Negative / Null Result Report
Sheeva Bhattarai, Tore Framstad, Jens Peter Nielsen · 2019 · Acta Veterinaria Scandinavica
Abstract Background Anemia characterized by low hemoglobin concentration (HbC) is common in indoor housed pregnant sows. Iron is essential for hemoglobin synthesis and a number of metabolic processes including DNA synthesis and regulation…
View details →DOI: 10.1186/s13028-019-0497-6Cited by 22 Negative / Null Result Report
Stephanie K. Courtney Jones, Adam J. Munn, Phillip G. Byrne · 2018 · Royal Society Open Science
Captive breeding programmes are increasingly relied upon for threatened species management. Changes in morphology can occur in captivity, often with unknown consequences for reintroductions. Few studies have examined the morphological…
View details →DOI: 10.1098/rsos.172470Cited by 22 Negative / Null Result Report
Miled El Hajji · 2018 · International Journal of Biomathematics
In this paper, I consider two species feeding on limiting substrate in a chemostat taking into account some possible effects of each species on the other one. System of differential equations is proposed as model of these effects with…
View details →DOI: 10.1142/s1793524518501115Cited by 22 Negative / Null Result ReportOpen accessMedicine
Ángel Herráiz-Adillo, Viktor H. Ahlqvist, Sara Higueras‐Fresnillo et al. · 2023 · Frontiers in Cardiovascular Medicine
Background To quantify cardiovascular health (CVH), the American Heart Association (AHA) recently launched an updated construct of the “Life's Simple 7” (LS7) score, the “Life's Essential 8” (LE8) score. This study aims to analyse the association between both CVH scores and carotid artery plaques and to compare the predictive capacity of such scores for carotid plaques. Methods Randomly recruited participants aged 50–64 years from the Swedish CArdioPulmonary bioImage Study (SCAPIS) were analysed. According to the AHA definitions, two CVH scores were calculated: i) the LE8 score (0, worst CVH;
View details →DOI: 10.3389/fcvm.2023.1173550Cited by 22 Negative / Null Result Report
Vasilios A. Raoulis, Aristidis Zibis, Maria Dimitra Chiotelli et al. · 2021 · Knee Surgery, Sports Traumatology, Arthroscopy
Abstract Purpose The purpose of this study was to compare the maximum load to failure and stiffness of three medial patella‐femoral ligament (MPFL) reconstruction techniques: (i) suture anchor fixation (SA), (ii) interference screw…
View details →DOI: 10.1007/s00167-020-06389-4Cited by 22 Negative / Null Result ReportOpen accessMedicine
Minghua Wu, Shervin Assassi, Gloria A. Salazar et al. · 2016 · Arthritis Research & Therapy
BACKGROUND: Systemic sclerosis (SSc)-related interstitial lung disease (ILD) has phenotypic similarities to lung involvement in idiopathic interstitial pneumonia (IIP). We aimed to assess whether genetic susceptibility loci recently identified in the large IIP genome-wide association studies (GWASs) were also risk loci for SSc overall or severity of ILD in SSc. METHODS: A total of 2571 SSc patients and 4500 healthy controls were investigated from the US discovery GWAS and additional US replication cohorts. Thirteen IIP-related selected single nucleotide polymorphisms (SNPs) were genotyped and
View details →DOI: 10.1186/s13075-016-0923-3Cited by 22 Negative / Null Result ReportEnvironmental Science
Brittany N. Neilson, Curtis M. Craig, Raelyn Y. Curiel et al. · 2020 · Human Factors The Journal of the Human Factors and Ergonomics Society
OBJECTIVE: The aim of this study is to replicate Berto's (2005) heavily cited work on attention restoration. BACKGROUND: Nature interventions have gained increased interest for improving performance of attentionally demanding tasks. Berto…
View details →DOI: 10.1177/0018720820909287Cited by 22 Negative / Null Result ReportOpen accessPsychology
Sarah Kunkle, Manny Yip, Justin Hunt et al. · 2020 · JMIR Formative Research
BACKGROUND: Anxiety is an extremely prevalent condition, and yet, it has received notably less attention than depression and other mental health conditions from a research, clinical, and public health perspective. The COVID-19 pandemic has only exacerbated growing concerns about the burden of anxiety due to the confluence of physical health risks, economic stressors, social isolation, and general disruption of daily activities. OBJECTIVE: This study examines differences in anxiety outcomes by care modality (coaching, teletherapy and telepsychiatry, and combined care) within an on-demand mental
View details →DOI: 10.2196/24662Cited by 22 Negative / Null Result ReportMedicine
Matthew R. Pearson, Mark A. Prince, Adrián J. Bravo · 2017 · Substance Use & Misuse
BACKGROUND: Protective behavioral strategies (PBS) can be used to reduce alcohol-related harm when drinking. Despite much research demonstrating that use of protective behavioral strategies (PBS) is associated with decreased alcohol…
View details →DOI: 10.1080/10826084.2016.1267222Cited by 22 Negative / Null Result ReportOpen accessMedicine
Manou Sommen, Guy Van Camp, Balázs Liktor et al. · 2014 · Otology & Neurotology
BACKGROUND/HYPOTHESIS: Otosclerosis is a frequent cause of hearing impairment characterized by abnormal resorption and deposition of bone in the human otic capsule. It is a disease of complex etiopathogenesis that is caused by both…
View details →DOI: 10.1097/mao.0000000000000334Cited by 22 Negative / Null Result ReportOpen accessAgricultural and Biological Sciences
Dinggang Zhou, Liping Xu, Shiwu Gao et al. · 2016 · Frontiers in Plant Science
Cry1Ac transgenic sugarcane provides a promising way to control stem-borer pests. Biosafety assessment of soil ecosystem for cry1Ac transgenic sugarcane is urgently needed because of the important role of soil microorganisms in nutrient transformations and element cycling, however little is known. This study aimed to explore the potential impact of cry1Ac transgenic sugarcane on rhizosphere soil enzyme activities and microbial community diversity, and also to investigate whether the gene flow occurs through horizontal gene transfer. We found no horizontal gene flow from cry1Ac sugarcane to soi
View details →DOI: 10.3389/fpls.2016.00265Cited by 22 Negative / Null Result ReportPsychology
Samantha J. Heintzelman, Jason Trent, Laura A. King · 2014 · The Journal of Positive Psychology
Growing popular interest in positive psychology may have important implications for the measurement of well-being. Five studies tested the prediction that well-being ratings are influenced by desirability bias. In Study 1, participants (N…
View details →DOI: 10.1080/17439760.2014.927903Cited by 22 Negative / Null Result ReportOpen accessMedicine
Veronika V. Odintsova, Fiona A. Hagenbeek, Matthew Suderman et al. · 2019 · Nutrients
Breastfeeding has long-term benefits for children that may be mediated via the epigenome. This pathway has been hypothesized, but the number of empirical studies in humans is small and mostly done by using peripheral blood as the DNA source. We performed an epigenome-wide association study (EWAS) in buccal cells collected around age nine (mean = 9.5) from 1006 twins recruited by the Netherlands Twin Register (NTR). An age-stratified analysis examined if effects attenuate with age (median split at 10 years; n<10 = 517, mean age = 7.9; n>10 = 489, mean age = 11.2). We performed replication
View details →DOI: 10.3390/nu11112804Cited by 22 Negative / Null Result ReportOpen accessMedicine
Yuli Wang · 2019 · UNC Libraries
The human small intestinal epithelium possesses a distinct crypt-villus architecture and tissue polarity in which proliferative cells reside inside crypts while differentiated cells are localized to the villi. Indirect evidence has shown…
View details →DOI: 10.17615/k4tv-qt25Cited by 22 Negative / Null Result ReportOpen accessEnvironmental Science
Magnus Bergquist, Andréas Nilsson, Emma Ejelöv · 2019 · Sustainability
Setting up a contest is a popular means to promote pro-environmental behaviors. Yet, research on contest-based interventions is scarce while norm-based interventions have gained much attention. In two field experiments, we randomly assigned 79 apartments to either a contest-based or a norm-based electricity conservation intervention and measured kWh usage for 2 and 4 weeks, respectively. Results from both studies showed that contest-based interventions promote intensive but short-lived electricity saving. In Study 1 apartments assigned to a norm-based intervention showed more stable electricit
View details →DOI: 10.3390/su11020425Cited by 22 Negative / Null Result ReportOpen accessMedicine
Amir Arastehfar, Farnaz Daneshnia, Hrant Hovhannisyan et al. · 2023 · mBio
ABSTRACT Small colony variants are relatively common among some bacterial species and are associated with poor prognosis and recalcitrant infections. Similarly, Candida glabrata— a major intracellular fungal pathogen—produces small and slow-growing respiratory-deficient colonies, termed “petite.” Despite reports of clinical petite C. glabrata strains, our understanding of petite behavior in the host remains obscure. Moreover, controversies exist regarding in-host petite fitness and its clinical relevance. Herein, we employed whole-genome sequencing (WGS), dual-RNAseq, and extensive ex vivo and
View details →DOI: 10.1128/mbio.01180-23Cited by 22 Negative / Null Result ReportOpen accessComputer Science
Andreas Ketterer, Satoya Imai, Nikolai Wyderka et al. · 2022 · Physical review. A/Physical review, A
We consider statistical methods based on finite samples of locally randomized measurements in order to certify different degrees of multiparticle entanglement in intermediate-scale quantum systems. We first introduce hierarchies of…
View details →DOI: 10.1103/physreva.106.l010402Cited by 22 Negative / Null Result ReportOpen accessMedicine
Michael A. Mooney, Peter Ryabinin, Hannah E. Morton et al. · 2023 · JCPP Advances
Abstract Background attention‐deficit/hyperactivity disorder (ADHD) is associated with both polygenic liability and environmental exposures, both intrinsic to the family, such as family conflict, and extrinsic, such as air pollution. However, much less is known about the interplay between environmental and genetic risks relevant to ADHD—a better understanding of which could inform both mechanistic models and clinical prediction algorithms. Methods Two independent data sets, the population‐based Adolescent Brain Cognitive Development Study (ABCD) ( N = 11,876) and the case‐control Oregon‐ADHD‐1
View details →DOI: 10.1002/jcv2.12152Cited by 22 Negative / Null Result Report
Joy Leopold, Jason R. Lambert, Ifeyimika O. Ogunyomi et al. · 2019 · Equality, Diversity and Inclusion: An International Journal
Purpose The purpose of this paper is to propose that #MeToo is a social movement which has been more effective in changing norms around and increasing understanding about the prevalence and destructiveness of sexual harassment than decades…
View details →DOI: 10.1108/edi-04-2019-0129Cited by 22 Negative / Null Result ReportOpen accessMedicine
Maarten Korrel, Sanne Lof, Jony van Hilst et al. · 2020 · Annals of Surgical Oncology
BACKGROUND: Surgical factors, including resection of Gerota's fascia, R0-resection, and lymph node yield, may be associated with survival after distal pancreatectomy (DP) for pancreatic ductal adenocarcinoma (PDAC), but evidence from large multicenter studies is lacking. This study aimed to identify predictors for overall survival after DP for PDAC, especially those related to surgical technique. PATIENTS AND METHODS: Data from an international retrospective cohort including patients from 11 European countries and the USA who underwent DP for PDAC (2007-2015) were analyzed. Cox proportional ha
View details →DOI: 10.1245/s10434-020-08658-5Cited by 22 Negative / Null Result ReportOpen accessMedicine
Lawrence Grierson, Samantha Winemaker, Alan Taniguchi et al. · 2020 · Perspectives on Medical Education
INTRODUCTION: The medical education community has implemented writing exercises that foster critical analysis and nurture reflective capacity. The REFLECT rubric (Wald et al. 2012) was developed to address the challenge of assessing these written reflections. The objective of this replication work is to explore the reproducibility of the reliability characteristics presented by the REFLECT developers. METHODS: Five raters evaluated narratives written by medical students and experienced clinicians using the REFLECT rubric. Reliability across rubric domains was determined via intraclass correlat
View details →DOI: 10.1007/s40037-020-00611-2Cited by 22 Negative / Null Result ReportOpen accessMedicine
Aldina Mešić, Emahlea Jackson, Mathias Lalika et al. · 2022 · PLOS Global Public Health
The interferon (IFN) system is a potent line of defense against viral infections. IFN-based agents already tested may be of use in COVID-19 or future viral respiratory outbreaks. Here we review the comparative efficacy, safety/tolerability, and future potential of IFN-based therapeutics. We reviewed human studies in which IFN or IFN pathway-interacting agents were used for viral respiratory infections. We identified 977 articles, of which 194 were included for full-text review. Of these, we deemed 35 articles to be relevant. The use of IFN-based agents for pre-exposure prophylaxis (n = 19) and
View details →DOI: 10.1371/journal.pgph.0000231Cited by 22 Negative / Null Result ReportOpen accessMedicine
Annalisa Petrelli, Sabrina Rizzolio, Filippo Pietrantonio et al. · 2023 · Cancer Research
Despite negative results of clinical trials conducted on the overall population of patients with gastric cancer, PARP inhibitor (PARPi) therapeutic strategy still might represent a window of opportunity for a subpopulation of patients with…
View details →DOI: 10.1158/0008-5472.can-22-2620Cited by 22 Negative / Null Result ReportOpen accessNeuroscience
Adrienne L. Romer, Diego A. Pizzagalli · 2021 · Biological Psychiatry Global Open Science
A general psychopathology factor (p factor) captures shared variance across mental disorders in diverse samples and may partly reflect executive dysfunction. Higher p factor scores have been related to structural alterations within the…
View details →DOI: 10.1016/j.bpsgos.2021.06.002Cited by 22 Negative / Null Result ReportOpen accessMedicine
Kazuyuki Uehara, Takashi Sasayama, Daisuke Miyawaki et al. · 2012 · Radiation Oncology
BACKGROUND: The purpose of the present study was to analyze the recurrence pattern of high-grade glioma treated with a multimodal treatment approach and to evaluate whether the MIB-1 labeling index (LI) could be a useful marker for predicting the pattern of failure in glioblastoma (GB). METHODS AND MATERIALS: We evaluated histologically confirmed 131 patients with either anaplastic astrocytoma (AA) or GB. A median dose was 60 Gy. Concomitant and adjuvant chemotherapy were administered to 111 patients. MIB-1 LI was assessed by immunohistochemistry. Recurrence patterns were categorized according
View details →DOI: 10.1186/1748-717x-7-104Cited by 22 Negative / Null Result ReportOpen accessMedicine
Noriyuki Otsuki, Yuichiro Nakatsu, Toru Kubota et al. · 2013 · PLoS ONE
Canine distemper virus (CDV) becomes able to use human receptors through a single amino acid substitution in the H protein. In addition, CDV strains possessing an intact C protein replicate well in human epithelial H358 cells. The present study showed that CDV strain 007Lm, which was isolated from lymph node tissue of a dog with distemper, failed to replicate in H358 cells, although it possessed an intact C protein. Sequence analyses suggested that a cysteine-to-tyrosine substitution at position 267 of the V protein caused this growth defect. Analyses using H358 cells constitutively expressing
View details →DOI: 10.1371/journal.pone.0082343Cited by 22 Negative / Null Result ReportMedicine
TM Barber, Stephen Franks · 2010 · Expert Review of Endocrinology & Metabolism
Polycystic ovary syndrome (PCOS) is associated with obesity and manifests with reproductive, hyperandrogenic and metabolic features. Although the etiology of PCOS is complex and incompletely understood, genetics plays an important role…
View details →DOI: 10.1586/eem.10.32Cited by 22 Negative / Null Result ReportOpen accessMedicine
Antonella Ferro, Michela Campora, A. Caldara et al. · 2024 · Journal of Clinical Medicine
Estrogen receptor (ER)-positive breast cancer (BC) is the most common BC subtype. Endocrine therapy (ET) targeting ER signaling still remains the mainstay treatment option for hormone receptor (HR)-positive BC either in the early or in advanced setting, including different strategies, such as the suppression of estrogen production or directly blocking the ER pathway through SERMs—selective estrogen receptor modulators—or SERDs—selective estrogen receptor degraders. Nevertheless, the development of de novo or acquired endocrine resistance still remains challenging for oncologists. The use of no
View details →DOI: 10.3390/jcm13123611Cited by 22 Negative / Null Result ReportOpen accessMedicine
Yasushi Tojo, Yasuhiro Koh, Masayuki Amano et al. · 2010 · Antimicrobial Agents and Chemotherapy
Natural products with macrocyclic structural features often display intriguing biological properties. Molecular design incorporating macrocycles may lead to molecules with unique protein-ligand interactions. We generated novel human…
View details →DOI: 10.1128/aac.01766-09Cited by 22 Negative / Null Result ReportOpen accessMedicine
Berna Harmse, Herculina S. Kruger · 2011 · PubMed
Low-grade systemic inflammation is emerging as a component of the metabolic syndrome. The purpose of this study was to assess the association between serum C-reactive protein (CRP), physical activity and body composition in 193 black children aged 13 to 18 years from a South African township. Demographic information and anthropometric measurements were taken, and fasting blood samples were analysed for high-sensitivity serum CRP. Body fat was measured by air displacement plethysmography. There was a trend towards higher serum CRP in the boys with a higher percentage body fat. After multiple re
View details →DOI: 10.5830/cvja-2010-005Cited by 22 