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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

AllReplication FailureNegative / Null Result ReportFailed Experiment ReportAbandoned HypothesisMethods Dead-EndShort NoteNull DatasetProtocol

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

By fieldMedicine 12,301Computer Science 753Biochemistry, Genetics and Molecular Biology 443Social Sciences 312Psychology 309Physics 280Neuroscience 258Economics, Econometrics and Finance 209Environmental Science 186Mathematics 161Agricultural and Biological Sciences 151Engineering 150

422 results in Replication Failure · page 9 of 15

Replication FailureMedicine

AceScope<sup>TM</sup> monitor program revision does not facilitate tracheal intubation in novice physicians:A manikin simulation study.

Kobayashi A, Kawashima S, Kimura T et al. · 2026 · The journal of medical investigation : JMI

Whether the difference in video laryngoscope view affects the success of endotracheal intubation in beginners is unknown. In the current study, we aimed to investigate whether the revision of the monitor program in a Macintosh-type video…

View details →DOI: 10.2152/jmi.73.32
Replication FailureMedicine

Effect of transcutaneous auricular vagus nerve stimulation (taVNS) on inhibitory control as a function of motor task complexity.

Gálvez-García G, Romero-Arias T, Barramuño-Medina M et al. · 2026 · Behavioural brain research

This study examined the effects of transcutaneous auricular vagus nerve stimulation (taVNS) on inhibitory control during motor tasks of varying complexity. Motor task complexity was manipulated in a Simon task using two approaches: (1)…

View details →DOI: 10.1016/j.bbr.2026.116145
Replication FailureMedicine

β-Catenin Does Not Co-activate Vitamin D Receptor-mediated Transcription in Osteoblastic and Non-osteoblastic Cells.

Nguyen TT, Kanemoto Y, Sawada T et al. · 2026 · Bioscience, biotechnology, and biochemistry

Vitamin D (VD) and Wnt signaling both play important roles in bone metabolism and are targeted in osteoporosis therapy. Combination treatment with VD derivatives and anti-sclerostin antibodies that activate Wnt signaling improves clinical…

View details →DOI: 10.1093/bbb/zbag084
Replication Failure

Can Progressive Strength Training Counteract Frailty and Improve Short-Term Autonomic Compensatory Responses During Active Standing Orthostatic Stress? A Pilot Study

Gama de Matos D, de Santana JL, Aidar FJ et al. · 2026 · Preprint

Background: Frailty is a multifactorial condition that significantly impacts older adults' health and independence, which can be mitigated through training. This study examined the effects of a 12-week progressive strength training (PST)…

View details →DOI: 10.20944/preprints202602.0236.v1
Replication FailureMedicine

Can Progressive Strength Training Counteract Frailty and Improve Short-Term Autonomic Compensatory Responses During Active Standing Orthostatic Stress? A Pilot Study.

Gama de Matos D, de Santana JL, Aidar FJ et al. · 2026 · Journal of clinical medicine

Background : Frailty is a multifactorial condition that significantly impacts older adults' health and independence, which can be mitigated through training. This study examined the effects of a 12-week progressive strength training (PST)…

View details →DOI: 10.3390/jcm15051679
Replication FailureMedicine

Back on track: Feasibility and efficacy randomized trial of a two-week online self-guided intervention for cannabis use reduction.

Kroon E, Elsey JWB, Kuhns LN et al. · 2025 · Drug and alcohol dependence

Background and aims Many individuals aiming to reduce or quit cannabis use prefer self-guided interventions over formal treatment. In this pilot and feasibility randomized trial, we tested a two-week self-guided online intervention…

View details →DOI: 10.1016/j.drugalcdep.2025.112943
Replication FailureMedicine

Comparison of intramuscular medetomidine versus medetomidine-vatinoxan sedation in bearded dragons (Pogonavitticeps).

Pinho RH, Reed M, Chapman K et al. · 2025 · Veterinary anaesthesia and analgesia

Objective To assess sedation following intramuscular (IM) administration of medetomidine versus medetomidine-vatinoxan in bearded dragons. Study design Prospective, randomized, experimental, crossover study. Animals A group of 10 (five…

View details →DOI: 10.1016/j.vaa.2024.10.133
Replication FailureOpen accessMedicine

Guestimating Molecular Subtyping of Breast Cancer by Ki67 in the Era of Artificial Intelligence.

Connolly CE, Sgier BP, Masser R et al. · 2026 · International journal of breast cancer

Aims This study aimed to compare the performance of immunohistochemistry (IHC)-based luminal subtyping of breast cancer against gene expression panels at our institute and to evaluate a CE-certified artificial intelligence (AI) Ki67 image…

View details →DOI: 10.1155/ijbc/9640277
Replication FailureMedicine

Evidence of a limit to benefits from culling lionfish.

Hyman AC, Albins MA, Curtis JS et al. · 2026 · Scientific reports

Biological invasions threaten ecosystems worldwide, with invasive predators such as lionfish (Pterois spp.) altering marine communities through predation, competition, and habitat disruption. Since their introduction to the western…

View details →DOI: 10.1038/s41598-026-54653-3
Replication FailureMedicine

Implementation of a New MRI Contrast Policy at a Large Hospital System: Access to Contrast-Enhanced MRI and Development of NSF in Patients with Renal Insufficiency.

Ludwig DR, Zhang F, Minor B et al. · 2026 · Academic radiology

Rationale and objectives To evaluate access to contrast-enhanced MRI among patients with acute or chronic renal failure after implementation of a more permissive contrast policy and determine whether any patients developed nephrogenic…

View details →DOI: 10.1016/j.acra.2026.05.017
Replication FailureMedicine

Evaluating Appropriateness of Interfacility Transfers for Patients with Facial Trauma Including Acute Orbital Floor Fractures.

Islam AM, Baldwin RB, Dyer BJ et al. · 2026 · Facial plastic surgery & aesthetic medicine

Background Patients with orbital floor fractures are frequently transferred between facilities for suspected clinical need, although many of these transfers may be unnecessary. Objective To compare the characteristics among patients with…

View details →DOI: 10.1177/26893614261441472
Replication FailureOpen accessMedicine

Absence of item origin bias on a Brazilian interinstitutional Progress Test examination: A pooled analysis of items approach.

Hamamoto Filho PT, Hafner MLMB, Ribeiro ZMT et al. · 2025 · PloS one

Background It has been proposed that the school origin of items for cross-institutional Progress Tests (PTs) may introduce a bias in favour of students from the same school, posing a potential threat to the validity and reliability of PT…

View details →DOI: 10.1371/journal.pone.0325734
Replication FailureMedicine

First Constraints on Nuclear Coupling of Axionlike Particles from the Binary Neutron Star Gravitational Wave Event GW170817.

Zhang J, Lyu Z, Huang J et al. · 2021 · Physical review letters

Light axion fields, if they exist, can be sourced by neutron stars due to their coupling to nuclear matter, and play a role in binary neutron star mergers. We report on a search for such axions by analyzing the gravitational waves from the…

View details →DOI: 10.1103/physrevlett.127.161101
Replication FailureOpen accessMedicine

Cognitive control training as an add-on treatment for late-life depression: A multicenter randomized controlled trial.

Vander Zwalmen Y, Vrijsen JN, Meuleman B et al. · 2026 · Internet interventions

Background Late-life depression (LLD) is a prevalent and debilitating condition associated with a poor long-term prognosis and high rates of chronicity. Cognitive control impairments are common in LLD and contribute to symptom persistence,…

View details →DOI: 10.1016/j.invent.2026.100951
Replication FailureOpen accessMedicine

Medication Review and Enhanced Information Transfer at Discharge of Older Patients with Polypharmacy: a Cluster-Randomized Controlled Trial in Swiss Hospitals.

Grischott T, Rachamin Y, Senn O et al. · 2023 · Journal of general internal medicine

Background Medication safety in patients with polypharmacy at transitions of care is a focus of the current Third WHO Global Patient Safety Challenge. Medication review and communication between health care professionals are key targets to…

View details →DOI: 10.1007/s11606-022-07728-6
Replication FailureOpen accessMedicine

The association between early-life nutrition and palatine tonsil grading in preschool children: a cross-sectional study.

Guo G, Yan W, Zhou R et al. · 2026 · Frontiers in nutrition

Background Early-life nutritional factors play a crucial role in child health, but their association with palatine tonsil grading is not well understood. This study aimed to investigate the relationship between early-life nutrition and…

View details →DOI: 10.3389/fnut.2026.1789543
Replication FailureOpen accessMedicine

Liposomal Bupivacaine versus Ropivacaine with Dexamethasone in Rectus Sheath Block for Laparoscopic Gastrectomy: A Randomized Controlled Trial.

Yi K, Zhan Y, Wei A et al. · 2026 · Drug design, development and therapy

Background The optimal analgesia regimen for patients undergoing laparoscopic gastrectomy is still unclear. This study evaluated the efficacy of ultrasound-guided rectus sheath block (RSB) with liposomal bupivacaine in providing sustained…

View details →DOI: 10.2147/dddt.s574724
Replication FailureOpen accessMedicine

Effects of Metformin on Cancer Survival Among Men Diagnosed with Advanced Prostate Cancer Treated with Androgen-Deprivation Therapy: Emulating a Target Trial.

Lopez DS, Polychronopoulou E, Abdelgadir O et al. · 2025 · Cancers

Background/Objectives: Metformin is one of the most frequently used concomitant medications among prostate cancer (PCa) patients. However, the effects of metformin on all-cause and PCa-specific mortality among men diagnosed with…

View details →DOI: 10.3390/cancers17213579
Replication FailureMedicine

A preliminary randomized trial of reinforcement contingencies to improve compliance with ecological momentary assessment.

Gass JC, Tonkin S, Maguin E et al. · 2024 · Translational behavioral medicine

Ecological Momentary Assessment (EMA) methods are increasingly used by translational scientists to study real-world behavior and experience. The ability to draw meaningful conclusions from EMA research depends upon participant compliance…

View details →DOI: 10.1093/tbm/ibad066
Replication FailureMedicine

Efficacy, Tolerability, and Safety of TRPC4/5 Inhibitor BI 1358894 in Patients With Major Depressive Disorder and Inadequate Response to Antidepressants: A Phase 2 Randomized, Placebo-Controlled, Parallel Group, Dose-Ranging Trial.

Shelton RC, Pizzagalli DA, Cohen EA et al. · 2025 · The Journal of clinical psychiatry

Objective: To assess proof-of-concept (PoC) for efficacy, tolerability, and safety of TRPC4/5 inhibitor BI 1358894 vs placebo in patients with major depressive disorder (MDD) with inadequate response to ongoing antidepressants. Methods: In…

View details →DOI: 10.4088/jcp.25m15868
Replication FailureOpen accessMedicine

Factors Associated With Loss of Fecal Biomarker Accuracy During Routine Assessment of Inflammatory Bowel Disease.

Kendall C, Swaminathan A, Borichevsky GM et al. · 2026 · JGH open : an open access journal of gastroenterology and hepatology

Background Fecal calprotectin (fCal) and fecal myeloperoxidase (fMPO) have been proposed as biomarkers for monitoring inflammatory bowel disease (IBD); however, their reliability is not fully established. This study investigated clinical…

View details →DOI: 10.1002/jgh3.70301