A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
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Panagiotis Kerezoudis, Kathleen J Yost, Nicole M Tombers et al. · 2018 · Neurosurgery
Abstract BACKGROUND The diagnosis of vestibular schwannomas (VS) is associated with reduced patient quality of life (QOL). Minimal clinically important difference (MCID) was introduced as the lowest improvement in a patient-reported…
Kenneth Button · 2012 · Transportation Journal
Abstract The article examines the sustainability of the low-cost, or no-frills, airline business model. It looks at the background to the development of this managerial approach within the context of some prevailing business theories and…
Jianjun Liu, Zhanqing Li · 2018 · Geophysical Research Letters
Abstract Aerosol optical quantities have been widely employed as the proxy variables of cloud condensation nuclei concentration to study aerosol indirect effects (AIE). Due to the aerosol swelling effect, cloud condensation nuclei and…
Tao Zhang, Dan Gieseler, Rainer Jordan · 2016 · Polymer Chemistry
The influence of ambient laboratory light from common fluorescent lamps on AGET, ARGET, and classical ATRP reactions was investigated and significant differences were found except for ARGET ATRP.
Jean C C Vila, Yang-Yu Liu, Alvaro Sanchez · 2020 · The ISME Journal
Abstract The taxonomic composition of microbial communities can vary substantially across habitats and within the same habitat over time. Efforts to build quantitative and predictive models of microbial population dynamics are underway,…
Francisca Alves-Cardoso, Vanessa Campanacho · 2022 · Heritage
Advancements in digital technology have conquered a place in cultural heritage. The widespread use of three-dimensional scanners in bioanthropology have increased the production of 3D digital replicas of human bones that are freely…
Wanlong Ma, Hagop M. Kantarjian, Ke Zhang et al. · 2010 · BMC Medical Genetics
BACKGROUND: Myelodysplastic syndrome (MDS) may be induced by certain mutagenic environmental or chemotherapeutic toxins; however, the role of susceptibility genes remains unclear. The G/G genotype of the single-nucleotide polymorphism (SNP) rs1617640 in the erythropoietin (EPO) promoter has been shown to be associated with decreased EPO expression. We examined the association of rs1617640 genotype with MDS. METHODS: We genotyped the EPO rS1617640 SNP in 189 patients with MDS, 257 with acute myeloid leukemia (AML), 106 with acute lymphoblastic leukemia, 97 with chronic lymphocytic leukemia, 353
Marin L. Moravec, Georg F. Striedter, Nancy T. Burley · 2010 · Ethology
Abstract Parrots comprise one of the several taxa in which life‐long learning of new vocal signals used in intraspecific communication is known to occur routinely. The functions and evolutionary bases of this ability are largely unknown.…
Katherine D’Avignon, Michaël Kummert · 2015 · Journal of Thermal Science and Engineering Applications
To assess the potential of thermal energy storage systems using phase change materials (PCMs), numerical simulations rely on an enthalpy–temperature curve (or equivalent specific heat curve) to model the PCM thermal storage behavior. The…
Stacy D O’Connor, Anuj K Dalal, V Anik Sahni et al. · 2015 · Journal of the American Medical Informatics Association
Abstract Objective To assess whether integrating critical result management software—Alert Notification of Critical Results (ANCR)—with an electronic health record (EHR)-based results management application impacts closed-loop…
Jayson L. Parker, Jillian Clare Köhler · 2010 · Journal of Pharmacy & Pharmaceutical Sciences
PURPOSE: To determine the risk of drug failure during clinical trial testing in Crohn's disease and determine what steps can be taken to improve outcomes. This is the first study to quantify such risk for a single disease. METHODS: Moderate to severe Crohn's disease was investigated by reviewing press releases from 1998 to June 2008. Clinical trial failure causes were classified as commercial or clinical and compared with industry expectations. The risk of failure was also reviewed based on whether the compound was a small molecule drug or a biologic. Lastly, the role of the sponsor was examin
Lulu Yu, Yang Liu, Fei Xu · 2019 · BMC Plant Biology
BACKGROUND: Hydrogen cyanide (HCN) is a small gaseous molecule that is predominantly produced as an equimolar co-product of ethylene (ET) biosynthesis in plants. The function of ET is of great concern and is well studied; however, the function of HCN is largely unknown. Similar to ET, HCN is a simple and diffusible molecule that has been shown to play a regulatory role in the control of some metabolic processes in plants. Nevertheless, it is still controversial whether HCN should be regarded as a signalling molecule, and the cross-talk between HCN and ET in gene expression regulation remains u
HAELIM PARK, PATRICK VAN HORN · 2015 · Journal of Money, Credit and Banking
We analyze the impact of contractionary monetary policy through increases in reserve requirements on bank lending. We compare the lending behavior of banks that were subject to the requirement increases in 1936–37, Federal Reserve member…
Li Sian Goh · 2021 · Criminology & Public Policy
Research Summary Despite the widespread interest that de‐escalation training has attracted in law enforcement contexts over the past few years, we know little about its effectiveness in reducing use of force incidents. This study seeks to…
Mathias Roth, Christoph Holtmann, Loay Daas et al. · 2021 · Cornea
PURPOSE: Fungal keratitis (FK) is a serious ophthalmic disease with a potentially devastating outcome that seems to be increasing in recent years. The use of contact lenses (CLs) was evaluated as a risk factor for FK to determine possible…
Nan Bi, Jun Liang, Zongmei Zhou et al. · 2019 · JAMA Network Open
Importance: Treatment of locally advanced non-small cell lung cancer (NSCLC) remains challenging. The rationale of combining a cyclooxygenase 2 (COX-2) inhibitor with concurrent chemoradiation (CCRT) was based on results of preclinical research and prospective clinical studies; however, no randomized clinical trial has provided evidence of a direct comparison with CCRT alone. Objective: To determine the effect of combined selective COX-2 inhibition with standard CCRT on survival among patients with unresectable stage III NSCLC. Design, Setting, and Participants: A single-center, open-label, ra
Kennichi Kakudo · 2022 · Cancers
Histopathological diagnosis of papillary thyroid carcinomas (PTCs) is prone to significant observer variation due to different thresholds of RAS-like nuclear changes among pathologists. This gap recently widened due to a defensive attitude by Western pathologists where malpractice litigation is significant. Cases with delicate RAS-like nuclear changes are follicular adenomas when they are noninvasive, follicular carcinomas when invasive, and follicular variant PTCs when they have fully developed PTC-type nuclear features in Asian practice. The different diagnostic threshold of PTC nuclear feat
Francesca Faustini, Nicky Dunn, Nastya Kharlamova et al. · 2021 · Arthritis Research & Therapy
BACKGROUND: Anti-drug antibodies (ADAs) can impact on the efficacy and safety of biologicals, today used to treat several chronic inflammatory conditions. Specific patient groups may be more prone to develop ADAs. Rituximab is routinely used for ANCA-associated vasculitis (AAV) and as off-label therapy for systemic lupus erythematosus (SLE), but data on occurrence and predisposing factors to ADAs in these diseases is limited. OBJECTIVES: To elucidate the rate of occurrence, and risk factors for ADAs against rituximab in SLE and AAV. METHODS: ADAs were detected using a bridging electrochemilumi
Brintha K. Enestvedt, M. Brian Fennerty, A. Zaman et al. · 2011 · Alimentary Pharmacology & Therapeutics
BACKGROUND: In recent clinical trials (RCT) of bowel preparation, Golytely was more efficacious than MiraLAX. We hypothesised that there is a difference in adenoma detection between Golytely and MiraLAX. AIMS: To compare the adenoma…
A. V. Dyomina, Anna A. Kovalenko, Maria V. Zakharova et al. · 2022 · International Journal of Molecular Sciences
Metabotropic glutamate receptors (mGluRs) are expressed predominantly on neurons and glial cells and are involved in the modulation of a wide range of signal transduction cascades. Therefore, different subtypes of mGluRs are considered a promising target for the treatment of various brain diseases. Previous studies have demonstrated the seizure-induced upregulation of mGluR5; however, its functional significance is still unclear. In the present study, we aimed to clarify the effect of treatment with the selective mGluR5 antagonist 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]-pyridine (MTEP) on epile
Juan Zeng, Yukun Li, Feifei Quan et al. · 2020 · Molecular Medicine Reports
Propofol, a commonly used intravenous anesthetic agent during surgery, has relatively widespread pharmacological actions. Previous studies have reported that propofol may act as an antitumor drug in several cancer types, such as pancreatic…
Sean Coulborn, Howard Bowman, R. Chris Miall et al. · 2020 · Frontiers in Human Neuroscience
Mind-wandering is associated with switching our attention to internally directed thoughts and is by definition an intrinsic, self-generated cognitive function. Interestingly, previous research showed that it may be possible to modulate its propensity externally, with transcranial direct current stimulation (tDCS) targeting different regions in the default mode and executive control networks. However, these studies used highly heterogeneous montages (targeting the dorsolateral prefrontal cortex (DLPFC), the right inferior parietal lobule (IPL), or both concurrently), often showed contradicting
Klára Marečková, Amy Miles, Zhijie Liao et al. · 2022 · NeuroImage Clinical
BACKGROUND: Prenatal stress influences brain development and mood disorder vulnerability. Brain structural covariance network (SCN) properties based on inter-regional volumetric correlations may reflect developmentally-mediated shared…
Fumitaka Furuoka · 2016 · Applied Economics Letters
This article proposes a new unit root test to analyse unemployment hysteresis. The test is able to incorporate cross-sectional dependence, unattended nonlinearity and unknown structural breaks in the time-series data. This study used data…
Freija Verdoodt, Susanne K. Kjær, Christian Dehlendorff et al. · 2018 · British Journal of Cancer
BACKGROUND: Increasing data suggest that aspirin use may improve cancer survival; however, the evidence is sparse for ovarian cancer. METHODS: We examined the association between postdiagnosis use of low-dose aspirin and mortality in a…
Michael Schütt, Connor O’Farrell, Konstantinos Stamatopoulos et al. · 2022 · Pharmaceutics
The performance of solid oral dosage forms targeting the colon is typically evaluated using standardised pharmacopeial dissolution apparatuses. However, these fail to replicate colonic hydrodynamics. This study develops a digital twin of the Dynamic Colon Model; a physiologically representative in vitro model of the human proximal colon. Magnetic resonance imaging of the Dynamic Colon Model verified that the digital twin robustly replicated flow patterns under different physiological conditions (media viscosity, volume, and peristaltic wave speed). During local contractile activity, antegrade
Rouven Doran, Daniel Hanss, Torvald Øgaard · 2017 · Sustainability
Two online experiments explored the effects of social comparison feedback on indicators of eco-friendly travel choices. It was tested whether the chosen indicators are sensitive to the information conveyed, and if this varies as a function of in-group identification. Study 1 (N = 134) focused on unfavourable feedback (i.e., being told that one has a larger ecological footprint than the average member of a reference group). People who received unfavourable feedback reported stronger intentions to choose eco-friendly travel options than those who received nondiscrepant feedback, when in-group id
Jeni L. Burnette, Crystal L. Hoyt, Nicholas R. Buttrick et al. · 2021 · International Journal of Psychology
Communications about the Coronavirus Disease 2019 (COVID-19) often employ metaphors, which can help people understand complex issues. For example, public health messages may focus on "fighting" the disease, attempting to rouse people to…
Christian Bock, Thomas Gumbsch, Michael Moor et al. · 2018 · Bioinformatics
Motivation: Most modern intensive care units record the physiological and vital signs of patients. These data can be used to extract signatures, commonly known as biomarkers, that help physicians understand the biological complexity of…
Joseph Workman, Paul von Hippel, Joseph J. Merry · 2023 · Sociological Science
It is widely believed that (1) children lose months of reading and math skills over summer vacation and that (2) inequality in skills grows much faster during summer than during school. Concerns have been raised about the replicability of evidence for these claims, but an impression may exist that nonreplicable findings are limited to older studies. After reviewing the 100-year history of nonreplicable results on summer learning, we compared three recent data sources (ECLS- K:2011, NWEA, and Renaissance) that tracked U.S. elementary students' skills through school years and summers in the 2010