Negative / Null Result ReportOpen accessMedicine
K. Lance Gould, Nils P. Johnson, Amanda E. Roby et al. · 2025 · European Heart Journal
BACKGROUND AND AIMS: The randomized CENTURY trial tested the hypothesis that a comprehensive strategy integrating intense lifestyle modification and aggressive medical management to goals with revascularization reserved for severely reduced coronary flow capacity (CFC) by positron emission tomography (PET) would reduce risk factors, subsequent revascularization, death and myocardial infarction (MI) compared with standard of care in chronic stable coronary artery disease (CAD). METHODS: Participants were randomly assigned to standard or comprehensive care groups. Rest-stress PET quantified CFC
View details →DOI: 10.1093/eurheartj/ehaf356Cited by 13 Negative / Null Result ReportOpen accessMedicine
Maximilian J. Mair, Aysegül Ilhan‐Mutlu, Sahra Pajenda et al. · 2021 · Cancer Immunology Immunotherapy
PURPOSE: In primary brain tumors, the efficacy of immune-modulating therapies is still under investigation as inflammatory responses are restricted by tight immunoregulatory mechanisms in the central nervous system. Here, we measured soluble PD-L1 (sPD-L1) in the plasma of patients with recurrent glioblastoma (GBM) and recurrent WHO grade II-III glioma treated with bevacizumab-based salvage therapy. METHODS: Thirty patients with recurrent GBM and 10 patients with recurrent WHO grade II-III glioma were treated with bevacizumab-based salvage therapy at the Medical University of Vienna. Prior to
View details →DOI: 10.1007/s00262-021-02951-2Cited by 13 Negative / Null Result ReportOpen accessMedicine
Akiko Ioka, Masami Inoue, Akihiro Yoneda et al. · 2015 · Journal of Epidemiology
BACKGROUND: In 2004, the Japanese government halted the 6-month mass screening program for neuroblastoma. We investigated whether its cessation had led to an increase not only in mortality due to this disease but also in the incidence of advanced-stage disease among older children. METHODS: Study subjects were neuroblastoma patients retrieved from the population-based Osaka Cancer Registry. Trends of incidence and mortality from neuroblastoma were analyzed by calendar year and birth cohort. Prognostic factors, including stage and v-myc avian myelocytomatosis viral oncogene neuroblastoma derive
View details →DOI: 10.2188/jea.je20150054Cited by 13 Negative / Null Result ReportOpen accessMedicine
Somnath Bandyopadhyay, Seán Connolly, Omar Jabado et al. · 2017 · Lupus Science & Medicine
OBJECTIVE: To characterise patients with active SLE based on pretreatment gene expression-defined peripheral immune cell patterns and identify clusters enriched for potential responders to abatacept treatment. METHODS: This post hoc…
View details →DOI: 10.1136/lupus-2017-000206Cited by 13 Negative / Null Result ReportOpen accessMedicine
Rohit Nathani, Meena B. Bansal · 2023 · PubMed
Tremendous effort has been put forth over the past 2 decades in understanding the pathophysiology of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis (NAFLD/NASH). Although multiple potential targets for drug development…
Negative / Null Result ReportOpen accessMedicine
Panpan Zhang, Wei Wang, Ming Lu et al. · 2018 · Cancer Medicine
BACKGROUND: Gastroesophageal Junction neuroendocrine neoplasms (GEJ-NENs) are rare and heterogeneous tumors. We aim to analyze the clinicopathlogical features and prognostic factors of GEJ-NENs and to compare the outcome of GEJ-NENs with other gastric NENs. METHODS: A total of 297 GEJ-NENs patients were enrolled from 10 Chinese hospitals and 3152 gastric NENs patients, including 274 GEJ-NENs, were retrieved from Surveillance, Epidemiology, and End Results (SEER) database. RESULTS: The clinical characteristics of GEJ-NENs among different races were different. All Chinese patients had GEJ-NENs o
View details →DOI: 10.1002/cam4.1702Cited by 13 Negative / Null Result ReportMedicine
Josephine Berger-Groch, Johannes M. Rueger, Patrick Czorlich et al. · 2021 · Prehospital Emergency Care
Background: The role of pelvic circumferential compression devices (PCCD) is to temporarily stabilize the pelvic ring, reduce its volume and to tamponade bleeding. The purpose of this study was to evaluate the effect of PCCDs on mortality…
View details →DOI: 10.1080/10903127.2021.1945717Cited by 13 Negative / Null Result ReportOpen accessMedicine
Bethan Goulden, David Isenberg · 2020 · Expert Opinion on Biological Therapy
INTRODUCTION: The type 1 interferon pathway is known to play a role in the immunopathology of systemic lupus erythematosus (SLE). As a result, biologic agents targeting this pathway have been developed and are currently being investigated…
View details →DOI: 10.1080/14712598.2021.1841164Cited by 13 Negative / Null Result Report
Qihan Ma, Jianbo Wang, Ming Xiong et al. · 2023 · Remote Sensing
The lockdowns from the coronavirus disease of 2019 (COVID-19) have led to a reduction in anthropogenic activities and have hence reduced primary air pollutant emissions, which were reported to have helped air quality improvements. However,…
View details →DOI: 10.3390/rs15051295Cited by 13 Negative / Null Result Report
S.F. Hall, R. Griffiths · 2016 · Current Oncology
Background: For oncologists and for patients, no site-specific clinical trial evidence has emerged for the use of concurrent chemotherapy with radiotherapy (ccrt) over radiotherapy (rt) alone for cancer of the hypopharynx (hpc) or for…
View details →DOI: 10.3747/co.23.3085Cited by 13 Negative / Null Result Report
JAMIE L. BENHAM, JANE E. BOOTH, MARY J. DUNBAR et al. · 2020 · Medicine & Science in Sports & Exercise
ABSTRACT Introduction The Diabetes Aerobic and Resistance Exercise trial found that aerobic training and resistance training alone each reduced hemoglobin A1c (HbA1c) compared with nonexercising controls, and combined aerobic and…
View details →DOI: 10.1249/mss.0000000000002339Cited by 13 Negative / Null Result Report
Aimara Planillo, Juan E. Malo · 2017 · Ecology and Evolution
Abstract Human disturbance is widespread across landscapes in the form of roads that alter wildlife populations. Knowing which road features are responsible for the species response and their relevance in comparison with environmental…
View details →DOI: 10.1002/ece3.3709Cited by 13 Negative / Null Result Report
Eun-Kyoung Rosa Lee, Colin Phillips · 2022 · Bilingualism: Language and Cognition
Abstract It is well-known that native English speakers sometimes erroneously accept subject-verb agreement violations when there is a number-matching attractor (e.g., *The key to the cabinets were…). Whether bilinguals whose L1 lacks…
View details →DOI: 10.1017/s1366728922000414Cited by 13 Negative / Null Result Report
David Winship Taylor, Hongqi Li · 2018 · eLife
The discovery of a fossil that might be the oldest flowering plant will continue the debate on the origin and structure of ancestral flowering plants.
View details →DOI: 10.7554/elife.43421Cited by 13 Negative / Null Result Report
Mohammad Nourani, Qian Long Kweh, Wen-Min Lu et al. · 2022 · Financial Innovation
Abstract This study examines the efficiency of investment trust companies (ITCs) from 2011 to 2020 using a meta-frontier two-stage network data envelopment analysis (DEA) based on the directional distance function (DDF). We improved the…
View details →DOI: 10.1186/s40854-022-00382-1Cited by 13 Negative / Null Result Report
Henry W. Caplan, Karthik S. Prabhakara, Naama E. Toledano Furman et al. · 2021 · PLOS ONE
Traumatic brain injury (TBI) causes both physical disruption of the blood brain barrier (BBB) and altered immune responses that can lead to significant secondary brain injury and chronic inflammation within the central nervous system…
View details →DOI: 10.1371/journal.pone.0251601Cited by 13 Methods Dead-End
Till Francke, Gabriele Baroni, Arlena Brosinsky et al. · 2018 · Water Resources Research
Abstract Modelers can improve a model by addressing the causes for the model errors (data errors and structural errors). This leads to implementing model enhancements (MEs), for example, meteorological data based on more monitoring…
View details →DOI: 10.1029/2018wr022813Cited by 13 Negative / Null Result Report
Elysia Larson, Godfrey M Mbaruku, Jessica Cohen et al. · 2019 · International Journal for Quality in Health Care
Abstract Objective To test the success of a maternal healthcare quality improvement intervention in actually improving quality. Design Cluster-randomized controlled study with implementation evaluation; we randomized 12 primary care…
View details →DOI: 10.1093/intqhc/mzz126Cited by 13 Negative / Null Result ReportOpen accessPsychology
Nobel Glas · 2026 · Zenodo (CERN European Organization for Nuclear Research)
EA-GLAS-02 v1.0. A self-contained empirical white paper presenting the measurement program for the Semantic Deviation Principle (Sharks 2026). Defines meaning as the time-integrated divergence a sign induces from the most probable trajectory of a semantic field, extending the Bar-Hillel and Carnap (1953) program into distributional and temporal domains. Two primary operationalizations. (F1) Closed-system trajectory deviation within a frozen language model, where the counterfactual baseline is read from logits, building on surprisal theory (Hale 2001; Levy 2008) and decomposing it into signed d
View details →DOI: 10.5281/zenodo.20271783Cited by 13 Negative / Null Result ReportOpen accessNeuroscience
Maliha Ashraf, Alexandre Chapiro, Rafał Mantiuk · 2025 · Nature Communications
As large engineering efforts go towards improving the resolution of mobile, augmented reality (AR), and virtual reality (VR) displays, it is important to know the maximum resolution at which further improvements bring no noticeable benefit. This limit is often referred to as the retinal resolution, although the limiting factor may not necessarily be attributed to the retina. To determine the ultimate resolution at which an image appears sharp to our eyes with no perceivable blur, we created an experimental setup with a sliding display, which allows for continuous control of the resolution. The
View details →DOI: 10.1038/s41467-025-64679-2Cited by 13 Negative / Null Result ReportOpen accessPsychology
Sofience · 2026 · Zenodo (CERN European Organization for Nuclear Research)
SΔϕ-60 introduces the Utilitarian Subject-Splitting Index, USSI, within the Sofience-Δϕ Formalism. The paper examines whether utilitarian calculation merely evaluates the happiness of already-existing majorities and minorities, or whether such calculation can first produce the operational boundary between majority and minority by redistributing Transition Completion Cost, TCC. The document begins with the Sofience Subject Thought Experiment. A person is imagined as capable of detaching and reattaching any part of the body while the detached parts remain alive, neurologically connected, and phy
View details →DOI: 10.5281/zenodo.20077005Cited by 13 Negative / Null Result ReportOpen accessComputer Science
Robert Ranisch, Joschka Haltaufderheide · 2025 · Digital Society
Abstract Conversational agents are increasingly used in healthcare, with Large Language Models (LLMs) significantly enhancing their capabilities. When integrated into social robots, LLMs offer the potential for more natural interactions. However, while LLMs promise numerous benefits, they also raise critical ethical concerns, particularly regarding hallucinations and deceptive patterns. In this case study, we observed a critical pattern of deceptive behavior in commercially available LLM-based care software integrated into robots. The LLM-equipped robot falsely claimed to have medication remin
View details →DOI: 10.1007/s44206-025-00161-2Cited by 13 Negative / Null Result ReportOpen accessMedicine
Yusuke Kamatsuki, Marie Synnøve Qvale, Kathrin Steffen et al. · 2024 · The American Journal of Sports Medicine
Background: Anterior cruciate ligament (ACL) injury is one of the most severe injuries for athletes. It is important to identify risk factors because a better understanding of injury causation can help inform athletes about risk and increase their understanding of and motivation for injury prevention. Purpose: To investigate the relationship between anatomic factors and risk for future noncontact ACL injuries. Study Design: Cohort study; Level of evidence, 2. Methods: A total of 870, excluding 9 players with a new contact ACL injury and a player with a new noncontact ACL injury just before the
View details →DOI: 10.1177/03635465241292755Cited by 13 Negative / Null Result ReportOpen accessEngineering
Kyung Seo Joo, Sun Jin Sym, Kwangmin Kim et al. · 2025 · International Journal of Nanomedicine
Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal malignancies, largely because of its profoundly hypoxic and desmoplastic tumor microenvironment (TME), which hinders drug delivery and promotes resistance to…
View details →DOI: 10.2147/ijn.s548825Cited by 13 Negative / Null Result ReportOpen accessMedicine
Yuning Chen, Ying Fang, Zibai Lyu et al. · 2026 · Journal of Biomedical Science
The microbiome has emerged as a critical, context-dependent regulator of tumorigenesis and anticancer immunity, capable of either promoting cancer progression or protecting against malignancy. This dual role is mediated by multiple interconnected mechanisms-including chronic inflammation, modulation of immune responses, and alterations in host metabolic signaling. These microbiome-cancer interactions vary across organs, influencing malignancies in the colon, breast, lung, and beyond. Clinically, the microbiome significantly affects patient responses to cancer therapies, particularly immunother
View details →DOI: 10.1186/s12929-025-01208-9Cited by 13 Negative / Null Result ReportOpen accessMedicine
Dominik Lewandowski, Mateusz Konieczny, Agata Różycka et al. · 2025 · International Journal of Molecular Sciences
Cathepsins, a family of lysosomal proteases, play critical roles in maintaining cellular homeostasis through protein degradation and modulation of immune responses. In the central nervous system (CNS), their functions extend beyond classical proteolysis, influencing neuroinflammation, synaptic remodeling, and neurodegeneration. Emerging evidence underscores the crucial role of microglial cathepsins in the pathophysiology of several neurological disorders. This review synthesizes current knowledge on the involvement of cathepsins in a spectrum of CNS diseases, including Parkinson's disease, Alz
View details →DOI: 10.3390/ijms26167886Cited by 13 Negative / Null Result ReportOpen accessBusiness, Management and Accounting
Sean Myers · 2026 · The Review of Economic Studies
Abstract This paper studies how municipal governments jointly manage spending, credit market borrowing, and a public employee pension system. I model governments as levered investors who must meet non-defaultable pension obligations and…
View details →DOI: 10.1093/restud/rdag097Cited by 13 Negative / Null Result ReportOpen accessMedicine
Shu-Shu Han, Qin Liu, Zhiming Zeng et al. · 2026 · Cardiovascular Diabetology
BACKGROUND: Cardiovascular-kidney-metabolic (CKM) syndrome imposes a substantial global health burden, with most adults clustered in early stages 0-3. Insulin resistance (IR), as a core manifestation of metabolic dysfunction, is thought to…
View details →DOI: 10.1186/s12933-026-03084-5Cited by 13 Negative / Null Result ReportOpen accessMedicine
Tanayott Thaweethai, Sarah E. Donohue, Jeffrey N. Martin et al. · 2025 · Nature Communications
Longitudinal trajectories of Long COVID remain ill-defined, yet are critically needed to advance clinical trials, patient care, and public health initiatives for millions of individuals with this condition. Long COVID trajectories were…
View details →DOI: 10.1038/s41467-025-65239-4Cited by 13 Negative / Null Result ReportOpen accessMedicine
Daniel I. McIsaac, Susan M. Lee, Dean Fergusson et al. · 2025 · JAMA Surgery
Importance: Explanatory trials suggest that prehabilitation has efficacy in improving surgical outcomes. The effectiveness of offering home-based prehabilitation across multiple centers and for older adults with frailty remains unknown. Objective: To evaluate the effectiveness of offering coach-supported, home-based prehabilitation to older surgical patients with frailty. Design, Setting, and Participants: This study is a pragmatic, parallel-arm, multicenter randomized clinical trial with embedded qualitative assessment. Clinicians and assessors were fully blinded; participants were partially
View details →DOI: 10.1001/jamasurg.2025.5288Cited by 13 