A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
19808 results in Negative / Null Result Report · page 113 of 661
Jae Hong Park, Isabelle Rivière, Xiuyan Wang et al. · 2017 · Journal of Clinical Oncology
7008 Background: CD19-specific chimeric antigen receptor (CAR) T cells have demonstrated high initial responses in patients with relapsed B-ALL. However, clinical characteristics associated with the durability of response remain undefined.…
Suresh S. Ramalingam, Judy Foster, William E. Gooding et al. · 2010 · Cancer
BACKGROUND: Patients with extensive stage small cell lung cancer (SCLC) who develop disease progression with standard cisplatin-based therapy are reported to have a poor overall prognosis. Irinotecan and paclitaxel are active as single…
Wen Sun, Yan Yang, Shidong Hu et al. · 2022 · Annals of Translational Medicine
Background: Patients in the intensive care unit (ICU) are often under stress and fail to cooperate well with invasive treatments. Analgesia and sedation are of great significance for reducing the suffering of patients and ensuring the…
Joseph T. Yun, Brittany R. L. Duff, Patrick Vargas et al. · 2019 · Psychology & Marketing
Abstract Cause‐related marketing (CRM) refers to the phenomenon where brands partner with causes, such as nonprofit organizations. Consumers may see some CRM partnerships as less compatible than others, however the level of perceived…
Beryn A. Otieno, Helen F. Nahrung, Martin J. Steinbauer · 2019 · Forests
Research Highlights: We present the first attempts to model the distributions of the two cryptic and globally invasive species of Leptocybe invasa sensu lato (Fisher & LaSalle) (Hymenoptera: Eulophidae) in its purported country of origin,…
Jing Li, YUE-YIN PAN, Ying Zhang · 2012 · Oncology Letters
Sorafenib is a highly selective multi-targeted agent and has been reported to have potent antitumor effects against various tumors, including human non-small cell lung cancer (NSCLC). In the present study, we explored the antitumor effect…
Laila Kristoffersen, Ragnhild Støen, Håkon Bergseng et al. · 2019 · Acta Paediatrica
Abstract Aim We compared the pain relieving effect of skin‐to‐skin contact versus standard care in the incubator during screening for retinopathy of prematurity. Methods This randomised crossover study included 35 preterm infants of less…
Wanying Liang, Lihong Wang, Jian‐Hang Wei et al. · 2021 · Scientific Reports
Klotho, an important anti-aging protein, may be related to elevated blood pressure (BP) and arterial stiffness. We aimed to investigate associations between the serum klotho concentration and peripheral/central BP and arterial stiffness based on the carotid-femoral pulse wave velocity (cfPWV) in a Chinese population. We invited all inhabitants aged ≥ 18 years in two Dali communities for participation. The SphygmoCor system was used to record radial arterial waveforms. Aortic waveforms were derived using a generalized transfer function. The central BP was assessed by calibrating the brachial BP
Daniel Rasbash, Kevin Joseph Dillman, Jukka Heinonen et al. · 2023 · Sustainability
Electrification is considered key to decarbonizing the transport sector. While electric vehicles (EVs) lack tailpipe emissions, battery and electricity production can lead to significant emissions. This study analysed whether EVs can effectively mitigate GHG emissions in North America, by calculating two GHG breakeven indicators for EVs and comparing them to internal combustion engine vehicles (ICEVs). EV life cycle emissions were compared to those of ICEVs in Canada, Mexico, and the USA. In addition, this study considered potential national electricity grids evolutions and improvements in bat
Eyüp Özkan, Aslan Erdoğan, Ali Karagöz et al. · 2023 · Angiology
This study compared the predictive power of the systemic immune-inflammation index (SII) and Naples prognostic score (NPS) in determining the severity of coronary artery disease (CAD). The study included 1138 patients who underwent…
Yun Gi Kim, Jong‐Il Choi, Ki Yung Boo et al. · 2019 · Clinical Cardiology
Abstract Background Age is a well‐established risk factor for thromboembolic events in patients with atrial fibrillation (AF). However, the mechanism underlying the association between age and thromboembolic events in AF remains unknown. Methods The prognostic value of age as a risk factor for thromboembolic events was analyzed using data from the Korean National Health Insurance Service (NHIS). In a large‐scale single‐center registry, cardiac hemodynamic parameters were examined to elucidate the cause of increased risk of thromboembolic events in older patients. Results NHIS sample cohort dat
Katja Bächli, Patrick R. Schmidlin, Florian J. Wegehaupt et al. · 2019 · Materials
To assess the remineralizing potential of dentin matrix proteins and enamel matrix derivatives (DMPs and EMDs) after application on artificially induced dentin lesions, given the hypothesis that these materials increase the mineral uptake, binding, and mineralization. Forty-eight caries-free human premolars were used. Teeth were cut, polished, and embedded, leaving an open window on the root surface, of which one-third was covered with a flowable composite to preserve the healthy untreated dentin. Then, samples were demineralized in Buskes solution for 33 days. A micro-CT scan prior to treatme
Anca Jivănescu, Adrian Bara, Andrei-Bogdan Faur et al. · 2021 · Applied Sciences
Is the accuracy of the older generation of IOSs an impediment for obtaining a quality intraoral digital impression? The aim of this study was to evaluate the differences in accuracy between four intraoral scanners (two of the latest IOSs…
Zhili Wang, Mingsheng Liu, Zhengyi Cai et al. · 2020 · Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
Objective To determine the practical diagnostic utility of split-hand index (SI) values calculated from F-wave persistence (SIFP) and the F/M amplitude ratio (SIF/M) for differentiating patients with amyotrophic lateral sclerosis (ALS)…
Melissa B. Gilkey, Brigid K. Grabert, Jennifer Heisler-MacKinnon et al. · 2022 · PEDIATRICS
BACKGROUND AND OBJECTIVES: US health departments routinely conduct in-person quality improvement (QI) coaching to strengthen primary care clinics' vaccine delivery systems, but this intervention achieves only small, inconsistent…
Marlee R. Labroo, Jeffrey B. Endelman, Dorcus C. Gemenet et al. · 2023 · Theoretical and Applied Genetics
KEY MESSAGE: Reciprocal recurrent selection sometimes increases genetic gain per unit cost in clonal diploids with heterosis due to dominance, but it typically does not benefit autopolyploids. Breeding can change the dominance as well as additive genetic value of populations, thus utilizing heterosis. A common hybrid breeding strategy is reciprocal recurrent selection (RRS), in which parents of hybrids are typically recycled within pools based on general combining ability. However, the relative performances of RRS and other breeding strategies have not been thoroughly compared. RRS can have re
Maureen van Eijnatten, Leonardo Rundo, Batenburg, Joost et al. · 2021 · Data Archiving and Networked Services (DANS)
Background and Objectives: Deep learning is being increasingly used for deformable image registration and unsupervised approaches, in particular, have shown great potential. However, the registration of abdominopelvic Computed Tomography…
Bente Silnes Tandberg, Kathrine Frey Frøslie, Trond Markestad et al. · 2019 · Acta Paediatrica
Abstract Aim The aim was to compare growth in very premature infants cared for in a single‐family room (SFR) and an open‐bay (OB) unit. We recorded duration of parental presence and skin‐to‐skin contact as proxies for parental involvement…
Jekaterina Kazantseva, Roman Ivanov, Michael Gasik et al. · 2016 · Scientific Reports
Abstract Three-dimensional (3D) customized scaffolds capable to mimic a native extracellular matrix open new frontiers in cells manipulation and advanced therapy. The major challenge is in a proper substrate for in vitro models on…
Qiang Liu, Kevin K. Lin, Bogi Andersen et al. · 2010 · Bioinformatics
Abstract Motivation: Time-course gene expression datasets provide important insights into dynamic aspects of biological processes, such as circadian rhythms, cell cycle and organ development. In a typical microarray time-course experiment,…
Orekoya Adedapo, Norbert Boros, Anna Boglárka Dálnoki et al. · 2024 · Discover Sustainability
Abstract The research examined the ability of each treatment to recover a known quantity of particles and the impact on identifying polymer type using a microscope. By conducting extensive research on the changes induced in the chemical…
David R. Chalcraft · 2019 · Ecology Letters
Abstract Recent simulations suggest that ecologists can enhance the predictive ability of models by designing experiments that maximise the number of levels of an experimental factor by sacrificing replication. Here, I describe how these…
Haijiang Zhou · 2020 · World Journal of Emergency Medicine
BACKGROUND: To evaluate the accuracy of National Early Warning Score (NEWS) in predicting clinical outcomes (28-day mortality, intensive care unit [ICU] admission, and mechanical ventilation use) for septic patients with community-acquired…
Daniel M. Goldenholz, Celena Eccleston, Robert Moss et al. · 2024 · Epilepsia
OBJECTIVE: Recently, a deep learning artificial intelligence (AI) model forecasted seizure risk using retrospective seizure diaries with higher accuracy than random forecasts. The present study sought to prospectively evaluate the same…
K. C. Yates, B. S. Bauer, S. Fuelling et al. · 2019 · Physics of Plasmas
We report the first observation of a significant change in plasma formation and evolution caused by a small change in the material composition (metal alloy). Thick copper rod alloys were varied in the initial diameter from 0.5 mm to 1.59…
Attila Salamon, Stefania Uccheddu, Melitta Csepregi et al. · 2023 · Scientific Reports
Abstract The dog is a so far unique species to study interspecific communication and a promising evolutionary model for preverbal human communication. Recently cats were reported to show some similar skills to dogs. Here we directly…
Martin Grosse Holtforth, David Altenstein, Emily Ansell et al. · 2011 · Journal of Clinical Psychology
Abstract Whereas previous interpersonal research in depression has frequently used self‐reports, patients' impact on others is rarely analyzed. We analyzed impacts of 180 depressed psychotherapy outpatients out of 832 diagnostically…
Nicholas S. OSCROFT, Ian E. SMITH · 2010 · Respirology
ABSTRACT Background and objective: Volume‐assured non‐invasive positive pressure ventilation (va‐NIPPV) is a novel mode designed to adapt pressure support (PS) to achieve a target minute ventilation (TgV). This may optimize ventilation;…
Carolina Diller, Miguel Castañeda-Zárate, Steven D. Johnson · 2019 · Biology Letters
Bird pollination systems are dominated by specialist nectarivores, such as hummingbirds in the Americas and sunbirds in Africa. Opportunistic (generalist) avian nectarivores such as orioles, weavers and bulbuls have also been implicated as…
Kohei Ohnishi, Yuma Ono, Tatsuya Nomura et al. · 2014 · Scientific Reports
Abstract The combination between the spin-dependent and super-conducting (SC) transports is expected to provide intriguing properties such as crossed Andreev reflection and spin-triplet superconductivity. This may be able to open a new…