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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

21245 results · page 116 of 709

Negative / Null Result ReportOpen accessDentistry

Smear layer deproteinization with NaOCl and HOCl: Do application/wash-out times affect dentin bonding of one-step self-etch adhesives?

Kittisak Sanon, Takashi Hatayama, Antonín Tichý et al. · 2022 · Dental Materials Journal

This study investigated the influence of application/wash-out times of sodium hypochlorite (NaOCl) and hypochlorous acid (HOCl) on dentin bond strength of one-step self-etch adhesives (1-SEAs). Human coronal dentin discs with a…

View details →DOI: 10.4012/dmj.2021-208Cited by 18
Negative / Null Result Report

Using Bibliometrics to Demonstrate the Value of Library Journal Collections

Christopher W. Belter, Neal K. Kaske · 2016 · College & Research Libraries

Although cited reference studies are common in the library and information science literature, they are rarely performed in nonacademic institutions or in the atmospheric and oceanic sciences. In this paper, we analyze more than 400,000…

View details →DOI: 10.5860/crl.77.4.410Cited by 18
Negative / Null Result Report

Decreasing but still significant facilitation effect of cold-season macrophytes on wetlands purification function during cold winter

Xiangxu Zou, Hui Zhang, Jie Zuo et al. · 2016 · Scientific Reports

Abstract To identify the facilitation effect of a cool-season aquatic macrophyte (FE am ) for use in effluent purification via constructed floating wetlands (CFWs) and to determine the possible pathways used during a winter period with an…

View details →DOI: 10.1038/srep27011Cited by 18
Negative / Null Result ReportOpen accessEngineering

On the co-rotational method for geometrically nonlinear topology optimization

Peter D. Dunning · 2020 · Structural and Multidisciplinary Optimization

Abstract This paper investigates the application of the co-rotational method to solve geometrically nonlinear topology optimization problems. The main benefit of this approach is that the tangent stiffness matrix is naturally positive definite, which avoids some numerical issues encountered when using other approaches. Three different methods for constructing the tangent stiffness matrix are investigated: a simplified method, where the linear elastic stiffness matrix is simply rotated; the consistent method, where the tangent stiffness is derived by differentiating residual forces by displacem

View details →DOI: 10.1007/s00158-020-02605-4Cited by 18
Negative / Null Result Report

Did advice on the prescription of sodium valproate reduce prescriptions to women? An observational study in three European countries between 2007 and 2016

Rachel Charlton, Christine Damase‐Michel, Caroline Hurault‐Delarue et al. · 2019 · Pharmacoepidemiology and Drug Safety

Abstract Objectives In November 2014, the CMDh (a regulatory body representing EU Member States) advised doctors not to prescribe sodium valproate for epilepsy or bipolar disorder in preg nant women, in women who can become pregnant, or in…

View details →DOI: 10.1002/pds.4881Cited by 18
Negative / Null Result ReportOpen accessAgricultural and Biological Sciences

Refining Pheromone Lures for the Invasive Halyomorpha halys (Hemiptera: Pentatomidae) Through Collaborative Trials in the United States and Europe

Tracy Leskey, Heather Andrews, Angelika Bády et al. · 2021 · Journal of Economic Entomology

Brown marmorated stink bug, Halyomorpha halys, is native to Asia and has invaded North America and Europe inflicting serious agricultural damage to specialty and row crops. Tools to monitor the spread of H. halys include traps baited with…

View details →DOI: 10.1093/jee/toab088Cited by 18
Negative / Null Result Report

Single and repeated intra‐articular injections in the tarsocrural joint with allogeneic and autologous equine bone marrow‐derived mesenchymal stem cells are safe, but did not reduce acute inflammation in an experimental interleukin‐1β model of synovitis

Aimée C. Colbath, Steven W. Dow, Leone S. Hopkins et al. · 2020 · Equine Veterinary Journal

Abstract Background Allogeneic and autologous bone marrow‐derived mesenchymal stem cells (BMDMSCs) have been administered in equine joints for their anti‐inflammatory effects. However, allogeneic BMDMSC offer multiple clinical and…

View details →DOI: 10.1111/evj.13222Cited by 18
Negative / Null Result ReportBiochemistry, Genetics and Molecular Biology

Significant Association of Caveolin-1 Genotypes with Bladder Cancer Susceptibility in Taiwan

Da‐Tian Bau · 2011 · The Chinese Journal of Physiology

Many articles have reported the caveolin-1 gene to be down-regulated thus suggesting that it might be a candidate tumor suppressor gene in many tumors. However, its involvement in bladder cancer is not clear and may be depending on…

View details →DOI: 10.4077/cjp.2011.amm009Cited by 18
Negative / Null Result ReportOpen accessMedicine

Plasmodium falciparum gametocyte carriage in symptomatic patients shows significant association with genetically diverse infections, anaemia, and asexual stage density

Paul Sondo, Biébo Bihoun, Marc Christian Tahita et al. · 2021 · Malaria Journal

BACKGROUND: Multi-genotype malaria infections are frequent in endemic area, and people commonly harbour several genetically distinct Plasmodium falciparum variants. The influence of genetic multiplicity and whether some specific genetic variants are more or less likely to invest into gametocyte production is not clearly understood. This study explored host and parasite-related risk factors for gametocyte carriage, and the extent to which some specific P. falciparum genetic variants are associated with gametocyte carriage. METHODS: Gametocytes and asexual forms were detected by light microscopy

View details →DOI: 10.1186/s12936-020-03559-0Cited by 18
Negative / Null Result Report

Dimethyloxalylglycine (DMOG), a Hypoxia Mimetic Agent, Does Not Replicate a Rat Pheochromocytoma (PC12) Cell Biological Response to Reduced Oxygen Culture

RuoLi Chen, Mohammad Alkataan Ahmed, Nicholas Robert Forsyth · 2022 · Biomolecules

Cells respond to reduced oxygen availability predominately by activation of the hypoxia-inducible factor (HIF) pathway. HIF activation upregulates hundreds of genes that help cells survive in the reduced oxygen environment. The aim of this…

View details →DOI: 10.3390/biom12040541Cited by 18
Negative / Null Result ReportOpen accessMedicine

Hydroxychloroquine and short-course radiotherapy in elderly patients with newly diagnosed high-grade glioma: a randomized phase II trial

Lucy Brazil, Angela Swampillai, Ka Man Mak et al. · 2020 · Neuro-Oncology Advances

BACKGROUND: Effective treatment for patients at least 70 years with newly diagnosed glioblastoma remains challenging and alternatives to conventional cytotoxics are appealing. Autophagy inhibition has shown promising efficacy and safety in small studies of glioblastoma and other cancers. METHODS: We conducted a randomized phase II trial to compare radiotherapy with or without hydroxychloroquine (2:1 allocation). Patients aged at least 70 years with newly diagnosed high-grade glioma deemed suitable for short-course radiotherapy with an ECOG performance status of 0-1 were included. Radiotherapy

View details →DOI: 10.1093/noajnl/vdaa046Cited by 18
Negative / Null Result ReportOpen accessMedicine

Current potential therapeutics of amyotrophic lateral sclerosis

Lijun Lu, Youqing Deng, Renshi Xu · 2024 · Frontiers in Neurology

Amyotrophic lateral sclerosis (ALS) is a debilitating motor neurological disorder for which there is still no cure. The disease seriously jeopardizes the health and lifespan of adult populations. The authors extensively retrieved the current literature about clinical and experimental ALS treatments. Based on them, this review primarily focused on summarizing the current potential clinical usage and trialing therapeutics of ALS. Currently, the clinical ALS treatments have focused primarily on relieving symptoms to improve the quality of life yet. There are a number of therapeutic approaches suc

View details →DOI: 10.3389/fneur.2024.1402962Cited by 18
Negative / Null Result Report

Bystander Intervention Efficacy to Reduce Teen Dating Violence Among High School Youth Who Did and Did Not Witness Parental Partner Violence: A Path Analysis of A Cluster RCT

Annelise Mennicke, Heather M. Bush, Candace J. Brancato et al. · 2021 · Journal of Family Violence

Abstract Youth who witness parental intimate partner violence (IPV) are at increased risk of teen dating violence (DV). This analysis of secondary data investigated whether a bystander intervention program, Green Dot, was effective at…

View details →DOI: 10.1007/s10896-021-00297-yCited by 18
Negative / Null Result ReportOpen accessMedicine

Definitive Radiotherapy for Older Patients Aged ≥75 Years With Localized Esophageal Cancer

Gen Suzuki, Hideya Yamazaki, Norihiro Aibe et al. · 2019 · In Vivo

BACKGROUND/AIM: To evaluate the predictive factors in older patients with localized esophageal cancer treated with definitive radiotherapy. PATIENTS AND METHODS: We retrospectively analyzed patients aged ≥75 years who were treated with…

View details →DOI: 10.21873/invivo.11560Cited by 18
Negative / Null Result ReportOpen accessImmunology and Microbiology

Systemic Activation of TLR3-Dependent TRIF Signaling Confers Host Defense against Gram-Negative Bacteria in the Intestine

Jose Ruiz, Saravana Kanagavelu, Claudia Flores et al. · 2016 · Frontiers in Cellular and Infection Microbiology

Recognition of Gram-negative bacteria by toll-like receptor (TLR)4 induces MyD88 and TRIF mediated responses. We have shown that TRIF-dependent responses play an important role in intestinal defense against Gram-negative enteropathogens. In the current study, we examined underlying mechanisms of how systemic TRIF activation enhances intestinal immune defense against Gram-negative bacteria. First we confirmed that the protective effect of poly I:C against enteric infection of mice with Yersinia enterocolitica was dependent on TLR3-mediated TRIF signaling by using TLR3-deficient mice. This prote

View details →DOI: 10.3389/fcimb.2015.00105Cited by 18
Negative / Null Result ReportOpen accessMedicine

Uric acid as a predictor of endothelial dysfunction in patients with metabolic syndrome

Charanpreet Singh, Sanjay Jain, Veena Dhawan et al. · 2020 · Archives of Endocrinology and Metabolism

OBJECTIVE: We conducted a study to examine the association of endothelial dysfunction and oxidative stress with uric acid levels in patients of metabolic syndrome. METHODS: One hundred and two patients of Metabolic Syndrome (International Diabetes Federation definition) were included in the study. Anthropometric measurements, serum uric acid levels, fasting blood sugar levels and lipid levels, as well as malondialdehyde and reactive nitrogen intermediates were measured after an 8-hour fasting period. Flow mediated vasodilation (FMD) of the brachial artery was measured and endothelial dysfuncti

View details →DOI: 10.20945/2359-3997000000298Cited by 18
Negative / Null Result Report

Fresh‐frozen plasma transfusion did not reduce 30‐day mortality in patients undergoing cardiopulmonary bypass cardiac surgery with excessive bleeding: the PLASMACARD multicenter cohort study

Adélaïde Doussau, Paul Perez, Maryse Puntous et al. · 2013 · Transfusion

Background During on‐pump cardiac surgery, hemorrhagic complications occur frequently. Fresh‐frozen plasma ( FFP ) is widely transfused to provide coagulation factors. Yet, no randomized clinical trial has demonstrated its benefits on…

View details →DOI: 10.1111/trf.12422Cited by 18
Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology

Genetic polymorphisms of the adrenergic system and implantable cardioverter-defibrillator therapies in patients with heart failure

Diego Chemello, Luís Eduardo Paim Rohde, Kátia Gonçalves dos Santos et al. · 2010 · EP Europace

AIMS: We investigated whether the combination of beta(1)-Gly389Arg and GNB3 C825T, two genetic polymorphisms strictly related to adrenergic system modulation, could act as predictors of appropriate therapies in patients with heart failure…

View details →DOI: 10.1093/europace/euq040Cited by 18
Negative / Null Result ReportOpen accessImmunology and Microbiology

Significant Differences in RNA Structure Destabilization by HIV-1 Gag∆p6 and NCp7 Proteins

Micah J. McCauley, Ioulia Rouzina, Jasmine Li et al. · 2020 · Viruses

Retroviral nucleocapsid (NC) proteins are nucleic acid chaperones that play distinct roles in the viral life cycle. During reverse transcription, HIV-1 NC facilitates the rearrangement of nucleic acid secondary structures, allowing the transactivation response (TAR) RNA hairpin to be transiently destabilized and annealed to a complementary RNA hairpin. In contrast, during viral assembly, NC, as a domain of the group-specific antigen (Gag) polyprotein, binds the genomic RNA and facilitates packaging into new virions. It is not clear how the same protein, alone or as part of Gag, performs such d

View details →DOI: 10.3390/v12050484Cited by 18
Negative / Null Result ReportOpen accessMedicine

Cocultures of Mesenchymal Stem Cells and Endothelial Cells As Organotypic Models of Prostate Cancer Metastasis

Mark Seow Khoon Chong, Jing Lim, Junwei Goh et al. · 2014 · Molecular Pharmaceutics

In spite of recognized limitations in capturing species-specific responses and high costs, rodent models remain commonly used in prostate cancer metastasis research, due largely to the lack of available alternatives. We aim to develop an…

View details →DOI: 10.1021/mp500141bCited by 18
Negative / Null Result ReportOpen accessNeuroscience

Phase 1/2 study of epacadostat in combination with durvalumab in patients with metastatic solid tumors

Aung Naing, Alain P. Algazi, Gerald S. Falchook et al. · 2022 · Cancer

BACKGROUND: Targeting programmed cell death protein 1 (PD-1) and indoleamine 2,3-dioxygenase (IDO1) pathways is an appealing option for cancer treatment. METHODS: The open-label, phase 1/2 ECHO-203 study evaluated the safety, tolerability,…

View details →DOI: 10.1002/cncr.34512Cited by 18
Negative / Null Result ReportOpen accessMedicine

Design and baseline characteristics of the LANDMARK study

Etsuro Ogata, Masafumi Fukagawa, Hideki Hirakata et al. · 2016 · Clinical and Experimental Nephrology

BACKGROUND: Calcium (Ca)-based phosphate (P) binders, compared to non-Ca-based P binders, contribute to vascular calcification, which is associated with cardiovascular events. METHODS: The LANDMARK study is a multicenter, randomized, open-label, parallel comparative study of lanthanum carbonate (LC) and calcium carbonate (CC) in hemodialysis patients. Stable hemodialysis patients with intact parathyroid hormone ≤240 pg/mL meeting ≥1 of the following criteria (age >65 years, postmenopause, diabetes mellitus) were randomized into the LC and CC groups. LC group patients initially received LC 750

View details →DOI: 10.1007/s10157-016-1310-8Cited by 18
Negative / Null Result ReportOpen accessMedicine

Blood Pressure Trajectories Prior to Death in Patients With Diabetes

Mary A.M. Rogers, Kathleen Ward, Tanya R. Gure et al. · 2011 · Diabetes Care

OBJECTIVE: The goals of this study were to examine trajectories of blood pressure (BP) in adults with diabetes and investigate the association of trajectory patterns with mortality. RESEARCH DESIGN AND METHODS: A nonconcurrent longitudinal…

View details →DOI: 10.2337/dc11-0441Cited by 18
Negative / Null Result ReportOpen accessComputer Science

What Do Cognitive Networks Do? Simulations of Spoken Word Recognition Using the Cognitive Network Science Approach

Michael S. Vitevitch, Gavin J. D. Mullin · 2021 · Brain Sciences

Cognitive network science is an emerging approach that uses the mathematical tools of network science to map the relationships among representations stored in memory to examine how that structure might influence processing. In the present study, we used computer simulations to compare the ability of a well-known model of spoken word recognition, TRACE, to the ability of a cognitive network model with a spreading activation-like process to account for the findings from several previously published behavioral studies of language processing. In all four simulations, the TRACE model failed to retr

View details →DOI: 10.3390/brainsci11121628Cited by 18
Negative / Null Result ReportOpen accessArts and Humanities

Searching for the “native” speaker: A preregistered conceptual replication and extension of Reid, Trofimovich, and O’Brien (2019)

Bianca Brown, Botagoz Tusmagambet, Valentino Rahming et al. · 2023 · Applied Psycholinguistics

Abstract This study conceptually replicated and extended Reid, Trofimovich, and O’Brien (2019), who found that native English speakers could be biased positively (or negatively) relative to a control condition in terms of how they rate non-native English speech. Our internet-based study failed to replicate Reid et al. across a wider population sample of “native” speakers ( n = 189). Listeners did not change how they rated non-native English speech after social bias orientations and performed similarly across all five measures of speech and across age and race (Asian, Black, and Caucasian). We

View details →DOI: 10.1017/s0142716423000127Cited by 18
Negative / Null Result ReportOpen accessNeuroscience

When Science Replaces Religion: Science as a Secular Authority Bolsters Moral Sensitivity

Onurcan Yılmaz, Hasan G. Bahçekapılı · 2015 · PLoS ONE

Scientific and religious thinking compete with each other on several levels. For example, activating one generally weakens the other. Since priming religion is known to increase moral behaviour and moral sensitivity, priming science might be expected to have the opposite effect. However, it was recently demonstrated that, on the contrary, science priming increases moral sensitivity as well. The present set of studies sought to replicate this effect and test two explanations for it. Study 1 used a sentence unscrambling task for implicitly priming the concept of science but failed to replicate i

View details →DOI: 10.1371/journal.pone.0137499Cited by 18
Negative / Null Result ReportSocial Sciences

Revisiting a Criminological Classic: The Cycle of Violence

Wesley Myers, Kristin M. Lloyd, Jillian J. Turanovic et al. · 2018 · Journal of Contemporary Criminal Justice

There is a growing “replication crisis” in the social and behavioral sciences, where original research across a wide array of substantive areas has failed to replicate when conducted by others. This problem highlights the importance of…

View details →DOI: 10.1177/1043986218770003Cited by 18
Negative / Null Result ReportOpen accessEngineering

Hybrid AI–Taguchi–ANOVA Approach for Thermographic Monitoring of Electronic Devices

Filippo Laganà, Danilo Pratticò, Marco F. Quattrone et al. · 2026 · Eng—Advances in Engineering

Defects in printed circuit boards (PCBs), if not detected promptly, may persist over time until they cause the failure of critical components. Traditional monitoring methods, which are limited to simulations or superficial measurements, obstruct predictive maintenance and real-time fault detection. To address these issues and enhance real-time diagnostics of thermal anomalies in PCBs, this work proposes an integrated system that combines infrared thermography (IRT), artificial intelligence (AI) algorithms, and Taguchi–ANOVA statistical techniques. IR thermography was employed to identify therm

View details →DOI: 10.3390/eng7010028Cited by 18