Pancreatic cancer: molecular pathogenesis and emerging therapeutic strategies
Enrique Rozengurt; G. Eibl · 2026 · Signal Transduction and Targeted Therapy
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive disease for which there is no effective treatment. A deep understanding of the mechanisms underlying the molecular pathogenesis, signaling pathways and risk factors leading to PDAC is of paramount importance for identifying novel targets, prognostic markers, preventive strategies, and signature markers for use in specific and personalized therapeutic procedures. Activating somatic mutations in the KRAS oncogene play a critical role in PDAC initiation and maintenance. Here, we highlight the complex interplay between KRAS signaling, the tr
Abstract by Enrique Rozengurt; G. Eibl, Signal Transduction and Targeted Therapy (2026) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1038/s41392-025-02499-y