Therapeutic Potential of Calcium Channel Blockers in Neuropsychiatric, Endocrine and Pain Disorders
Aarish Manzar; Aleksandar Sič; Crystal E. Banh; Nebojša Nick Knežević · 2025 · Cells
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Calcium channel blockers (CCBs), originally developed for cardiovascular indications, have gained attention for their therapeutic potential in neuropsychiatric, endocrine, and pain-related disorders. In neuropsychiatry, nimodipine and isradipine, both L-type CCBs, show mood-stabilizing and neuroprotective effects, with possible benefits in depression, bipolar disorder, and schizophrenia. In endocrinology, verapamil, a non-dihydropyridine L-type blocker, has been associated with the preservation of pancreatic β-cell function and reduced insulin dependence in diabetes. CCBs may also aid in manag
Abstract by Aarish Manzar; Aleksandar Sič; Crystal E. Banh; Nebojša Nick Knežević, Cells (2025) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.3390/cells14141114