Innovative dual-functional hybrid cationic PEGylated proniosomes as a smart nano-platform for Boosted vaginal delivery: multi-level in-vitro, ex-vivo, microbiological, and in-vivo studies
Sadek Ahmed; Osama Saher; Heba Attia; Abdurrahman M. Fahmy; Islam M. Adel · 2026 · Frontiers in Pharmacology
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Introduction: Vaginal candidiasis remains a recurrent fungal infection affecting millions of women worldwide, necessitating innovative local delivery systems to overcome poor drug solubility and mucosal barriers. This study introduces Dual-Functional Hybrid Cationic PEGylated Proniosomes (DHCPP) as a smart nano-platform designed to boost the vaginal delivery of Fenticonazole Nitrate (FTN). Methods: DHCPP systems were fabricated via the coacervation phase separation method and optimized using a full 2 3 factorial design, achieving a high desirability value of 0.931. The optimized DHCPP exhibite
Abstract by Sadek Ahmed; Osama Saher; Heba Attia; Abdurrahman M. Fahmy; Islam M. Adel, Frontiers in Pharmacology (2026) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.3389/fphar.2025.1746918