various methodological drawbacks from earlier ESDM investigations must be…
View details →DOI: 10.1002/aur.3006Cited by 12 