Negative / Null Result ReportOpen accessNeuroscience
Hye-Won Yang, Danyeong Kim, YoungSoon Yang et al. · 2025 · International Journal of Molecular Sciences
TREM2 (triggering receptor expressed on myeloid cells 2) is a membrane-bound receptor primarily expressed on microglia in the central nervous system (CNS). TREM2 plays a crucial role in regulating immune responses, phagocytosis, lipid metabolism, and inflammation. Mutations in the TREM2 gene have been linked to various neurodegenerative diseases, including Alzheimer’s disease (AD), frontotemporal dementia (FTD), Parkinson’s disease (PD), and Nasu–Hakola disease (NHD). These mutations are suggested to impair microglial activation and reduce the ability to clear amyloid aggregates, leading to ex
View details →DOI: 10.3390/ijms26157057Cited by 19 Negative / Null Result ReportOpen accessPhysics and Astronomy
M. Bernert, T.O.S.J. Bosman, T. Lunt et al. · 2025 · Nuclear Materials and Energy
Power exhaust is a crucial issue for future fusion reactors. Divertor detachment and the required power dissipation fractions of about 95% are foreseen to be achieved by impurity seeding. In a tokamak, at high seeding levels the radiation often concentrates in a small region inside the confined plasma near the X-point. In early observations the so-called X-point radiator (XPR) often led to back-transitions to L-mode or disruptions. In metal tokamaks or with higher available heating power, these regimes can be stabilized and are now established on AUG, JET, TCV, KSTAR and WEST. The XPR is a col
View details →DOI: 10.1016/j.nme.2025.101916Cited by 19 Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance
Ihsen Abid · 2025 · Engineering Technology & Applied Science Research
Saudi Arabia, as one of the world’s leading oil producers, faces critical challenges in transitioning to sustainable economic growth. The heavy reliance on oil exports, coupled with rapid urbanization and environmental degradation, underscores the urgent need for green growth strategies tailored to the Kingdom’s unique socioeconomic and environmental context. This study aims to investigate the factors influencing the Green Growth Index (GGI), which measures sustainable economic growth, and analyze the short-term and long-term relationships between key variables such as environmental technology
View details →DOI: 10.48084/etasr.9836Cited by 19 Negative / Null Result ReportOpen accessMedicine
Ömer Aydın, Enis Karaarslan, Fatih Safa Erenay et al. · 2026 · Turkish Journal of Engineering
DeepSeek v3, developed in China, was released in December 2024, followed by Alibaba’s Qwen 2.5 Max in January 2025 and Qwen3 235B in April 2025. These free and open-source models offer significant potential for academic writing and content…
View details →DOI: 10.31127/tuje.1838765Cited by 19 Negative / Null Result ReportOpen accessPsychology
Terence J. Lyons, Merle Spriggs, Leevi Kerkelä et al. · 2026 · Nature Communications
Psychedelics have robust effects on acute brain function and long-term behavior but whether they also cause enduring functional and anatomical brain changes is largely unknown. In an exploratory, placebo-controlled, within-subjects, electroencephalography (EEG), and magnetic resonance imaging (MRI) study in 28 healthy, entirely psychedelic-naive participants, anatomical and functional brain changes are detected from one-hour to one-month after a single high-dose (25 mg) of psilocybin. Increases in cognitive flexibility, psychological insight, and well-being are seen at one-month. Diffusion ten
View details →DOI: 10.1038/s41467-026-71962-3Cited by 19 Negative / Null Result ReportOpen accessPsychology
Emilou Noser, Jessica Schoch, Ulrike Ehlert · 2018 · PLoS ONE
Research has indicated that men's facial width-to-height ratio (fWHR) is part of an evolved system of social dominance, aggression, and power. fWHR has been linked to antisocial behavior, measured by self-reported aggression, but recent studies have failed to replicate this finding. To overcome these inconsistencies, influencing factors such as social status have to be taken into account in order to explain the relationship between fWHR and aggression. In particular, income has been shown to be an important influencing factor in this relationship. Furthermore, previous findings suggested that
View details →DOI: 10.1371/journal.pone.0207333Cited by 19 Negative / Null Result ReportOpen accessComputer Science
Julio Cesar Munguía Mondragón, Paula Branco, Guy-Vincent Jourdan et al. · 2025 · Applied Intelligence
Globally, cyberattacks are growing and mutating each month. Intelligent Intrusion Network Detection Systems are developed to analyze and detect anomalous traffic to face these threats. A way to address this is by using network flows, an…
View details →DOI: 10.1007/s10489-025-06422-4Cited by 19 Negative / Null Result ReportOpen accessPsychology
Joyce S. Pang, Hiram Ring, Kate Y Huang et al. · 2026 · Journal of Personality Assessment
Implicit motives have a clear relation to observed behavior but are time-consuming to measure. Automating the content coding of implicit motives has been a pursuit since the 1960s, but has not been widely adopted due to limitations with…
View details →DOI: 10.1080/00223891.2026.2630930Cited by 19 Negative / Null Result ReportOpen accessPhysics and Astronomy
Joop Schaye, Evgenii Chaikin, Matthieu Schaller et al. · 2026 · Monthly Notices of the Royal Astronomical Society
ABSTRACT We present the COLIBRE galaxy formation model and the COLIBRE suite of cosmological hydrodynamical simulations. COLIBRE includes new models for radiative cooling, dust grains, star formation, stellar mass loss, turbulent diffusion, pre-supernova stellar feedback, supernova feedback, supermassive black holes, and active galactic nucleus (AGN) feedback. The multiphase interstellar medium is explicitly modelled without a pressure floor. Hydrogen and helium are tracked in non-equilibrium, with their contributions to the free electron density included in metal-line cooling calculations. Th
View details →DOI: 10.1093/mnras/stag375Cited by 19 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Luiz Carlos Vieira, Morgan L. Handojo, Claus O. Wilke · 2025 · Scientific Reports
Protein language models (pLMs) can offer deep insights into evolutionary and structural properties of proteins. While larger models, such as the 15 billion parameter model ESM-2, promise to capture more complex patterns in sequence space, they also present practical challenges due to their high dimensionality and high computational cost. We systematically evaluated the performance of various ESM-style models across multiple biological datasets to assess the impact of model size on transfer learning via feature extraction. Surprisingly, we found that larger models do not necessarily outperform
View details →DOI: 10.1038/s41598-025-05674-xCited by 19 Negative / Null Result ReportOpen accessSocial Sciences
Sara Vitoria-Estruch, Ángel Romero‐Martínez, Marisol Lila et al. · 2018 · International Journal of Environmental Research and Public Health
Proactively aggressive individuals have been shown to present a different pattern of autonomic nervous system (ANS) dysregulation from that of individuals characterized by reactive violence. Although attempts have been made to classify intimate partner violence (IPV) perpetrators based on ANS reactivity to acute stress, subsequent studies have failed to replicate this classification. Notably, the proposed classification neglected the role of chronic alcohol abuse in ANS dysregulation and the fact that this dysregulation entails an abnormal stress response. The aim of the present study was to a
View details →DOI: 10.3390/ijerph15122729Cited by 19 Negative / Null Result Report
Jacques Demongeot, Hervé Seligmann · 2020 · Scientific Reports
Abstract Ribosomal RNAs are complex structures that presumably evolved by tRNA accretions. Statistical properties of tRNA secondary structures correlate with genetic code integration orders of their cognate amino acids. Ribosomal RNA…
View details →DOI: 10.1038/s41598-020-64627-8Cited by 19 Negative / Null Result ReportMedicine
Haruo Ohtani, Hiroyasu Ishida, Yuka Ito et al. · 2011 · Pathology International
Autoimmune pancreatitis (AIP) (also called IgG4-related sclerosing pancreatitis (IgG4-SP)) and IgG4-related sclerosing cholangitis (IgG4-SC) are frequently associated with each other. It is generally believed that association of these…
View details →DOI: 10.1111/j.1440-1827.2011.02684.xCited by 19 Negative / Null Result Report
Naiyue Hu, Chenghang Du, Wanqing Zhang et al. · 2022 · Agronomy
Grain yield and quality of wheat are both important components for food security. Great effort has been made in the genetic improvement of wheat grain yield in China. However, wheat grain quality (i.e., protein concentration and protein…
View details →DOI: 10.3390/agronomy12092109Cited by 19 Negative / Null Result ReportOpen accessNeuroscience
Amit Walia, Matthew Shew, Jordan Varghese et al. · 2023 · JAMA Otolaryngology–Head & Neck Surgery
Importance: Cochlear implantation produces remarkable results in postlingual deafness, although auditory outcomes vary. Electrocochleography (ECochG) has emerged as a valuable tool for assessing the cochlear-neural substrate and evaluating…
View details →DOI: 10.1001/jamaoto.2023.2988Cited by 19 Negative / Null Result ReportOpen accessMedicine
Stefano Fiorucci, Ginevra Urbani, Eleonora Distrutti et al. · 2025 · Pharmaceuticals
The Farnesoid-X-receptor (FXR) is a bile sensor involved in the regulation of bile acid homeostasis, fibrosis, inflammation, and metabolism. Obeticholic acid (OCA), a semisynthetic derivative of chenodeoxycholic acid (CDCA), initially named 6-ethyl-CDCA or INT-747, is the first in a class of FXR ligands that have been approved for clinical use for the treatment of patients with primary biliary cholangitis (PBC) who are unresponsive or intolerant to ursodeoxycholic acid. In this narrative review, we will examine the current status and future perspective of clinical use of OCA. Based on results
View details →DOI: 10.3390/ph18091424Cited by 19 Failed Experiment ReportOpen accessMedicine
Harm A.W.M. Tiddens, Eleni‐Rosalina Andrinopoulou, Joe McIntosh et al. · 2020 · PLoS ONE
A phase 3 randomized double blind controlled, trial in 238 people with cystic fibrosis (CF) and at least one nonsense mutation (nmCF) investigated the effect of ataluren on FEV1. The study was of 48 weeks duration and failed to meet its primary endpoint. Unexpectedly, while FEV1 declined, chest computed tomography (CT) scores using the Brody-II score as secondary outcome measures did not show progression in the placebo group. Based on this observation it was concluded that the role of CT scans in CF randomized clinical trials was limited. However, more sensitive scoring systems were developed
View details →DOI: 10.1371/journal.pone.0240898Cited by 19 Negative / Null Result ReportSocial Sciences
Kitae Sohn, Illoong Kwon · 2016 · The Singapore Economic Review
Trust was found to promote entrepreneurship in the US. We investigated whether this was true in a developing country, Indonesia. We failed to replicate this; this failure was true whether trust was estimated at the individual or community…
View details →DOI: 10.1142/s0217590816500144Cited by 19 Negative / Null Result ReportOpen accessSocial Sciences
Richard Fendler, Craig Ruff, Milind Shrikhande · 2018 · Online Learning
Much of the e-education literature suggests that there is no significant difference in aggregate student learning outcomes between online and face-to-face instruction. In this study, we develop a model that forecasts the grade that individual students would have most likely earned in the alternate class setting. Students for whom the difference between the actual grade received in one class format (for example, online) and the forecasted grade in the other class setting (for example, face-to-face) is one full letter grade or higher are called “jumpers.” Our findings indicate that jumpers are n
View details →DOI: 10.24059/olj.v22i1.887Cited by 19 Negative / Null Result ReportOpen accessMedicine
Caterina Peraldo‐Neia, Giuliana Cavalloni, Elisabetta Fenocchio et al. · 2018 · PLoS ONE
The association of anti-EGFR to gemcitabine and oxaliplatin (GEMOX) chemotherapy did not improve survival in biliary tract carcinoma (BTC) patients. Multiple mechanisms might be involved in the resistance to anti-EGFR. Here, we explored the mutation profile of EGFR extracellular domain (ECD), of tyrosine kinase domain (TKD), and its amplification status. EGFR mutational status of exons 12, 18-21 was analyzed in 57 tumors by Sanger sequencing. EGFR amplification was evaluated in 37 tumors by Fluorescent In Situ Hybridization (FISH). Kaplan-Meier curves were calculated using the log-rank test. S
View details →DOI: 10.1371/journal.pone.0191593Cited by 19 Negative / Null Result ReportOpen accessImmunology and Microbiology
Soumik Barman, Francesco Borriello, Byron Brook et al. · 2022 · ACS Chemical Biology
) cells, and germinal center (GC) B cells along with the IgG2c-skewed humoral response in vivo. Dual-loaded cGAMP/CL075-PSs did not outperform admixed cGAMP-PS and CL075-PS in vivo. These data validate an optimally designed adjuvantation…
View details →DOI: 10.1021/acschembio.2c00497Cited by 19 Negative / Null Result ReportOpen accessNeuroscience
Onurcan Yılmaz, Hasan G. Bahçekapılı · 2015 · PLoS ONE
Scientific and religious thinking compete with each other on several levels. For example, activating one generally weakens the other. Since priming religion is known to increase moral behaviour and moral sensitivity, priming science might be expected to have the opposite effect. However, it was recently demonstrated that, on the contrary, science priming increases moral sensitivity as well. The present set of studies sought to replicate this effect and test two explanations for it. Study 1 used a sentence unscrambling task for implicitly priming the concept of science but failed to replicate i
View details →DOI: 10.1371/journal.pone.0137499Cited by 18 Negative / Null Result ReportOpen accessArts and Humanities
Bianca Brown, Botagoz Tusmagambet, Valentino Rahming et al. · 2023 · Applied Psycholinguistics
Abstract This study conceptually replicated and extended Reid, Trofimovich, and O’Brien (2019), who found that native English speakers could be biased positively (or negatively) relative to a control condition in terms of how they rate non-native English speech. Our internet-based study failed to replicate Reid et al. across a wider population sample of “native” speakers ( n = 189). Listeners did not change how they rated non-native English speech after social bias orientations and performed similarly across all five measures of speech and across age and race (Asian, Black, and Caucasian). We
View details →DOI: 10.1017/s0142716423000127Cited by 18 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Andrea J. Savio, Mathieu Lemire, Miralem Mrkonjic et al. · 2012 · PLoS ONE
Single nucleotide polymorphisms (SNPs) are the most common form of genetic variation. We previously demonstrated that SNPs (rs1800734, rs749072, and rs13098279) in the MLH1 gene region are associated with MLH1 promoter island methylation, loss of MLH1 protein expression, and microsatellite instability (MSI) in colorectal cancer (CRC) patients. Recent studies have identified less CpG-dense "shore" regions flanking many CpG islands. These shores often exhibit distinct methylation profiles between different tissues and matched normal versus tumor cells of patients. To date, most epigenetic studie
View details →DOI: 10.1371/journal.pone.0051531Cited by 18 Negative / Null Result Report
RuoLi Chen, Mohammad Alkataan Ahmed, Nicholas Robert Forsyth · 2022 · Biomolecules
Cells respond to reduced oxygen availability predominately by activation of the hypoxia-inducible factor (HIF) pathway. HIF activation upregulates hundreds of genes that help cells survive in the reduced oxygen environment. The aim of this…
View details →DOI: 10.3390/biom12040541Cited by 18 Negative / Null Result Report
Aidan E. Gilchrist, Brendan A. C. Harley · 2022 · Advanced Healthcare Materials
Abstract Hematopoietic stem cells are the progenitors of the blood and immune system and represent the most widely used regenerative therapy. However, their rarity and limited donor base necessitate the design of ex vivo systems that…
View details →DOI: 10.1002/adhm.202102130Cited by 18 Negative / Null Result Report
Margarida Arrobas, João V. Decker, Bruna L. Feix et al. · 2021 · Soil Use and Management
Abstract Soil conditioners, such as biochar and zeolites, may play an important role in agriculture if they increase nutrient use efficiency, in particular, that of phosphorus (P), due to the depletion of phosphate rocks from which…
View details →DOI: 10.1111/sum.12704Cited by 18 Negative / Null Result Report
Chris M. Smith-Martin, Steven Jansen, Timothy J. Brodribb et al. · 2022 · Frontiers in Forests and Global Change
One of the most prominent changes in neotropical forests has been the increase in abundance and size of lianas. Studies suggest that lianas have more acquisitive strategies than trees, which could allow them to take advantage of water more…
View details →DOI: 10.3389/ffgc.2022.834891Cited by 18 Negative / Null Result Report
Kristina B Beck, Ben C Sheldon, Josh A Firth · 2023 · eLife
The emergence and spread of novel behaviours via social learning can lead to rapid population-level changes whereby the social connections between individuals shape information flow. However, behaviours can spread via different mechanisms…
View details →DOI: 10.7554/elife.85703Cited by 18 Negative / Null Result ReportOpen accessSocial Sciences
Chloe Wittenberg, Ziv Epstein, Gabrielle Péloquin-Skulski et al. · 2025 · PNAS Nexus
Abstract Recent advancements in generative AI have raised widespread concern about the use of this technology to spread audio and visual misinformation. In response, there has been a major push among policymakers and technology companies to label AI-generated media appearing online. It remains unclear, however, what types of labels are most effective for this purpose. Here, we evaluate two (potentially complementary) strategies for labeling AI-generated content online: (i) a process-based approach, aimed at clarifying how content was made and (ii) a harm-based approach, aimed at highlighting c
View details →DOI: 10.1093/pnasnexus/pgaf170Cited by 18 