Liver exerkine reverses aging- and Alzheimer’s-related memory loss via vasculature
Gregor Bieri; Karishma J.B. Pratt; Yasuhiro Fuseya; Turan Aghayev; Juliana Sucharov; Alana Horowitz; Amber R. Philp; Karla Fonseca-Valencia · 2026 · Cell
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Blood factors transfer the benefits of exercise to the aged brain independent of physical activity. Here, we show that the liver-derived exercise factor (exerkine) glycosylphosphatidylinositol (GPI)-specific phospholipase D1 (GPLD1), a GPI-degrading enzyme, reverses aging- and Alzheimer's-related memory loss by targeting the brain vasculature. GPLD1 has the potential to cleave over 100 putative GPI-anchored proteins, necessitating the identification of downstream targets that mediate cognitive rejuvenation for translational application. We identified GPI-anchored tissue-nonspecific alkaline ph
Abstract by Gregor Bieri; Karishma J.B. Pratt; Yasuhiro Fuseya; Turan Aghayev; Juliana Sucharov; Alana Horowitz; Amber R. Philp; Karla Fonseca-Valencia, Cell (2026) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1016/j.cell.2026.01.024