Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Raya Kh. Yashooa, Ari Q. Nabi, Shukur Wasman Smail et al. · 2026 · Frontiers in Neurology
CRISPR-Cas genome-editing technologies have emerged as powerful tools for precise DNA and RNA modulation, offering promising therapeutic strategies for neurodegenerative disorders such as Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), and amyotrophic lateral sclerosis (ALS). This review critically evaluates current CRISPR/Cas applications in neurodegeneration, with emphasis on mechanistic insights, therapeutic outcomes, and translational feasibility. Preclinical and early translational studies demonstrate that CRISPR-Cas platforms can correct pathogenic mutation
View details →DOI: 10.3389/fneur.2025.1737468Cited by 13 Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance
Alhasan Osman, Mohd Afjal, Majed Alharthi et al. · 2025 · Humanities and Social Sciences Communications
Abstract This study examines the complex interplay between financial development, natural resources, and renewable energy consumption in Sub-Saharan Africa from 2000 to 2020, highlighting the pivotal role of financial strategies in enhancing sustainable energy practices. Employing an array of analytical techniques, including panel-corrected standard errors (PCSE), fixed effects, random effects models, and panel-fixed quantile regression, we delve into the nuanced relationships among these critical variables. The findings reveal that while natural resources and financial development generally e
View details →DOI: 10.1057/s41599-025-04364-3Cited by 13 Negative / Null Result ReportOpen accessPsychology
Sofience · 2026 · Zenodo (CERN European Organization for Nuclear Research)
SΔϕ-60 introduces the Utilitarian Subject-Splitting Index, USSI, within the Sofience-Δϕ Formalism. The paper examines whether utilitarian calculation merely evaluates the happiness of already-existing majorities and minorities, or whether such calculation can first produce the operational boundary between majority and minority by redistributing Transition Completion Cost, TCC. The document begins with the Sofience Subject Thought Experiment. A person is imagined as capable of detaching and reattaching any part of the body while the detached parts remain alive, neurologically connected, and phy
View details →DOI: 10.5281/zenodo.20077005Cited by 13 Negative / Null Result ReportOpen accessMedicine
Timo F. W. Soeterik, Joris G. Heetman, Rick Hermsen et al. · 2024 · European Urology Oncology
BACKGROUND AND OBJECTIVE: The role of prostate-specific membrane antigen (PSMA)-based positron emission tomography (PET)/computed tomography (CT) in addition to magnetic resonance imaging (MRI) for local staging of prostate cancer (PC) has been poorly addressed so far. Our aim was to assess the diagnostic accuracy of PSMA PET/CT and MRI, alone and combined, for detection of extraprostatic extension (EPE) and seminal vesicle invasion (SVI) in PC. METHODS: We conducted a multicenter retrospective study evaluating patients undergoing PSMA PET/CT and MRI before radical prostatectomy. The sensitivi
View details →DOI: 10.1016/j.euo.2024.11.002Cited by 13 Negative / Null Result ReportOpen accessNeuroscience
Shao-Chin Hung, Aaron R. Seitz · 2011 · PLoS ONE
Consolidation, a process that stabilizes memory trace after initial acquisition, has been studied for over a century. A number of studies have shown that a skill or memory must be consolidated after acquisition so that it becomes resistant to interference from new information. Previous research found that training on a peripheral 3-dot hyperacuity task could retrogradely interfere with earlier training on the same task but with a mirrored stimulus configuration. However, a recent study failed to replicate this finding. Here we address the controversy by replicating both patterns of results, ho
View details →DOI: 10.1371/journal.pone.0024556Cited by 13 Negative / Null Result ReportOpen accessMaterials Science
Wenwen Zhang, Qilin Wang, Wei Yi et al. · 2026 · Biomolecules
To overcome the limitations of traditional motion sickness medications—slow onset of action, short duration of efficacy, and poor patient compliance—this study employed coaxial electrospinning technology. Poly(lactic acid) (PLA) and polyvinylpyrrolidone K90 (PVP K90) were used as composite carrier materials. The sheath layer is composed of highly hydrophilic PVP K90, loaded with the antihistamine diphenhydramine (DPH). The core layer, composed of biodegradable PLA with excellent sustained-release properties, carries the anticholinergic drug scopolamine hydrobromide (SH). This core–sheath nanos
View details →DOI: 10.3390/biom16030363Cited by 13 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Ignacio J. Melero‐Jiménez, Yael Sorokin, Ami Merlin et al. · 2025 · Nature Communications
Populations facing lethal environmental change can escape extinction through rapid genetic adaptation, a process known as evolutionary rescue. Despite extensive study, evolutionary rescue is largely unexplored in mutualistic communities, where it is likely constrained by the less adaptable partner. Here, we explored empirically the likelihood, population dynamics, and genetic mechanisms underpinning evolutionary rescue in an obligate mutualism involving cross-feeding of amino acids between auxotrophic Escherichia coli strains. We found that over 80% of populations overcame a severe decline whe
View details →DOI: 10.1038/s41467-025-58742-1Cited by 13 Negative / Null Result ReportOpen accessMedicine
Ulla Lång, Johanna Metsälä, Hugh Ramsay et al. · 2025 · American Journal of Psychiatry
OBJECTIVE: As many as half of individuals who develop psychosis had attended child and adolescent psychiatric services at some stage in childhood, highlighting substantial opportunities for prevention within these services if an effective preventive intervention were identified. The authors hypothesized that adolescent psychiatric patients exposed to doxycycline, an antibiotic with putative neuroprotective properties, would have a lower risk of developing schizophrenia. METHODS: This was an emulated target trial using nationwide Finnish health register data on all individuals born between 1987
View details →DOI: 10.1176/appi.ajp.20240958Cited by 13 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Burooj Ghani, Vincent J. Kalkman, Bob Planqué et al. · 2025 · Scientific Reports
Animal sounds can be recognised automatically by machine learning, and this has an important role to play in biodiversity monitoring. Yet despite increasingly impressive capabilities, bioacoustic species classifiers still exhibit imbalanced performance across species and habitats, especially in complex soundscapes. In this study, we explore the effectiveness of transfer learning in large-scale bird sound classification across various conditions, including single- and multi-label scenarios, and across different model architectures such as CNNs and Transformers. Our experiments demonstrate that
View details →DOI: 10.1038/s41598-025-00996-2Cited by 13 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Raissa Relator, Aika Terada, Jun Sese · 2018 · BMC Medical Genomics
BACKGROUND: Survival analysis methods have been widely applied in different areas of health and medicine, spanning over varying events of interest and target diseases. They can be utilized to provide relationships between the survival time of individuals and factors of interest, rendering them useful in searching for biomarkers in diseases such as cancer. However, some disease progression can be very unpredictable because the conventional approaches have failed to consider multiple-marker interactions. An exponential increase in the number of candidate markers requires large correction factor
View details →DOI: 10.1186/s12920-018-0346-xCited by 13 Negative / Null Result ReportOpen accessMathematics
Changye Wu, Pierre Pudlo, Christian P. Robert et al. · 2026 · Statistics and Computing
stands for empirical, leverages importance sampling to construct an empirical distribution on discretization parameters, thereby eliminating the need for manual burn-in diagnostics and online adaptation. The proposal distribution used in the calibration stage is obtained via a Population Monte Carlo scheme with tempering and relies on flexible parametric variational families such as normalizing flows. Once the calibration stage complete, the resulting algorithm defines a homogeneous Markov chain via a mixture of HMC kernels with a fixed mixing distribution, and hence preserves the target distr
View details →DOI: 10.1007/s11222-026-10972-zCited by 13 Negative / Null Result ReportOpen accessEarth and Planetary Sciences
Xavier A. Jenkins, Roger Benson, David P. Ford et al. · 2025 · Peer Community Journal
Living reptiles include more than 20,000 species with disparate ecologies. Direct anatomical evidence from Neodiapsida, which includes the reptile crown-group and its closest extinct relatives, shows that this diversity originates from a single common ancestor that lived over 255 million years ago in the Paleozoic. However, the evolutionary assembly of crown reptile traits is poorly understood due to the lack of anatomically close relatives of Neodiapsida. We present a substantially revised phylogenetic hypothesis, informed by new anatomical data from high-resolution synchrotron tomography of
View details →DOI: 10.24072/pcjournal.620Cited by 13 Negative / Null Result ReportBiochemistry, Genetics and Molecular Biology
Luca‐Cesare Blawitzki, Nina Bartels, Lorand Bonda et al. · 2024 · Biomacromolecules
The glycocalyx, a complex carbohydrate layer on cell surfaces, plays a crucial role in various biological processes. Understanding native glycocalyces' complexity is challenging due to their intricate and dynamic nature. Simplified mimics…
View details →DOI: 10.1021/acs.biomac.4c00646Cited by 13 Negative / Null Result ReportPsychology
Olga Perepelkina, Maria Boboleva, Галина Арина et al. · 2017 · Multisensory Research
The aim of the study was to investigate how emotion information processing factors, such as alexithymia and emotional intelligence, modulate body ownership and influence multisensory integration during the ‘rubber hand illusion’ (RHI)…
View details →DOI: 10.1163/22134808-00002577Cited by 13 Negative / Null Result Report
Fabio Bovenga, Guido Pasquariello, Alberto Refice · 2021 · Remote Sensing
Current multi-temporal interferometric Synthetic Aperture Radar (MTInSAR) datasets cover long time periods with regular temporal sampling. This allows high-rate and non-linear trends to be observed, which typically characterize pre-failure…
View details →DOI: 10.3390/rs13122302Cited by 13 Negative / Null Result ReportSocial Sciences
Branden B. Johnson, Marcus Mayorga · 2020 · Human and Ecological Risk Assessment An International Journal
Cross-sectional surveys, despite their value, are unable to probe dynamics of risk perceptions over time. An earlier longitudinal panel study of Americans’ views on Ebola risk inspired this partial replication on Americans’ views of Zika…
View details →DOI: 10.1080/10807039.2020.1820852Cited by 13 Negative / Null Result ReportOpen accessEngineering
Khuzairi Masrakin, Hasliza A. Rahim, Ping Jack Soh et al. · 2019 · IEEE Access
This paper presents the assessment of short-term wireless body area network (WBAN) exposure, which is operated at the industrial, scientific, and medical (ISM) band (2.45 GHz) in the vicinity of the human body. The experiment utilizes two popular textile antenna topologies, a planar monopole and a patch antenna as the radiating sources. The objective of this experiment is to investigate whether the exposure from WBAN may influence the physiological parameters (body temperature, blood pressure, and heart rate) and the well-being of the wearer. Counter-balanced, crossover, and the single-blind m
View details →DOI: 10.1109/access.2019.2928343Cited by 13 Negative / Null Result ReportOpen accessEnvironmental Science
Barbara Smith, Dan Carpenter, J. M. Holland et al. · 2023 · Journal of Applied Ecology
Abstract Lowland heath is a priority habitat for conservation, nowadays largely managed for biodiversity. Historically, prescribed burning has been the principal management tool, but there are increasing calls to substitute burning with cutting to improve biodiversity outcomes. However, poor understanding of potential impacts compromises decision making. Our study was carried out in the New Forest National Park, the largest area of lowland heath in Europe. Using a multi‐trophic approach, we compared the ecological impact of prescribed burning with two types of vegetation cutting (swiping and b
View details →DOI: 10.1111/1365-2664.14471Cited by 13 Negative / Null Result ReportOpen accessSocial Sciences
Penny Holding, Amina Abubakar, Elizabeth Obiero et al. · 2011
The aim of this paper is to describe the adaptations made to the Infant-Toddler version of the Home Observation Measure of the Environment for use in a low income Kenyan population. A total of 425 (214 girls) children aged 6-35 months were…
View details →DOI: 10.4087/ngnw9101Cited by 13 Negative / Null Result ReportOpen accessNeuroscience
Thomas Cope, Manon Grube, Arnab Mandal et al. · 2014 · Neuropsychologia
Bilateral, high-frequency stimulation of the basal ganglia (STN-DBS) is in widespread use for the treatment of the motor symptoms of Parkinson׳s disease (PD). We present here the first psychophysical investigation of the effect of STN-DBS upon perceptual timing in the hundreds of milliseconds range, with both duration-based (absolute) and beat-based (relative) tasks; 13 patients with PD were assessed with their STN-DBS 'on', 'off', and then 'on' again. Paired parametric analyses revealed no statistically significant differences for any task according to DBS status. We demonstrate, from the exa
View details →DOI: 10.1016/j.neuropsychologia.2014.02.021Cited by 13 Null DatasetOpen accessNeuroscience
Cyril Pernet, Christopher R. Madan · 2019 · European Journal of Neuroscience
Tomographic imaging (i.e. magnetic resonance imaging [MRI], positron emission tomography [PET], X-ray computed tomography [CT]) offers a unique window in understanding structure-function relationships in the living brain. Nowadays, it is standard practice to acquire entire brain volumes and perform statistical analyses at each voxel, an approach known as statistical parametric mapping (Friston, Frith, Liddle, & Frackowiak, 1991). Because it is impossible to report the statistical results in every voxel, summary tables and figures are of importance. The choice made by authors to create such fig
View details →DOI: 10.1111/ejn.14430Cited by 13 Negative / Null Result ReportOpen accessImmunology and Microbiology
Alex B. Kleinpeter, Donna L. Mallery, Nadine Renner et al. · 2024 · Nature Communications
The HIV-1 capsid is composed of capsid (CA) protein hexamers and pentamers (capsomers) that contain a central pore hypothesised to regulate capsid assembly and facilitate nucleotide import early during post-infection. These pore functions are mediated by two positively charged rings created by CA Arg-18 (R18) and Lys-25 (K25). Here we describe the forced evolution of viruses containing mutations in R18 and K25. Whilst R18 mutants fail to replicate, K25A viruses acquire compensating mutations that restore nearly wild-type replication fitness. These compensating mutations, which rescue reverse t
View details →DOI: 10.1038/s41467-024-51971-wCited by 13 Negative / Null Result ReportMedicine
Jing Luo, Zheng Dong, Hui Xie et al. · 2022 · Liver International
BACKGROUND & AIMS: Management of elderly patients with hepatocellular carcinoma (HCC) has become a major concern. Some data suggest that cryoablation improves the outcomes of elderly patients with HCC, but its efficacy and safety remain…
View details →DOI: 10.1111/liv.15169Cited by 13 Failed Experiment ReportPhysics and Astronomy
Prabir Kumar Haldar, Sanjib Kumar Manna · 2011 · Chinese Physics Letters
We present an analysis of ring-like and jet-like events in terms of factorial correlations and oscillatory multiplicity moments of 32S-Ag/Br interactions at 200 A GeV. The investigation reveals that the correlated moments increase with…
View details →DOI: 10.1088/0256-307x/28/1/012502Cited by 13 Replication FailureOpen accessMedicine
Yitao Zheng, Yan‐Jun Xiang, Hongqi Shi et al. · 2024 · Journal of Hepatocellular Carcinoma
Purpose: Combining transarterial chemoembolization (TACE) with systemic therapy has shown significant efficacy for intermediate-stage hepatocellular carcinoma (HCC) patients. This study aimed to validate the therapeutic efficacy of TACE…
View details →DOI: 10.2147/jhc.s461630Cited by 13 Negative / Null Result ReportOpen accessPsychology
Hanno Andreas Ohmann, Niclas Kuper, Jan Wacker · 2022 · PLoS ONE
The Effort-Expenditure for Rewards Task (EEfRT) has gained validity evidence from several studies. However, various modifications have been applied to the original version, which have never been compared systematically. In Study 1, we tested 120 healthy participants to directly compare two versions of the EEfRT. In Study 2, we tested a larger sample of 394 healthy participants to further examine the original EEfRT. We replicated the split-half reliability of both task versions. However, self-reported personality traits (e.g., trait BAS) correlated with only some task performance parameters in
View details →DOI: 10.1371/journal.pone.0262902Cited by 13 Negative / Null Result ReportOpen accessNeuroscience
Ian C. Fiebelkorn · 2021 · European Journal of Neuroscience
Recent research suggests that environmental sampling is a fundamentally rhythmic process (Benedetto et al., 2019; Fiebelkorn & Kastner, 2019; Schroeder et al., 2010). In primates, both attention-related sampling and exploratory eye…
View details →DOI: 10.1111/ejn.15322Cited by 13 Negative / Null Result Report
Martin S. Davey, Eoghan T. Hurley, Tom R. Doyle et al. · 2022 · The American Journal of Sports Medicine
Background: Debate centering on the management of anterior shoulder instability (ASI) in recent years has led to many randomized controlled trials (RCTs) being published on the topic. The fragility index (FI) has subsequently emerged as a…
View details →DOI: 10.1177/03635465221077268Cited by 13 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Stella Aslibekyan, Hassan S. Dashti, Toshiko Tanaka et al. · 2014 · Chronobiology International
Sunlight exposure has been shown to alter DNA methylation patterns across several human cell-types, including T-lymphocytes. Since epigenetic changes establish gene expression profiles, changes in DNA methylation induced by sunlight…
View details →DOI: 10.3109/07420528.2014.944266Cited by 13 Negative / Null Result ReportOpen accessNeuroscience
Anne Krogh Nøhr, Morten Lindow, Annika Forsingdal et al. · 2021 · Neuropsychopharmacology
A better understanding of the biological factors underlying antidepressant treatment in patients with major depressive disorder (MDD) is needed. We perform gene expression analyses and explore sources of variability in peripheral blood related to antidepressant treatment and treatment response in patients suffering from recurrent MDD at baseline and after 8 weeks of treatment. The study includes 281 patients, which were randomized to 8 weeks of treatment with vortioxetine (N = 184) or placebo (N = 97). To our knowledge, this is the largest dataset including both gene expression in blood and pl
View details →DOI: 10.1038/s41386-021-01002-9Cited by 13 