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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

21247 results · page 132 of 709

Negative / Null Result Report

The Fragility Index of Statistically Significant Findings From Randomized Controlled Trials Comparing the Management Strategies of Anterior Shoulder Instability

Martin S. Davey, Eoghan T. Hurley, Tom R. Doyle et al. · 2022 · The American Journal of Sports Medicine

Background: Debate centering on the management of anterior shoulder instability (ASI) in recent years has led to many randomized controlled trials (RCTs) being published on the topic. The fragility index (FI) has subsequently emerged as a…

View details →DOI: 10.1177/03635465221077268Cited by 13
Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology

PRKCZmethylation is associated with sunlight exposure in a North American but not a Mediterranean population

Stella Aslibekyan, Hassan S. Dashti, Toshiko Tanaka et al. · 2014 · Chronobiology International

Sunlight exposure has been shown to alter DNA methylation patterns across several human cell-types, including T-lymphocytes. Since epigenetic changes establish gene expression profiles, changes in DNA methylation induced by sunlight…

View details →DOI: 10.3109/07420528.2014.944266Cited by 13
Negative / Null Result ReportOpen accessNeuroscience

A large-scale genome-wide gene expression analysis in peripheral blood identifies very few differentially expressed genes related to antidepressant treatment and response in patients with major depressive disorder

Anne Krogh Nøhr, Morten Lindow, Annika Forsingdal et al. · 2021 · Neuropsychopharmacology

A better understanding of the biological factors underlying antidepressant treatment in patients with major depressive disorder (MDD) is needed. We perform gene expression analyses and explore sources of variability in peripheral blood related to antidepressant treatment and treatment response in patients suffering from recurrent MDD at baseline and after 8 weeks of treatment. The study includes 281 patients, which were randomized to 8 weeks of treatment with vortioxetine (N = 184) or placebo (N = 97). To our knowledge, this is the largest dataset including both gene expression in blood and pl

View details →DOI: 10.1038/s41386-021-01002-9Cited by 13
Negative / Null Result ReportOpen accessNeuroscience

Emotion in Chinese Words Could Not Be Extracted in Continuous Flash Suppression

Kaiwen Cheng, Aolin Ding, Lianfang Jiang et al. · 2019 · Frontiers in Human Neuroscience

Previous studies have demonstrated the automatic vigilance effect for faces and pictures and have attributed it to the brain's prioritized unconscious evaluation of early evolutionary stimuli that are critical to survival. Whether this effect exists for evolutionarily more recent stimuli, such as written words, has become the center of much debate. Apparently contradicting results have been reported in different languages, such as Hebrew, English, and Traditional Chinese (TC), with regard to the unconscious processing of emotional words in breaking continuous flash suppression (b-CFS). Our cur

View details →DOI: 10.3389/fnhum.2019.00309Cited by 13
Negative / Null Result ReportOpen accessNeuroscience

Large-scale multi-site study shows no association between musical training and early auditory neural sound encoding

Kelly L. Whiteford, Lucas S. Baltzell, Matt Chiu et al. · 2025 · Nature Communications

Musical training has been reported to be associated with enhanced neural processing of sounds, as measured via the frequency following response (FFR), implying the potential for human subcortical neural plasticity. We conducted a…

View details →DOI: 10.1038/s41467-025-62155-5Cited by 13
Failed Experiment Report

Multiple subtraction using statistically estimated inverse wavelets

Yike Liu, Degang Jin, Xu Chang et al. · 2010 · Geophysics

Abstract Surface-related multiple elimination (SRME) typically consists of two steps: The first step is prediction and the second step is subtraction. In subtraction, it is important to effectively attenuate multiple events and preserve…

View details →DOI: 10.1190/1.3494082Cited by 13
Negative / Null Result ReportOpen accessMathematics

The role of analytical variability in secondary data replications: a replication of Kim et al. (2014)

Christian Bokhove · 2022 · Educational Research and Evaluation

An article by Kim et al. from 2014 examined individual- and school-level variables affecting the information and communication technology (ICT) literacy level of Korean elementary school students, finding differential gender effects. In…

View details →DOI: 10.1080/13803611.2021.2022319Cited by 13
Negative / Null Result ReportOpen accessNeuroscience

Little Support for Discrete Item Limits in Visual Working Memory

Klaus Oberauer · 2022 · Psychological Science

Some theorists argue that working memory is limited to a discrete number of items and that additional items are not encoded at all. Adam et al. (2017) presented evidence supporting this hypothesis: Participants reproduced visual features of up to six items in a self-chosen order. After the third or fourth response, error distributions were indistinguishable from guessing. I present four experiments with young adults (each N = 24) reexamining this finding. Experiment 1 presented items slowly and sequentially. Experiment 2 presented them simultaneously but longer than in the experiments of Adam

View details →DOI: 10.1177/09567976211068045Cited by 13
Negative / Null Result Report

A convolutional neural network-based anthropomorphic model observer for signal-known-statistically and background-known-statistically detection tasks

Minah Han, Jongduk Baek · 2020 · Physics in Medicine & Biology

Abstract The purpose of this study is implementation of an anthropomorphic model observer using a convolutional neural network (CNN) for signal-known-statistically (SKS) and background-known-statistically (BKS) detection tasks. We conduct…

View details →DOI: 10.1088/1361-6560/abbf9dCited by 13
Negative / Null Result ReportOpen accessNeuroscience

Autistic Traits in the Neurotypical Population do not Predict Increased Response Conservativeness in Perceptual Decision Making

Angelo Pirrone, Wen Wen, Sheng Li et al. · 2018 · Perception

Recent research has shown that adults and children with autism spectrum disorders have a more conservative decision criterion in perceptual decision making compared to neurotypical individuals, meaning that autistic participants prioritise…

View details →DOI: 10.1177/0301006618802689Cited by 13
Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology

Genome-wide association study identifies common variants associated with breast cancer in South African Black women

M Hayat, Wenlong Carl Chen, Chantal Babb de Villiers et al. · 2025 · Nature Communications

Abstract Genome-wide association studies (GWAS) have characterized the contribution of common variants to breast cancer (BC) risk in populations of European ancestry, however GWAS have not been reported in resident African populations. This GWAS included 2485 resident African BC cases and 1101 population matched controls. Two risk loci were identified, located between UNC13C and RAB27A on chromosome 15 (rs7181788, p = 1.01 × 10 −08 ) and in USP22 on chromosome 17 (rs899342, p = 4.62 × 10 −08 ). Several genome-wide significant signals were also detected in hormone receptor subtype analysis. The

View details →DOI: 10.1038/s41467-025-58789-0Cited by 13
Negative / Null Result ReportOpen accessBusiness, Management and Accounting

Comparative analysis of family businesses with nonfamily businesses: Empirical evidence from India

Hima Bindu Kota, Ramanjeet Singh · 2016 · Serbian Journal of Management

Family businesses are fundamental to nation building as they contribute towards the GDP of any country and are also major employment creators. Therefore, family business management is an emerging area of academic interest. In this regard, comparison between family and non-family businesses has become an important area of research. The present study analyses the performance of Indian family businesses in comparison to non-family business for firms listed on BSE 500 Index for a period of 11 years from 2005-2015. Any firm with 40% or more promoter or promoter group holding has been identified as

View details →DOI: 10.5937/sjm11-9165Cited by 13
Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance

A new flow-based centrality method for identifying statistically significant centers

Xi Wang, Tao Pei, Ci Song et al. · 2023 · Sustainable Cities and Society

Quantifying the centrality of places and identifying centers constitute the basis for assessing the urban spatial structure, which is essential for sustainable spatial planning. Both the existence and intensity of linkages contribute to…

View details →DOI: 10.1016/j.scs.2023.104984Cited by 13
Negative / Null Result ReportOpen accessHealth Professions

Chemosignalling effects of human tears revisited: Does exposure to female tears decrease males’ perception of female sexual attractiveness?

Asmir Gračanin, Marcel A. L. M. van Assen, Višnja Omrčen et al. · 2016 · Cognition & Emotion

Gelstein et al. reported the results of three experiments suggesting a dampening influence of inhalation of female emotional tears on males' arousal and perception of female sexual attractiveness, specifically in non-sexual situations.…

View details →DOI: 10.1080/02699931.2016.1151402Cited by 13
Negative / Null Result ReportOpen accessComputer Science

Gender and task effects of human – machine communication on trusting a Korean intelligent virtual assistant

Sun Kyong Lee, Hyunjin Park, Seoyoung C. Kim · 2024 · Behaviour and Information Technology

This study investigated the impact of task types (functional vs. social) and the gendered voices (female vs. male) of Siri, an intelligent virtual assistant (IVA), on social presence and trust perceptions toward the IVA.In an online…

View details →DOI: 10.1080/0144929x.2024.2306136Cited by 13
Negative / Null Result ReportOpen accessSocial Sciences

Size, skills, and suffrage: Motivated distortions in perceived formidability of political leaders

Jill E. P. Knapen, Nancy M. Blaker, Thomas V. Pollet · 2017 · PLoS ONE

Research shows that perception of physical size and status are positively associated. The current study was developed to replicate and extend earlier research on height perceptions of political leaders, indicating that supporters perceive their leaders as taller than non-supporters do, and winners are perceived as taller after the elections, while losers are perceived as shorter after the elections (winner/loser effects). Individuals use greater height and strength as indications of greater physical formidability. We hypothesized that in-group leaders' height and strength, but not weight, woul

View details →DOI: 10.1371/journal.pone.0188485Cited by 13
Negative / Null Result ReportOpen accessMedicine

Inhibition of Toll-like receptor 4 and Interleukin-1 receptor prevent SARS-CoV-2 mediated kidney injury

Daigo Nakazawa, Yohei Takeda, Masatoshi Kanda et al. · 2023 · Cell Death Discovery

Acute kidney injury (AKI) is a common and severe complication of the coronavirus disease 2019 (COVID-19). Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) directly affects the glomerular and tubular epithelial cells to induce AKI; however, its pathophysiology remains unclear. Here, we explored the underlying mechanisms and therapeutic targets of renal involvement in COVID-19. We developed an in vitro human kidney cellular model, including immortalized tubular epithelial and endothelial cell lines, demonstrating that SARS-CoV-2 directly triggers cell death. To identify the molecular

View details →DOI: 10.1038/s41420-023-01584-xCited by 13
Negative / Null Result ReportOpen accessMedicine

The intragenic epistatic association of ADD3 with biliary atresia in Southern Han Chinese population

Zhe Wang, Xiaoli Xie, Jinglu Zhao et al. · 2018 · Bioscience Reports

Biliary atresia (BA) is a multifactorial pathogenic disease with possible genetic components. As a member of membrane skeletal proteins in the liver and bile ducts, a haplotype composed by five single nucleotide polymorphisms (SNPs) on adducin 3 (ADD3) has been identified as associated with BA. However, limited study was designed to further elaborate the mutual relationship amongst those replicated SNPs to disease. We selected three susceptibility SNPs in ADD3 and conducted a replication study using 510 BA cases and 1473 controls to evaluate the individual function of the SNPs and further stra

View details →DOI: 10.1042/bsr20171688Cited by 13
Negative / Null Result ReportOpen accessMedicine

Mycophenolic acid pharmacogenomics in kidney transplantation

Fabiana Dalla Vecchia Genvigir, Álvaro Cerda, Thiago Dominguez Crespo Hirata et al. · 2020 · Journal of Translational Genetics and Genomics

Mycophenolic acid (MPA) is a potent antiproliferative drug prescribed to prevent acute rejection in kidney transplantation. MPA reversibly inhibits the enzymes involved in the synthesis of guanosine nucleotides, thus preventing DNA replication of immune cells. Consequently, the repression of both cell and humoral immunity induces renal allograft tolerance. MPA is an effective and safe immunosuppressive drug, but some patients show variability in drug concentration, acute rejection, graft dysfunction, or MPA-related adverse events. Although the pharmacogenomics of immunosuppressive drugs has be

View details →DOI: 10.20517/jtgg.2020.37Cited by 13
Negative / Null Result Report

Content Analysis of YouTube Videos That Demonstrate Panoramic Radiography

Marlene Grillon, Andy Wai Kan Yeung · 2022 · Healthcare

In this digital era, dental students often search for online resources for self-directed learning. YouTube is one of the most commonly sought online platforms for educational or instructional videos. No prior study has examined the…

View details →DOI: 10.3390/healthcare10061093Cited by 13
Negative / Null Result ReportOpen accessMedicine

Urine Exosomal bkv-miR-B1-5p and BK Virus Nephropathy in Kidney Transplant Recipients

Su Woong Jung, Won-Hee Cho, Jung-Woo Seo et al. · 2022 · The Journal of Infectious Diseases

BACKGROUND: Urine exosomal bkv-miR-B1-5p is associated with BK virus (BKV) nephropathy (BKVN); however, its posttransplantation changes and predictability for BKVN have not been determined in kidney transplant recipients (KTRs). METHODS:…

View details →DOI: 10.1093/infdis/jiac440Cited by 13
Negative / Null Result Report

Significant geometry and charge difference between the E 5 4− bare clusters of group 14 Zintl anions and their coordinated form in [E 5 {M(CO) 3 } 2 ] 4− (E = Si, Ge, Sn, Pb; M = Cr, Mo, W) complexes

Yasin Gholiee, Sadegh Salehzadeh, Shiva Khodaveisi · 2019 · New Journal of Chemistry

It is shown that while none of the E 5 n (E = Si, Ge, Sn, Pb; n = 0, 2−, 4−) bare clusters can be stabilized in planar pentagon ( D 5h ) geometry, E 5 4− ions as a five-membered planar ring form stable complexes with two {M(CO) 3 } (M =…

View details →DOI: 10.1039/c9nj00162jCited by 13
Negative / Null Result ReportOpen accessEngineering

Predicting Hourly Residential Energy Consumption using Random Forest and Support Vector Regression : An Analysis of the Impact of Household Clustering on the Performance Accuracy

William Hedén · 2016 · KTH Publication Database DiVA (KTH Royal Institute of Technology)

The recent increase of smart meters in the residential sector has lead to large available datasets. The electricity consumption of individual households can be accessed in close to real time, and allows both the demand and supply side to…

View details →Cited by 13
Failed Experiment Report

A note on Nakano generalized difference sequence space

Awad A. Bakery, Afaf R. Abou Elmatty · 2020 · Advances in Difference Equations

Abstract In this paper, we investigate the necessary conditions on any s -type sequence space to form an operator ideal. As a result, we show that the s -type Nakano generalized difference sequence space X fails to generate an operator…

View details →DOI: 10.1186/s13662-020-03082-1Cited by 13
Negative / Null Result Report

Daily Intake of Lemna minor or Spinach as Vegetable Does Not Show Significant Difference on Health Parameters and Taste Preference

Jurriaan J. Mes, Diederik Esser, Dianne Somhorst et al. · 2022 · Plant Foods for Human Nutrition

Abstract The growing world population will increase the demand for new sustainable foods and ingredients. Here we studied the safety and tolerance of Lemna minor, a new sustainable vegetable crop from the duckweed family. Twenty-four…

View details →DOI: 10.1007/s11130-022-00952-9Cited by 13
Negative / Null Result ReportOpen accessMedicine

Improving patient identification for advanced cardiac imaging through machine learning-integration of clinical and coronary CT angiography data

Jan Walter Benjamins, Ming Wai Yeung, Teemu Maaniitty et al. · 2021 · International Journal of Cardiology

BACKGROUND: Standard computed tomography angiography (CTA) outputs a myriad of interrelated variables in the evaluation of suspected coronary artery disease (CAD). But an important proportion of obstructive lesions does not cause significant myocardial ischemia. Nowadays, machine learning (ML) allows integration of numerous variables through complex interdependencies that optimize classification and prediction at the individual level. We evaluated ML performance in integrating CTA and clinical variables to identify patients that demonstrate myocardial ischemia through PET and those who ultimat

View details →DOI: 10.1016/j.ijcard.2021.04.009Cited by 13
Negative / Null Result ReportOpen accessMedicine

Thyroid Autoimmunity and Behçet’s Disease: Is There a Significant Association?

Filiz Cebeci, Nahide Onsun, Ayşe Pekdemir et al. · 2013 · The Scientific World JOURNAL

BACKGROUND: Behcet's disease (BD) could be regarded as an autoimmune disease in many aspects. Autoimmune thyroid disease (ATD) is frequently accompanied by other various autoimmune diseases. Nevertheless, there is not still enough data showing the association between BD and ATD. In addition, no controlled study is present in the PubMed, which evaluates thyroidal autoimmunity using antithyroid peroxidase antibody in a large series of patients with BD. METHODS: We aimed to investigate the frequency of ATD in patients with BD. The study included 124 patients with BD and 99 age- and sex-matched he

View details →DOI: 10.1155/2013/956837Cited by 13
Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology

Fusing metabolomics data sets with heterogeneous measurement errors

Sandra Waaijenborg, Oksana Korobko, Ko Willems van Dijk et al. · 2018 · PLoS ONE

Combining different metabolomics platforms can contribute significantly to the discovery of complementary processes expressed under different conditions. However, analysing the fused data might be hampered by the difference in their quality. In metabolomics data, one often observes that measurement errors increase with increasing measurement level and that different platforms have different measurement error variance. In this paper we compare three different approaches to correct for the measurement error heterogeneity, by transformation of the raw data, by weighted filtering before modelling

View details →DOI: 10.1371/journal.pone.0195939Cited by 13
Negative / Null Result ReportOpen accessNeuroscience

A Psychometric Comparison of Two Carer Quality of Life Questionnaires in Huntington's Disease: Implications for Neurodegenerative Disorders

Peter Hagell, Stephen S. Smith · 2013 · Journal of Huntington s Disease

BACKGROUND: The carer impact of neurodegenerative disorders such as Huntington's disease (HD) is vast. Attempts to measure carer QoL in neurodegenerative disorders include the three-dimensional (Practical aspects of Caregiving, PC;…

View details →DOI: 10.3233/jhd-130065Cited by 13
Negative / Null Result Report

Host Dark Matter Halos of SDSS Red and Blue Quasars: No Significant Difference in Large-scale Environment

Grayson C. Petter, Ryan C. Hickox, David M. Alexander et al. · 2022 · The Astrophysical Journal

Abstract The observed optical colors of quasars are generally interpreted in one of two frameworks: unified models that attribute the color to the random orientation of the accretion disk along the line of sight, and evolutionary models…

View details →DOI: 10.3847/1538-4357/ac4d31Cited by 13