A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
21697 results · page 132 of 724
Deborah Salvo, Inácio Crochemore-Silva, Andrea Wendt et al. · 2026 · Nature Medicine
With over 5 million attributed deaths per year, physical inactivity is a major global public health issue. Although the importance of physical activity is well recognized within the scope of obesity and cardiometabolic disease prevention…
Aayush Saxena, Alex J. Cameron, Harley Katz et al. · 2026 · Monthly Notices of the Royal Astronomical Society
ABSTRACT The ultraviolet (UV) continuum slope of galaxies, $\beta$, is a powerful diagnostic of the metallicity and ages of stars, nebular gas properties, dust content, and the escape of Lyman continuum (LyC) photons. In this study, we present $\beta$ measurements for 395 spectroscopically confirmed galaxies at $5 \lt z \lt 14.3$ selected primarily from JADES, using high-quality JWST (James Webb Space Telescope) NIRSpec/PRISM spectra. We find a median $\beta = -2.15$, finding a mild increase in blueness of $\beta$ with increasing redshift and fainter UV magnitudes. Interestingly, we find evide
M Lebwohl, Andrew Blauvelt, Cynthia E. Kartman et al. · 2026 · JAMA Dermatology
Importance: Overweight and obesity affect 60% to 78% of patients with psoriasis, affecting disease severity, treatment response, and clinical outcomes. However, no large, randomized, active-controlled clinical trial has evaluated a treatment strategy that addresses both diseases simultaneously. Objective: To evaluate the efficacy and safety of ixekizumab with or without tirzepatide in participants with psoriasis and overweight or obesity. Design, Setting, and Participants: This phase 3b, randomized, open-label, 52-week clinical trial was conducted at 72 sites in the US in adults with moderate
Jeremy McGale, Harrison J. Howell, Arnaud Beddok et al. · 2024 · Pharmaceuticals
The integration of artificial intelligence (AI) and positron emission tomography (PET) imaging has the potential to become a powerful tool in drug discovery. This review aims to provide an overview of the current state of research and highlight the potential for this alliance to advance pharmaceutical innovation by accelerating the development and deployment of novel therapeutics. We previously performed a scoping review of three databases (Embase, MEDLINE, and CENTRAL), identifying 87 studies published between 2018 and 2022 relevant to medical imaging (e.g., CT, PET, MRI), immunotherapy, arti
Margareth C. Ozelo, Jane Mason, Amy L. Dunn et al. · 2025 · Journal of Thrombosis and Haemostasis
BACKGROUND: Valoctocogene roxaparvovec, an adeno-associated virus vector that transfers a human factor (F)VIII (FVIII) coding sequence to hepatocytes, provides bleeding protection for people with severe hemophilia A. OBJECTIVES: Determine…
Scott Grimm, Louise McNally · 2026 · Proceedings of the Amsterdam Colloquium
Syntacticians have widely assumed since [11] that there is a fundamental difference between so-called argument structure nominals (AS-nominals, also called Complex Event Nominals), e.g. destruction, and non-AS-nominals, e.g. book ([1, 5], i.a.). Grimshaw provided a list of properties characterizing AS-nominals, most notably that they have obligatory arguments (e.g. the destruction *(of Carthage) by the Romans). She and others have associated having argument structure with having event structure, but it has never been clear what having or lacking such structures amounts to semantically. In this
Shyanthony R. Synigal, Andrew J. Anderson, Edmund C. Lalor · 2026 · eNeuro
ABSTRACT The past few years have seen an increase in the use of encoding models to explain neural responses to natural speech. The goal of these models is to characterize how the human brain converts acoustic energy into distinct linguistic representations that enable everyday speech comprehension. For example, researchers have shown that electroencephalography (EEG) data can be modeled in terms of acoustic features of speech, such as its amplitude envelope or spectrogram, linguistic features such as phonemes and phoneme probability, and higher-level linguistic features like context-based word
Aarish Manzar, Aleksandar Sič, Crystal E. Banh et al. · 2025 · Cells
Calcium channel blockers (CCBs), originally developed for cardiovascular indications, have gained attention for their therapeutic potential in neuropsychiatric, endocrine, and pain-related disorders. In neuropsychiatry, nimodipine and isradipine, both L-type CCBs, show mood-stabilizing and neuroprotective effects, with possible benefits in depression, bipolar disorder, and schizophrenia. In endocrinology, verapamil, a non-dihydropyridine L-type blocker, has been associated with the preservation of pancreatic β-cell function and reduced insulin dependence in diabetes. CCBs may also aid in manag
David Hong, Yue Sheng, Edgar Dobriban · 2026 · Journal of the American Statistical Association
Principal component analysis (PCA) is a foundational tool in modern data analysis, and a crucial step in PCA is selecting the number of components to keep. However, classical selection methods (e.g., scree plots, parallel analysis, etc.)…
Rong Guo, Qiuzheng Du, Yaping He et al. · 2026 · Nano-Micro Letters
Single-atom nanozymes (SAzymes) exhibit exceptional catalytic efficiency due to their maximized atom utilization and precisely modulated metal-carrier interactions, which have attracted significant attention in the biomedical field. However, stability issues may impede the clinical translation of SAzymes. This review provides a comprehensive overview of the applications of SAzymes in various biomedical fields, including disease diagnosis (e.g., biosensors and diagnostic imaging), antitumor therapy (e.g., photothermal therapy, photodynamic therapy, sonodynamic therapy, and immunotherapy), antim
Rasit Dinc, Nurittin Ardıç · 2026 · Cells
Exosomes and other extracellular vesicles (EVs) carry microRNAs, proteins, and lipids that reflect cardiovascular pathophysiology and can enable minimally invasive biomarker discovery. However, EV datasets are highly dimensional and heterogeneous, strongly influenced by pre-analytic variables and non-standardized isolation/characterization workflows, limiting reproducibility across studies. Artificial intelligence (AI), including machine learning (ML), deep learning (DL), and network-based approaches, can support EV biomarker development by integrating multi-omics profiles with clinical metada
Stefan Schreiber, Konrad Aden, Florian Tran et al. · 2025 · Gut
The clinical and molecular heterogeneity of IBD—both between patients and within the same individual over time—continues to pose a significant challenge to the implementation of truly personalised treatment strategies. Unlike oncology,…
Yue Zhao, Jiang Su, Zhengzhen An et al. · 2026 · Applied Sciences
Coal gangue is one of the most abundant solid wastes generated during coal mining. The use of coal gangue for underground backfilling is widely recognized as an effective approach to reducing waste accumulation and promoting sustainable utilization. To further investigate the bearing and deformation behavior of underground gangue filling materials, combined with the underground occurrence conditions of crushed gangue in goaf, a self-designed loading apparatus for crushed gangue was employed to perform lateral compression experiments on crushed gangue. The compaction deformation, fractal dimens
Sumit Agarwal, Meghana Ayyagari, Yuxi Cheng et al. · 2026 · Management Science
This paper examines how infrastructure development affects stock market participation in India using trading data from more than 13 million individuals. Using the phased rollout of a national road construction program as a natural…
Anne Bülow, Savannah Boele, Jessica P. Lougheed et al. · 2025 · Journal of Psychopathology and Clinical Science
= 14.37 years, 72% girls, 96% Dutch, data collection: 2019-2020) were used. By aggregating measurements, multiple timescales could be assessed within the same data set. Multilevel structural equation modeling revealed that conflict…
Miao Cai, Taeyoung Choi, Yan Xie et al. · 2026 · BMJ
OBJECTIVES: To investigate whether initiation of glucagon-like peptide-1 (GLP-1) receptor agonists is associated with both reduced risks of incident alcohol, cannabis, cocaine, nicotine, opioid, and other substance use disorders (SUDs) in…
Alì Soltani, Parviz Azizi, Aliasghar Rahimioun et al. · 2025 · Journal of Urban Management
The escalating complexities of rapid urbanization necessitate a paradigm shift in urban form evaluation, moving beyond traditional horizontal analyses to incorporate the crucial dimension of vertical growth. This study pioneers a volumetric approach, integrating 3D and 2D spatial analyses, to dissect compactness, sprawl, and their underlying drivers across two contrasting metropolitan regions: the Tehran Metropolitan Region (TMR) and the Greater Sydney Region (GSR) over a 40-year period (1980s–2020s). Our findings reveal a striking dichotomy: TMR exhibits pronounced ‘vertical sprawl,’ characte
Yuldoshboy Sobirov, Beruniy Artikov, Elbek Khodjaniyazov et al. · 2025 · Sustainability
This study examines the long-run relationship between carbon dioxide (CO2) emissions and key macroeconomic and sectoral drivers in ten ASEAN economies from 1995 to 2023. Employing Driscoll–Kraay standard errors, Prais–Winsten regression, heteroskedastic panel-corrected standard errors, Fully Modified Ordinary Least Squares (FMOLS), Dynamic Ordinary Least Squares (DOLS), and Canonical Cointegrating Regression (CCR) estimators, the analysis accounts for cross-sectional dependence, slope heterogeneity, and endogeneity. Results indicate that GDP exerts a more-than-unitary positive effect on emissi
Imre Fertő, Gábor Harangozó · 2025 · Scientific Reports
This study investigates the complex relationships between globalization, economic growth, urbanization, and ecological footprint in the context of advancing the United Nations Sustainable Development Goals (SDGs). Employing a club convergence framework, we evaluate global SDG Index from 2000 to 2023 for 149 countries with 3212 observations, identifying five converging clubs and one non-converging group. Our analysis demonstrates that higher GDP per capita and various dimensions of globalization positively impact SDG outcomes, whereas rapid urbanization and expansive ecological footprints exert
Yayaati Chachan, Jonathan J. Fortney, Kazumasa Ohno et al. · 2025 · The Astrophysical Journal
Abstract The rate at which giant planets accumulate solids and gas is a critical component of planet formation models, yet it is extremely challenging to predict from first principles. Characterizing the heavy element (everything other than hydrogen and helium) content of giant planets provides important clues about their provenance. Using thermal evolution models with an updated H–He equation of state and atmospheric boundary conditions that vary with envelope metallicity, we quantify the bulk heavy element content of 147 warm (<1000 K) giant planets with well-measured masses and radii, mo
Pan Min, Huike Chen, Kai Deng et al. · 2025 · Micromachines
The female reproductive system represents a highly complex regulatory network governing critical physiological functions, encompassing reproductive capacity and endocrine regulation that maintains female physiological homeostasis. The in vitro simulation system provides a novel tool for biomedical research and can be used as physiological and pathological models to study the female reproductive system. Recent advances in this technology have evolved from 2D and 3D printing to organ-on-a-chip (OOC) and microfluidic systems, which has emerged as a transformative platform for modeling the female
Astrid Marinoni, John L. Voorheis · 2026 · Research Policy
The question of who gains from high-quality entrepreneurship is crucial to understanding whether investments in innovative startup firms produce socially beneficial outcomes. Although entrepreneurship is widely viewed as a central driver…
Daniela Rothschild-Rodriguez, John P. Campbell, Frankie Brown et al. · 2026 · PubMed
BACKGROUND: The complement system is comprised of the classical, lectin and alternative pathways that result in the formation of: pro-inflammatory anaphylatoxins; opsonins that label cells for phagocytic removal; and, a membrane attack…
Xiaoyu Kang, Mingxing Xia, Jun Wang et al. · 2025 · Gut
BACKGROUND: Recent meta-analyses suggested diclofenac may be superior to indomethacin in preventing post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis (PEP). The aim of our study was to compare the efficacy of 100 mg…
Xavier A. Jenkins, Roger Benson, David P. Ford et al. · 2025 · Peer Community Journal
Living reptiles include more than 20,000 species with disparate ecologies. Direct anatomical evidence from Neodiapsida, which includes the reptile crown-group and its closest extinct relatives, shows that this diversity originates from a single common ancestor that lived over 255 million years ago in the Paleozoic. However, the evolutionary assembly of crown reptile traits is poorly understood due to the lack of anatomically close relatives of Neodiapsida. We present a substantially revised phylogenetic hypothesis, informed by new anatomical data from high-resolution synchrotron tomography of
Zhu‐Nan Li, Feng Liu, Yu‐Jin Jung et al. · 2025 · Nature Communications
The unprecedented 2.3.4.4b. A(H5N1) outbreak in dairy cattle, poultry, and spillover to humans in the United States (US) poses a major public health threat. Population immunity is a critical component of influenza pandemic risk assessment. We assessed the pre-existing cross-reactive immunity to 2.3.4.4b A(H5N1) viruses and analyzed 1794 sera from 723 people (0.5-88 yrs) in multiple US geographic regions during 2021-2024. Pre-existing neutralizing and hemagglutinin (HA)-head-binding antibodies to A(H5N1) were low, but there were substantial cross-reactive binding antibodies to N1 neuraminidase
Celia Sequera, Margherita Grattarola, Floriane Cannet et al. · 2025 · Nature Communications
Histone deacetylases (HDACs) are epigenetic regulators frequently altered in cancer. Here we report that overexpression of HDAC1/2 occurs in Hepatocellular Carcinoma (HCC) patients, correlating with poor prognosis. We show that romidepsin,…
Junjie Dong, Zhidan Tan, Y Zhang et al. · 2025 · BMC Psychology
BACKGROUND: With the advancement of globalization and technology, remote work has gradually become a feasible and popular work model, particularly with the rapid adoption of working from home driven by the COVID-19 pandemic. This shift not…
Yukun Kuang, Weiping Tan, Chaohui Hu et al. · 2024 · Frontiers in Cellular and Infection Microbiology
Background: Targeted next-generation sequencing (tNGS) has become a trending tool in the field of infection diagnosis, but concerns are also raising about its performance compared with metagenomic next-generation sequencing (mNGS). This study aims to explore the clinical feasibility of a tNGS panel for respiratory tract infection diagnosis and compare it with mNGS in the same cohort of inpatients. Methods: 180 bronchoalveolar lavage fluid samples were collected and sent to two centers for mNGS and tNGS blinded tests, respectively. The concordance between pathogen reports of both methods and th
Nichola Cooper, James B. Bussel, Maciej Kaźmierczak et al. · 2024 · British Journal of Haematology
Summary Primary immune thrombocytopenia (ITP) is an antiplatelet‐antibody‐mediated disorder with accelerated platelet clearance and decreased platelet production. Rozanolixizumab, a monoclonal IgG4 anti‐FcRn antibody, blocks IgG recycling and decreases IgG levels. We report efficacy and safety of rozanolixizumab in adults with persistent/chronic ITP in 24‐week phase 3 studies (TP0003; TP0006), and their 52‐week open‐label extension (OLE). Primary end‐point was durable clinically meaningful platelet response (DCMPR) of ≥50 × 10 9 /L for 8/12 weeks during Weeks 13–25 in the double‐blind studies.