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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

403 results in Replication Failure · page 9 of 14

Replication FailureOpen accessMedicine

Prevalence and concomitance of diabetic peripheral sensory neuropathy and lower limb peripheral arterial disease in type II diabetics and its correlation with obesity.

Solanki JD, Shah AP, Lalwani N et al. · 2025 · Journal of family medicine and primary care

Introduction Among type 2 diabetics (T2D), macrovascular complication lower limb Peripheral Arterial Disease (PAD) and microvascular complication Diabetic Peripheral Sensory Neuropathy (DPSN) have scarcely studied concordance and their…

View details →DOI: 10.4103/jfmpc.jfmpc_1168_24
Replication FailureOpen accessMedicine

Lack of association between <i>MALAT1</i> rs591291 and rs3200401 polymorphisms and venous malformation risk in the Chinese pediatric population.

Lin X, Ou J, Wu G et al. · 2025 · Biochemistry and biophysics reports

Introduction Venous malformations are the most common congenital vascular anomaly, accounting for 65 % of all congenital vascular abnormalities. This study aims to investigate the correlation between genetic polymorphisms of MALAT1 and the…

View details →DOI: 10.1016/j.bbrep.2025.102209
Replication FailureOpen accessMedicine

Longitudinal Assessment of Area of Reticular Pseudodrusen in Eyes with Age-Related Macular Degeneration.

Velaga SB, Alagorie AR, Nittala MG et al. · 2025 · Ophthalmology science

Purpose To evaluate the change in the area of reticular pseudodrusen (RPD) and choroidal thickness over 2 years in eyes with age-related macular degeneration (AMD). Design Longitudinal cohort study. Subjects The study reviewed 1332 eyes…

View details →DOI: 10.1016/j.xops.2025.100881
Replication FailureMedicine

Impact of Vitamin D Supplementation on IVF Outcomes in Vitamin D-Deficient Poor Responders: a Randomized Controlled Trial.

Mirsharifi MS, Shirdel S, Ghaderi E et al. · 2026 · Reproductive sciences (Thousand Oaks, Calif.)

OBJECTIVE: This study aimed to evaluate the effect of vitamin D supplementation on in vitro fertilization (IVF) outcomes in poor responder women with vitamin D deficiency, focusing on fertilization rates, oocyte quality, and pregnancy…

View details →DOI: 10.1007/s43032-025-02022-2
Replication FailureMedicine

Partial rebreathing is not effective for early treatment of migraine with aura attacks: Results of a double-blind, randomized, controlled trial (PAREMA1).

Gaul C, Ferreira S, Johansen T · 2026 · Headache

Objective Evaluate the efficacy and safety of a novel partial rebreathing device for early treatment of acute attacks of migraine with aura. Background Earlier clinical studies have indicated a potential for CO 2 -enriched gas to be…

View details →DOI: 10.1111/head.15090
Replication FailureMedicine

Association between cognitive adverse effects of anticholinergic medication and development of dementia in Parkinson's disease.

Ha SH, Kim S, Lee S et al. · 2026 · Parkinsonism & related disorders

Introduction Approximately one-third of patients with Parkinson's disease (PD) develop dementia, and anticholinergic use has been implicated as a risk factor, particularly with prolonged exposure. This study examined whether short-term…

View details →DOI: 10.1016/j.parkreldis.2025.108136
Replication FailureOpen accessMedicine

Lack of effect of a parent-delivered early language intervention: Evidence from a randomised controlled trial completed during COVID-19.

Burgoyne K, Hargreaves S, Akhter N et al. · 2025 · JCPP advances

Background Parents play a key role in their child's early development but evidence that parental engagement strategies are effective is unclear. The current study evaluated a parent-delivered early language teaching programme that aimed to…

View details →DOI: 10.1002/jcv2.12279
Replication Failure

Perceived Psychological Stress and Fecundability among Women Planning Pregnancy: Evidence from a Large Preconception Cohort Study from China

Lan T, Ming J, Liu J et al. · 2026 · Preprint

Objective: Evidence on the stress–fecundability relationship is mixed, and both the population heterogeneity and the effects of moderate stress remain understudied. We aimed to investigate the association of stress with fecundability in…

View details →DOI: 10.22541/au.177095736.68250416/v1
Replication FailureMedicine

UGT76B1 and 41 Additional Arabidopsis UDP-Glycosyltransferases Show No Detectable In Vitro Glycosylation Activity Toward <i>N</i>-Hydroxypipecolic Acid.

Bao J, Uchiyama T, Kusunoki K et al. · 2026 · Life (Basel, Switzerland)

N -hydroxypipecolic acid (NHP) is a key mobile signal in systemic acquired resistance in plants, and its glycosylation has been proposed to regulate immune signaling. Previous studies have demonstrated that the UDP-glycosyltransferase…

View details →DOI: 10.3390/life16060992
Replication FailureMedicine

Consistent Efficacy of Vutrisiran Across Sexes in Transthyretin Cardiac Amyloidosis: Evidence from the HELIOS-B Trial.

Mansell J, Wang X, Jering KS et al. · 2026 · European journal of heart failure

Sex differences in transthyretin cardiac amyloidosis (ATTR-CM) are increasingly recognised; however, women are underrepresented in trials and sex-specific treatment effects remain incompletely understood. We evaluated sex differences in…

View details →DOI: 10.1093/ejhf/xuag208
Replication FailureOpen accessMedicine

Platelet desialylation, apoptosis, and T-lymphocyte-mediated immune dysregulation: unveiling the pathways of platelet clearance in platelet transfusion refractoriness.

Zhou Y, Zhong Z, Mo H et al. · 2026 · Research and practice in thrombosis and haemostasis

Background Platelet transfusion refractoriness (PTR) is a clinical challenge that can be classified into nonimmunologic and immunologic types, the latter resulting from both platelet alloimmunization and autoimmunity. Recent studies have…

View details →DOI: 10.1016/j.rpth.2026.103395
Replication FailureOpen accessMedicine

Searching for vertically transmitted endosymbionts in over 4,000 wild strains of three self-fertilizing <i>Caenorhabditis</i> species.

O'Connor LM, Singh A, Luallen RJ et al. · 2026 · microPublication biology

Vertically transmitted endosymbionts are microbes that live inside host cells and are transmitted between parent and offspring. Free-living nematodes interact with a wide variety of microbes but no vertically transmitted microbes have been…

View details →DOI: 10.17912/micropub.biology.002151
Replication FailureMedicine

Procedure-Specific Efficacy of Tranexamic Acid in Breast Surgery: A Propensity-Score Adjusted Analysis of 5,202 Procedures.

Friedman O, Maiershon D, Paniri Y et al. · 2026 · Plastic and reconstructive surgery

Background Hematoma remains a major complication following breast surgery. While tranexamic acid (TXA) efficacy is established in reduction mammaplasty, its utility across other breast procedures remains unclear. Methods This retrospective…

View details →DOI: 10.1097/prs.0000000000013206
Replication FailureMedicine

Balancing the Game: The Relationship of Lower-Limb Asymmetry With Youth Soccer (Football) Performance - Laboratory vs. Field Insights.

Bartusevičius D, Stanislovaitienė J, Conte D · 2026 · Journal of strength and conditioning research

Abstract Bartusevičius, D, Stanislovaitienė, J, and Conte, D. Balancing the game: the relationship of lower-limb asymmetry with youth soccer (football) performance - laboratory vs. field insights. J Strength Cond Res XX(X): 000-000,…

View details →DOI: 10.1519/jsc.0000000000005570
Replication FailureMedicine

Association between hemoglobin, albumin, lymphocyte, and platelet (HALP) score and rheumatoid arthritis: A cross-sectional study from NHANES 1999-2018.

Yang, Xu, Liu et al. · 2026 · Medicine

The hemoglobin, albumin, lymphocyte, and platelet (HALP) score is a potential composite biomarker that integrates nutritional and immune-inflammatory profiles. However, its association with rheumatoid arthritis (RA) prevalence remains…

View details →DOI: 10.1097/md.0000000000049349
Replication FailureMedicine

The use of a smartphone application to influence the Knowledge, Attitude, and Practice (KAP) of patients towards a better glaucoma medication compliance.

Tsoi, Zhu, Wong et al. · 2026 · Health education research

Glaucoma is a chronic eye disease that requires consistent and timely eye drop medication management. However, suboptimal treatment outcomes of glaucoma patients were attributed to poor medication compliance. To address this problem, the…

View details →DOI: 10.1093/her/cyaf051
Replication FailureOpen accessNutritional diseases. Deficiency diseases

Sex-specific associations between type 2 diabetes and muscle health in middle-aged adults

Yijia Wang, Songting Gao, Qiang Xu et al. · 2025 · Diabetology & Metabolic Syndrome

Abstract Background Type 2 diabetes mellitus (T2DM) and sarcopenia have emerged as significant public health challenges that disproportionately affect middle-aged adults. However, the relationship between T2DM and muscle parameters in this critical age remains inadequately elucidated. Methods We conducted a comprehensive analysis of cross-sectional data derived from 2,446 middle-aged participants (aged 40–59 years; 1,230 men and 1,216 women) enrolled in the National Health and Nutrition Examination Survey (NHANES) 2011–2014. T2DM was defined by physician-confirmed diagnosis and/or glycohemoglo

View details →DOI: 10.1186/s13098-025-01963-7
Replication FailureOpen accessInternal medicine

Correlation between Vitamin D Receptor Gene FOKI and BSMI Polymorphisms and the Susceptibility to Pulmonary Tuberculosis in an Indonesian Batak-ethnic Population

Bintang Y.M. Sinaga, Muhammad Amin, Yahwardiah Siregar et al. · 2014 · Acta Medica Indonesiana

Aim: to explore the role of FokI and BsmI polymorphisms the VDR gene in the susceptibility to pulmonary tuberculosis (PTB) in an Indonesian Batak ethnic population. Methods: matched case-control study was conducted on 76 PTB patients and 76 healthy normal control. Genetic polymorphisms of Vitamin D Receptor (VDR) gene were analysed using PCR-RFLP. Results: the frequencies of FokI genotypes were FF 35.5%, Ff 55.3%, ff 9.2% for PTB patients and FF 39.5%, Ff 44.7.% and ff 15.8% for normal control. The BsmI genotypes frequencies were BB 0%, Bb 68.4%, bb 31.6% for TB patients and BB 2.6%, Bb 23.7%

Replication Failure

PENGARUH PENDIDIKAN KARYAWAN DAN PELATIHAN KARYAWAN TERHADAP KUALITAS KERJA KARYAWAN (Studi Kasus Karyawan PT. Anugrah Mandiri Sejaterah

Anisatul Fauziah · 2023 · SIGNIFICANT : Journal Of Research And Multidisciplinary

Persaingan dalam lingkungan kerja saat ini semakin ketat, ini menuntut perusahaan terus menerus mengembangkan usahanya untuk dapat bersaing dengan perusahaan lain. Oleh karena itu dibutuhkan pengelola manajemen perusahaan yang biasa…

View details →DOI: 10.62668/significant.v2i02.863
Replication FailureOpen access

Effect of feeding low protein diets supplemented with selected essential amino acids on growth performance and gut health in early weaned Large White Yorkshire piglets

N. Mohan, M. Dipu, K. Ally et al. · 2023 · Journal of Veterinary and Animal Sciences

A study was conducted to assess the effect of feeding low protein diets supplemented with selected amino acids on growth performance and gut health in early weaned Large White Yorkshire piglets. Thirty Large White Yorkshire female piglets…

View details →DOI: 10.51966/jvas.2023.54.2.537-543